Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling

Structure

Volumn 24, Issue 8, 2016, Pages 1271-1281

  Broughton, Sophie E ^a   Hercus, Timothy R ^b   Nero, Tracy L ^a   Dottore, Mara ^b   McClure, Barbara J ^b   Dhagat, Urmi ^a   Taing, Houng ^b   Gorman, Michael A ^a   King Scott, Jack ^a   Lopez, Angel F ^b   Parker, Michael W ^a,c  

^a ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE RECEPTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR ALPHA; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR BETA C; INTERLEUKIN 13; INTERLEUKIN 13 RECEPTOR ALPHA1; INTERLEUKIN 13 RECEPTOR ALPHA2; INTERLEUKIN 3; INTERLEUKIN 4; INTERLEUKIN 5; UNCLASSIFIED DRUG; PROTEIN BINDING; PROTEIN SUBUNIT; RECOMBINANT PROTEIN;

ARTICLE; CELL PROLIFERATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DISULFIDE BOND; FLOW CYTOMETRY; HINGE REGION; HUMAN; HUMAN CELL; HYDROGEN BOND; MUTAGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RECEPTOR AFFINITY; RECEPTOR BINDING; SIGNAL TRANSDUCTION; ALPHA HELIX; BETA SHEET; BINDING SITE; CHEMISTRY; ESCHERICHIA COLI; GENE EXPRESSION; GENETICS; METABOLISM; MOLECULAR CLONING; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MUTATION; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN MULTIMERIZATION; PROTEIN SUBUNIT; X RAY CRYSTALLOGRAPHY;

AMINO ACID MOTIFS; BINDING SITES; CLONING, MOLECULAR; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; GENE EXPRESSION; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; MOLECULAR DOCKING SIMULATION; MOLECULAR DYNAMICS SIMULATION; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION, ALPHA-HELICAL; PROTEIN CONFORMATION, BETA-STRAND; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN MULTIMERIZATION; PROTEIN SUBUNITS; RECEPTORS, GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION;

EID: 84980002167     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2016.05.017     Document Type: Article

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