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Volumn 18, Issue 12, 2012, Pages 1509-1518

High mobility group box 1 contributes to the pathogenesis of experimental pulmonary hypertension via activation of toll-like receptor 4

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; ALPHA SMOOTH MUSCLE ACTIN; HIGH MOBILITY GROUP B1 PROTEIN; HIGH MOBILITY GROUP B1 PROTEIN NEUTRALIZING ANTIBODY; NEUTRALIZING ANTIBODY; NUCLEAR PROTEIN; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

EID: 84873509875     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.2119/molmed.2012.00283     Document Type: Article
Times cited : (90)

References (56)
  • 1
    • 2942522878 scopus 로고    scopus 로고
    • Clinical classification of pulmonary hypertension
    • Simonneau G, et al. (2004) Clinical classification of pulmonary hypertension. J. Am. Coll. Cardiol. 43:5S-12S.
    • (2004) J. Am. Coll. Cardiol. , vol.43
    • Simonneau, G.1
  • 2
    • 2942541475 scopus 로고    scopus 로고
    • Cellular and molecular pathobiology of pulmonary arterial hypertension
    • Humbert M, et al. (2004) Cellular and molecular pathobiology of pulmonary arterial hypertension. J. Am. Coll. Cardiol. 43:13S-24S.
    • (2004) J. Am. Coll. Cardiol. , vol.43
    • Humbert, M.1
  • 3
    • 46749142123 scopus 로고    scopus 로고
    • Molecular pathogenesis of pulmonary arterial hypertension
    • Rabinovitch M. (2008) Molecular pathogenesis of pulmonary arterial hypertension. J. Clin. Invest. 118:2372-9.
    • (2008) J. Clin. Invest. , vol.118 , pp. 2372-2379
    • Rabinovitch, M.1
  • 4
    • 67649620066 scopus 로고    scopus 로고
    • Development and pathology of pulmonary hypertension
    • Tuder RM, et al. (2009) Development and pathology of pulmonary hypertension. J. Am. Coll. Cardiol. 54:S3-9.
    • (2009) J. Am. Coll. Cardiol. , vol.54
    • Tuder, R.M.1
  • 6
    • 54049138069 scopus 로고    scopus 로고
    • Emerging concepts and translational priorities in pulmonary arterial hypertension
    • Michelakis ED, Wilkins MR, Rabinovitch M. (2008) Emerging concepts and translational priorities in pulmonary arterial hypertension. Circulation. 118:1486-95.
    • (2008) Circulation. , vol.118 , pp. 1486-1495
    • Michelakis, E.D.1    Wilkins, M.R.2    Rabinovitch, M.3
  • 7
    • 62749192201 scopus 로고    scopus 로고
    • A meta-analysis of randomized controlled trials in pulmonary arterial hypertension
    • Galie N, et al. (2009) A meta-analysis of randomized controlled trials in pulmonary arterial hypertension. Eur. Heart J. 30:394-403.
    • (2009) Eur. Heart J. , vol.30 , pp. 394-403
    • Galie, N.1
  • 8
    • 34249302372 scopus 로고    scopus 로고
    • A meta-analysis of trials of pulmonary hypertension: A clinical condition looking for drugs and research methodology
    • Macchia A, et al. (2007) A meta-analysis of trials of pulmonary hypertension: a clinical condition looking for drugs and research methodology. Am. Heart J. 153:1037-47.
    • (2007) Am. Heart J. , vol.153 , pp. 1037-1047
    • Macchia, A.1
  • 9
    • 33845951211 scopus 로고    scopus 로고
    • DAMPs, PAMPs and alarmins: All we need to know about danger
    • Bianchi ME. (2007) DAMPs, PAMPs and alarmins: all we need to know about danger. J. Leukoc. Biol. 81:1-5.
    • (2007) J. Leukoc. Biol. , vol.81 , pp. 1-5
    • Bianchi, M.E.1
  • 10
    • 4243824006 scopus 로고    scopus 로고
    • The DNA chaperone HMGB1 facilitates ACF/CHRAC-dependent nucleosome sliding
    • Bonaldi T, Langst G, Strohner R, Becker PB, Bianchi ME. (2002) The DNA chaperone HMGB1 facilitates ACF/CHRAC-dependent nucleosome sliding. EMBO J. 21:6865-73.
    • (2002) EMBO J. , vol.21 , pp. 6865-6873
    • Bonaldi, T.1    Langst, G.2    Strohner, R.3    Becker, P.B.4    Bianchi, M.E.5
  • 11
    • 33645461206 scopus 로고    scopus 로고
    • High mobility group box 1 protein interacts with multiple Toll-like receptors
    • Park JS, et al. (2006) High mobility group box 1 protein interacts with multiple Toll-like receptors. Am. J. Physiol. Cell Physiol. 290:C917-24.
