메뉴 건너뛰기




Volumn 84, Issue 8, 2016, Pages 2233-2242

Purification of plasmodium sporozoites enhances parasite-specific CD8+ T cell responses

Author keywords

[No Author keywords available]

Indexed keywords

PARASITE ANTIGEN; SPOROZOITE VACCINE; EPITOPE; MALARIA VACCINE;

EID: 84979787290     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.01439-15     Document Type: Article
Times cited : (19)

References (59)
  • 2
    • 84871666296 scopus 로고    scopus 로고
    • A statistical interaction between circumsporozoite protein-specific T cell and antibody responses and risk of clinical malaria episodes following vaccination with RTS,S/AS01E
    • Ndungu FM, Mwacharo J, Kimani D, Kai O, Moris P, Jongert E, Vekemans J, Olotu A, Bejon P. 2012. A statistical interaction between circumsporozoite protein-specific T cell and antibody responses and risk of clinical malaria episodes following vaccination with RTS,S/AS01E. PLoS One 7:e52870. http://dx.doi.org/10.1371/journal.pone.0052870.
    • (2012) PLoS One , vol.7
    • Ndungu, F.M.1    Mwacharo, J.2    Kimani, D.3    Kai, O.4    Moris, P.5    Jongert, E.6    Vekemans, J.7    Olotu, A.8    Bejon, P.9
  • 3
    • 70349416541 scopus 로고    scopus 로고
    • Plasmodium falciparum-specific cellular immune responses after immunization with the RTS,S/AS02D candidate malaria vaccine in infants living in an area of high endemicity in Mozambique
    • Barbosa A, Naniche D, Aponte JJ, Manaca MN, Mandomando I, Aide P, Sacarlal J, Renom M, Lafuente S, Ballou WR, Alonso PL. 2009. Plasmodium falciparum-specific cellular immune responses after immunization with the RTS,S/AS02D candidate malaria vaccine in infants living in an area of high endemicity in Mozambique. Infect Immun 77:4502- 4509. http://dx.doi.org/10.1128/IAI.00442-09.
    • (2009) Infect Immun , vol.77 , pp. 4502- 4509
    • Barbosa, A.1    Naniche, D.2    Aponte, J.J.3    Manaca, M.N.4    Mandomando, I.5    Aide, P.6    Sacarlal, J.7    Renom, M.8    Lafuente, S.9    Ballou, W.R.10    Alonso, P.L.11
  • 4
    • 37749015262 scopus 로고    scopus 로고
    • Preclinical evaluation of the safety and immunogenicity of a vaccine consisting of Plasmodium falciparum liver-stage antigen 1 with adjuvant AS01B administered alone or concurrently with the RTS,S/AS01B vaccine in rhesus primates
    • Pichyangkul S, Kum-Arb U, Yongvanitchit K, Limsalakpetch A, Gettayacamin M, Lanar DE, Ware LA, Stewart VA, Heppner DG, Mettens P, Cohen JD, Ballou WR, Fukuda MM. 2008. Preclinical evaluation of the safety and immunogenicity of a vaccine consisting of Plasmodium falciparum liver-stage antigen 1 with adjuvant AS01B administered alone or concurrently with the RTS,S/AS01B vaccine in rhesus primates. Infect Immun 76:229-238. http://dx.doi.org/10.1128/IAI.00977-07.
    • (2008) Infect Immun , vol.76 , pp. 229-238
    • Pichyangkul, S.1    Kum-Arb, U.2    Yongvanitchit, K.3    Limsalakpetch, A.4    Gettayacamin, M.5    Lanar, D.E.6    Ware, L.A.7    Stewart, V.A.8    Heppner, D.G.9    Mettens, P.10    Cohen, J.D.11    Ballou, W.R.12    Fukuda, M.M.13
  • 5
    • 0014202885 scopus 로고
    • Protective immunity produced by the injection of x-irradiated sporozoites of plasmodium berghei
    • Nussenzweig RS, Vanderberg J, Most H, Orton C. 1967. Protective immunity produced by the injection of x-irradiated sporozoites of plasmodium berghei. Nature 216:160 -162. http://dx.doi.org/10.1038 /216160a0.
