YY1 and NF1 both activate the human p53 promoter by alternatively binding to a composite element, and YY1 and E1A cooperate to amplify p53 promoter activity

Molecular and Cellular Biology

Volumn 16, Issue 10, 1996, Pages 5933-5945

  Furlong, Eileen E M ^a   Rein, Theo ^b   Martin, Finian ^a  

^a UNIVERSITY COLLEGE DUBLIN   (Ireland)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MUTANT PROTEIN; NUCLEAR FACTOR I; PROTEIN P53; TRANSCRIPTION FACTOR; ZINC FINGER PROTEIN;

ARTICLE; DNA REPAIR; GENE MUTATION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HELA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; TISSUE SPECIFICITY; TRANSCRIPTION INITIATION; TUMOR SUPPRESSOR GENE;

TRIXIS;

EID: 0029813256     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.10.5933     Document Type: Article

References (69)

1. Almon, E., N. Goldfinger, A. Kapon, D. Schwartz, A. Levine, and V. Rotter. 1993. Testicular tissue-specific expression of the p53 suppressor gene. Dev. Biol. 156:107-116.
2. Andrews, N. C., and D. F. Faller. 1991. A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells. Nucleic Acids Res. 19:2499.
3. Apt, D., Y. Liu, and H.-U. Bernard. 1994. Cloning and functional analysis of spliced isoforms of human nuclear factor 1-X: interference with transcriptional activation by NF1/CTF in a cell-type specific manner. Nucleic Acids Res. 22:3825-3833.
4. Ausubel, F. A., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl (ed.). 1987. Current protocols in molecular biology, vol. 1 and 2. Greene Publishing Associates and John Wiley and Sons, Boston.
5. Barak, Y., T. Juven, R. Haffner, and M. Oren. 1993. mdm2 expression is induced by wild type p53 activity. EMBO J. 12:461-468.
6. Bauknecht, T., F. Jundt, I. Herr, T. Oehler, H. Delius, Y. Shi, P. Angel, and H. zur Hausen. 1995. A switch region determines the cell type-specific positive or negative action of YY1 on the activity of the human papillomavirus type 18 promoter. J. Virol. 69:1-12.
7. Bienz-Tadmor, B., R. Zakut-Houri, S. Libresco, D. Givol, and M. Oren. 1985. The 5′ region of the p53 gene: evolutionary conservation and evidence for a negative regulatory element. EMBO J. 4:3209-3213.
8. Borgmeyer, U., J. Nowock, and A. E. Sippel. 1984. The TGGCA-binding protein: eukaryotic nuclear protein recognizing a symmetrical sequence on double-stranded linear DNA. Nucleic Acids Res. 12:4295-4311.
9. Braithwaite, A., C. Nelson, A. Skulimowski, J. McGovern, D. Pigott, and J. Jenkins. 1990. Transactivation of the p53 oncogene by E1A gene products. Virology 177:595-605.
10. Deffie, A., H. Wu, V. Reinke, and G. Lozano. 1993. The tumor suppressor p53 regulates its own transcription. Mol. Cell. Biol. 13:3415-3423.
11. Dittmer, D., S. Pati, G. Zambetti, S. Chu, A. K. Teresky, M. Moore, C. Finlay, and A. J. Levine. 1993. Gain of function mutations in p53. Nat. Genet. 4:42-46.
12. El-Deiry, W. S., T. Tokino, V. E. Velculescu, D. B. Levy, R. T. Parsons, J. M. Trent, D. Lin, W. E. Mercer, K. W. Kinzler, and B. Vogelstein. 1993. WAF1, a potential mediator of p53 tumor suppression. Cell 75:817-825.
13. Ephrussi, A., G. M. Church, S. Tonegawa, and W. Gilbert. 1985. B lineage-specific interactions of an immunoglobulin enhancer with cellular factors in vivo. Science 227:134-140.
14. Farnham, P. J., and A. L. Means. 1990. Sequences downstream of the transcription initiation site modulate the activity of the murine dihydrofolate reductase promoter. Mol. Cell. Biol. 10:1390-1398.