    • (2006) Am. J. Physiol. Cell Physiol. , vol.290
    • Park, J.S.1
  • 12
    • 1542380035 scopus 로고    scopus 로고
    • Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein
    • Park JS, et al. (2004) Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein. J. Biol. Chem. 279:7370-7.
    • (2004) J. Biol. Chem. , vol.279 , pp. 7370-7377
    • Park, J.S.1
  • 13
    • 0028851635 scopus 로고
    • The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin: Mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous system
    • Hori O, et al. (1995) The receptor for advanced glycation end products (RAGE) is a cellular binding site for amphoterin: mediation of neurite outgrowth and co-expression of rage and amphoterin in the developing nervous system. J. Biol. Chem. 270:25752-61.
    • (1995) J. Biol. Chem. , vol.270 , pp. 25752-25761
    • Hori, O.1
  • 14
    • 72249103413 scopus 로고    scopus 로고
    • Toll-like receptor-4 inhibits enterocyte proliferation via impaired betacatenin signaling in necrotizing enterocolitis
    • Sodhi CP, et al. (2010) Toll-like receptor-4 inhibits enterocyte proliferation via impaired betacatenin signaling in necrotizing enterocolitis. Gastroenterology. 138:185-96.
    • (2010) Gastroenterology. , vol.138 , pp. 185-196
    • Sodhi, C.P.1
  • 15
    • 2942756123 scopus 로고    scopus 로고
    • Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response
    • Liliensiek B, et al. (2004) Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response. J. Clin. Invest. 113:1641-50.
    • (2004) J. Clin. Invest. , vol.113 , pp. 1641-1650
    • Liliensiek, B.1
  • 16
    • 9144241208 scopus 로고    scopus 로고
    • Reversing established sepsis with antagonists of endogenous high-mobility group box 1
    • Yang H, et al. (2004) Reversing established sepsis with antagonists of endogenous high-mobility group box 1. Proc. Natl. Acad. Sci. U. S. A. 101:296-301.
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 296-301
    • Yang, H.1
  • 17
    • 84872298261 scopus 로고    scopus 로고
    • High mobility group box 1 inhibits human pulmonary artery endothelial cell migration via a toll-like receptor 4-and interferon response factor 3-dependent mechanism(s)
    • Bauer EM, Shapiro R, Billiar TR, Bauer PM. (2013) High mobility group box 1 inhibits human pulmonary artery endothelial cell migration via a toll-like receptor 4-and interferon response factor 3-dependent mechanism(s). J. Biol. Chem. 288:1365-73.
    • (2013) J. Biol. Chem. , vol.288 , pp. 1365-1373
    • Bauer, E.M.1    Shapiro, R.2    Billiar, T.R.3    Bauer, P.M.4
  • 18
    • 83355176600 scopus 로고    scopus 로고
    • Complement C3 deficiency attenuates chronic hypoxia-induced pulmonary hypertension in mice
    • Bauer EM, et al. (2011) Complement C3 deficiency attenuates chronic hypoxia-induced pulmonary hypertension in mice. PLoS One. 6:e28578.
    • (2011) PLoS One. , vol.6
    • Bauer, E.M.1
  • 19
    • 84873500081 scopus 로고    scopus 로고
    • Circulating levels of HMGB1 are correlated strongly with MD2 in HIV-infection: Possible implication for TLR4-signalling and chronic immune activation
    • 2012, Oct 15 [Epub ahead of print]
    • Troseid M, et al. (2012) Circulating levels of HMGB1 are correlated strongly with MD2 in HIV-infection: possible implication for TLR4-signalling and chronic immune activation. Innate Immun. 2012, Oct 15 [Epub ahead of print].
    • (2012) Innate Immun.
    • Troseid, M.1
  • 20
    • 84872816507 scopus 로고    scopus 로고
    • Circulating immunogenic cell death biomarkers HMGB1 and RAGE in breast cancer patients during neoadjuvant chemotherapy
    • 2012, Sep 15 [Epub ahead of print]
    • Stoetzer OJ, et al. (2012) Circulating immunogenic cell death biomarkers HMGB1 and RAGE in breast cancer patients during neoadjuvant chemotherapy. Tumour Biol. 2012, Sep 15 [Epub ahead of print].
    • (2012) Tumour Biol.
