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Volumn 36, Issue 3, 2016, Pages 1649-1657

Involvement of endoplasmic reticulum stress and p53 in lncRNA MEG3-induced human hepatoma HepG2 cell apoptosis

Author keywords

Apoptosis; Caspase 3; Endoplasmic reticulum stress; Hepatocelluar carcinoma; LnCRNA MEG3; NF KB; P53

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; CASPASE 3; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LENTIVIRUS VECTOR; LONG UNTRANSLATED RNA; PROTEIN IRE1; PROTEIN KINASE; PROTEIN P53; RNA DEPENDENT PROTEIN KINASE LIKE ER KINASE; UNCLASSIFIED DRUG; MEG3 NON-CODING RNA, HUMAN;

EID: 84980410110     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2016.4919     Document Type: Article
Times cited : (49)

References (32)
  • 1
    • 79957840356 scopus 로고    scopus 로고
    • Long noncoding RNAs and human disease
    • Wapinski O and Chang HY: Long noncoding RNAs and human disease. Trends Cell Biol 21: 354-361, 2011.
    • (2011) Trends Cell Biol , vol.21 , pp. 354-361
    • Wapinski, O.1    Chang, H.Y.2
  • 2
    • 84859561616 scopus 로고    scopus 로고
    • Overexpression of the long non-coding RNA MEG3 impairs in vitro glioma cell proliferation
    • Wang P, Ren Z and Sun P: Overexpression of the long non-coding RNA MEG3 impairs in vitro glioma cell proliferation. J Cell Biochem 113: 1868-1874, 2012.
    • (2012) J Cell Biochem , vol.113 , pp. 1868-1874
    • Wang, P.1    Ren, Z.2    Sun, P.3
  • 3
    • 84939415873 scopus 로고    scopus 로고
    • Expression of the long non-coding RNAs MEG3, HOTAIR, and MALAT-1 in non-functioning pituitary adenomas and their relationship to tumor behavior
    • Li Z, Li C, Liu C, Yu S and Zhang Y: Expression of the long non-coding RNAs MEG3, HOTAIR, and MALAT-1 in non-functioning pituitary adenomas and their relationship to tumor behavior. Pituitary 18: 42-47, 2015.
    • (2015) Pituitary , vol.18 , pp. 42-47
    • Li, Z.1    Li, C.2    Liu, C.3    Yu, S.4    Zhang, Y.5
  • 5
    • 84861156701 scopus 로고    scopus 로고
    • MEG3 noncoding RNA: A tumor suppressor
    • Zhou Y, Zhang X and Klibanski A: MEG3 noncoding RNA: A tumor suppressor. J Mol Endocrinol 48: R45-R53, 2012.
    • (2012) J Mol Endocrinol , vol.48 , pp. R45-R53
    • Zhou, Y.1    Zhang, X.2    Klibanski, A.3
  • 7
    • 84885015533 scopus 로고    scopus 로고
    • Long non-coding RNA MEG3 inhibits NSCLC cells proliferation and induces apoptosis by affecting p53 expression
    • Lu KH, Li W, Liu XH, Sun M, Zhang ML, Wu WQ, Xie WP and Hou YY: Long non-coding RNA MEG3 inhibits NSCLC cells proliferation and induces apoptosis by affecting p53 expression. BMC Cancer 13: 461, 2013.
    • (2013) BMC Cancer , vol.13 , pp. 461
    • Lu, K.H.1    Li, W.2    Liu, X.H.3    Sun, M.4    Zhang, M.L.5    Wu, W.Q.6    Xie, W.P.7    Hou, Y.Y.8
  • 9
    • 77950193818 scopus 로고    scopus 로고
    • Maternally expressed gene 3, an imprinted noncoding RNA gene, is associated with meningioma pathogenesis and progression
    • Zhang X, Gejman R, Mahta A, Zhong Y, Rice KA, Zhou Y, Cheunsuchon P, Louis DN and Klibanski A: Maternally expressed gene 3, an imprinted noncoding RNA gene, is associated with meningioma pathogenesis and progression. Cancer Res 70: 2350-2358, 2010.
    • (2010) Cancer Res , vol.70 , pp. 2350-2358
    • Zhang, X.1    Gejman, R.2    Mahta, A.3    Zhong, Y.4    Rice, K.A.5    Zhou, Y.6    Cheunsuchon, P.7    Louis, D.N.8    Klibanski, A.9
  • 11
    • 43249109174 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress responses
    • Schröder M: Endoplasmic reticulum stress responses. Cell Mol Life Sci 65: 862-894, 2008.
