Exposure to air pollution as a potential contributor to cognitive function, cognitive decline, brain imaging, and dementia: A systematic review of epidemiologic research

NeuroToxicology

Volumn 56, Issue , 2016, Pages 235-253

  Power, Melinda C ^a,b   Adar, Sara D ^c   Yanosky, Jeff D ^d   Weuve, Jennifer ^e,f  

^a GEORGE WASHINGTON UNIVERSITY   (United States)

^b JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^c UNIVERSITY OF MICHIGAN SCHOOL OF PUBLIC HEALTH   (United States)

^d PENN STATE COLLEGE OF MEDICINE   (United States)

^e RUSH UNIVERSITY MEDICAL CENTER   (United States)

^f BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Air pollution; Alzheimer disease; Cognitive decline; Cognitive function; Dementia; Systematic review

Indexed keywords

OZONE;

ADVERSE OUTCOME; AIR POLLUTION; ARTICLE; BRAIN; CLASSIFICATION; COGNITION; COGNITIVE DEFECT; DEMENTIA; ENVIRONMENTAL EXPOSURE; EXHAUST GAS; HUMAN; LONG TERM EXPOSURE; NEUROIMAGING; NEUROPATHOLOGY; OUTCOME ASSESSMENT; PARTICULATE MATTER; POLLUTANT; POPULATION EXPOSURE; PRIORITY JOURNAL; QUALITY CONTROL; SYSTEMATIC REVIEW; CHEMICALLY INDUCED; COMPLICATION; DIAGNOSTIC IMAGING;

AIR POLLUTION; BRAIN; COGNITION DISORDERS; DEMENTIA; EPIDEMIOLOGIC STUDIES; HUMANS;

EID: 84979710862     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2016.06.004     Document Type: Article

References (123)