    • Stoetzer, O.J.1
  • 21
    • 84858699517 scopus 로고    scopus 로고
    • Circulating highmobility group box 1 and cardiovascular mortality in unstable angina and non-ST-segment elevation myocardial infarction
    • Hashimoto T, et al. (2012) Circulating highmobility group box 1 and cardiovascular mortality in unstable angina and non-ST-segment elevation myocardial infarction. Atherosclerosis. 221:490-5.
    • (2012) Atherosclerosis. , vol.221 , pp. 490-495
    • Hashimoto, T.1
  • 22
    • 84878016406 scopus 로고    scopus 로고
    • Elevated serum levels of high mobility group box protein 1 (HMGB1) in patients with ankylosing spondylitis and its association with disease activity and quality of life
    • 2012, Nov 10 [Epub ahead of print]
    • Oktayoglu P, et al. (2012) Elevated serum levels of high mobility group box protein 1 (HMGB1) in patients with ankylosing spondylitis and its association with disease activity and quality of life. Rheumatol. Int. 2012, Nov 10 [Epub ahead of print].
    • (2012) Rheumatol. Int.
    • Oktayoglu, P.1
  • 23
    • 84866398727 scopus 로고    scopus 로고
    • Elevated serum levels of high mobility group box 1 (HMGB1) protein in dengue-infected patients are associated with disease symptoms and secondary infection
    • Allonso D, et al. (2012) Elevated serum levels of high mobility group box 1 (HMGB1) protein in dengue-infected patients are associated with disease symptoms and secondary infection. J. Clin. Virol. 55:214-9.
    • (2012) J. Clin. Virol. , vol.55 , pp. 214-219
    • Allonso, D.1
  • 24
    • 84865773782 scopus 로고    scopus 로고
    • Serum high mobility group box-1 is a powerful diagnostic and prognostic biomarker for pancreatic ductal adenocarcinoma
    • Chung HW, et al. (2012) Serum high mobility group box-1 is a powerful diagnostic and prognostic biomarker for pancreatic ductal adenocarcinoma. Cancer Sci. 103:1714-21.
    • (2012) Cancer Sci. , vol.103 , pp. 1714-1721
    • Chung, H.W.1
  • 25
    • 84857133496 scopus 로고    scopus 로고
    • Renal expression and serum levels of high mobility group box 1 protein in lupus nephritis
    • Zickert A, et al. (2012) Renal expression and serum levels of high mobility group box 1 protein in lupus nephritis. Arthritis Res. Ther. 14:R36.
    • (2012) Arthritis Res. Ther. , vol.14
    • Zickert, A.1
  • 26
    • 84858382416 scopus 로고    scopus 로고
    • Increased serum levels of high-mobility group box 1 (HMGB1) in primary Sjogren's syndrome
    • Dupire G, Nicaise C, Gangji V, Soyfoo MS. (2012) Increased serum levels of high-mobility group box 1 (HMGB1) in primary Sjogren's syndrome. Scand. J. Rheumatol. 41:120-3.
    • (2012) Scand. J. Rheumatol. , vol.41 , pp. 120-123
    • Dupire, G.1    Nicaise, C.2    Gangji, V.3    Soyfoo, M.S.4
  • 27
    • 47949095665 scopus 로고    scopus 로고
    • Bosentan regulates the expression of adhesion molecules on circulating T cells and serum soluble adhesion molecules in systemic sclerosis-associated pulmonary arterial hypertension
    • Iannone F, et al. (2008) Bosentan regulates the expression of adhesion molecules on circulating T cells and serum soluble adhesion molecules in systemic sclerosis-associated pulmonary arterial hypertension. Ann. Rheum. Dis. 67:1121-6.
    • (2008) Ann. Rheum. Dis. , vol.67 , pp. 1121-1126
    • Iannone, F.1
  • 28
    • 0027324745 scopus 로고
    • Expression of endothelin-1 in the lungs of patients with pulmonary hypertension
    • Giaid A, et al. (1993) Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. N. Engl. J. Med. 328:1732-9.
    • (1993) N. Engl. J. Med. , vol.328 , pp. 1732-1739
    • Giaid, A.1
  • 29
    • 0035818316 scopus 로고    scopus 로고
    • Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: A randomised placebo-controlled study
    • Channick RN, et al. (2001) Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebo-controlled study. Lancet. 358:1119-23.
    • (2001) Lancet. , vol.358 , pp. 1119-1123
    • Channick, R.N.1
  • 30
    • 77954758530 scopus 로고    scopus 로고
    • Survival in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era
    • Humbert M, et al. (2010) Survival in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era. Circulation. 122:156-63.
