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Volumn 66, Issue , 2015, Pages 17-29

Metformin in cancer treatment and prevention

Author keywords

clinical trials; diabetes; epidemiology; oncology

Indexed keywords

METFORMIN; ANTIDIABETIC AGENT;

EID: 84921405225     PISSN: 00664219     EISSN: 1545326X     Source Type: Book Series    
DOI: 10.1146/annurev-med-062613-093128     Document Type: Article
Times cited : (384)

References (72)
  • 1
    • 2342466734 scopus 로고    scopus 로고
    • Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030
    • Wild S, Roglic G, Green A, et al. 2004. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 27:1047-53
    • (2004) Diabetes Care , vol.27 , pp. 1047-1053
    • Wild, S.1    Roglic, G.2    Green, A.3
  • 2
    • 84975856269 scopus 로고    scopus 로고
    • Economic costs of diabetes in the US 2012
    • American Diabetes Association.
    • American Diabetes Association. 2013. Economic costs of diabetes in the U.S. in 2012. Diabetes Care 36:1033-46
    • (2013) Diabetes Care , vol.36 , pp. 1033-1046
  • 3
    • 0035856949 scopus 로고    scopus 로고
    • Insulin signalling and the regulation of glucose and lipid metabolism
    • Saltiel AR, Kahn CR. 2001. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414:799-806
    • (2001) Nature , vol.414 , pp. 799-806
    • Saltiel, A.R.1    Kahn, C.R.2
  • 4
    • 77955873660 scopus 로고    scopus 로고
    • Pathophysiology of type 2 diabetes: Targeting islet cell dysfunction
    • Spellman CW. 2010. Pathophysiology of type 2 diabetes: targeting islet cell dysfunction. J. Am. Osteopath. Assoc. 110:S2-7
    • (2010) J. Am. Osteopath. Assoc. , vol.110 , pp. S2-7
    • Spellman, C.W.1
  • 6
    • 58049192725 scopus 로고    scopus 로고
    • Long-Term all-cause mortality in cancer patients with preexisting diabetes mellitus: A systematic review and meta-Analysis
    • Barone BB, Yeh HC, Snyder CF, et al. 2008. Long-Term all-cause mortality in cancer patients with preexisting diabetes mellitus: a systematic review and meta-Analysis. JAMA 300:2754-64
    • (2008) JAMA , vol.300 , pp. 2754-2764
    • Barone, B.B.1    Yeh, H.C.2    Snyder, C.F.3
  • 7
    • 84883486166 scopus 로고    scopus 로고
    • Systematic review and meta-Analysis of the association between diabetes mellitus and incidence and mortality in breast and colorectal cancer
    • De Bruijn KM, Arends LR, Hansen BE, et al. 2013. Systematic review and meta-Analysis of the association between diabetes mellitus and incidence and mortality in breast and colorectal cancer. Br. J. Surg. 100:1421-29
    • (2013) Br. J. Surg. , vol.100 , pp. 1421-1429
    • De Bruijn, K.M.1    Arends, L.R.2    Hansen, B.E.3
  • 8
    • 84895539904 scopus 로고    scopus 로고
    • Type 2 diabetes and the risk of mortality among patients with prostate cancer
    • Bensimon L, Yin H, Suissa S, et al. 2014. Type 2 diabetes and the risk of mortality among patients with prostate cancer. Cancer Causes Control 25:329-38
    • (2014) Cancer Causes Control , vol.25 , pp. 329-338
    • Bensimon, L.1    Yin, H.2    Suissa, S.3
  • 9
    • 54349083481 scopus 로고    scopus 로고
    • Prediagnostic body-mass index, plasma C-peptide concentration, and prostate cancer-specific mortality in men with prostate cancer: A long-Term survival analysis
    • Ma J, Li H, Giovannucci E, et al. 2008. Prediagnostic body-mass index, plasma C-peptide concentration, and prostate cancer-specific mortality in men with prostate cancer: a long-Term survival analysis. Lancet Oncol. 9:1039-47
    • (2008) Lancet Oncol. , vol.9 , pp. 1039-1047
