Ligand-induced conformational change of Plasmodium falciparum AMA1 detected using 19F NMR

Journal of Medicinal Chemistry

Volumn 57, Issue 15, 2014, Pages 6419-6427

  Ge, Xiaopeng ^a   Macraild, Christopher A ^b   Devine, Shane M ^b   Debono, Cael O ^b   Wang, Geqing ^b   Scammells, Peter J ^b   Scanlon, Martin J ^b   Anders, Robin F ^a   Foley, Michael ^a   Norton, Raymond S ^b  

^a LA TROBE UNIVERSITY   (Australia)

^b MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

5 FLUOROTRYPTOPHAN; APICAL MEMBRANE ANTIGEN 1; LIGAND; MICROORGANISM PROTEIN; PEPTIDE DERIVATIVE; R1 PEPTIDE; RON2L PEPTIDE; TRYPTOPHAN DERIVATIVE; UNCLASSIFIED DRUG; ANTIMALARIAL AGENT; APICAL MEMBRANE ANTIGEN I, PLASMODIUM; FLUORINE; MEMBRANE PROTEIN; PARASITE ANTIGEN; PROTEIN BINDING; PROTOZOAL PROTEIN; RECOMBINANT PROTEIN;

ALLOSTERISM; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DRUG LABELING; DRUG TARGETING; FLUORINE NUCLEAR MAGNETIC RESONANCE; LIGAND BINDING; PLASMODIUM FALCIPARUM; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS; ANTAGONISTS AND INHIBITORS; CHEMISTRY; GENETICS; METABOLISM; MUTATION; NUCLEAR MAGNETIC RESONANCE; PROTEIN CONFORMATION;

ANTIGENS, PROTOZOAN; ANTIMALARIALS; FLUORINE RADIOISOTOPES; LIGANDS; MEMBRANE PROTEINS; MUTATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PLASMODIUM FALCIPARUM; PROTEIN BINDING; PROTEIN CONFORMATION; PROTOZOAN PROTEINS; RECOMBINANT PROTEINS;

EID: 84906076014     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm500390g     Document Type: Article

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