1. Ailshire, J.A., Clarke, P., Fine particulate matter air pollution and cognitive function among U.S. older adults. J. Gerontol. Ser. B: Psychol. Sci. Soc. Sci. 0:2 (2015), 322–328.
2. Ailshire, J.A., Crimmins, E.M., Fine particulate matter air pollution and cognitive function among older US adults. Am. J. Epidemiol. 180:4 (2014), 359–366.
3. Akiyama, H., Barger, S., Barnum, S., Bradt, B., Bauer, J., Cole, G.M., Cooper, N.R., Eikelenboom, P., Emmerling, M., Fiebich, B.L., Finch, C.E., Frautschy, S., Griffin, W.S., Hampel, H., Hull, M., Landreth, G., Lue, L., Mrak, R., Mackenzie, I.R., McGeer, P.L., O'Banion, M.K., Pachter, J., Pasinetti, G., Plata-Salaman, C., Rogers, J., Rydel, R., Shen, Y., Streit, W., Strohmeyer, R., Tooyoma, I., Van Muiswinkel, F.L., Veerhuis, R., Walker, D., Webster, S., Wegrzyniak, B., Wenk, G., Wyss-Coray, T., Inflammation and alzheimer's disease. Neurobiol. Aging 21:3 (2000), 383–421.
4. Al-Hamdan, M.Z., Crosson, W.L., Economou, S.A., Estes, M.G. Jr., Estes, S.M., Hemmings, S.N., Kent, S.T., Puckett, M., Quattrochi, D.A., Rickman, D.L., Wade, G.M., McClure, L.A., Environmental public health applications using remotely sensed data. Geocarto Int. 29:1 (2014), 85–98.
5. Albert, M.S., DeKosky, S.T., Dickson, D., Dubois, B., Feldman, H.H., Fox, N.C., Gamst, A., Holtzman, D.M., Jagust, W.J., Petersen, R.C., Snyder, P.J., Carrillo, M.C., Thies, B., Phelps, C.H., The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 7:3 (2011), 270–279.
6. Alonso, A., Seguí-Gómez, M., Irala, J., Sánchez-Villegas, A., Beunza, J., Martínez-Gonzalez, M., Predictors of follow-up and assessment of selection bias from dropouts using inverse probability weighting in a cohort of university graduates. Eur. J. Epidemiol. 21:5 (2006), 351–358.
7. Alzheimer's Association, Alzheimer's disease facts and figures. Alzheimers Dement. 7:2 (2011), 208–244.
8. Alzheimer's Association, Alzheimer's disease facts and figures. Alzheimers Dement. 10:2 (2014), e47–e92.
9. Alzheimer's Association, Alzheimer's disease facts and figures. Alzheimers Dement. 11:3 (2015), 332–384.
10. American Psychological Association, 2013. Neurocognitive Disorders, Diagnostic and Statistical Manual of Mental Disorders: DSM-5.
11. Anderson, J.O., Thundiyil, J.G., Stolbach, A., Clearing the air: a review of the effects of particulate matter air pollution on human health. J. Med. Toxicol. 8:2 (2012), 166–175.
12. Bennett, D.A., Wilson, R.S., Schneider, J.A., Evans, D.A., Beckett, L.A., Aggarwal, N.T., Barnes, L.L., Fox, J.H., Bach, J., Natural history of mild cognitive impairment in older persons. Neurology 59:2 (2002), 198–205.
13. Bind, M.A., Vanderweele, T.J., Coull, B.A., Schwartz, J.D., Causal mediation analysis for longitudinal data with exogenous exposure. Biostatistics 17:1 (2016), 122–134.
14. Block, M.L., Elder, A., Auten, R.L., Bilbo, S.D., Chen, H., Chen, J.C., Cory-Slechta, D.A., Costa, D., Diaz-Sanchez, D., Dorman, D.C., Gold, D.R., Gray, K., Jeng, H.A., Kaufman, J.D., Kleinman, M.T., Kirshner, A., Lawler, C., Miller, D.S., Nadadur, S.S., Ritz, B., Semmens, E.O., Tonelli, L.H., Veronesi, B., Wright, R.O., Wright, R.J., The outdoor air pollution and brain health workshop. Neurotoxicology 33:5 (2012), 972–984.
15. Brook, R.D., Rajagopalan, S., Particulate matter air pollution and atherosclerosis. Curr. Atheroscler. Rep. 12:5 (2010), 291–300.