    • (2010) Circulation. , vol.122 , pp. 156-163
    • Humbert, M.1
  • 31
    • 0028282859 scopus 로고
    • Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension
    • Tuder RM, Groves B, Badesch DB, Voelkel NF. (1994) Exuberant endothelial cell growth and elements of inflammation are present in plexiform lesions of pulmonary hypertension. Am. J. Pathol. 144:275-85.
    • (1994) Am. J. Pathol. , vol.144 , pp. 275-285
    • Tuder, R.M.1    Groves, B.2    Badesch, D.B.3    Voelkel, N.F.4
  • 32
    • 67649844313 scopus 로고    scopus 로고
    • Inflammation, growth factors, and pulmonary vascular remodeling
    • Hassoun PM, et al. (2009) Inflammation, growth factors, and pulmonary vascular remodeling. J. Am. Coll. Cardiol. 54:S10-9.
    • (2009) J. Am. Coll. Cardiol. , vol.54
    • Hassoun, P.M.1
  • 33
    • 0026447678 scopus 로고
    • Ten year survival of a patient with advanced pulmonary hypertension and mixed connective tissue disease treated with immunosuppressive therapy
    • Dahl M, Chalmers A, Wade J, Calverley D, Munt B. (1992) Ten year survival of a patient with advanced pulmonary hypertension and mixed connective tissue disease treated with immunosuppressive therapy. J. Rheumatol. 19:1807-9.
    • (1992) J. Rheumatol. , vol.19 , pp. 1807-1809
    • Dahl, M.1    Chalmers, A.2    Wade, J.3    Calverley, D.4    Munt, B.5
  • 34
    • 0026687836 scopus 로고
    • Recovery from pulmonary hypertension in an adolescent with mixed connective tissue disease
    • Friedman DM, Mitnick HJ, Danilowicz D. (1992) Recovery from pulmonary hypertension in an adolescent with mixed connective tissue disease. Ann. Rheum. Dis. 51:1001-4.
    • (1992) Ann. Rheum. Dis. , vol.51 , pp. 1001-1004
    • Friedman, D.M.1    Mitnick, H.J.2    Danilowicz, D.3
  • 35
    • 0035902447 scopus 로고    scopus 로고
    • Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia
    • Minamino T, et al. (2001) Targeted expression of heme oxygenase-1 prevents the pulmonary inflammatory and vascular responses to hypoxia. Proc. Natl. Acad. Sci. U. S. A. 98:8798-803.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 8798-8803
    • Minamino, T.1
  • 36
    • 61549104663 scopus 로고    scopus 로고
    • Impact of interleukin-6 on hypoxia-induced pulmonary hypertension and lung inflammation in mice
    • Savale L, et al. (2009) Impact of interleukin-6 on hypoxia-induced pulmonary hypertension and lung inflammation in mice. Respir. Res. 10:6.
    • (2009) Respir. Res. , vol.10 , pp. 6
    • Savale, L.1
  • 37
    • 59849118025 scopus 로고    scopus 로고
    • Interleukin-6 overexpression induces pulmonary hypertension
    • Steiner MK, et al. (2009) Interleukin-6 overexpression induces pulmonary hypertension. Circ. Res. 104:236-44.
    • (2009) Circ. Res. , vol.104 , pp. 236-244
    • Steiner, M.K.1
  • 38
    • 78751560494 scopus 로고    scopus 로고
    • Pathogen recognition by the innate immune system
    • Kumar H, Kawai T, Akira S. (2011) Pathogen recognition by the innate immune system. Int. Rev. Immunol. 30:16-34.
    • (2011) Int. Rev. Immunol. , vol.30 , pp. 16-34
    • Kumar, H.1    Kawai, T.2    Akira, S.3
  • 39
    • 0028201732 scopus 로고
    • Tolerance, danger, and the extended family
    • Matzinger P. (1994) Tolerance, danger, and the extended family. Annu. Rev. Immunol. 12:991-1045.
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 991-1045
    • Matzinger, P.1
  • 41
    • 84873509379 scopus 로고    scopus 로고
    • The role of high mobility group box1 in monocrotaline-induced pulmonary hypertension in rats
    • Sadamura Y, et al. (2011) The role of high mobility group box1 in monocrotaline-induced pulmonary hypertension in rats. Am. J. Respir. Crit. Care Med. 183:A3413.
    • (2011) Am. J. Respir. Crit. Care Med. , vol.183
    • Sadamura, Y.1
  • 42
    • 20244373939 scopus 로고    scopus 로고
    • The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion
    • Tsung A, et al. (2005) The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion. J. Exp. Med. 201:1135-43.