    • (1967) Nature , vol.216 , pp. 160 -162
    • Nussenzweig, R.S.1    Vanderberg, J.2    Most, H.3    Orton, C.4
  • 6
    • 0015699215 scopus 로고
    • Immunization of man against sporozite-induced falciparum malaria
    • Clyde DF, Most H, McCarthy VC, Vanderberg JP. 1973. Immunization of man against sporozite-induced falciparum malaria. Am J Med Sci 266: 169-177. http://dx.doi.org/10.1097/00000441-197309000-00002.
    • (1973) Am J Med Sci , vol.266 , pp. 169-177
    • Clyde, D.F.1    Most, H.2    McCarthy, V.C.3    Vanderberg, J.P.4
  • 7
    • 12744278200 scopus 로고    scopus 로고
    • Genetically modified Plasmodium parasites as a protective experimental malaria vaccine
    • Mueller AK, Labaied M, Kappe SH, Matuschewski K. 2005. Genetically modified Plasmodium parasites as a protective experimental malaria vaccine. Nature 433:164-167. http://dx.doi.org/10.1038/nature03188.
    • (2005) Nature , vol.433 , pp. 164-167
    • Mueller, A.K.1    Labaied, M.2    Kappe, S.H.3    Matuschewski, K.4
  • 8
    • 65649092055 scopus 로고    scopus 로고
    • Vaccine-like immunity against malaria by repeated causal-prophylactic treatment of liver-stage Plasmodium parasites
    • Putrianti ED, Silvie O, Kordes M, Borrmann S, Matuschewski K. 2009. Vaccine-like immunity against malaria by repeated causal-prophylactic treatment of liver-stage Plasmodium parasites. J Infect Dis 199:899-903. http://dx.doi.org/10.1086/597121.
    • (2009) J Infect Dis , vol.199 , pp. 899-903
    • Putrianti, E.D.1    Silvie, O.2    Kordes, M.3    Borrmann, S.4    Matuschewski, K.5
  • 10
    • 0034254649 scopus 로고    scopus 로고
    • The complexity of protective immunity against liver-stage malaria
    • Doolan DL, Hoffman SL. 2000. The complexity of protective immunity against liver-stage malaria. J Immunol 165:1453-1462. http://dx.doi.org /10.4049/jimmunol.165.3.1453.
    • (2000) J Immunol , vol.165 , pp. 1453-1462
    • Doolan, D.L.1    Hoffman, S.L.2
  • 12
    • 77952694574 scopus 로고    scopus 로고
    • Comparison of Plasmodium berghei challenge models for the evaluation of preerythrocytic malaria vaccines and their effect on perceived vaccine efficacy
    • Leitner WW, Bergmann-Leitner ES, Angov E. 2010. Comparison of Plasmodium berghei challenge models for the evaluation of preerythrocytic malaria vaccines and their effect on perceived vaccine efficacy. Malar J 9:145. http://dx.doi.org/10.1186/1475-2875-9-145.
    • (2010) Malar J , vol.9 , pp. 145
    • Leitner, W.W.1    Bergmann-Leitner, E.S.2    Angov, E.3
  • 16
    • 84927910961 scopus 로고    scopus 로고
    • The innate and adaptive response to mosquito saliva and Plasmodium sporozoites in the skin
    • Hopp CS, Sinnis P. 2015. The innate and adaptive response to mosquito saliva and Plasmodium sporozoites in the skin. Ann N Y Acad Sci 1342: 37-43. http://dx.doi.org/10.1111/nyas.12661.
    • (2015) Ann N Y Acad Sci , vol.1342 , pp. 37-43
    • Hopp, C.S.1    Sinnis, P.2
  • 17
    • 84920517938 scopus 로고    scopus 로고
    • Meta-analysis of the effects of insect vector saliva on host immune responses and infection of vectortransmitted pathogens: a focus on leishmaniasis
    • Ockenfels B, Michael E, McDowell MA. 2014. Meta-analysis of the effects of insect vector saliva on host immune responses and infection of vectortransmitted pathogens: a focus on leishmaniasis. PLoS Negl Trop Dis 8:e3197. http://dx.doi.org/10.1371/journal.pntd.0003197.
