YAP regulates S-phase entry in endothelial

PLoS ONE

Volumn 10, Issue 1, 2015, Pages

  Shen, Zhewei ^a,b   Stanger, Ben Z ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

REGULATOR PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; YES ASSOCIATED PROTEIN; PHOSPHOPROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; YAP1 (YES-ASSOCIATED) PROTEIN, HUMAN;

ARTICLE; BIOACCUMULATION; CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CELL PROLIFERATION; CONTROLLED STUDY; DNA RECOMBINATION; ENDOTHELIUM CELL; HELA CELL LINE; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; MICROARRAY ANALYSIS; PROTEIN FUNCTION; TRANSCRIPTION REGULATION; CELL COUNT; CELL CYCLE; CELL CYCLE G1 PHASE; CYTOLOGY; DNA REPAIR; GENE DELETION; GENE SILENCING; METABOLISM; UMBILICAL VEIN ENDOTHELIAL CELL;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CELL COUNT; CELL CYCLE; CELL PROLIFERATION; DNA REPAIR; G1 PHASE; GENE DELETION; GENE KNOCKDOWN TECHNIQUES; HOMOLOGOUS RECOMBINATION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; PHOSPHOPROTEINS; S PHASE;

EID: 84922161680     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0117522     Document Type: Article

References (58)