    • Ma, J.1    Li, H.2    Giovannucci, E.3
  • 11
    • 47349101284 scopus 로고    scopus 로고
    • The role of insulin receptors and IGF-I receptors in cancer and other diseases
    • Frasca F, Pandini G, Sciacca L, et al. 2008. The role of insulin receptors and IGF-I receptors in cancer and other diseases. Arch. Physiol. Biochem. 114:23-37
    • (2008) Arch. Physiol. Biochem. , vol.114 , pp. 23-37
    • Frasca, F.1    Pandini, G.2    Sciacca, L.3
  • 12
    • 33846807433 scopus 로고    scopus 로고
    • Disrupting insulin-like growth factor signaling as a potential cancer therapy
    • Sachdev D, Yee D. 2007. Disrupting insulin-like growth factor signaling as a potential cancer therapy. Mol. Cancer Ther. 6:1-12
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 1-12
    • Sachdev, D.1    Yee, D.2
  • 13
    • 0026028184 scopus 로고
    • A direct effect of hyperinsulinemia on serum sex hormonebinding globulin levels in obese women with the polycystic ovary syndrome
    • Nestler JE, Powers LP, Matt DW, et al. 1991. A direct effect of hyperinsulinemia on serum sex hormonebinding globulin levels in obese women with the polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 72:83-89
    • (1991) J. Clin. Endocrinol. Metab. , vol.72 , pp. 83-89
    • Nestler, J.E.1    Powers, L.P.2    Matt, D.W.3
  • 14
    • 0037123341 scopus 로고    scopus 로고
    • Endogenous sex hormones and breast cancer in postmenopausal women: Reanalysis of nine prospective studies
    • Key T, Appleby P, Barnes I, Reeves G. 2002. Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies. J. Natl. Cancer Inst. 94:606-16
    • (2002) J. Natl. Cancer Inst. , vol.94 , pp. 606-616
    • Key, T.1    Appleby, P.2    Barnes, I.3    Reeves, G.4
  • 15
    • 67650550499 scopus 로고    scopus 로고
    • Chronic inflammation, the tumor microenvironment and carcinogenesis
    • Gonda TA, Tu S, Wang TC. 2009. Chronic inflammation, the tumor microenvironment and carcinogenesis. Cell Cycle 8:2005-13
    • (2009) Cell Cycle , vol.8 , pp. 2005-2013
    • Gonda, T.A.1    Tu, S.2    Wang, T.C.3
  • 16
    • 60449089649 scopus 로고    scopus 로고
    • Medical management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: A consensus statement of the american diabetes association and the european association for the study of diabetes
    • NathanDM, Buse JB, Davidson MB, et al. 2009. Medical management of hyperglycemia in type 2 diabetes: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care 32:193-203
    • (2009) Diabetes Care , vol.32 , pp. 193-203
    • Nathan, D.M.1    Buse, J.B.2    Davidson, M.B.3
  • 17
    • 84855603512 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of metformin: An overview
    • Viollet B, Guigas B, Sanz Garcia N, et al. 2012. Cellular and molecular mechanisms of metformin: an overview. Clin. Sci. 122:253-70
    • (2012) Clin. Sci. , vol.122 , pp. 253-270
    • Viollet, B.1    Guigas, B.2    Sanz Garcia, N.3
  • 18
    • 0034614420 scopus 로고    scopus 로고
    • Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex i
    • El-Mir MY, Nogueira V, Fontaine E, et al. 2000. Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I. J. Biol. Chem. 275:223-28
    • (2000) J. Biol. Chem. , vol.275 , pp. 223-228
    • El-Mir, M.Y.1    Nogueira, V.2    Fontaine, E.3
  • 19
    • 63849206613 scopus 로고    scopus 로고
    • AMP-Activated protein kinase in the regulation of hepatic energy metabolism: From physiology to therapeutic perspectives