    • (2014) PLoS Negl Trop Dis , vol.8
    • Ockenfels, B.1    Michael, E.2    McDowell, M.A.3
  • 18
    • 33646853171 scopus 로고    scopus 로고
    • Natural human humoral response to salivary gland proteins of Anopheles mosquitoes in Thailand
    • Waitayakul A, Somsri S, Sattabongkot J, Looareesuwan S, Cui L, Udomsangpetch R. 2006. Natural human humoral response to salivary gland proteins of Anopheles mosquitoes in Thailand. Acta Trop 98:66-73. http://dx.doi.org/10.1016/j.actatropica.2006.02.004.
    • (2006) Acta Trop , vol.98 , pp. 66-73
    • Waitayakul, A.1    Somsri, S.2    Sattabongkot, J.3    Looareesuwan, S.4    Cui, L.5    Udomsangpetch, R.6
  • 20
    • 81755189033 scopus 로고    scopus 로고
    • Members of the salivary gland surface protein (SGS) family are major immunogenic components of mosquito saliva
    • King JG, Vernick KD, Hillyer JF. 2011. Members of the salivary gland surface protein (SGS) family are major immunogenic components of mosquito saliva. J Biol Chem 286:40824-40834. http://dx.doi.org/10 .1074/jbc.M111.280552.
    • (2011) J Biol Chem , vol.286 , pp. 40824-40834
    • King, J.G.1    Vernick, K.D.2    Hillyer, J.F.3
  • 22
    • 79954558608 scopus 로고    scopus 로고
    • Anopheles stephensi saliva enhances progression of cerebral malaria in a murine model
    • Schneider BS, Mathieu C, Peronet R, Mecheri S. 2011. Anopheles stephensi saliva enhances progression of cerebral malaria in a murine model. Vector Borne Zoonotic Dis 11:423-432. http://dx.doi.org/10.1089 /vbz.2010.0120.
    • (2011) Vector Borne Zoonotic Dis , vol.11 , pp. 423-432
    • Schneider, B.S.1    Mathieu, C.2    Peronet, R.3    Mecheri, S.4
  • 23
    • 33646039388 scopus 로고    scopus 로고
    • Mast cell-dependent down-regulation of antigen-specific immune responses by mosquito bites
    • Depinay N, Hacini F, Beghdadi W, Peronet R, Mecheri S. 2006. Mast cell-dependent down-regulation of antigen-specific immune responses by mosquito bites. J Immunol 176:4141-4146. http://dx.doi.org/10.4049 /jimmunol.176.7.4141.
    • (2006) J Immunol , vol.176 , pp. 4141-4146
    • Depinay, N.1    Hacini, F.2    Beghdadi, W.3    Peronet, R.4    Mecheri, S.5
  • 24
    • 77956282037 scopus 로고    scopus 로고
    • Why functional preerythrocytic and bloodstage malaria vaccines fail: a meta-analysis of fully protective immunizations and novel immunological model
    • Guilbride DL, Gawlinski P, Guilbride PD. 2010. Why functional preerythrocytic and bloodstage malaria vaccines fail: a meta-analysis of fully protective immunizations and novel immunological model. PLoS One 5:e10685. http://dx.doi.org/10.1371/journal.pone.0010685.
    • (2010) PLoS One , vol.5
    • Guilbride, D.L.1    Gawlinski, P.2    Guilbride, P.D.3
  • 25
    • 84899626405 scopus 로고    scopus 로고
    • Interferon- mediated innate immune responses against malaria parasite liver stages
    • Miller JL, Sack BK, Baldwin M, Vaughan AM, Kappe SH. 2014. Interferon- mediated innate immune responses against malaria parasite liver stages. Cell Rep 7:436-447. http://dx.doi.org/10.1016/j.celrep.2014.03 .018.
    • (2014) Cell Rep , vol.7 , pp. 436-447
    • Miller, J.L.1    Sack, B.K.2    Baldwin, M.3    Vaughan, A.M.4    Kappe, S.H.5
  • 26
    • 77957659569 scopus 로고    scopus 로고
    • Extreme CD8 T cell requirements for anti-malarial liver-stage immunity following immunization with radiation attenuated sporozoites
    • Schmidt NW, Butler NS, Badovinac VP, Harty JT. 2010. Extreme CD8 T cell requirements for anti-malarial liver-stage immunity following immunization with radiation attenuated sporozoites. PLoS Pathog 6:e1000998. http://dx.doi.org/10.1371/journal.ppat.1000998.