15. Field, S., and S. K. Jang. 1990. Presence of a potent transcription activating sequence in the p53 protein. Science 249:1046-1049.
16. Frain, M., G. Swart, P. Monaci, A. Nicosia, S. Stämpfli, R. Frank, and R. Cortese. 1989. The liver-specific transcription factor LF-B1 contains a highly diverged homeobox DNA binding domain. Cell 59:145-157.
17. Gedrich, R. W., and D. A. Engel. 1995. Identification of a novel E1A response element in the mouse c-fos promoter. J. Virol. 69:2333-2340.
18. Ginsberg, D., M. Oren, M. Yaniv, and J. Piette. 1990. Protein-binding elements in the promoter region of the mouse p53 gene. Oncogene 5:1285-1290.
19. Gualberlo, A., D. LePage, G, Pons, S. L. Mader, K. Park, M. L. Atchison, and K. Walsh. 1992. Functional antagonism between YY1 and the scrum response factor. Mol. Cell. Biol. 12:4209-4214.
20. Hariharan, N., D. E. Kelley, and R. P. Perry. 1991. δ, a transcription factor that binds to downstream elements in several polymerase II promoters, is a functionally versatile zinc finger protein. Proc. Natl. Acad. Sci. USA 88: 9799-9803.
21. Haupt, Y., S. Rowan, E. Shaulian, K. H. Vousden, and M. Oren. 1995. Induction of apoptosis in HeLa cells by trans-activation-deficient p53. Genes Dev. 9:2170-2183.
22. Hay, R. T. 1985. The origin of adenovirus DNA replication: minimal DNA sequence requirement in vivo. EMBO J. 4:421-426.
23. Hiebert, S. W., M. Lipp, and J. R. Nevins. 1989. E1A-dependent trans-activation of the human MYC promoter is mediated by the E2F factor. Proc. Natl. Acad. Sci. USA 86:3594-3598.
24. Hyde-DeRuyscher, R. P., E. Jennings, and T. Shenk. 1995 DNA binding sites for the transcriptional activator/repressor YY1. Nucleic Acids Res. 23:4457-4465.
25. Jackson, D. A., K. E. Rowader, K. Stevens, C. Jiang, P. Milos, and K. S. Zaret. 1993. Modulation of liver-specific transcription by interactions between hepatocyte nuclear factor 3 and nuclear factor 1 binding DNA in close apposition. Mol. Cell. Biol. 13:2401-2410.
26. Kawamura, H., K. Nagata, Y. Masamune, and Y. Nakanishi. 1993. Phosphorylation of NF1 in vitro by cdc2 kinase. Biochem. Biophys. Res. Commun. 192:1424-1431.
27. Kawasaki, T., Y. Tomita, R. Watanabe, T. Tanikawa, T. kumanishi, and S. Sato. 1994. mRNA and protein expression of p53 mutations in human bladder cancer cell lines. Cancer Lett. 82:113-121.
28. Kley, N., R. Y. Chung, S. Fay, J. P. Loeffler, and B. R. Seizinger. 1992. Repression of the basal c-fos promoter by wild-type p53. Nucleic Acids Res. 220:4083-4087.
29. Kouzarides, T. 1995. Functions of pRb and p53: what's the connection? Trends Cell Biol. 5:448-450.
30. Kuipers, O. P., H. J. Boot, and W. M. De Vas. 1991. Improved site-directed mutagenesis method using PCR. Nucleic Acids Res. 19:4558-4560.
31. Lane, D. P. 1992. p53, guardian of the genome. Nature (London) 358:15-16.
32. Lee, J.-S., K. M. Galvin, R. H. See, R. Eckner, D. Livingston, E. Moran, and Y. Shi. 1995. Relief of YY1 transcriptional repression by adenovirus E1A is mediated hy E1A-associated protein p300. Genes Dev. 9:1188-1198.
33. Lee, J.-S., R. H. See, K. M. Galvin, J. Wang, and Y. Shi. 1995. Functional interactions between YY1 and adenovirus E1A. Nucleic Acids Res. 23:925-931.
