Stored red blood cell transfusions: Iron, inflammation, immunity, and infection

Transfusion Clinique et Biologique

Volumn 19, Issue 3, 2012, Pages 84-89

  Hod, E A ^a   Spitalnik, S L ^a  

^a Columbia University College of Physicians and Surgeons New York Presbyterian Hospital ^*  (United States)

Author keywords

Cytokines; Infection; Inflammation; Iron; Red blood cell transfusion

Indexed keywords

CD40 LIGAND; CRYOPYRIN; FERROPORTIN; HEPCIDIN; INTERLEUKIN 6; IRON; LIPOCALIN; LIPOPOLYSACCHARIDE; MONOCYTE CHEMOTACTIC PROTEIN 1; REACTIVE OXYGEN METABOLITE; TOLL LIKE RECEPTOR;

ARTICLE; CYTOKINE PRODUCTION; ERYTHROCYTE PRESERVATION; ERYTHROCYTE TRANSFUSION; HEMOLYSIS; HOST SUSCEPTIBILITY; HUMAN; IMMUNE SYSTEM; IMMUNITY; INFECTION; INFLAMMATION; IRON METABOLISM; LYSOSOME; NONHUMAN; PHAGOCYTE; PHAGOCYTOSIS; QUALITY CONTROL; REPRODUCIBILITY; SIGNAL TRANSDUCTION;

BLOOD PRESERVATION; ERYTHROCYTE TRANSFUSION; HUMANS; IMMUNITY; INFECTION; INFLAMMATION; IRON;

EID: 84864768706     PISSN: 12467820     EISSN: 19538022     Source Type: Journal    
DOI: 10.1016/j.tracli.2012.04.001     Document Type: Article

References (30)