    • Viollet B, Guigas B, Leclerc J, et al. 2009. AMP-Activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives. Acta Physiol. 196:81-98
    • (2009) Acta Physiol. , vol.196 , pp. 81-98
    • Viollet, B.1    Guigas, B.2    Leclerc, J.3
  • 20
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: Themetabolic requirements of cell proliferation
    • VanderHeidenMG, CantleyLC, Thompson CB. 2009. Understanding the Warburg effect: themetabolic requirements of cell proliferation. Science 324:1029-33
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 21
    • 78649711427 scopus 로고    scopus 로고
    • The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes
    • Levine AJ, Puzio-Kuter AM. 2010. The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes. Science 330:1340-44
    • (2010) Science , vol.330 , pp. 1340-1344
    • Levine, A.J.1    Puzio-Kuter, A.M.2
  • 22
    • 84872159532 scopus 로고    scopus 로고
    • AMPKis a negative regulator of theWarburg effect and suppresses tumor growth in vivo
    • Faubert B, Boily G, Izreig S, et al. 2013.AMPKis a negative regulator of theWarburg effect and suppresses tumor growth in vivo. Cell Metab. 17:113-24
    • (2013) Cell Metab. , vol.17 , pp. 113-124
    • Faubert, B.1    Boily, G.2    Izreig, S.3
  • 23
    • 83255189409 scopus 로고    scopus 로고
    • AMPK-mediated increase of glycolysis as an adaptive response to oxidative stress in human cells: Implication of the cell survival in mitochondrial diseases
    • WuSB, Wei YH. 2012. AMPK-mediated increase of glycolysis as an adaptive response to oxidative stress in human cells: implication of the cell survival in mitochondrial diseases. Biochim. Biophys. Acta 1822:233-47
    • (2012) Biochim. Biophys. Acta , vol.1822 , pp. 233-247
    • Wusb Wei, Y.H.1
  • 24
    • 0032471851 scopus 로고    scopus 로고
    • Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity
    • Mehenni H, Gehrig C, Nezu J, et al. 1998. Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity. Am. J. Hum. Genet. 63:1641-50
    • (1998) Am. J. Hum. Genet. , vol.63 , pp. 1641-1650
    • Mehenni, H.1    Gehrig, C.2    Nezu, J.3
  • 25
    • 64749108996 scopus 로고    scopus 로고
    • Tumours with PI3K activation are resistant to dietary restriction
    • KalaanyNY, Sabatini DM. 2009. Tumours with PI3K activation are resistant to dietary restriction. Nature 458:725-31
    • (2009) Nature , vol.458 , pp. 725-731
    • Kalaany, N.Y.1    Sabatini, D.M.2
  • 26
    • 0034904776 scopus 로고    scopus 로고
    • Growth factors can influence cell growth and survival through effects on glucose metabolism
    • Vander Heiden MG, Plas DR, Rathmell JC, et al. 2001. Growth factors can influence cell growth and survival through effects on glucose metabolism. Mol. Cell. Biol. 21:5899-912
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 5899-5912
    • Vander Heiden, M.G.1    Plas, D.R.2    Rathmell, J.C.3
  • 27
    • 84873584845 scopus 로고    scopus 로고
    • LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin
    • Shackelford DB, Abt E, Gerken L, et al. 2013. LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin. Cancer Cell 23:143-58
    • (2013) Cancer Cell , vol.23 , pp. 143-158
    • Shackelford, D.B.1    Abt, E.2    Gerken, L.3
  • 28
    • 38549147538 scopus 로고    scopus 로고
    • Overexpression of fatty acid synthase gene activates HER1/HER2 tyrosine kinase receptors in human breast epithelial cells
    • Vazquez-Martin A, Colomer R, Brunet J, et al. 2008. Overexpression of fatty acid synthase gene activates HER1/HER2 tyrosine kinase receptors in human breast epithelial cells. Cell Prolif. 41:59-85