34. Lee, T.-C., K.-L. Chow, P. Fang, and R. J. Schwartz. 1991. Activation of skeletal α-actin gene transcription: the cooperative formation of scrum response factor-binding complexes over positive cis-acting promoter serum response elements displaces a negative-acting nuclear factor enriched in replicating myoblasts and nonmyogenic cells. Mol. Cell Biol, 11:5090-5100.
35. Lewis, B. A., G. Tullis, E. Seto, N. Horikoshi, R. Weinmann, and T. Shenk. 1995. Adenovirus E1A proteins interact with the cellular YY1 transcription factor. J. Virol. 69:1628-1636.
36. Lu, S.-Y., M. Rodriguez, and W. S.-L. Liao. 1994. YY1 represses rat serum amyloid A1 gene transcription and is antagonized by NF-κB during acute-phase response. Mol. Cell. Biol. 14:6253-6263.
37. Marx, J. 1994. New link found between p53 and DNA repair. Science 266:1321-1322.
38. McKnight, S. L., and R. Kingsbury. 1982. Transcriptional control signals of a eukaryotic protein-coding gene. Science 217:316-324.
39. Meier, V. S., and B. Groner. 1994. The nuclear factor YY1 participates in repression of the β-casein gene promoter in mammary epithelial cells and is counteracted by mammary gland factor during lactogenic hormone induction. Mol. Cell. Biol. 14:128-137.
40. Morgan, W. D., G. T. Williams, R. I. Morimoto, J. Greene, R. E. Kingston, and R. Tjian. 1987. Two transcriptional activators, CCAAT-box-binding transcription factor and heat shock transcription factor, interact with a human hsp70 gene promoter. Mol. Cell. Biol. 7:1129-1138.
41. Morris, G. F., and M. B. Mathews. 1991. The adenovirus E1A transforming protein activates the proliferating cell nuclear antigen promoter via an activating transcription factor site. J. Virol. 65:6397-6406.
42. Mul, Y. M., and P. C. Van der Vilet. 1992. Nuclear factor 1 enhances adenovirus DNA replication by increasing the stability of a preinitiation complex. EMBO J. 11:751-760.
43. Nagata, K., R. A. Guggenheimer, and J. Hurwitz. 1983. Specific binding of a cellular DNA replication protein to the origin of replication of adenovirus DNA. Proc. Natl. Acad. Sci. USA 80:6177-6181.
44. Natesan, S., and M. Z. Gilman. 1993. DNA bending and orientation-dependent function of YY1 in the c-fos promoter. Genes Dev. 7:2497-2509.
45. Novak, A., N. Goyal, and R. M. Gronostajski. 1992. Four conserved cysteine residues are required for the DNA binding activity of nuclear factor 1. J. Biol. Chem. 267:12986-12990.
46. Park, K., and M. L. Atchison. 1991. Isolation of a candidate repressor/ activator, NF-E1 (YY-1, δ), that binds to the immunoglobulin κ 3′ enhancer and the immunoglobulin heavy-chain niE1 site. Proc. Natl. Acad. Sci. USA 88:9804-9808.
47. Pavletich, N. P., and C. O. Pabo. 1993. Crystal structure of a five-finger GLI-DNA complex: new perspectivies on zinc fingers. Science 261:1701-1707.
48. Rein, T., R. Forster, A. Krause, E. L. Winnacker, and H. Zorbas. 1995. Organization of the alpha-globin promoter and possible role for nuclear factor 1 in an alpha-globin-inducible and noninducible cell line. J. Biol. Chem. 270:19643-19650.
49. Reisman, D., and V. Rotter. 1993. The helix-loop-helix containing transcription factor USF binds to and transactivates the promoter of the p53 tumor suppressor gene. Nucleic Acids Res. 21:345-350.
50. Riggs, K. J., S. Saleque, K. K. Wong, K. T. Merrell, J. S. Lee, Y. Shi, and K. Calame. 1993. Yin-yang 1 activates the c-myc promoter. Mol. Cell. Biol. 13:7487-7495.
51. Robidoux, S., P. Gosselin, M. Harvey, S. Leclerc, and S. L. Guérin. 1992. Transcription of the mouse secretory protease inhibitor p12 gene is activated by the developmentally regulated positive transcription factor Sp1. Mol. Cell. Biol. 12:3796-3806.
