Aged human stored red blood cell supernatant inhibits macrophage phagocytosis in an hmgb1 dependent manner after trauma in a murine model

Shock

Volumn 47, Issue 2, 2017, Pages 217-224

  Zettel, Kent R ^a   Dyer, Mitchell ^a   Raval, Jay S ^b   Wu, Xubo ^a,c   Klune, John R ^a   Gutierrez, Andres ^a   Triulzi, Darrell J ^d   Billiar, Timothy R ^a   Neal, Matthew D ^a  

^a PRESBYTERIAN UNIVERSITY HOSPITAL   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c FUDAN UNIVERSITY   (China)

^d UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

Author keywords

High mobility group box 1; Innate immunity; Massive transfusion; Transfusion storage lesion

Indexed keywords

GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE (NADP); HIGH MOBILITY GROUP B1 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL CLEARANCE; CELL CULTURE; CONTROLLED STUDY; ERYTHROCYTE; ERYTHROCYTE TRANSFUSION; ESCHERICHIA COLI; GENE EXPRESSION; HEMORRHAGIC SHOCK; HUMAN; HUMAN CELL; IMMUNOSUPPRESSIVE TREATMENT; INJURY; LEUKOCYTE; MACROPHAGE; MACROPHAGE FUNCTION; MALE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PHAGOCYTOSIS; SUPERNATANT; ANIMAL; C57BL MOUSE; CYTOLOGY; DISEASE MODEL; IMMUNOLOGY; METABOLISM; PATHOGENICITY; PHYSIOLOGY;

ANIMALS; DISEASE MODELS, ANIMAL; ERYTHROCYTES; ESCHERICHIA COLI; HMGB1 PROTEIN; HUMANS; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; PHAGOCYTOSIS; SHOCK, HEMORRHAGIC; WOUNDS AND INJURIES;

EID: 84980340113     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0000000000000716     Document Type: Article

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