TLR4, TLR7/8 agonist-induced miR-146a promotes macrophage tolerance to MyD88-dependent TLR agonists

Journal of Leukocyte Biology

Volumn 100, Issue 2, 2016, Pages 339-349

  Abu Nahid, M ^a,b   Benso, Lia M ^a,c   Shin, John D ^a,d   Mehmet, Huseyin ^a,e   Hicks, Alexandra ^a   Ramadas, Ravisankar A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b TRIPLER ARMY MEDICAL CENTER   (United States)

^c BIOGEN   (United States)

^d Proteostasis Therapeutics   (United States)

^e Onkaido   (United States)

Author keywords

MicroRNA; Tolerance

Indexed keywords

CHEMOKINE; CYTOKINE; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MICRORNA 146A; MYELOID DIFFERENTIATION FACTOR 88; RESIQUIMOD; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR AGONIST; TUBULIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; IMIDAZOLE DERIVATIVE; MICRORNA; MIRN146 MICRORNA, HUMAN; TLR4 PROTEIN, HUMAN; TLR7 PROTEIN, HUMAN; TLR8 PROTEIN, HUMAN;

ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOSOME; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; IMMUNOLOGICAL TOLERANCE; IMMUNOREGULATION; INNATE IMMUNITY; MACROPHAGE; MEDIATOR RELEASE; MONOCYTE; PATHOGEN CLEARANCE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; AGONISTS; CELL CULTURE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; METABOLISM;

CELLS, CULTURED; CYTOKINES; GENE EXPRESSION REGULATION; HUMANS; IMIDAZOLES; IMMUNE TOLERANCE; LIPOPOLYSACCHARIDES; MACROPHAGES; MICRORNAS; MYELOID DIFFERENTIATION FACTOR 88; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTOR 7; TOLL-LIKE RECEPTOR 8;

EID: 84980373391     PISSN: 07415400     EISSN: 19383673     Source Type: Journal    
DOI: 10.1189/jlb.2A0515-197R     Document Type: Article

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