    • (2008) Cell Prolif. , vol.41 , pp. 59-85
    • Vazquez-Martin, A.1    Colomer, R.2    Brunet, J.3
  • 29
    • 3543025724 scopus 로고    scopus 로고
    • AMP-Activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanisms
    • Xiang X, Saha AK, Wen R, et al. 2004. AMP-Activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanisms. Biochem. Biophys. Res. Commun. 321:161-67
    • (2004) Biochem. Biophys. Res. Commun. , vol.321 , pp. 161-167
    • Xiang, X.1    Saha, A.K.2    Wen, R.3
  • 30
    • 84872401752 scopus 로고    scopus 로고
    • Role of AMP-Activated protein kinase in adipose tissue metabolism and inflammation
    • Bijland S, Mancini SJ, Salt IP. 2013. Role of AMP-Activated protein kinase in adipose tissue metabolism and inflammation. Clin. Sci. 124:491-507
    • (2013) Clin. Sci. , vol.124 , pp. 491-507
    • Bijland, S.1    Mancini, S.J.2    Salt, I.P.3
  • 31
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: A leading role for STAT3
    • Yu H, Pardoll D, Jove R. 2009. STATs in cancer inflammation and immunity: a leading role for STAT3. Nat. Rev. Cancer 9:798-809
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 32
    • 84872529696 scopus 로고    scopus 로고
    • Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth
    • Hirsch HA, Iliopoulos D, Struhl K. 2013. Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth. Proc. Natl. Acad. Sci. USA 110:972-77
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 972-977
    • Hirsch, H.A.1    Iliopoulos, D.2    Struhl, K.3
  • 33
    • 44649103918 scopus 로고    scopus 로고
    • The effect of metformin treatment on VEGF and PAI-1 levels in obese type 2 diabetic patients
    • Ersoy C, Kiyici S, Budak F, et al. 2008. The effect of metformin treatment on VEGF and PAI-1 levels in obese type 2 diabetic patients. Diabetes Res. Clin. Pract. 81:56-60
    • (2008) Diabetes Res. Clin. Pract. , vol.81 , pp. 56-60
    • Ersoy, C.1    Kiyici, S.2    Budak, F.3
  • 35
    • 79955490053 scopus 로고    scopus 로고
    • Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types
    • Iliopoulos D, Hirsch HA, Struhl K. 2011. Metformin decreases the dose of chemotherapy for prolonging tumor remission in mouse xenografts involving multiple cancer cell types. Cancer Res. 71:3196-201
    • (2011) Cancer Res. , vol.71 , pp. 3196-3201
    • Iliopoulos, D.1    Hirsch, H.A.2    Struhl, K.3
  • 36
    • 84864619407 scopus 로고    scopus 로고
    • Metformin sensitizes endometrial cancer cells to chemotherapy by repressing glyoxalase i expression
    • Dong L, Zhou Q, Zhang Z, et al. 2012. Metformin sensitizes endometrial cancer cells to chemotherapy by repressing glyoxalase I expression. J. Obstet. Gynaecol. Res. 38:1077-85
    • (2012) J. Obstet. Gynaecol. Res. , vol.38 , pp. 1077-1085
    • Dong, L.1    Zhou, Q.2    Zhang, Z.3
  • 37
    • 84887496514 scopus 로고    scopus 로고
    • Metformin, at concentrations corresponding to the treatment of diabetes, potentiates the cytotoxic effects of carboplatin in cultures of ovarian cancer cells
    • EricesR, Bravo ML, Gonzalez P, et al. 2013. Metformin, at concentrations corresponding to the treatment of diabetes, potentiates the cytotoxic effects of carboplatin in cultures of ovarian cancer cells. Reprod. Sci. 20:1433-46
    • (2013) Reprod. Sci. , vol.20 , pp. 1433-1446
    • Erices, R.1    Bravo, M.L.2    Gonzalez, P.3
  • 38
    • 80054789258 scopus 로고    scopus 로고
    • Metformin protects against doxorubicin-induced cardiotoxicity: Involvement of the adiponectin cardiac system
