Memory CD8+ T cell responses expand when antigen presentation overcomes T cell self-regulation

Journal of Immunology

Volumn 180, Issue 1, 2008, Pages 64-71

  Cockburn, Ian A ^a   Chakravarty, Sumana ^a   Overstreet, Michael G ^a   García Sastre, Adolfo ^b   Zavala, Fidel ^a  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; ANTIGEN; MALARIA VACCINE; SERYLTYROSYLVALYLPROLYLSERYLALANYLGLUTAMYLGLUTAMINYLISOLEUCINE; UNCLASSIFIED DRUG; VIRUS VECTOR;

ANIMAL EXPERIMENT; ARTICLE; AUTOREGULATION; CD8+ T LYMPHOCYTE; CELL EXPANSION; CELLULAR IMMUNITY; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; GENE TARGETING; IMMUNIZATION; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; VACCINIA VIRUS; ANIMAL; ANTIGEN PRESENTATION; BAGG ALBINO MOUSE; CD4+ T LYMPHOCYTE; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION;

ANIMALS; ANTIGEN PRESENTATION; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; DENDRITIC CELLS; FEMALE; IMMUNIZATION, SECONDARY; IMMUNOLOGIC MEMORY; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; VACCINIA VIRUS;

EID: 40449116443     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.180.1.64     Document Type: Article

References (54)