    • (2010) PLoS Pathog , vol.6
    • Schmidt, N.W.1    Butler, N.S.2    Badovinac, V.P.3    Harty, J.T.4
  • 27
    • 84876069319 scopus 로고    scopus 로고
    • A T-cell response to a liver-stage Plasmodium antigen is not boosted by repeated sporozoite immunizations
    • Murphy SC, Kas A, Stone BC, Bevan MJ. 2013. A T-cell response to a liver-stage Plasmodium antigen is not boosted by repeated sporozoite immunizations. Proc Natl Acad Sci U S A 110:6055-6060. http://dx.doi.org /10.1073/pnas.1303834110.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 6055-6060
    • Murphy, S.C.1    Kas, A.2    Stone, B.C.3    Bevan, M.J.4
  • 28
    • 33845884017 scopus 로고    scopus 로고
    • The circumsporozoite protein is an immunodominant protective antigen in irradiated sporozoites
    • Kumar KA, Sano G, Boscardin S, Nussenzweig RS, Nussenzweig MC, Zavala F, Nussenzweig V. 2006. The circumsporozoite protein is an immunodominant protective antigen in irradiated sporozoites. Nature 444:937-940. http://dx.doi.org/10.1038/nature05361.
    • (2006) Nature , vol.444 , pp. 937-940
    • Kumar, K.A.1    Sano, G.2    Boscardin, S.3    Nussenzweig, R.S.4    Nussenzweig, M.C.5    Zavala, F.6    Nussenzweig, V.7
  • 30
    • 84887212463 scopus 로고    scopus 로고
    • Conserved protective mechanisms in radiation and genetically attenuated uis3(-) and uis4(-) Plasmodium sporozoites
    • Kumar KA, Baxter P, Tarun AS, Kappe SH, Nussenzweig V. 2009. Conserved protective mechanisms in radiation and genetically attenuated uis3(-) and uis4(-) Plasmodium sporozoites. PLoS One 4:e4480. http://dx .doi.org/10.1371/journal.pone.0004480.
    • (2009) PLoS One , vol.4
    • Kumar, K.A.1    Baxter, P.2    Tarun, A.S.3    Kappe, S.H.4    Nussenzweig, V.5
  • 31
    • 77951227194 scopus 로고    scopus 로고
    • Minimal role for the circumsporozoite protein in the induction of sterile immunity by vaccination with live rodent malaria sporozoites
    • Mauduit M, Tewari R, Depinay N, Kayibanda M, Lallemand E, Chavatte JM, Snounou G, Renia L, Gruner AC. 2010. Minimal role for the circumsporozoite protein in the induction of sterile immunity by vaccination with live rodent malaria sporozoites. Infect Immun 78:2182- 2188. http://dx.doi.org/10.1128/IAI.01415-09.
    • (2010) Infect Immun , vol.78 , pp. 2182- 2188
    • Mauduit, M.1    Tewari, R.2    Depinay, N.3    Kayibanda, M.4    Lallemand, E.5    Chavatte, J.M.6    Snounou, G.7    Renia, L.8    Gruner, A.C.9
  • 35
    • 84876146784 scopus 로고    scopus 로고
    • Quantitative bioluminescent imaging of pre-erythrocytic malaria parasite infection using luciferase-expressing Plasmodium yoelii
    • Miller JL, Murray S, Vaughan AM, Harupa A, Sack B, Baldwin M, Crispe IN, Kappe SH. 2013. Quantitative bioluminescent imaging of pre-erythrocytic malaria parasite infection using luciferase-expressing Plasmodium yoelii. PLoS One 8:e60820. http://dx.doi.org/10.1371 /journal.pone.0060820.
    • (2013) PLoS One , vol.8
    • Miller, J.L.1    Murray, S.2    Vaughan, A.M.3    Harupa, A.4    Sack, B.5    Baldwin, M.6    Crispe, I.N.7    Kappe, S.H.8
  • 36
    • 34248346704 scopus 로고    scopus 로고
    • Uninfected mosquito bites confer protection against infection with malaria parasites
    • Donovan MJ, Messmore AS, Scrafford DA, Sacks DL, Kamhawi S, McDowell MA. 2007. Uninfected mosquito bites confer protection against infection with malaria parasites. Infect Immun 75:2523-2530. http://dx.doi.org/10.1128/IAI.01928-06.