16. Brook, R.D., Rajagopalan, S., Pope, C.A. 3rd, Brook, J.R., Bhatnagar, A., Diez-Roux, A.V., Holguin, F., Hong, Y., Luepker, R.V., Mittleman, M.A., Peters, A., Siscovick, D., Smith, S.C. Jr., Whitsel, L., Kaufman, J.D., Particulate matter air pollution and cardiovascular disease: an update to the scientific statement from the american heart association. Circulation 121:21 (2010), 2331–2378.
17. Bullinger, M., Association between air pollution and well-being. Sozial- und Praventivmedizin 34:5 (1989), 231–238.
18. Calderon-Garciduenas, L., Azzarelli, B., Acuna, H., Garcia, R., Gambling, T.M., Osnaya, N., Monroy, S., DEL Tizapantzi, M.R., Carson, J.L., Villarreal-Calderon, A., Rewcastle, B., Air pollution and brain damage. Toxicol. Pathol. 30:3 (2002), 373–389.
19. Calderon-Garciduenas, L., Maronpot, R.R., Torres-Jardon, R., Henriquez-Roldan, C., Schoonhoven, R., Acuna-Ayala, H., Villarreal-Calderon, A., Nakamura, J., Fernando, R., Reed, W., Azzarelli, B., Swenberg, J.A., DNA damage in nasal and brain tissues of canines exposed to air pollutants is associated with evidence of chronic brain inflammation and neurodegeneration. Toxicol. Pathol. 31:5 (2003), 524–538.
20. Calderon-Garciduenas, L., Reed, W., Maronpot, R.R., Henriquez-Roldan, C., Delgado-Chavez, R., Calderon-Garciduenas, A., Dragustinovis, I., Franco-Lira, M., Aragon-Flores, M., Solt, A.C., Altenburg, M., Torres-Jardon, R., Swenberg, J.A., Brain inflammation and Alzheimer's-like pathology in individuals exposed to severe air pollution. Toxicol. Pathol. 32:6 (2004), 650–658.
21. Calderon-Garciduenas, L., Mora-Tiscareno, A., Ontiveros, E., Gomez-Garza, G., Barragan-Mejia, G., Broadway, J., Chapman, S., Valencia-Salazar, G., Jewells, V., Maronpot, R.R., Henriquez-Roldan, C., Perez-Guille, B., Torres-Jardon, R., Herrit, L., Brooks, D., Osnaya-Brizuela, N., Monroy, M.E., Gonzalez-Maciel, A., Reynoso-Robles, R., Villarreal-Calderon, R., Solt, A.C., Engle, R.W., Air pollution, cognitive deficits and brain abnormalities: a pilot study with children and dogs. Brain Cogn. 68:2 (2008), 117–127.
22. Calderon-Garciduenas, L., Solt, A.C., Henriquez-Roldan, C., Torres-Jardon, R., Nuse, B., Herritt, L., Villarreal-Calderon, R., Osnaya, N., Stone, I., Garcia, R., Brooks, D.M., Gonzalez-Maciel, A., Reynoso-Robles, R., Delgado-Chavez, R., Reed, W., Long-term air pollution exposure is associated with neuroinflammation, an altered innate immune response, disruption of the blood-brain barrier, ultrafine particulate deposition, and accumulation of amyloid beta-42 and alpha-synuclein in children and young adults. Toxicol. Pathol. 36:2 (2008), 289–310.
23. Cetin, F., Role of oxidative stress in Aβ animal model of alzheimer's disease: vicious circle of apoptosis. Nitric Oxide Age, 2013 http://www.intechopen.com/books/neurodegenerative-diseases/role-of-oxidative-stress-in-a-animal-model-of-alzheimer-s-disease-vicious-circle-of-apoptosis-nitric (accessed 24.04.14.).
24. Chang, K.H., Chang, M.Y., Muo, C.H., Wu, T.N., Chen, C.Y., Kao, C.H., Increased risk of dementia in patients exposed to nitrogen dioxide and carbon monoxide: a population-based retrospective cohort study. PLoS One, 9(8), 2014, e103078.
25. Chen, J.C., Schwartz, J., Neurobehavioral effects of ambient air pollution on cognitive performance in US adults. Neurotoxicology 30:2 (2009), 231–239.
26. Chen, J.C., Wang, X., Espeland, M.A., Chui, H., Particulate air pollutants and white matter brain aging. Alzheimer's Dement., 10, 2014, P266.