    • (2008) Cell Mol Life Sci , vol.65 , pp. 862-894
    • Schröder, M.1
  • 12
    • 79955814847 scopus 로고    scopus 로고
    • Involvement of endoplasmic reticulum stress in adenosine-induced human hepatoma HepG2 cell apoptosis
    • Wu LF, Ye YQ, Huang GY, Li HB, Li GP, Pu ZJ, Wei BL and Feng JL: Involvement of endoplasmic reticulum stress in adenosine-induced human hepatoma HepG2 cell apoptosis. Oncol Rep 26: 73-79, 2011.
    • (2011) Oncol Rep , vol.26 , pp. 73-79
    • Wu, L.F.1    Ye, Y.Q.2    Huang, G.Y.3    Li, H.B.4    Li, G.P.5    Pu, Z.J.6    Wei, B.L.7    Feng, J.L.8
  • 14
    • 84891798869 scopus 로고    scopus 로고
    • Enhanced antitumor effects of adenoviral-mediated siRNA against GRP78 gene on adenosine-induced apoptosis in human hepatoma HepG2 cells
    • Wu LF, Guo YT, Zhang QH, Xiang MQ, Deng W, Ye YQ, Pu ZJ, Feng JL and Huang GY: Enhanced antitumor effects of adenoviral-mediated siRNA against GRP78 gene on adenosine-induced apoptosis in human hepatoma HepG2 cells. Int J Mol Sci 15: 525-544, 2014.
    • (2014) Int J Mol Sci , vol.15 , pp. 525-544
    • Wu, L.F.1    Guo, Y.T.2    Zhang, Q.H.3    Xiang, M.Q.4    Deng, W.5    Ye, Y.Q.6    Pu, Z.J.7    Feng, J.L.8    Huang, G.Y.9
  • 16
    • 0034610743 scopus 로고    scopus 로고
    • Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta
    • Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA and Yuan J: Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 403: 98-103, 2000.
    • (2000) Nature , vol.403 , pp. 98-103
    • Nakagawa, T.1    Zhu, H.2    Morishima, N.3    Li, E.4    Xu, J.5    Yankner, B.A.6    Yuan, J.7
  • 17
    • 0034723235 scopus 로고    scopus 로고
    • Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
    • Urano F, Wang X, Bertolotti A, Zhang Y, Chung P, Harding HP and Ron D: Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 287: 664-666, 2000.
    • (2000) Science , vol.287 , pp. 664-666
    • Urano, F.1    Wang, X.2    Bertolotti, A.3    Zhang, Y.4    Chung, P.5    Harding, H.P.6    Ron, D.7
  • 19
    • 84889566398 scopus 로고    scopus 로고
    • Zebularine inhibits tumorigenesis and stemness of colorectal cancer via p53-dependent endoplasmic reticulum stress
    • Yang PM, Lin YT, Shun CT, Lin SH, Wei TT, Chuang SH, Wu MS and Chen CC: Zebularine inhibits tumorigenesis and stemness of colorectal cancer via p53-dependent endoplasmic reticulum stress. Sci Rep 3: 3219, 2013.
    • (2013) Sci Rep , vol.3 , pp. 3219
    • Yang, P.M.1    Lin, Y.T.2    Shun, C.T.3    Lin, S.H.4    Wei, T.T.5    Chuang, S.H.6    Wu, M.S.7    Chen, C.C.8
  • 20
    • 77954326944 scopus 로고    scopus 로고
    • NC3Rs reporting guidelines working group: Animal research: Reporting in vivo experiments: The ARRIVE guidelines
    • Kilkenny C, Browne W, Cuthill IC, Emerson M and Altman DG; NC3Rs Reporting Guidelines Working Group: Animal research: Reporting in vivo experiments: The ARRIVE guidelines. Br J Pharmacol 160: 1577-1579, 2010.
    • (2010) Br J Pharmacol , vol.160 , pp. 1577-1579
    • Kilkenny, C.1    Browne, W.2    Cuthill, I.C.3    Emerson, M.4    Altman, D.G.5
  • 21
    • 15944366885 scopus 로고    scopus 로고
    • The ER chaperone and signaling regulator GRP78/BiP as a monitor of endoplasmic reticulum stress
    • Lee AS: The ER chaperone and signaling regulator GRP78/BiP as a monitor of endoplasmic reticulum stress. Methods 35: 373-381, 2005.
    • (2005) Methods , vol.35 , pp. 373-381
    • Lee, A.S.1
  • 23
    • 0028167599 scopus 로고
    • NF-kappa B activation of p53. A potential mechanism for suppressing cell growth in response to stress