    • (2005) J. Exp. Med. , vol.201 , pp. 1135-1143
    • Tsung, A.1
  • 43
    • 77950539231 scopus 로고    scopus 로고
    • Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures
    • Maroso M, et al. (2010) Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures. Nat. Med. 16:413-9.
    • (2010) Nat. Med. , vol.16 , pp. 413-419
    • Maroso, M.1
  • 44
    • 77954951851 scopus 로고    scopus 로고
    • TLR4-mediated skin carcinogenesis is dependent on immune and radioresistant cells
    • Mittal D, et al. (2010) TLR4-mediated skin carcinogenesis is dependent on immune and radioresistant cells. EMBO J. 29:2242-52.
    • (2010) EMBO J. , vol.29 , pp. 2242-2252
    • Mittal, D.1
  • 45
    • 35148861150 scopus 로고    scopus 로고
    • Systemic inflammation and remote organ injury following trauma require HMGB1
    • Levy RM, et al. (2007) Systemic inflammation and remote organ injury following trauma require HMGB1. Am. J. Physiol. Regul. Integr. Comp. Physiol. 293:R1538-44.
    • (2007) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.293
    • Levy, R.M.1
  • 46
    • 84862991350 scopus 로고    scopus 로고
    • Early interleukin 6 production by leukocytes during ischemic acute kidney injury is regulated by TLR4
    • Chen J, et al. (2011) Early interleukin 6 production by leukocytes during ischemic acute kidney injury is regulated by TLR4. Kidney Int. 80:504-15.
    • (2011) Kidney Int. , vol.80 , pp. 504-515
    • Chen, J.1
  • 47
    • 68749095004 scopus 로고    scopus 로고
    • TLR2 and TLR4 agonists induce production of the vasoactive peptide endothelin-1 by human dendritic cells
    • Spirig R, et al. (2009) TLR2 and TLR4 agonists induce production of the vasoactive peptide endothelin-1 by human dendritic cells. Mol. Immunol. 46:3178-82.
    • (2009) Mol. Immunol. , vol.46 , pp. 3178-3182
    • Spirig, R.1
  • 49
    • 77955403878 scopus 로고    scopus 로고
    • A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release
    • Yang H, et al. (2010) A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release. Proc. Natl. Acad. Sci. U. S. A. 107:11942-7.
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 11942-11947
    • Yang, H.1
  • 50
    • 27144539508 scopus 로고    scopus 로고
    • Platelets express functional Toll-like receptor-4
    • Andonegui G, et al. (2005) Platelets express functional Toll-like receptor-4. Blood. 106:2417-23.
    • (2005) Blood. , vol.106 , pp. 2417-2423
    • Andonegui, G.1
  • 51
    • 0031577596 scopus 로고    scopus 로고
    • Type II alveolar epithelial cells in lung express receptor for advanced glycation end products (RAGE) gene
    • Katsuoka F, et al. (1997) Type II alveolar epithelial cells in lung express receptor for advanced glycation end products (RAGE) gene. Biochem. Biophys. Res. Commun. 238:512-6.
    • (1997) Biochem. Biophys. Res. Commun. , vol.238 , pp. 512-516
    • Katsuoka, F.1
  • 52
    • 77951922772 scopus 로고    scopus 로고
    • The receptor for advanced glycation end products (RAGE) and the lung
    • Buckley ST, Ehrhardt C. (2010) The receptor for advanced glycation end products (RAGE) and the lung. J. Biomed. Biotechnol. 2010:917108.
    • (2010) J. Biomed. Biotechnol. , vol.2010 , pp. 917108
    • Buckley, S.T.1    Ehrhardt, C.2
  • 53
    • 1642434067 scopus 로고    scopus 로고
    • Dealing with death: HMGB1 as a novel target for cancer therapy
    • Lotze MT, DeMarco RA. (2003) Dealing with death: HMGB1 as a novel target for cancer therapy. Curr. Opin. Investig. Drugs. 4:1405-9.
    • (2003) Curr. Opin. Investig. Drugs. , vol.4 , pp. 1405-1409
    • Lotze, M.T.1    DeMarco, R.A.2
  • 56
    • 52649114296 scopus 로고    scopus 로고
    • Cardiac inflammation associated with a Western diet is mediated via activation of RAGE by AGEs
    • Tikellis C, et al. (2008) Cardiac inflammation associated with a Western diet is mediated via activation of RAGE by AGEs. Am. J. Physiol. Endocrinol. Metab. 295:E323-30.
    • (2008) Am. J. Physiol. Endocrinol. Metab. , vol.295
    • Tikellis, C.1


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