52. Rosenthal, N. 1987. Identification of regulatory elements of cloned genes with functional assays. Methods Enzymol. 152:704-720.
53. Rosselli, F., A. Ridet, T. Soussi, E. Duchaud, C. Alapetite, and E. Moustacchi. 1995. p53-dependent pathway of radio-induced apoptosis is altered in Fancomi anemia. Oncogene 10:9-17.
54. Rotter, V., D. Schwartz, E. Almon, N. Goldfinger, A. Kapon, A. Meshorer, L. A. Donehower, and A. J. Levine. 1993. Mice with reduced levels of p53 protein exhibit the testicular giant-cell degenerative syndrome. Proc. Natl. Acad. Sci. USA 90:9075-9079.
55. Roy, B., J. Beamon, E. Balint, and D. Reisman. 1994. Transactivation of the human p53 tumor suppressor gene by c-Myc/Max contributes to elevated mutant p53 expression in some tumors. Mol. Cell. Biol. 14:7805-7815.
56. Seto, E., Y. Shi, and T. Shenk. 1991. YY1 is an initiator sequence-binding protein that directs and activates transcription in vitro. Nature (London) 354:241-245.
57. Shi, Y., E. Seto, L.-S. Chang, and T. Shenk. 1991. Transcriptional repression by YY1, a human GL1-Krüppel-related protein, and relief of repression by adenovirus E1A protein. Cell 67:377-388.
58. Shiio, Y., T. Yamamoto, and N. Yamaguchi. 1992. Negative regulation of Rb expression by the p53 gene product. Proc. Natl. Acad. Sci. USA 89:5206-5210.
59. Shrivastava, A., and K. Calame. 1994. An analysis of genes regulated by the multifunctional transcriptional regulator Yin Yang-1. Nucleic Acids Res. 22:5151-5155.
60. Stuart, E. T., R. Haffner, M. Oren, and P. Gruss. 1995. Loss of p53 function through PAX-mediated transcriptional repression. EMBO J. 14:5638-5645.
61. Sun, X., H. Shimizu, and K.-I. Yamamoto. 1995. Identification of a novel p53 promoter element involved in genotoxic stress-inducible p53 gene expression. Mol. Cell. Biol. 15:4489-4496.
62. Tuck, S. P., and L. Crawford. 1989. Characterization of the human p53 gene promoter. Mol. Cell. Biol. 9:2163-2172.
63. Uittenbogaard, M. N., H. A. Giebler, D. Reisman, and J. K. Nyborg. 1995. Transcriptional repression of p53 by human T-cell leukemia virus type I Tax protein. J. Biol. Chem. 270:28503-28506.
64. Waston, C. J., K. E. Gordon, M. Robertson, and J. A. Clark. 1991. Interaction of DNA-binding proteins with a milk protein gene promoter in vitro: identification of a mammary gland-specific factor. Nucleic Acids Res. 19: 6603-6610.
65. Wigler, M., R. Sweet, G. K. Sim, B. Wold, A. Pellicer, E. Lacy, T. Maniatis, S. Silverstein, and R. Axel. 1979. Transformation of mammalian cells with genes from prokaryotes and eukaryotes. Cell 16:777-785.
66. Wu, H., and G. Lozano. 1994. NF-κB activation of p53. J. Biol. Chem. 269:20067-20074.
67. Wu, X. W., and A. L. Levine. 1994. p53 and E2F-1 cooperate to mediate apoptosis. Proc. Natl. Acad. Sci. USA 91:36112-3606.
68. Yant, S. R., W. Zhu, D. Millinoff, J. L. Slightom, M. Goodman, and D. L. Gumucio. 1995. High affinity YY1 binding motifs: identification of two core types (ACAT and CCAT) and distribution of potential binding sites within the human β globin cluster. Nucleic Acids Res. 23:4353-4362.
69. Yichun, D. A., Y. Liu, and H.-U. Bernard. 1994. Cloning and functional analysis of spliced isoforms of human nuclear factor 1-X: interference with transcriptional activation by NF1/CTF in a cell-type specific manner. Nucleic Acids Res. 22:3825-3833.