27. Chen, Y.C., Wu, Y.C., Lin, Y.C., Yu, H.L., Chen, J.H., Chen, T.F., Sun, Y., Wen, L.L., Yip, P.K., Chu, Y.M., The spatial relationship between air pollutants and the risk of dementia. Alzheimer's Dement., 10, 2014, P748.
28. Chen, J.C., Wang, X., Wellenius, G.A., Serre, M.L., Driscoll, I., Casanova, R., McArdle, J.J., Manson, J.E., Chui, H.C., Espeland, M.A., Ambient air pollution and neurotoxicity on brain structure: evidence from women's health initiative memory study. Ann. Neurol. 78:3 (2015), 466–476.
29. Costa, L.G., Cole, T.B., Coburn, J., Chang, Y.C., Dao, K., Roque, P., Neurotoxicants are in the air: convergence of human, animal, and in vitro studies on the effects of air pollution on the brain. Biomed. Res. Int., 2014, 2014, 736385.
30. Dadvand, P., Figueras, F., Basagana, X., Beelen, R., Martinez, D., Cirach, M., Schembari, A., Hoek, G., Brunekreef, B., Nieuwenhuijsen, M.J., Ambient air pollution and preeclampsia: a spatiotemporal analysis. Environ. Health Perspect. 121:11–12 (2013), 1365–1371.
31. Debette, S., Beiser, A., DeCarli, C., Au, R., Himali, J.J., Kelly-Hayes, M., Romero, J.R., Kase, C.S., Wolf, P.A., Seshadri, S., Association of MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia and mortality: the framingham offspring study. Stroke 41:4 (2010), 600–606.
32. Early, D.R., Widaman, K.F., Harvey, D., Beckett, L., Park, L.Q., Farias, S.T., Reed, B.R., Decarli, C., Mungas, D., Demographic predictors of cognitive change in ethnically diverse older persons. Psychol. Aging 28:3 (2013), 633–645.
33. Euser, S.M., Schram, M.T., Hofman, A., Westendorp, R.G., Breteler, M.M., Measuring cognitive function with age: the influence of selection by health and survival. Epidemiology (Cambridge, Mass.) 19:3 (2008), 440–447.
34. Friedrich, M.J., Researchers test strategies to prevent alzheimer disease [news]. JAMA 311:16 (2014), 1596–1598.
35. Ganguli, M., Lee, C.W., Hughes, T., Snitz, B.E., Jakubcak, J., Duara, R., Chang, C.C., Who wants a free brain scan? Assessing and correcting for recruitment biases in a population-based sMRI pilot study. Brain Imaging Behav. 9:2 (2015), 204–212.
36. Gatto, N.M., Henderson, V.W., Hodis, H.N., St John, J.A., Lurmann, F., Chen, J.C., Mack, W.J., Components of air pollution and cognitive function in middle-aged and older adults in Los Angeles. Neurotoxicology 40 (2014), 1–7.
37. Gorelick, P.B., Scuteri, A., Black, S.E., Decarli, C., Greenberg, S.M., Iadecola, C., Launer, L.J., Laurent, S., Lopez, O.L., Nyenhuis, D., Petersen, R.C., Schneider, J.A., Tzourio, C., Arnett, D.K., Bennett, D.A., Chui, H.C., Higashida, R.T., Lindquist, R., Nilsson, P.M., Roman, G.C., Sellke, F.W., Seshadri, S., Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association. Stroke 42:9 (2011), 2672–2713.
38. Grober, E., Hall, C.B., Lipton, R.B., Zonderman, A.B., Resnick, S.M., Kawas, C., Memory impairment, executive dysfunction, and intellectual decline in preclinical Alzheimer's disease. J. Int. Neuropsychol. Soc. 14:2 (2008), 266–278.
39. Gross, A.L., Mungas, D.M., Crane, P.K., Gibbons, L.E., MacKay-Brandt, A., Manly, J.J., Mukherjee, S., Romero, H., Sachs, B., Thomas, M., Potter, G.G., Jones, R.N., Effects of education and race on cognitive decline: an integrative study of generalizability versus study-specific results. Psychol. Aging 30:4 (2015), 863–880.
