Genetically modified Plasmodium parasites as a protective experimental malaria vaccine

Nature

Volumn 433, Issue 7022, 2005, Pages 164-167

  Mueller, Ann Kristin ^a   Labaled, Mehdi ^b   Kappe, Stefan H I ^b,c   Matuschewski, Kai ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b SEATTLE BIOMEDICAL RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; GENES; LIVING SYSTEMS STUDIES; STERILIZATION (CLEANING); VACCINES;

INOCULATION; MALARIA; PATHOGENIC MEROZOITES; PLASMODIUM PARASITES;

MALARIA CONTROL;

MALARIA VACCINE;

GENETICALLY MODIFIED ORGANISM; MALARIA; VACCINE;

ARTICLE; CELL PROTECTION; DNA MODIFICATION; EXPERIMENTAL ANIMAL; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; MALARIA; MEROZOITE; NONHUMAN; PARASITE; PATHOGENICITY; PLASMODIUM; PRIORITY JOURNAL; SPOROZOITE; TARGET CELL; VACCINATION;

ANIMALS; FEMALE; GENE DELETION; GENE TARGETING; LIVER; MALARIA; MALARIA VACCINES; MICE; MICE, INBRED C57BL; PHENOTYPE; PLASMODIUM BERGHEI; VACCINES, ATTENUATED;

ANIMALIA; RODENTIA;

EID: 12744278200     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature03188     Document Type: Article

References (18)

1. Kappe, S. H., Kaiser, K. & Matuschewski, K. The Plasmodium sporozoite journey: a rite of passage. Trends Parasitol. 19, 135-143 (2003).
2. Shortt, H. E. & Garnham, P. C. C. Pre-erythrocytic stage in mammalian malaria parasites. Nature 161, 126 (1948).
3. Hoffman, S. L. & Doolan, D. L. Malaria vaccines-targeting infected hepatocytes. Nature Med. 6, 1218-1219 (2000).
4. Matuschewski, K. et al. Infectivity-associated changes in the transcriptional repertoire of the malaria parasite sporozoite stage. J. Biol Chem. 277, 41948-41953 (2002).
5. Kaiser, K., Matuschewski, K., Camargo, N., Ross, J. & Kappe, S. H. Differential transcriptome profiling identifies Plasmodium genes encoding pre-erythrocytic stage-specific proteins. Mol. Microbiol. 51, 1221-1232 (2004).
6. Sachs, J. & Malaney, P. The economic and social burden of malaria. Nature 415, 680-685 (2002).
7. Hoffman, S. L. Save the children. Nature 430, 940-941 (2004).
8. Nussenzweig, R. S., Vanderberg, J., Most, H. & Orton, C. Protective immunity produced by the injection of X-irradiated sporozoites of Plasmodium berghei. Nature 216, 160-162 (1967).
9. Hoffman, S. L. et al. Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites. J. Infect. Dis. 185, 1155-1164 (2002).
10. Gardner, M. J. et al. Genome sequence of the human malaria parasite Plasmodium falciparum. Nature 419, 498-511 (2002).
11. Carlton, J. M. et al. Genome sequence and comparative analysis of the model rodent malaria parasite Plasmodium yoelii yoelii. Nature 419, 512-519 (2002).
12. Thathy, V. & Menard, R. Gene targeting in Plasmodium berghei. Methods Mol. Med. 72, 317-331 (2002).
13. Sibley, L. D. Intracellular parasite invasion strategies. Science 304, 248-253 (2004).
14. Meis, J. F., Verhave, J. P., Jap, P. H., Sinden, R. E. & Meuwissen, J. H. Malaria parasites-discovery of the early liver form. Nature 302, 424-426 (1983).
15. Meis, J. F., Verhave, J. P., Jap, P. H. & Meuwissen, J. H. Transformation of sporozoites of Plasmodium berghei into exoerythrocytic forms in the liver of its mammalian host. Cell Tissue Res. 241, 353-360 (1985).
16. Potocnjak, P., Yoshida, N., Nussenzweig, R. S. & Nussenzweig, V. Monovalent fragments (Fab) of monoclonal antibodies to a sporozoite surface antigen (Pb44) protect mice against malarial infection. J. Exp. Med. 151, 1504-1513 (1980).
17. Tsuji, M. et al. Demonstration of heat-shock protein 70 in the sporozoite stage of malaria parasites. Parasitol. Res. 80, 16-21 (1994).
18. Renia, L. et al. Malaria sporozoite penetration. A new approach by double staining. J. Immunol. Methods 112, 201-205 (1988).