Protein-observed 19F-NMR for fragment screening, affinity quantification and druggability assessment

Nature Protocols

Volumn 11, Issue 8, 2016, Pages 1414-1427

  Gee, Clifford T ^a   Arntson, Keith E ^a   Urick, Andrew K ^a   Mishra, Neeraj K ^a   Hawk, Laura M L ^a   Wisniewski, Andrea J ^b   Pomerantz, William C K ^a  

^a University of Minnesota   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRD4 PROTEIN; BRDT PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; KIX PROTEIN; PEPTIDES AND PROTEINS; UNCLASSIFIED DRUG; DRUG; LIGAND; PROTEIN;

ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; FLUORINE NUCLEAR MAGNETIC RESONANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN STABILITY; SEQUENCE ANALYSIS; THERMOSTABILITY; CHEMISTRY; HALOGENATION; METABOLISM; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROCEDURES;

HALOGENATION; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PHARMACEUTICAL PREPARATIONS; PROTEIN CONFORMATION; PROTEINS;

EID: 84979955137     PISSN: 17542189     EISSN: 17502799     Source Type: Journal    
DOI: 10.1038/nprot.2016.079     Document Type: Article

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