1. Creteur J., Vincent J.L. Hemoglobin solutions. Crit Care Med 2003, 31:S698-S707.
2. Wang D, Sun J, Solomon SB, Klein HG, Natanson C. Transfusion of older stored blood and risk of death: a meta-analysis. Transfusion 2011 [doi:10.1111/j.1537-2995.2011.03466.x].
3. Dzik W. Fresh blood for everyone? Balancing availability and quality of stored RBCs. Transfus Med 2008, 18:260-265.
4. Koch C.G., Li L., Sessler D.I., Figueroa P., Hoeltge G.A., Mihaljevic T., et al. Duration of red-cell storage and complications after cardiac surgery. New Engl J Med 2008, 358:1229-1239.
5. Steiner M.E., Assmann S.F., Levy J.H., Marshall J., Pulkrabek S., Sloan S.R., et al. Addressing the question of the effect of RBC storage on clinical outcomes: the Red Cell Storage Duration Study (RECESS) (Section 7). Transfus Apher Sci 2010, 43:107-116.
6. Lacroix J., Hebert P., Fergusson D., Tinmouth A., Blajchman M.A., Callum J., et al. The Age of Blood Evaluation (ABLE) randomized controlled trial: study design. Transfus Med Rev 2011, 25:197-205.
7. Fergusson D., Hutton B., Hogan D.L., LeBel L., Blajchman M.A., Ford J.C., et al. The age of red blood cells in premature infants (ARIPI) randomized controlled trial: study design. Transfus Med Rev 2009, 23:55-61.
8. Tinmouth A., Fergusson D., Yee I.C., Hebert P.C. Clinical consequences of red cell storage in the critically ill. Transfusion 2006, 46:2014-2027.
9. Bennett-Guerrero E., Veldman T.H., Doctor A., Telen M.J., Ortel T.L., Reid T.S., et al. Evolution of adverse changes in stored RBCs. Proc Natl Acad Sci USA 2007, 104:17063-17068.
10. Dumont L.J., AuBuchon J.P. Evaluation of proposed FDA criteria for the evaluation of radiolabeled red cell recovery trials. Transfusion 2008, 48:1053-1060.
11. Luten M., Roerdinkholder-Stoelwinder B., Schaap N.P., de Grip W.J., Bos H.J., Bosman G.J. Survival of red blood cells after transfusion: a comparison between red cells concentrates of different storage periods. Transfusion 2008, 48:1478-1485.
12. Spinella P.C., Sparrow R.L., Hess J.R., Norris P.J. Properties of stored red blood cells: understanding immune and vascular reactivity. Transfusion 2011, 51:894-900.
13. Jy W., Ricci M., Shariatmadar S., Gomez-Marin O., Horstman L.H., Ahn Y.S. Microparticles in stored red blood cells as potential mediators of transfusion complications. Transfusion 2011, 51:886-893.
14. Roback J.D., Neuman R.B., Quyyumi A., Sutliff R. Insufficient nitric oxide bioavailability: a hypothesis to explain adverse effects of red blood cell transfusion. Transfusion 2011, 51:859-866.
15. Kim-Shapiro D.B., Lee J., Gladwin M.T. Storage lesion: role of red blood cell breakdown. Transfusion 2011, 51:844-851.
16. Grimshaw K., Sahler J., Spinelli S.L., Phipps R.P., Blumberg N. New frontiers in transfusion biology: identification and significance of mediators of morbidity and mortality in stored red blood cells. Transfusion 2011, 51:874-880.
17. Reynolds J.D., Hess D.T., Stamler J.S. The transfusion problem: role of aberrant S-nitrosylation. Transfusion 2011, 51:852-858.
18. Weinberg J.A., Barnum S.R., Patel R.P. Red blood cell age and potentiation of transfusion-related pathology in trauma patients. Transfusion 2011, 51:867-873.
19. Strowig T., Henao-Mejia J., Elinav E., Flavell R. Inflammasomes in health and disease. Nature 2012, 481:278-286.
20. Moresco E.M., LaVine D., Beutler B. Toll-like receptors. Curr Bio 2011, 21:R488-R493.
21. Bao G., Clifton M., Hoette T.M., Mori K., Deng S.X., Qiu A., et al. Iron traffics in circulation bound to a siderocalin (Ngal)-catechol complex. Nat Chem Biol 2010, 6:602-609.
22. Valdebenito M., Muller S.I., Hantke K. Special conditions allow binding of the siderophore salmochelin to siderocalin (NGAL-lipocalin). FEMS Microbiol Lett 2007, 277:182-187.
23. Weinberg E.D. Iron availability and infection. Biochim Biophys Acta 2009, 1790:600-605.
24. Tipple M.A., Bland L.A., Murphy J.J., Arduino M.J., Panlilio A.L., Farmer J.J., et al. Sepsis associated with transfusion of red cells contaminated with Yersinia enterocolitica. Transfusion 1990, 30:207-213.
25. Gilson C.R., Kraus T.S., Hod E.A., Hendrickson J.E., Spitalnik S.L., Hillyer C.D., et al. A novel mouse model of red blood cell storage and posttransfusion in vivo survival. Transfusion 2009, 49:1546-1553.
26. Hod E.A., Zhang N., Sokol S.A., Wojczyk B.S., Francis R.O., Ansaldi D., et al. Transfusion of red blood cells after prolonged storage produces harmful effects that are mediated by iron and inflammation. Blood 2010, 115:4284-4292.
27. Hod EA, Hendrickson JE, Sharma S, Francis RO, Wojczyk BS, Zimring JC, et al. Transfusion of mouse RBCs stored in AS-1 induces inflammation and exacerbates bacterial sepsis. Transfusion 2010;50:S23-010D.
28. Hendrickson J.E., Hod E.A., Spitalnik S.L., Hillyer C.D., Zimring J.C. Storage of murine red blood cells enhances alloantibody responses to an erythroid-specific model antigen. Transfusion 2010, 50:642-648.
29. Hod E.A., Brittenham G.M., Billote G.B., Francis R.O., Ginzburg Y.Z., Hendrickson J.E., et al. Transfusion of human volunteers with older, stored red blood cells produces extravascular hemolysis and circulating non-transferrin-bound iron. Blood 2011, 118:6675-6682.
30. Cholette JM, Henrichs KF, Alfieris GM, Powers KS, Phipps R, Spinelli SL, et al. Washing red blood cells and platelets transfused in cardiac surgery reduces postoperative inflammation and number of transfusions: results of a prospective, randomized, controlled clinical trial. Pediatr Crit Care Med 2011 [doi:10.1097/PCC.0b013e31822f173c].