40. Hebert, L.E., Beckett, L.A., Scherr, P.A., Evans, D.A., Annual incidence of Alzheimer disease in the United States projected to the years 2000 through 2050. Alzheimer Dis. Assoc. Disord. 15:4 (2001), 169–173.
41. Hebert, L.E., Weuve, J., Scherr, P.A., Evans, D.A., Alzheimer disease in the United States (2010–2050) estimated using the 2010 census. Neurology 80:19 (2013), 1778–1783.
42. Hebert, L.E., Weuve, J., Scherr, P.A., Evans, D.A., Alzheimer disease in the United States (2010–2050) estimated using the 2010 census. Neurology 80:19 (2013), 1778–1783.
43. Hurd, M.D., Martorell, P., Delavande, A., Mullen, K.J., Langa, K.M., Monetary costs of dementia in the United States. N. Engl. J. Med. 368:14 (2013), 1326–1334.
44. IOM (Institute of Medicine), Cognitive Aging: Progress in Understanding and Opportunities for Action. 2015, The National Academies Press, Washington, D.C.
45. Jack, C.R. Jr., Knopman, D.S., Jagust, W.J., Shaw, L.M., Aisen, P.S., Weiner, M.W., Petersen, R.C., Trojanowski, J.Q., Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade. Lancet Neurol. 9:1 (2010), 119–128.
46. Jaramillo, S.A., Felton, D., Andrews, L., Desiderio, L., Hallarn, R.K., Jackson, S.D., Coker, L.H., Robinson, J.G., Ockene, J.K., Espeland, M.A., for the Women's Health Initiative Memory Study Research, G., Enrollment in a Brain Magnetic Resonance Study: Results From the Women's Health Initiative Memory Study Magnetic Resonance Imaging Study (WHIMS-MRI). Academic radiology 14(5), 2007, 603–612.
47. Johnson, D.K., Storandt, M., Morris, J.C., Galvin, J.E., Longitudinal study of the transition from healthy aging to Alzheimer disease. Arch. Neurol. 66:10 (2009), 1254–1259.
48. Jung, C.R., Lin, Y.T., Hwang, B.F., Ozone, particulate matter, and newly diagnosed Alzheimer's disease: a population-based cohort study in Taiwan. J. Alzheimer's Dis. 44:2 (2015), 573–584.
49. Kawas, C.H., Corrada, M.M., Brookmeyer, R., Morrison, A., Resnick, S.M., Zonderman, A.B., Arenberg, D., Visual memory predicts Alzheimer's disease more than a decade before diagnosis. Neurology 60:7 (2003), 1089–1093.
50. Kawas, C.H., Kim, R.C., Sonnen, J.A., Bullain, S.S., Trieu, T., Corrada, M.M., Multiple pathologies are common and related to dementia in the oldest-old: the 90+ Study. Neurology 85:6 (2015), 535–542.
51. Kim, S.H., Knight, E.M., Saunders, E.L., Cuevas, A.K., Popovech, M., Chen, L.C., Gandy, S., Rapid doubling of Alzheimer's amyloid-beta40 and 42 levels in brains of mice exposed to a nickel nanoparticle model of air pollution [brief report]. F1000Res, 1, 2012, 70.
52. Kioumourtzoglou, M.A., Spiegelman, D., Szpiro, A.A., Sheppard, L., Kaufman, J.D., Yanosky, J.D., Williams, R., Laden, F., Hong, B., Suh, H., Exposure measurement error in PM2.5 health effects studies: a pooled analysis of eight personal exposure validation studies. Environ. Health, 13(1), 2014, 2.
53. Kioumourtzoglou, M.A., Schwartz, J.D., Weisskopf, M.G., Melly, S.J., Wang, Y., Dominici, F., Zanobetti, A., Long-term PM2.5 exposure and neurological hospital admissions in the northeastern United States. Environ. Health Perspect. 124:1 (2016), 23–29.
54. Krishnan, R.M., Adar, S.D., Szpiro, A.A., Jorgensen, N.W., Van Hee, V.C., Barr, R.G., O'Neill, M.S., Herrington, D.M., Polak, J.F., Kaufman, J.D., Vascular responses to long- and short-term exposure to fine particulate matter: MESA Air (Multi-Ethnic Study of Atherosclerosis and Air Pollution). J. Am. Coll. Cardiol. 60:21 (2012), 2158–2166.
