The HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin modulates radiosensitivity by downregulating serine/threonine kinase 38 via Sp1 inhibition

European Journal of Cancer

Volumn 49, Issue 16, 2013, Pages 3547-3558

  Enomoto, Atsushi ^a   Fukasawa, Takemichi ^a   Takamatsu, Nobuhiko ^b   Ito, Michihiko ^b   Morita, Akinori ^c   Hosoi, Yoshio ^c   Miyagawa, Kiyoshi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b KITASATO UNIVERSITY   (Japan)

^c HIROSHIMA UNIVERSITY   (Japan)

Author keywords

17 AAG; Radiosensitization; Sp1; STK38

Indexed keywords

HEAT SHOCK PROTEIN 90 INHIBITOR; PROTEIN SERINE THREONINE KINASE; TANESPIMYCIN; TRANSCRIPTION FACTOR SP1;

ARTICLE; DOWN REGULATION; ENZYME ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; IONIZING RADIATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; RADIOSENSITIVITY; SITE DIRECTED MUTAGENESIS;

17-AAG; RADIOSENSITIZATION; SP1; STK38;

APOPTOSIS; BENZOQUINONES; BINDING SITES; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HCT116 CELLS; HEK293 CELLS; HELA CELLS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; LACTAMS, MACROCYCLIC; MCF-7 CELLS; NEOPLASMS; PROMOTER REGIONS, GENETIC; PROTEIN-SERINE-THREONINE KINASES; RADIATION-SENSITIZING AGENTS; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSCRIPTION FACTOR AP-1; TRANSFECTION;

EID: 84885191034     PISSN: 09598049     EISSN: 18790852     Source Type: Journal    
DOI: 10.1016/j.ejca.2013.06.034     Document Type: Article

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