    • Wu H and Lozano G: NF-kappa B activation of p53. A potential mechanism for suppressing cell growth in response to stress. J Biol Chem 269: 20067-20074, 1994.
    • (1994) J Biol Chem , vol.269 , pp. 20067-20074
    • Wu, H.1    Lozano, G.2
  • 24
    • 0029813256 scopus 로고    scopus 로고
    • YY1 and NF1 both activate the human p53 promoter by alternatively binding to a composite element, and YY1 and E1A cooperate to amplify p53 promoter activity
    • Furlong EE, Rein T and Martin F: YY1 and NF1 both activate the human p53 promoter by alternatively binding to a composite element, and YY1 and E1A cooperate to amplify p53 promoter activity. Mol Cell Biol 16: 5933-5945, 1996.
    • (1996) Mol Cell Biol , vol.16 , pp. 5933-5945
    • Furlong, E.E.1    Rein, T.2    Martin, F.3
  • 25
    • 78751556358 scopus 로고    scopus 로고
    • Control of NF-κB and inflammation by the unfolded protein response
    • Kitamura M: Control of NF-κB and inflammation by the unfolded protein response. Int Rev Immunol 30: 4-15, 2011.
    • (2011) Int Rev Immunol , vol.30 , pp. 4-15
    • Kitamura, M.1
  • 26
    • 1442321303 scopus 로고    scopus 로고
    • Activation signal of nuclear factor-kappa B in response to endoplasmic reticulum stress is transduced via IRE1 and tumor necrosis factor receptor-associated factor 2
    • Kaneko M, Niinuma Y and Nomura Y: Activation signal of nuclear factor-kappa B in response to endoplasmic reticulum stress is transduced via IRE1 and tumor necrosis factor receptor-associated factor 2. Biol Pharm Bull 26: 931-935, 2003.
    • (2003) Biol Pharm Bull , vol.26 , pp. 931-935
    • Kaneko, M.1    Niinuma, Y.2    Nomura, Y.3
  • 27
    • 0043133837 scopus 로고    scopus 로고
    • Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses
    • Jiang HY, Wek SA, McGrath BC, Scheuner D, Kaufman RJ, Cavener DR and Wek RC: Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses. Mol Cell Biol 23: 5651-5663, 2003.
    • (2003) Mol Cell Biol , vol.23 , pp. 5651-5663
    • Jiang, H.Y.1    Wek, S.A.2    McGrath, B.C.3    Scheuner, D.4    Kaufman, R.J.5    Cavener, D.R.6    Wek, R.C.7
  • 29
    • 84948672332 scopus 로고    scopus 로고
    • Long noncoding RNA MEG3 interacts with p53 protein and regulates partial p53 target genes in hepatoma cells
    • Zhu J, Liu S, Ye F, Shen Y, Tie Y, Zhu J, Wei L, Jin Y, Fu H, Wu Y, et al: Long noncoding RNA MEG3 interacts with p53 protein and regulates partial p53 target genes in hepatoma cells. PLoS One 10: e0139790, 2015.
    • (2015) PLoS One , vol.10
    • Zhu, J.1    Liu, S.2    Ye, F.3    Shen, Y.4    Tie, Y.5    Zhu, J.6    Wei, L.7    Jin, Y.8    Fu, H.9    Wu, Y.10
  • 31
    • 41549158258 scopus 로고    scopus 로고
    • The ubiquitin-proteasome pathway and enhanced activity of NF-kappaB in gastric carcinoma
    • Wu L, Pu Z, Feng J, Li G, Zheng Z and Shen W: The ubiquitin-proteasome pathway and enhanced activity of NF-kappaB in gastric carcinoma. J Surg Oncol 97: 439-444, 2008.
    • (2008) J Surg Oncol , vol.97 , pp. 439-444
    • Wu, L.1    Pu, Z.2    Feng, J.3    Li, G.4    Zheng, Z.5    Shen, W.6
  • 32
    • 77954925223 scopus 로고    scopus 로고
    • Involvement of NF-kappaB activation in the apoptosis induced by extracellular adenosine in human hepatocellular carcinoma HepG2 cells
    • Wu LF, Li GP, Su JD, Pu ZJ, Feng JL, Ye YQ and Wei BL: Involvement of NF-kappaB activation in the apoptosis induced by extracellular adenosine in human hepatocellular carcinoma HepG2 cells. Biochem Cell Biol 88: 705-714, 2010.
    • (2010) Biochem Cell Biol , vol.88 , pp. 705-714
    • Wu, L.F.1    Li, G.P.2    Su, J.D.3    Pu, Z.J.4    Feng, J.L.5    Ye, Y.Q.6    Wei, B.L.7


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