    • Asensio-LopezMC, LaxA, Pascual-Figal DA, et al. 2011. Metformin protects against doxorubicin-induced cardiotoxicity: involvement of the adiponectin cardiac system. Free Radic. Biol. Med. 51:1861-71
    • (2011) Free Radic. Biol. Med. , vol.51 , pp. 1861-1871
    • Asensio-Lopez, M.C.1    Lax, A.2    Pascual-Figal, D.A.3
  • 39
    • 84897021769 scopus 로고    scopus 로고
    • Protective effect of metformin against cisplatin-induced ototoxicity in an auditory cell line
    • Chang J, Jung HH, Yang JY, et al. 2013. Protective effect of metformin against cisplatin-induced ototoxicity in an auditory cell line. J. Assoc. Res. Otolaryngol. 15:149-58
    • (2013) J. Assoc. Res. Otolaryngol. , vol.15 , pp. 149-158
    • Chang, J.1    Jung, H.H.2    Yang, J.Y.3
  • 40
    • 75149179169 scopus 로고    scopus 로고
    • Metformin associated with lower cancermortality in type 2 diabetes: ZODIAC-16
    • LandmanGW, Kleefstra N, vanHateren KJ, et al. 2010. Metformin associated with lower cancermortality in type 2 diabetes: ZODIAC-16. Diabetes Care 33:322-26
    • (2010) Diabetes Care , vol.33 , pp. 322-326
    • Landman, G.W.1    Kleefstra, N.2    Van Hateren, K.J.3
  • 41
    • 77953537179 scopus 로고    scopus 로고
    • Glucose-lowering agents and cancer mortality rates in type 2 diabetes: Assessing effects of time-varying exposure
    • Bowker SL, Yasui Y, Veugelers P, Johnson JA. 2010. Glucose-lowering agents and cancer mortality rates in type 2 diabetes: assessing effects of time-varying exposure. Diabetologia 53:1631-37
    • (2010) Diabetologia , vol.53 , pp. 1631-1637
    • Bowker, S.L.1    Yasui, Y.2    Veugelers, P.3    Johnson, J.A.4
  • 42
    • 84859029647 scopus 로고    scopus 로고
    • Mortality after incident cancer in people with and without type 2 diabetes: Impact of metformin on survival
    • Currie CJ, Poole CD, Jenkins-Jones S, et al. 2012. Mortality after incident cancer in people with and without type 2 diabetes: impact of metformin on survival. Diabetes Care 35:299-304
    • (2012) Diabetes Care , vol.35 , pp. 299-304
    • Currie, C.J.1    Poole, C.D.2    Jenkins-Jones, S.3
  • 43
    • 84880974660 scopus 로고    scopus 로고
    • Metformin therapy and risk of cancer in patients with type 2 diabetes: Systematic review
    • Franciosi M, Lucisano G, Lapice E, et al. 2013. Metformin therapy and risk of cancer in patients with type 2 diabetes: systematic review. PLOS ONE 8:e71583
    • (2013) PLOS ONE , vol.8 , pp. e71583
    • Franciosi, M.1    Lucisano, G.2    Lapice, E.3
  • 44
    • 67749144226 scopus 로고    scopus 로고
    • Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer
    • Jiralerspong S, Palla SL, Giordano SH, et al. 2009. Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer. J. Clin. Oncol. 27:3297-302
    • (2009) J. Clin. Oncol. , vol.27 , pp. 3297-3302
    • Jiralerspong, S.1    Palla, S.L.2    Giordano, S.H.3
  • 45
    • 84857372409 scopus 로고    scopus 로고
    • Effect of metformin on survival outcomes in diabetic patients with triple receptor-negative breast cancer
    • Bayraktar S, Hernadez-Aya LF, Lei X, et al. 2012. Effect of metformin on survival outcomes in diabetic patients with triple receptor-negative breast cancer. Cancer 118:1202-11
    • (2012) Cancer , vol.118 , pp. 1202-1211
    • Bayraktar, S.1    Hernadez-Aya, L.F.2    Lei, X.3
  • 46
    • 84879325892 scopus 로고    scopus 로고
    • Clinical pathological characteristics and prognostic analysis of 1, 013 breast cancer patients with diabetes
