Metformin mediates resensitivity to 5-fluorouracil in hepatocellular carcinoma via the suppression of YAP

Oncotarget

Volumn 7, Issue 29, 2016, Pages 46230-46241

  Tian, Yu ^a   Tang, Bo ^b   Wang, Chengye ^a   Sun, Deguang ^a   Zhang, Rixin ^a   Luo, Nan ^a   Han, Zhao ^a   Liang, Rui ^a   Gao, Zhenming ^a   Wang, Liming ^a  

^a DALIAN MEDICAL UNIVERSITY   (China)

^b GUILIN MEDICAL UNIVERSITY   (China)

Author keywords

5 fluorouracil; Hepatocellular carcinoma; Metformin; YAP

Indexed keywords

BINDING PROTEIN; FLUOROURACIL; METFORMIN; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN YAP; UNCLASSIFIED DRUG; ANTIDIABETIC AGENT; ANTINEOPLASTIC AGENT; PHOSPHOPROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; YAP1 (YES-ASSOCIATED) PROTEIN, HUMAN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL PROLIFERATION; CELL VIABILITY; CHEMOEMBOLIZATION; COLONY FORMATION; CONTROLLED STUDY; DOWN REGULATION; DRUG SENSITIVITY; FEMALE; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; HEPATOCELLULAR CARCINOMA CELL LINE; HUMAN; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OVERALL SURVIVAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TUNEL ASSAY; WESTERN BLOTTING; AGED; ANIMAL; BIOSYNTHESIS; COMPLICATION; DRUG EFFECTS; DRUG RESISTANCE; DRUG SCREENING; LIVER TUMOR; MIDDLE AGED; MORTALITY; NUDE MOUSE; PROCEDURES; PROGNOSIS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADULT; AGED; ANIMALS; ANTINEOPLASTIC AGENTS; CARCINOMA, HEPATOCELLULAR; CHEMOEMBOLIZATION, THERAPEUTIC; DIABETES MELLITUS, TYPE 2; DRUG RESISTANCE, NEOPLASM; FEMALE; FLUOROURACIL; HUMANS; HYPOGLYCEMIC AGENTS; LIVER NEOPLASMS; MALE; METFORMIN; MICE; MICE, NUDE; MIDDLE AGED; PHOSPHOPROTEINS; PROGNOSIS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84979936590     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.10079     Document Type: Article

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