    • (2007) Infect Immun , vol.75 , pp. 2523-2530
    • Donovan, M.J.1    Messmore, A.S.2    Scrafford, D.A.3    Sacks, D.L.4    Kamhawi, S.5    McDowell, M.A.6
  • 37
    • 73449101488 scopus 로고    scopus 로고
    • Neither mosquito saliva nor immunity to saliva has a detectable effect on the infectivity of Plasmodium sporozoites injected into mice
    • Kebaier C, Voza T, Vanderberg J. 2010. Neither mosquito saliva nor immunity to saliva has a detectable effect on the infectivity of Plasmodium sporozoites injected into mice. Infect Immun 78:545-551. http://dx.doi .org/10.1128/IAI.00807-09.
    • (2010) Infect Immun , vol.78 , pp. 545-551
    • Kebaier, C.1    Voza, T.2    Vanderberg, J.3
  • 38
    • 84878176994 scopus 로고    scopus 로고
    • Liver or blood-stage arrest during malaria sporozoite immunization: the later the better?
    • Nganou-Makamdop K, Sauerwein RW. 2013. Liver or blood-stage arrest during malaria sporozoite immunization: the later the better? Trends Parasitol 29:304-310. http://dx.doi.org/10.1016/j.pt.2013.03.008.
    • (2013) Trends Parasitol , vol.29 , pp. 304-310
    • Nganou-Makamdop, K.1    Sauerwein, R.W.2
  • 40
    • 84890087376 scopus 로고    scopus 로고
    • The mechanism of anti-CD20-mediated B cell depletion revealed by intravital imaging
    • Montalvao F, Garcia Z, Celli S, Breart B, Deguine J, Van Rooijen N, Bousso P. 2013. The mechanism of anti-CD20-mediated B cell depletion revealed by intravital imaging. J Clin Investig 123:5098-5103. http://dx .doi.org/10.1172/JCI70972.
    • (2013) J Clin Investig , vol.123 , pp. 5098-5103
    • Montalvao, F.1    Garcia, Z.2    Celli, S.3    Breart, B.4    Deguine, J.5    Van Rooijen, N.6    Bousso, P.7
  • 41
    • 0035038271 scopus 로고    scopus 로고
    • Malaria sporozoites actively enter and pass through rat Kupffer cells prior to hepatocyte invasion
    • Pradel G, Frevert U. 2001. Malaria sporozoites actively enter and pass through rat Kupffer cells prior to hepatocyte invasion. Hepatology 33: 1154-1165. http://dx.doi.org/10.1053/jhep.2001.24237.
    • (2001) Hepatology , vol.33 , pp. 1154-1165
    • Pradel, G.1    Frevert, U.2
  • 42
    • 33748470471 scopus 로고    scopus 로고
    • Nomadic or sessile: can Kupffer cells function as portals for malaria sporozoites to the liver?
    • Frevert U, Usynin I, Baer K, Klotz C. 2006. Nomadic or sessile: can Kupffer cells function as portals for malaria sporozoites to the liver? Cell Microbiol 8:1537-1546. http://dx.doi.org/10.1111/j.1462-5822 .2006.00777.x.
    • (2006) Cell Microbiol , vol.8 , pp. 1537-1546
    • Frevert, U.1    Usynin, I.2    Baer, K.3    Klotz, C.4
  • 43
    • 77955275842 scopus 로고    scopus 로고
    • Plasmodium yoelii: influence of immune modulators on the development of the liver stage
    • Wen-Yue X, Xing-Xiang W, Jie Q, Jian-Hua D, Fu-Sheng H. 2010. Plasmodium yoelii: influence of immune modulators on the development of the liver stage. Exp Parasitol 126:254-258. http://dx.doi.org/10.1016/j .exppara.2010.05.005.
    • (2010) Exp Parasitol , vol.126 , pp. 254-258
    • Wen-Yue, X.1    Xing-Xiang, W.2    Jie, Q.3    Jian-Hua, D.4    Fu-Sheng, H.5
  • 46
    • 35649000383 scopus 로고    scopus 로고
    • Direct microscopic quantification of dynamics of Plasmodium berghei sporozoite transmission from mosquitoes to mice
    • Jin Y, Kebaier C, Vanderberg J. 2007. Direct microscopic quantification of dynamics of Plasmodium berghei sporozoite transmission from mosquitoes to mice. Infect Immun 75:5532-5539. http://dx.doi.org/10.1128 /IAI.00600-07.
