Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites

Journal of Infectious Diseases

Volumn 185, Issue 8, 2002, Pages 1155-1164

  Hoffman, Stephen L ^a,g   Goh, Lucy M L ^c,h   Luke, Thomas C ^d   Schneider, Imogene ^b   Le, Thong P ^a,i   Doolan, Denise L ^a,e   Sacci, John ^a,f   De la Vega, Patricia ^a,f   Dowler, Megan ^b   Paul, Chris ^a   Gordon, Daniel M ^b   Stoute, Jose A ^b,j   Preston Church, L W ^a,k   Sedegah, Martha ^a,f   Gray Heppner, D ^b   Ripley Ballou, W ^b,l   Richie, Thomas L ^a  

^a Malaria Program   (Singapore)

^b WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^c HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE   (United States)

^d WALTER REED ARMY MEDICAL CENTER   (United States)

^e JOHNS HOPKINS UNIVERSITY   (United States)

^f UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^g CELERA GENOMICS   (United States)

^h Pediatric Specialty Center   (United States)

ⁱ ST LUKE S HOSPITAL   (United States)

^j KENYA MEDICAL RESEARCH INSTITUTE   (Kenya)

^k MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^l MEDIMMUNE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

SPOROZOITE VACCINE;

ADULT; ARTICLE; BITE; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; EXPOSURE; FEMALE; GENETIC STRAIN; HUMAN; HUMAN EXPERIMENT; IMMUNITY; IMMUNIZATION; INFECTION PREVENTION; MALARIA FALCIPARUM; MALE; MOLECULAR CLONING; MOSQUITO; NONHUMAN; NORMAL HUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; RADIATION ATTENUATION;

ADOLESCENT; ADULT; ANIMALS; CULICIDAE; ERYTHROCYTES; HUMANS; IMMUNIZATION; MALARIA; MALARIA VACCINES; MALE; MIDDLE AGED; PLASMODIUM FALCIPARUM; VACCINES, ATTENUATED;

EID: 0037090258     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/339409     Document Type: Article

References (35)

1. Protective immunity produced by the injection of x-irradiated sporozoites of Plasmodium berghei
2. Immunization of man against sporozoite-induced falciparum malaria
3. Specificity of protection of man immunized against sporozoite-induced falciparum malaria
4. Immunization of man against falciparum and vivax malaria by use of attenuated sporozoites
5. Immunity to falciparum and vivax malaria induced by irradiated sporozoites: A review of the University of Maryland studies, 1971-75
6. Sporozoite induced immunity in man against an Ethiopian strain of Plasmodium falciparum
7. Use of attenuated sporozoites in the immunization of human volunteers against falciparum malaria
8. Human immunization with attenuated sporozoites
9. Plasmodium vivax: Correlation of circumsporozoite precipitation (CSP) reaction with sporozoite-induced protective immunity in man
10. Rationale for the development of an engineered sporozoite malaria vaccine
11. Attacking the infected hepatocyte
12. Perspectives on malaria vaccine development
13. Humoral immune responses in volunteers immunized with irradiated Plasmodium falciparum sporozoites
14. Human cytotoxic T lymphocytes against the Plasmodium falciparum circumsporozoite protein
15. Irradiated sporozoite vaccine induces HLA-B8-restricted cytotoxic T lymphocyte responses against two overlapping epitopes of the Plasmodium falciparum surface sporozoite protein 2
16. HLA-A2-restricted cytotoxic T lymphocyte responses to multiple Plasmodium falciparum sporozoite surface protein 2 epitopes in sporozoite-immunized volunteers
17. T lymphocytes from volunteers immunized with irradiated Plasmodium falciparum sporozoites recognize liver and blood stage malaria antigens
18. Degenerate cytotoxic T cell epitopes from P. falciparum restricted by HLA-A and HLA-B super-types alleles
19. HLA-DR-promiscuous T cell epitopes from Plasmodium falciparum pre-erythrocytic-stage antigens restricted by multiple HLA class II alleles
20. Successful immunization of humans with irradiated sporozoites: Humoral and cellular responses of the protected individuals
21. Long-term persistence of sterile immunity in a volunteer immunized with X-irradiated Plasmodium falciparum sporozoites
22. + clones from a malaria-immunized volunteer
23. T cell responses in a sporozoite-immunized human volunteer and a chimpanzee
24. Cellular and humoral immune responses to a recombinant P. falciparum CS protein in sporozoite-immunized rodents and human volunteers
25. + T cells from a sporozoite-immunized volunteer recognize the Plasmodium falciparum CS protein
26. + T cell clones obtained from Plasmodium falciparum sporozoite-immunized volunteers recognize polymorphic sequences of the circumsporozoite protein
27. Genetic analysis of the human malaria parasite Plasmodium falciparum
28. Malaria transmitted to humans by mosquitoes infected from cultured Plasmodium falciparum
29. Plasmodium falciparum-infected Anopheles stephensi inconsistently transmit malaria to humans
30. Experimental challenge of volunteers with malaria
31. Infectivity to mosquitoes of Plasmodium falciparum clones grown in vitro from the same isolate
32. Protection against malaria induced by irradiated sporozoites
33. Clinical manifestations of Plasmodium falciparum malaria experimentally induced by mosquito challenge
34. Maintenance of protective immunity against malaria by persistent hepatic parasites derived from irradiated sporozoites
35. Research toward vaccines against malaria