    • Hou G, Zhang S, Zhang X, et al. 2013. Clinical pathological characteristics and prognostic analysis of 1, 013 breast cancer patients with diabetes. Breast Cancer Res. Treat. 137:807-16
    • (2013) Breast Cancer Res. Treat. , vol.137 , pp. 807-816
    • Hou, G.1    Zhang, S.2    Zhang, X.3
  • 47
    • 79954478103 scopus 로고    scopus 로고
    • Metformin associated with lower mortality in diabetic patients with early stage hepatocellular carcinoma after radiofrequency ablation
    • Chen TM, Lin CC, Huang PT, Wen CF. 2011. Metformin associated with lower mortality in diabetic patients with early stage hepatocellular carcinoma after radiofrequency ablation. J. Gastroenterol. Hepatol. 26:858-65
    • (2011) J. Gastroenterol. Hepatol. , vol.26 , pp. 858-865
    • Chen, T.M.1    Lin, C.C.2    Huang, P.T.3    Wen, C.F.4
  • 48
    • 84255169908 scopus 로고    scopus 로고
    • Relationship of type II diabetes and metformin use to ovarian cancer progression, survival, and chemosensitivity
    • Romero IL, McCormick A, McEwen KA, et al. 2012. Relationship of type II diabetes and metformin use to ovarian cancer progression, survival, and chemosensitivity. Obstet. Gynecol. 119:61-67
    • (2012) Obstet. Gynecol. , vol.119 , pp. 61-67
    • Romero, I.L.1    McCormick, A.2    McEwen, K.A.3
  • 49
    • 84872978681 scopus 로고    scopus 로고
    • Metformin intake is associated with better survival in ovarian cancer: A case-control study
    • Kumar S, Meuter A, Thapa P, et al. 2013. Metformin intake is associated with better survival in ovarian cancer: a case-control study. Cancer 119:555-62
    • (2013) Cancer , vol.119 , pp. 555-562
    • Kumar, S.1    Meuter, A.2    Thapa, P.3
  • 51
    • 84859631091 scopus 로고    scopus 로고
    • Survival advantage observed with the use of metformin in patients with type II diabetes and colorectal cancer
    • Garrett CR, Hassabo HM, Bhadkamkar NA, et al. 2012. Survival advantage observed with the use of metformin in patients with type II diabetes and colorectal cancer. Br. J. Cancer 106:1374-78
    • (2012) Br. J. Cancer , vol.106 , pp. 1374-1378
    • Garrett, C.R.1    Hassabo, H.M.2    Bhadkamkar, N.A.3
  • 52
    • 84861127026 scopus 로고    scopus 로고
    • Metformin use is associated with better survival of diabetic patients with pancreatic cancer
    • Sadeghi N, Abbruzzese JL, Yeung SC, Hassan M, Li D. 2012. Metformin use is associated with better survival of diabetic patients with pancreatic cancer. Clin. Cancer Res. 18:2905-12
    • (2012) Clin. Cancer Res. , vol.18 , pp. 2905-2912
    • Sadeghi, N.1    Abbruzzese, J.L.2    Yeung, S.C.3    Hassan, M.4    Li, D.5
  • 53
    • 84877353837 scopus 로고    scopus 로고
    • Metformin use and improved response to therapy in esophageal adenocarcinoma
    • SkinnerHD, McCurdyMR, Echeverria AE, et al. 2013. Metformin use and improved response to therapy in esophageal adenocarcinoma. Acta Oncol. 52:1002-9
    • (2013) Acta Oncol. , vol.52 , pp. 1002-1009
    • Skinner, H.D.1    McCurdy, M.R.2    Echeverria, A.E.3
  • 54
    • 80555126838 scopus 로고    scopus 로고
    • Prognostic influence of metformin as first-line chemotherapy for advanced nonsmall cell lung cancer in patients with type 2 diabetes
    • Tan BX, Yao WX, Ge J, et al. 2011. Prognostic influence of metformin as first-line chemotherapy for advanced nonsmall cell lung cancer in patients with type 2 diabetes. Cancer 117:5103-11
    • (2011) Cancer , vol.117 , pp. 5103-5111
    • Tan, B.X.1    Yao, W.X.2    Ge, J.3
  • 55
    • 79960845901 scopus 로고    scopus 로고
    • Evidence for biological effects ofmetformin in operable breast cancer: A pre-operative, window-of-opportunity, randomized trial