1. Harvey K, Tapon N (2007) The Salvador-Warts-Hippo pathway-an emerging tumour-suppressor network. Nat Rev 7: 182-191. doi: 10.1038/nrc2070 PMID: 17318211
2. Saucedo LJ, Edgar BA (2007) Filling out the Hippo pathway. Nat Rev cell Biol 8: 613-621. doi: 10.1038/nrm2221 PMID: 17622252
3. Pan D (2007) Hippo signaling in organ size control. Genes Dev 21: 886-897. doi: 10.1101/gad.1536007 PMID: 17437995
4. Zhao B, Ye X, Yu JJ, Li L, Li W, et al. (2008) TEAD mediates YAP-dependent gene induction and growth control. Genes Dev 22: 1962-1971. doi: 10.1101/gad.1664408.2007 PMID: 18579750
5. Ota M, Sasaki H (2008) Mammalian Tead proteins regulate cell proliferation and contact inhibition as transcriptional mediators of Hippo signaling. Development 135: 4059-4069. doi: 10.1242/dev.027151 PMID: 19004856
6. Avruch J, Zhou D, Fitamant J, Bardeesy N (2011) Mst1/2 signalling to Yap: gatekeeper for liver size and tumour development. Br J Cancer 104: 24-32. doi:10.1038/sj.bjc.6606011 PMID: 21102585
7. Harvey KF, Zhang X, Thomas DM (2013) The Hippo pathway and human cancer. Nat Rev 13: 246-257. doi: 10.1038/nrc3458 PMID: 23467301
8. Xiao W, Wang J, Ou C, Zhang Y, Ma L, et al. (2013) Mutual interaction between YAP and c-Myc is critical for carcinogenesis in liver cancer. Biochem Biophys Res Commun 1: 6-11. doi: 10.1016/j.bbrc. 2013.08.071
9. Lu L, Li Y, Kim SM, Bossuyt W, Liu P, et al. (2010) Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc Natl Acad Sci U S A 107: 1437-1442. doi: 10.1073/ pnas.0911427107 PMID: 20080689
10. Camargo FD, Gokhale S, Johnnidis JB, Fu D, Bell GW, et al. (2007) YAP1 increases organ size and expands undifferentiated progenitor cells. Curr Biol 17: 2054-2060. doi: 10.1016/j.cub.2007.10.039 PMID: 17980593
11. Song H, Mak KK, Topol L, Yun K, Hu J, et al. (2010) Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression. Proc Natl Acad Sci U S A 107: 1431-1436. doi: 10. 1073/pnas.0911409107 PMID: 20080598
12. Zhou D, Conrad C, Xia F, Park J- S, Payer B, et al. (2009) Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer Cell 16: 425-438. doi: 10.1016/j.ccr.2009.09.026 PMID: 19878874
13. Yi C, Shen Z, Stemmer-Rachamimov A, Dawany N, Troutman S, et al. (2013) The p130 isoform of angiomotin is required for Yap-mediated hepatic epithelial cell proliferation and tumorigenesis. Sci Signal 6: ra77. doi: 10.1126/scisignal.2004060 PMID: 24003254
14. Dong J, Feldmann G, Huang J, Wu S, Zhang N, et al. (2007) Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell 130: 1120-1133. doi: 10.1016/j.cell.2007.07.019 PMID: 17889654
15. Zhang N, Bai H, David KK, Dong J, Zheng Y, et al. (2010) The Merlin/NF2 Tumor Suppressor Functions through the YAP Oncoprotein to Regulate Tissue Homeostasis in Mammals. Dev Cell 19: 27-38. doi: 10.1016/j.devcel.2010.06.015 PMID: 20643348
16. Steinhardt AA, Gayyed MF, Klein AP, Dong J, Maitra A, et al. (2008) Expression of Yes-associated protein in common solid tumors. Hum Pathol 39: 1582-1589. doi: 10.1016/j.humpath.2008.04.012 PMID: 18703216
17. Xia Y, Chang T, Wang Y, Liu Y, Li W, et al. (2014) YAP promotes ovarian cancer cell tumorigenesis and is indicative of a poor prognosis for ovarian cancer patients. PLoS One 9: e91770. doi: 10.1371/journal.pone.0091770 PMID: 24622501
18. Hall C a, Wang R, Miao J, Oliva E, Shen X, et al. (2010) Hippo pathway effector Yap is an ovarian cancer oncogene. Cancer Res 70: 8517-8525. doi: 10.1158/0008-5472.CAN-10-1242 PMID: 20947521
19. Mizuno T, Murakami H, Fujii M, Ishiguro F, Tanaka I, et al. (2012) YAP induces malignant mesothelioma cell proliferation by upregulating transcription of cell cycle-promoting genes. Oncogene 31: 5117-5122. doi: 10.1038/onc.2012.5 PMID: 22286761