    • (2007) Infect Immun , vol.75 , pp. 5532-5539
    • Jin, Y.1    Kebaier, C.2    Vanderberg, J.3
  • 52
    • 0037768834 scopus 로고    scopus 로고
    • Early self-regulatory mechanisms control the magnitude of CD8+ T cell responses against liver stages of murine malaria
    • Hafalla JC, Morrot A, Sano G, Milon G, Lafaille JJ, Zavala F. 2003. Early self-regulatory mechanisms control the magnitude of CD8+ T cell responses against liver stages of murine malaria. J Immunol 171:964-970. http://dx.doi.org/10.4049/jimmunol.171.2.964.
    • (2003) J Immunol , vol.171 , pp. 964-970
    • Hafalla, J.C.1    Morrot, A.2    Sano, G.3    Milon, G.4    Lafaille, J.J.5    Zavala, F.6
  • 53
    • 40449116443 scopus 로고    scopus 로고
    • Memory CD8+T cell responses expand when antigen presentation overcomes T cell self-regulation
    • Cockburn IA, Chakravarty S, Overstreet MG, Garcia-Sastre A, Zavala F. 2008. Memory CD8+T cell responses expand when antigen presentation overcomes T cell self-regulation. J Immunol 180:64-71. http://dx.doi.org /10.4049/jimmunol.180.1.64.
    • (2008) J Immunol , vol.180 , pp. 64-71
    • Cockburn, I.A.1    Chakravarty, S.2    Overstreet, M.G.3    Garcia-Sastre, A.4    Zavala, F.5
  • 55
    • 84926669210 scopus 로고    scopus 로고
    • Differential antibody response to the Anopheles gambiae gSG6 and cE5 salivary proteins in individuals naturally exposed to bites of malaria vectors
    • Rizzo C, Lombardo F, Ronca R, Mangano V, Sirima SB, Nebie I, Fiorentino G, Modiano D, Arca B. 2014. Differential antibody response to the Anopheles gambiae gSG6 and cE5 salivary proteins in individuals naturally exposed to bites of malaria vectors. Parasit Vectors 7:549. http: //dx.doi.org/10.1186/s13071-014-0549-8.
    • (2014) Parasit Vectors , vol.7 , pp. 549
    • Rizzo, C.1    Lombardo, F.2    Ronca, R.3    Mangano, V.4    Sirima, S.B.5    Nebie, I.6    Fiorentino, G.7    Modiano, D.8    Arca, B.9
  • 58
    • 84871333424 scopus 로고    scopus 로고
    • Visualizing non infectious and infectious Anopheles gambiae blood feedings in naive and salivaimmunized mice
    • Choumet V, Attout T, Chartier L, Khun H, Sautereau J, Robbe-Vincent A, Brey P, Huerre M, Bain O. 2012. Visualizing non infectious and infectious Anopheles gambiae blood feedings in naive and salivaimmunized mice. PLoS One 7:e50464. http://dx.doi.org/10.1371/journal .pone.0050464.
    • (2012) PLoS One , vol.7
    • Choumet, V.1    Attout, T.2    Chartier, L.3    Khun, H.4    Sautereau, J.5    Robbe-Vincent, A.6    Brey, P.7    Huerre, M.8    Bain, O.9
  • 59
    • 79958717556 scopus 로고    scopus 로고
    • Superior antimalarial immunity after vaccination with late liver stage-arresting genetically attenuated parasites
    • Butler NS, Schmidt NW, Vaughan AM, Aly AS, Kappe SH, Harty JT. 2011. Superior antimalarial immunity after vaccination with late liver stage-arresting genetically attenuated parasites. Cell Host Microbe 9:451- 462. http://dx.doi.org/10.1016/j.chom.2011.05.008
    • (2011) Cell Host Microbe , vol.9 , pp. 451-462
    • Butler, N.S.1    Schmidt, N.W.2    Vaughan, A.M.3    Aly, A.S.4    Kappe, S.H.5    Harty, J.T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.