1. Amara, R. R., F. Villinger, J. D. Altman, S. L. Lydy, S. P. O'Neil, S. I. Staprans, D. C. Montefiori, Y. Xu, J. G. Herndon, L. S. Wyatt, et al. 2001. Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine. Science 292: 69-74.
2. Goonetilleke, N. P., H. McShane, C. M. Hannan, R. J. Anderson, R. H. Brookes, and A. V. Hill. 2003. Enhanced immunogenicity and protective efficacy against Mycobacterium tuberculosis of bacille Calmette-Guérin vaccine using mucosal administration and boosting with a recombinant modified vaccinia virus Ankara. J. Immunol. 171: 1602-1609.
3. McConkey, S. J., W. H. Reece, V. S. Moorthy, D. Webster, S. Dunachie, G. Butcher, J. M. Vuola, T. J. Blanchard, P. Gothard, K. Watkins, et al. 2003. Enhanced T-cell immunogenicity of plasmid DNA vaccines boosted by recombinant modified vaccinia virus Ankara in humans. Nat. Med. 9: 729-735.
4. Shedlock, D. J., and H. Shen. 2003. Requirement for CD4 T cell help in generating functional CD8 T cell memory. Science 300: 337-339.
5. Sun, J. C., and M. J. Bevan. 2003. Defective CD8 T cell memory following acute infection without CD4 T cell help. Science 300: 339-342.
6. Zammit, D. J., L. S. Cauley, Q. M. Pham, and L. Lefrancois. 2005. Dendritic cells maximize the memory CD8 T cell response to infection. Immunity 22: 561-570.
7. + T cells is required for the development of protective memory responses against liver stages of malaria parasites. J. Exp. Med. 202: 551-560.
8. + T cells play a prominent role in recall responses to secondary viral infection in the lung. J. Immunol. 172: 6533-6537.
9. Wherry, E. J., V. Teichgraber, T. C. Becker, D. Masopust, S. M. Kaech, R. Antia, U. H. von Andrian, and R. Ahmed. 2003. Lineage relationship and protective immunity of memory CD8 T cell subsets. Nat. Immunol. 4: 225-234.
10. + T cell responses to malaria liver stages. Proc. Natl. Acad. Sci. USA 99: 11819-11824.
11. Woodberry, T., J. Gardner, S. L. Elliott, S. Leyrer, D. M. Purdie, P. Chaplin, and A. Suhrbier. 2003. Prime boost vaccination strategies: CD8 T cell numbers, protection, and Th1 bias. J. Immunol. 170: 2599-2604.
12. Woodland, D. L. 2004. Jump-starting the immune system: prime-boosting comes of age. Trends Immunol. 25: 98-104.
13. + T and B cell epitopes: comparison of their immunogenicity and capacity to induce protective immunity. J. Immunol. 153: 4636-4648.
14. + T-cell-mediated protective immunity against malaria. Proc. Natl. Acad. Sci. USA 90: 5214-5218.
15. + T cells against malaria liver stages. J. Exp. Med. 194: 173-180.
16. + T cells by exogenous cell-associated antigens. Immunity 17: 211-220.
17. Bruna-Romero, O., G. Gonzalez-Aseguinolaza, J. C. Hafalla, M. Tsuji, and R. S. Nussenzweig. 2001. Complete, long-lasting protection against malaria of mice primed and boosted with two distinct viral vectors expressing the same plasmodial antigen. Proc. Natl. Acad. Sci. USA 98: 11491-11496.
18. Altman, J. D., P. A. Moss, P. J. Goulder, D. H. Barouch, M. G. McHeyzer-Williams, J. I. Bell, A. J. McMichael, and M. M. Davis. 1996. Phenotypic analysis of Ag-specific T lymphocytes. Science 274: 94-96.
19. + T cell responses. J. Immunol. Methods 252: 207-218.
20. Wilson, N. S., G. M. Behrens, R. J. Lundie, C. M. Smith, J. Waithman, L. Young, S. P. Forehan, A. Mount, R. J. Steptoe, K. D. Shortman, et al. 2006. Systemic activation of dendritic cells by Toll-like receptor ligands or malaria infection impairs cross-presentation and antiviral immunity. Nat. Immunol. 7: 165-172.
21. + T lymphocyte response to P. falciparum circumsporozoite protein in naturally-exposed malaria endemic populations in Thailand. Southeast Asian J. Trop. Med. Public Health 30: 405-411.
22. Doolan, D. L., C. Khamboonruang, H. P. Beck, R. A. Houghten, and M. F. Good. 1993. Cytotoxic T lymphocyte (CTL) low-responsiveness to the Plasmodium falciparum circumsporozoite protein in naturally-exposed endemic populations: analysis of human CTL response to most known variants. Int. Immunol. 5: 37-46.
23. + T cell-mediated protective immunity against malaria. J. Immunol. 158: 1268-1274.
24. + T cell responses induced by recombinant influenza and vaccinia viruses. Cell. Immunol. 173: 96-107.
25. + T cells. Virology 280: 155-159.
26. + T cell immune response against a V3 loop multi-epitope polypeptide (TAB13) of HIV-1 Env after priming with purified fusion protein and booster with modified vaccinia virus Ankara (MVA-TAB) recombinant: a comparison of humoral and cellular immune responses with the vaccinia virus Western Reserve (WR) vector. Vaccine 20: 961-971.