20. Kapoor A, Yao W, Ying H, Hua S, Liewen A, et al. (2014) Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer. Cell. doi: 10.1016/j.cell.2014.06.003 PMID: 25557080
21. Morin-Kensicki EM, Boone BN, Howell M, Stonebraker JR, Teed J, et al. (2006) Defects in yolk sac vasculogenesis, chorioallantoic fusion, and embryonic axis elongation in mice with targeted disruption of Yap65. Mol Cell Biol 26: 77-87. doi: 10.1128/MCB.26.1.77 PMID: 16354681
22. Flygare J, Benson F, Hellgren D (1996) Expression of the human RAD51 gene during the cell cycle in primary human peripheral blood lymphocytes. Biochim Biophys Acta-Mol Cell Res 1312: 231-236. doi: 10.1016/0167-4889(96)00040-7 PMID: 25603556
23. Logan TJ, Evans DL, Mercer WE, Bjornsti MA, Hall DJ (1995) Expression of a deletion mutant of the E2F1 transcription factor in fibroblasts lengthens S phase and increases sensitivity to S phase-specific toxins. Cancer Res 55: 2883-2891. PMID: 7540951
24. Huang DW, Sherman BT, Lempicki RA (2009) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4: 44-57. doi: 10.1038/nprot.2008.211 PMID: 19131956
25. Huang DW, Sherman BT, Lempicki RA (2009) Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res 37: 1-13. doi: 10.1093/nar/gkn923 PMID: 19033363
26. Mootha VK, Lindgren CM, Eriksson K- F, Subramanian A, Sihag S, et al. (2003) PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet 34: 267-273. doi: 10.1038/ng1180 PMID: 12808457
27. Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, et al. (2005) Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A 102: 15545-15550. doi: 10.1073/pnas.0506580102 PMID: 16199517
28. Kelly TJ, Brown GW (2000) Regulation of chromosome replication. Annu Rev Biochem 69: 829-880. doi: 10.1146/annurev.biochem.69.1.829 PMID: 10966477
29. Li X, Heyer W-D (2008) Homologous recombination in DNA repair and DNA damage tolerance. Cell Res 18: 99-113. doi: 10.1038/cr.2008.1 PMID: 18166982
30. Glover DM, Leibowitz MH, McLean DA, Parry H (1995) Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles. Cell 81: 95-105. doi: 10.1016/0092-8674(95) 90374-7 PMID: 7720077
31. Vader G, Lens SMA (2008) The Aurora kinase family in cell division and cancer. Biochim Biophys Acta 1786: 60-72. doi: 10.1016/j.bbcan.2008.07.003 PMID: 18662747
32. Dong J, Feldmann G, Huang J, Wu S, Zhang N, et al. (2007) Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell 130: 1120-1133. doi: 10.1016/j.cell.2007.07.019 PMID: 17889654
33. Yuan M, Tomlinson V, Lara R, Holliday D, Chelala C, et al. (2008) Yes-associated protein (YAP) functions as a tumor suppressor in breast. Cell Death Differ 15: 1752-1759. doi: 10.1038/cdd.2008.108 PMID: 18617895
34. Zhao B, Li L, Lei Q, Guan K- L (2010) The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version. Genes Dev 24: 862-874. doi: 10.1101/gad.1909210 PMID: 20439427
35. Muramatsu T, Imoto I, Matsui T, Kozaki K- I, Haruki S, et al. (2011) YAP is a candidate oncogene for esophageal squamous cell carcinoma. Carcinogenesis 32: 389-398. doi: 10.1093/carcin/bgq254 PMID: 21112960
36. Konsavage WM, Kyler SL, Rennoll SA, Jin G, Yochum GS (2012)Wnt/β-catenin signaling regulates Yesassociated protein (YAP) gene expression in colorectal carcinoma cells. J Biol Chem 287: 11730-11739. doi: 10.1074/jbc.M111.327767 PMID: 22337891
37. Hao Y, Chun A, Cheung K, Rashidi B, Yang X (2008) Tumor suppressor LATS1 is a negative regulator of oncogene YAP. J Biol Chem 283: 5496-5509. doi: 10.1074/jbc.M709037200 PMID: 18158288
38. Stoeber K, Tlsty TD, Happerfield L, Thomas GA, Romanov S, et al. (2001) DNA replication licensing and human cell proliferation. J Cell Sci 114: 2027-2041. PMID: 11493639
39. Bochman ML, Schwacha A (2009) The Mcm complex: unwinding the mechanism of a replicative helicase. Microbiol Mol Biol Rev 73: 652-683. doi: 10.1128/MMBR.00019-09 PMID: 19946136