    • Hadad S, Iwamoto T, Jordan L, et al. 2011. Evidence for biological effects ofmetformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial. Breast Cancer Res. Treat. 128:783-94
    • (2011) Breast Cancer Res. Treat. , vol.128 , pp. 783-794
    • Hadad, S.1    Iwamoto, T.2    Jordan, L.3
  • 56
    • 84866538325 scopus 로고    scopus 로고
    • Metformin in early breast cancer: A prospective window of opportunity neoadjuvant study
    • Niraula S, Dowling RJ, Ennis M, et al. 2012. Metformin in early breast cancer: a prospective window of opportunity neoadjuvant study. Breast Cancer Res. Treat. 135:821-30
    • (2012) Breast Cancer Res. Treat. , vol.135 , pp. 821-830
    • Niraula, S.1    Dowling, R.J.2    Ennis, M.3
  • 57
    • 84864075329 scopus 로고    scopus 로고
    • Dual effect of metformin on breast cancer proliferation in a randomized presurgical trial
    • Bonanni B, PuntoniM, CazzanigaM, et al. 2012. Dual effect of metformin on breast cancer proliferation in a randomized presurgical trial. J. Clin. Oncol. 30:2593-600
    • (2012) J. Clin. Oncol. , vol.30 , pp. 2593-2600
    • Bonanni, B.1    Puntoni, M.2    Cazzaniga, M.3
  • 58
    • 77956411030 scopus 로고    scopus 로고
    • Metformin suppresses colorectal aberrant crypt foci in a short-Term clinical trial
    • Hosono K, Endo H, Takahashi H, et al. 2010. Metformin suppresses colorectal aberrant crypt foci in a short-Term clinical trial. Cancer Prev. Res. 3:1077-83
    • (2010) Cancer Prev. Res. , vol.3 , pp. 1077-1083
    • Hosono, K.1    Endo, H.2    Takahashi, H.3
  • 59
    • 20444461067 scopus 로고    scopus 로고
    • Metformin and reduced risk of cancer in diabetic patients
    • Evans JM, Donnelly LA, Emslie-Smith AM, et al. 2005. Metformin and reduced risk of cancer in diabetic patients. BMJ 330:1304-5
    • (2005) BMJ , vol.330 , pp. 1304-1305
    • Evans, J.M.1    Donnelly, L.A.2    Emslie-Smith, A.M.3
  • 60
    • 84879552899 scopus 로고    scopus 로고
    • Metformin and sulfonylureas in relation to cancer risk in type II diabetes patients: A meta-Analysis using primary data of published studies
    • Thakkar B, Aronis KN, Vamvini MT, et al. 2013. Metformin and sulfonylureas in relation to cancer risk in type II diabetes patients: a meta-Analysis using primary data of published studies. Metab. Clin. Exp. 62:922-34
    • (2013) Metab. Clin. Exp. , vol.62 , pp. 922-934
    • Thakkar, B.1    Aronis, K.N.2    Vamvini, M.T.3
  • 61
    • 84876334434 scopus 로고    scopus 로고
    • Association of metformin use with cancer incidence and mortality: A meta-Analysis
    • Zhang P, Li H, Tan X, et al. 2013. Association of metformin use with cancer incidence and mortality: a meta-Analysis. Cancer Epidemiol. 37:207-18
    • (2013) Cancer Epidemiol. , vol.37 , pp. 207-218
    • Zhang, P.1    Li, H.2    Tan, X.3
  • 62
    • 77955558076 scopus 로고    scopus 로고
    • Experience of malignancies with oral glucose-lowering drugs in the randomised controlled adopt (a diabetes outcome progression trial) and record (rosiglitazone evaluated for cardiovascular outcomes and regulation of glycaemia in diabetes) clinical trials
    • Home PD, Kahn SE, Jones NP, et al. 2010. Experience of malignancies with oral glucose-lowering drugs in the randomised controlled ADOPT (A Diabetes Outcome Progression Trial) and RECORD (Rosiglitazone Evaluated for Cardiovascular Outcomes and Regulation of Glycaemia in Diabetes) clinical trials. Diabetologia 53:1838-45
    • (2010) Diabetologia , vol.53 , pp. 1838-1845
