Is NMR fragment screening fine-tuned to assess druggability of protein-protein interactions?

ACS Medicinal Chemistry Letters

Volumn 5, Issue 1, 2014, Pages 23-28

  Dias, David M ^a,b   Van Molle, Inge ^a   Baud, Matthias G J ^a   Galdeano, Carles ^a   Geraldes, Carlos F G C ^b   Ciulli, Alessio ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

binding affinity; druggability; NMR fragment screening; protein protein interactions

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; VON HIPPEL LINDAU PROTEIN;

ARTICLE; EPITOPE MAPPING; ISOTHERMAL TITRATION CALORIMETRY; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN INTERACTION; X RAY CRYSTALLOGRAPHY;

EID: 84892581838     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml400296c     Document Type: Article

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