19F NMR as a probe of ligand interactions with the iNOS binding site of SPRY domain-containing SOCS box protein 2

Chemical Biology and Drug Design

Volumn 84, Issue 5, 2014, Pages 616-625

  Leung, Eleanor W W ^a   Yagi, Hiromasa ^a   Harjani, Jitendra R ^a   Mulcair, Mark D ^a   Scanlon, Martin J ^a   Baell, Jonathan B ^a   Norton, Raymond S ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

19F NMR; Anti infective agents; Fragment elaboration; Isothermal titration calorimetry; Peptide; Surface plasmon resonance

Indexed keywords

5 FLUOROTRYPTOPHAN; ANTIINFECTIVE AGENT; FLUORINE; INDUCIBLE NITRIC OXIDE SYNTHASE; PROTEIN; PROTEIN INHIBITOR; SPRY DOMAIN CONTAINING SOCS BOX PROTEIN 2; TRYPTOPHAN; UNCLASSIFIED DRUG; CARRIER PROTEIN; LIGAND; NOS2 PROTEIN, HUMAN; PEPTIDE;

AMINO TERMINAL SEQUENCE; ARTICLE; AUXOTROPHY; BACTERIAL STRAIN; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; ESCHERICHIA COLI; FLUORINE NUCLEAR MAGNETIC RESONANCE; ISOTHERMAL TITRATION CALORIMETRY; LIGAND BINDING; NONHUMAN; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS; SURFACE PLASMON RESONANCE; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; METABOLISM; MUTATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROCEDURES; PROTEIN CONFORMATION;

BINDING SITES; CARRIER PROTEINS; FLUORINE; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MUTATION; NITRIC OXIDE SYNTHASE TYPE II; PEPTIDES; PROTEIN CONFORMATION; SURFACE PLASMON RESONANCE; TRYPTOPHAN;

EID: 84908073324     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/cbdd.12355     Document Type: Article

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