The combination of Hsp90 inhibitor 17AAG and heavy-ion irradiation provides effective tumor control in human lung cancer cells

Cancer Medicine

Volumn 4, Issue 3, 2015, Pages 426-436

  Hirakawa, Hirokazu ^a   Fujisawa, Hiroshi ^a,b   Masaoka, Aya ^a   Noguchi, Miho ^c   Hirayama, Ryoichi ^a   Takahashi, Momoko ^d   Fujimori, Akira ^a   Okayasu, Ryuichi ^a  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c JAPAN ATOMIC ENERGY AGENCY   (Japan)

^d FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

Author keywords

17AAG; DNA repair; Heavy ions; Hsp90 inhibitor; Lung cancer

Indexed keywords

TANESPIMYCIN; ANTINEOPLASTIC AGENT; BENZOQUINONE DERIVATIVE; HEAT SHOCK PROTEIN 90; MACROCYCLIC LACTAM; RAD51 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CONTROL; CELL CYCLE G2 PHASE; CELL SURVIVAL; CONTROLLED STUDY; DOUBLE STRANDED DNA BREAK; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; ION THERAPY; LUNG CANCER CELL LINE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECOMBINATION REPAIR; TUMOR GROWTH; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; DNA REPAIR; DRUG EFFECTS; LUNG NEOPLASMS; MALE; METABOLISM; MULTIMODALITY CANCER THERAPY; NUDE MOUSE; PATHOLOGY; RADIATION RESPONSE; TUMOR CELL LINE; TUMOR VOLUME;

ANIMALS; ANTINEOPLASTIC AGENTS; BENZOQUINONES; CELL LINE, TUMOR; CELL SURVIVAL; COMBINED MODALITY THERAPY; DNA REPAIR; HEAVY ION RADIOTHERAPY; HSP90 HEAT-SHOCK PROTEINS; HUMANS; LACTAMS, MACROCYCLIC; LUNG NEOPLASMS; MALE; MICE, INBRED BALB C; MICE, NUDE; RAD51 RECOMBINASE; TUMOR BURDEN;

EID: 84979862595     PISSN: None     EISSN: 20457634     Source Type: Journal    
DOI: 10.1002/cam4.377     Document Type: Article

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