27. Gherardi, M. M., J. L. Najera, E. Perez-Jimenez, S. Guerra, A. Garcia-Sastre, and M. Esteban. 2003. Prime-boost immunization schedules based on influenza virus and vaccinia virus vectors potentiate cellular immune responses against human immunodeficiency virus Env protein systemically and in the genitorectal draining lymph nodes. J. Virol. 77: 7048-7057.
28. +-T-cell epitope induced by virus vector vaccination can successfully control Trypanosoma cruzi infection. Infect. Immun. 73: 7356-7365.
29. + T cells by infected dendritic cells in vivo. Nat. Immunol. 3: 265-271.
30. + T cells. J. Immunol. 168: 5403-5408.
31. + CTL following exposure to vaccinia virus via different routes. J. Immunol. 169: 4222-4229.
32. + T cells by viral and tumor antigens is a robust phenomenon. Eur. J. Immunol. 34: 194-199.
33. + T cell responses against liver stages of murine malaria. J. Immunol. 171: 964-970.
34. Wong, P., and E. G. Pamer. 2003. Feedback regulation of pathogen-specific T cell priming. Immunity 18: 499-511.
35. Willis, R. A., J. W. Kappler, and P. C. Marrack. 2006. CD8 T cell competition for dendritic cells in vivo is an early event in activation. Proc. Natl. Acad. Sci. USA 103: 12063-12068.
36. Borrow, P., C. F. Evans, and M. B. Oldstone. 1995. Virus-induced immunosuppression: immune system-mediated destruction of virus-infected dendritic cells results in generalized immune suppression. J. Virol. 69: 1059-1070.
37. Odermatt, B., M. Eppler, T. P. Leist, H. Hengartner, and R. M. Zinkernagel. 1991. Virus-triggered acquired immunodeficiency by cytotoxic T-cell-dependent destruction of Ag-presenting cells and lymph follicle structure. Proc. Natl. Acad. Sci. USA 88: 8252-8256.
38. + T cell-dependent elimination of dendritic cells in vivo limits the induction of antitumor immunity. J. Immunol. 164: 3095-3101.
39. Hudrisier, D., J. Riond, H. Mazarguil, J. E. Gairin, and E. Joly. 2001. Cutting edge: CTLs rapidly capture membrane fragments from target cells in a TCR signaling-dependent manner. J. Immunol. 166: 3645-3649.
40. Kedl, R. M., B. C. Schaefer, J. W. Kappler, and P. Marrack. 2002. T cells down-modulate peptide-MHC complexes on APCs in vivo. Nat. Immunol. 3: 27-32.
41. Kedl, R. M., W. A. Rees, D. A. Hildeman, B. Schaefer, T. Mitchell, J. Kappler, and P. Marrack. 2000. T cells compete for access to Ag-bearing Ag-presenting cells. J. Exp. Med. 192: 1105-1113.
42. + T cells enter reactive lymph nodes and kill dendritic cells. Nat. Immunol. 8: 743-752.
43. + T lymphocytes protective against malaria liver stages are primed in skin-draining lymph nodes. Nat. Med. 13: 1035-1041.
44. Kennedy, R., and G. A. Poland. 2007. T-Cell epitope discovery for variola and vaccinia viruses. Rev. Med. Virol. 17: 93-113.
45. + T-cell determinants and cross-reactivity in BALB/c mice. J. Virol. 80: 6318-6323.
46. + memory T cells specific for a subdominant epitope following Sendai virus infection. J. Immunol. 158: 4301-4309.
47. Palmowski, M. J., E. M. Choi, I. F. Hermans, S. C. Gilbert, J. L. Chen, U. Gileadi, M. Salio, A. Van Pel, S. Man, E. Bonin, et al. 2002. Competition between CTL narrows the immune response induced by prime-boost vaccination protocols. J. Immunol. 168: 4391-4398.
48. Brimnes, M. K., L. Bonifaz, R. M. Steinman, and T. M. Moran. 2003. Influenza virus-induced dendritic cell maturation is associated with the induction of strong T cell immunity to a coadministered, normally nonimmunogenic protein. J. Exp. Med. 198: 133-144.
49. Morelli, A. E., A. T. Larregina, R. W. Ganster, A. F. Zahorchak, J. M. Plowey, T. Takayama, A. J. Logar, P. D. Robbins, L. D. Falo, and A. W. Thomson. 2000. Recombinant adenovirus induces maturation of dendritic cells via an NF-κB-dependent pathway. J. Virol. 74: 9617-9628.
50. Yao, Y., P. Li, P. Singh, A. T. Thiele, D. S. Wilkes, G. J. Renukaradhya, R. R. Brutkiewicz, J. B. Travers, G. D. Luker, S. C. Hong, et al. 2007. Vaccinia virus infection induces dendritic cell maturation but inhibits antigen presentation by MHC class II. Cell. Immunol. 246: 92-102.
51. Katze, M. G., Y. He, and M. Gale, Jr. 2002. Viruses and interferon: a fight for supremacy. Nat. Rev. Immunol. 2: 675-687.
52. Dasgupta, A., E. Hammarlund, M. K. Slifka, and K. Fruh. 2007. Cowpox virus evades CTL recognition and inhibits the intracellular transport of MHC class I molecules. J. Immunol. 178: 1654-1661.
53. Gilbert, S. C., J. Schneider, C. M. Hannan, J. T. Hu, M. Plebanski, R. Sinden, and A. V. Hill. 2002. Enhanced CD8 T cell immunogenicity and protective efficacy in a mouse malaria model using a recombinant adenoviral vaccine in heterologous prime-boost immunisation regimes. Vaccine 20: 1039-1045.
54. + T-lymphocyte induction through priming with recombinant Mycobacterium smegmatis. J. Virol. 81: 74-83.