    • Home, P.D.1    Kahn, S.E.2    Jones, N.P.3
  • 63
    • 78650677585 scopus 로고    scopus 로고
    • Metformin reduces cisplatin-mediated apoptotic death of cancer cells through AMPK-independent activation of Akt
    • Janjetovic K, Vucicevic L, MisirkicM, et al. 2011. Metformin reduces cisplatin-mediated apoptotic death of cancer cells through AMPK-independent activation of Akt. Eur. J. Pharmacol. 651:41-50
    • (2011) Eur. J. Pharmacol. , vol.651 , pp. 41-50
    • Janjetovic, K.1    Vucicevic, L.2    Misirkic, M.3
  • 64
    • 84869788946 scopus 로고    scopus 로고
    • Metformin and the risk of cancer: Time-related biases in observational studies
    • Suissa S, Azoulay L. 2012. Metformin and the risk of cancer: time-related biases in observational studies. Diabetes Care 35:2665-73
    • (2012) Diabetes Care , vol.35 , pp. 2665-2673
    • Suissa, S.1    Azoulay, L.2
  • 65
    • 79951592967 scopus 로고    scopus 로고
    • Metformin and the incidence of prostate cancer in patients with type 2 diabetes
    • Azoulay L, Dell'Aniello S, Gagnon B, et al. 2011. Metformin and the incidence of prostate cancer in patients with type 2 diabetes. Cancer Epidemiol. Biomark. Prev. 20:337-44
    • (2011) Cancer Epidemiol. Biomark. Prev. , vol.20 , pp. 337-344
    • Azoulay, L.1    Dell'aniello, S.2    Gagnon, B.3
  • 66
    • 84886416382 scopus 로고    scopus 로고
    • The use of metformin and colorectal cancer incidence in patients with type II diabetes mellitus
    • Smiechowski B, Azoulay L, Yin H, et al. 2013. The use of metformin and colorectal cancer incidence in patients with type II diabetes mellitus. Cancer Epidemiol. Biomark. Prev. 22:1877-83
    • (2013) Cancer Epidemiol. Biomark. Prev. , vol.22 , pp. 1877-1883
    • Smiechowski, B.1    Azoulay, L.2    Yin, H.3
  • 67
    • 84872019209 scopus 로고    scopus 로고
    • The use of metformin and the incidence of lung cancer in patients with type 2 diabetes
    • Smiechowski BB, Azoulay L, Yin H, et al. 2013. The use of metformin and the incidence of lung cancer in patients with type 2 diabetes. Diabetes Care 36:124-29
    • (2013) Diabetes Care , vol.36 , pp. 124-129
    • Smiechowski, B.B.1    Azoulay, L.2    Yin, H.3
  • 68
    • 84903549117 scopus 로고    scopus 로고
    • Incidence of bladder cancer in patients with type 2 diabetes treated with metformin or sulfonylureas
    • Mamtani R, Pfanzelter N, Haynes K, et al. 2014. Incidence of bladder cancer in patients with type 2 diabetes treated with metformin or sulfonylureas. Diabetes Care 37:1910-17
    • (2014) Diabetes Care , vol.37 , pp. 1910-1917
    • Mamtani, R.1    Pfanzelter, N.2    Haynes, K.3
  • 71
    • 0037130889 scopus 로고    scopus 로고
    • Cancer risk estimates for BRCA1 mutation carriers identified in a risk evaluation program
    • Brose MS, Rebbeck TR, Calzone KA, et al. 2002. Cancer risk estimates for BRCA1 mutation carriers identified in a risk evaluation program. J. Natl. Cancer Inst. 94:1365-72
    • (2002) J. Natl. Cancer Inst. , vol.94 , pp. 1365-1372
    • Brose, M.S.1    Rebbeck, T.R.2    Calzone, K.A.3
  • 72
    • 84858729797 scopus 로고    scopus 로고
    • Metformin efficacy and safety for colorectal polyps: A double-blind randomized controlled trial
    • Higurashi T, Takahashi H, Endo H, et al. 2012. Metformin efficacy and safety for colorectal polyps: a double-blind randomized controlled trial. BMC Cancer 12:118
    • (2012) BMC Cancer , vol.12 , pp. 118
    • Higurashi, T.1    Takahashi, H.2    Endo, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.