40. Tsuyama T, Tada S, Watanabe S, Seki M, Enomoto T (2005) Licensing for DNA replication requires a strict sequential assembly of Cdc6 and Cdt1 onto chromatin in Xenopus egg extracts. Nucleic Acids Res 33: 765-775. doi: 10.1093/nar/gki226 PMID: 15687385
41. Nishitani N (2004) DNA replication licensing. Front Biosci 9: 2115. doi: 10.2741/1315 PMID: 15353274
42. Nishitani H, Lygerou Z (2002) Control of DNA replication licensing in a cell cycle. Genes to Cells 7: 523-534. doi: 10.1046/j.1365-2443.2002.00544.x PMID: 12059957
43. Pollok S, Bauerschmidt C, Sänger J, Nasheuer H-P, Grosse F (2007) Human Cdc45 is a proliferationassociated antigen. FEBS J 274: 3669-3684. doi: 10.1111/j.1742-4658.2007.05900.x PMID: 17608804
44. Osborn AJ, Elledge SJ, Zou L (2002) Checking on the fork: the DNA-replication stress-response pathway. Trends Cell Biol 12: 509-516. doi: 10.1016/S0962-8924(02)02380-2 PMID: 12446112
45. Cook JG, Park C- H, Burke TW, Leone G, DeGregori J, et al. (2002) Analysis of Cdc6 function in the assembly of mammalian prereplication complexes. Proc Natl Acad Sci U S A 99: 1347-1352. doi: 10. 1073/pnas.032677499 PMID: 11805305
46. Kim JM, Yamada M, Masai H (2003) Functions of mammalian Cdc7 kinase in initiation/monitoring of DNA replication and development. Mutat Res 532: 29-40. doi: 10.1016/j.mrfmmm.2003.08.008 PMID: 14643427
47. Xu X, Bieda M, Jin VX, Rabinovich A, Oberley MJ, et al. (2007) A comprehensive ChIP-chip analysis of E2F1, E2F4, and E2F6 in normal and tumor cells reveals interchangeable roles of E2F family members. Genome Res 17: 1550-1561. doi: 10.1101/gr.6783507 PMID: 17908821
48. Liu T, Huang J (2014) Quality control of homologous recombination. Cell Mol Life Sci. doi: 10.1007/ s00018-014-1649-5 PMID: 25548803
49. Misteli T, Soutoglou E (2009) The emerging role of nuclear architecture in DNA repair and genome maintenance. Nat Rev Mol Cell Biol 10: 243-254. doi: 10.1038/nrm2651 PMID: 19277046
50. Cottini F, Hideshima T, Xu C, Sattler M, Dori M, et al. (2014) Rescue of Hippo coactivator YAP1 triggers DNA damage-induced apoptosis in hematological cancers. Nat Med 20: 599-606. doi: 10.1038/nm.3562 PMID: 24813251
51. Chalasani P, Livingston R (2013) Differential chemotherapeutic sensitivity for breast tumors with "BRCAness": a review. Oncologist 18: 909-916. doi: 10.1634/theoncologist.2013-0039 PMID: 23881989
52. Shimizu Y, Luk H, Horio D, Miron P, Griswold M, et al. (2012) BRCA1-IRIS overexpression promotes formation of aggressive breast cancers. PLoS One 7: e34102. doi: 10.1371/journal.pone.0034102 PMID: 22511931
53. MacLachlan TK, El-Deiry W(2000) Functional Interactions Between BRCA1 and the Cell Cycle. Madame Curie Biosci Database.
54. Welcsh PL (2001) BRCA1 and BRCA2 and the genetics of breast and ovarian cancer. Hum Mol Genet 10: 705-713. doi: 10.1093/hmg/10.7.705 PMID: 11257103
55. Francken AB, Schouten PC, Bleiker EMA, Linn SC, Rutgers EJT (2013) Breast cancer in women at high risk: the role of rapid genetic testing for BRCA1 and-2 mutations and the consequences for treatment strategies. Breast 22: 561-568. doi: 10.1016/j.breast.2013.07.045 PMID: 23972475
56. Rosell R, Skrzypski M, Jassem E, Taron M, Bartolucci R, et al. (2007) BRCA1: a novel prognostic factor in resected non-small-cell lung cancer. PLoS One 2: e1129. doi: 10.1371/journal.pone.0001129 PMID: 17987116
57. Huang J, Wu S, Barrera J, Matthews K, Pan D (2005) The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. Cell 122: 421-434. doi: 10.1016/j.cell.2005.06.007 PMID: 16096061
58. Bertini E, Oka T, Sudol M, Strano S, Blandino G, et al. (2009) YAP: At the crossroad between transformation and tumor supression. Cell Cycle 8: 49-57. doi: 10.4161/cc.8.1.7259 PMID: 19106601