55. Lanphear, B.P., Hornung, R., Khoury, J., Yolton, K., Baghurst, P., Bellinger, D.C., Canfield, R.L., Dietrich, K.N., Bornschein, R., Greene, T., Rothenberg, S.J., Needleman, H.L., Schnaas, L., Wasserman, G., Graziano, J., Roberts, R., Low-level environmental lead exposure and children's intellectual function: an international pooled analysis. Environ. Health Perspect. 113:7 (2005), 894–899.
56. Laurijssens, B., Aujard, F., Rahman, A., Animal models of Alzheimer's disease and drug development. Drug Discov. Today Technol. 10:3 (2013), e319–327.
57. Lee, M., Koutrakis, P., Coull, B., Kloog, I., Schwartz, J., Acute effect of fine particulate matter on mortality in three Southeastern states from 2007 to 2011. J. Exposure Sci. Environ. Epidemiol. 26:2 (2016), 173–179.
58. Linn, R.T., Wolf, P.A., Bachman, D.L., Knoefel, J.E., Cobb, J.L., Belanger, A.J., Kaplan, E.F., D'Agostino, R.B., The ‘preclinical phase’ of probable Alzheimer's disease. A 13-year prospective study of the Framingham cohort. Arch. Neurol. 52:5 (1995), 485–490.
59. Liu, L., Chan, C., The role of inflammasome in Alzheimer's disease. Ageing Res. Rev. 15C (2014), 6–15.
60. Loop, M.S., Kent, S.T., Al-Hamdan, M.Z., Crosson, W.L., Estes, S.M., Estes, M.G. Jr., Quattrochi, D.A., Hemmings, S.N., Wadley, V.G., McClure, L.A., Fine particulate matter and incident cognitive impairment in the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort. PLoS One, 8(9), 2013, e75001.
61. Loop, M.S., Kent, S.T., Al-Hamdan, M.Z., Crosson, W.L., Estes, S.M., Estes, M.G., Quattrochi, D.A., Hemmings, S.N., Wadley, V.G., McClure, L.A., Fine particulate matter and incident cognitive impairment in the reasons for geographic and racial differences in stroke (REGARDS) cohort. PLoS One, 10(4), 2015, 10.1371/journal.pone.0075001 (PLoS ONE (2013) 8:9 (e75001).
62. Maccioni, R.B., Farias, G., Morales, I., Navarrete, L., The revitalized tau hypothesis on Alzheimer's disease. Arch. Med. Res. 41:3 (2010), 226–231.
63. McKhann, G.M., Knopman, D.S., Chertkow, H., Hyman, B.T., Jack, C.R. Jr., Kawas, C.H., Klunk, W.E., Koroshetz, W.J., Manly, J.J., Mayeux, R., Mohs, R.C., Morris, J.C., Rossor, M.N., Scheltens, P., Carrillo, M.C., Thies, B., Weintraub, S., Phelps, C.H., The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement. 7:3 (2011), 263–269.
64. Moher, D., Liberati, A., Tetzlaff, J., Altman, D.G., The, P.G., Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med., 6(7), 2009, e1000097.
65. Morgan, T.E., Davis, D.A., Iwata, N., Tanner, J.A., Snyder, D., Ning, Z., Kam, W., Hsu, Y.T., Winkler, J.W., Chen, J.C., Petasis, N.A., Baudry, M., Sioutas, C., Finch, C.E., Glutamatergic neurons in rodent models respond to nanoscale particulate urban air pollutants in vivo and in vitro. Environ. Health Perspect. 119:7 (2011), 1003–1009.
66. Newcomer, R., Clay, T., Luxenberg, J.S., Miller, R.H., Misclassification and selection bias when identifying Alzheimer's disease solely from Medicare claims records. J. Am. Geriatr. Soc. 47:2 (1999), 215–219.
67. Oberdorster, G., Utell, M.J., Ultrafine particles in the urban air: to the respiratory tract-and beyond?. Environ. Health Perspect. 110:8 (2002), A440–A441.
68. Oberdorster, G., Sharp, Z., Atudorei, V., Elder, A., Gelein, R., Kreyling, W., Cox, C., Translocation of inhaled ultrafine particles to the brain. Inhal. Toxicol. 16:6–7 (2004), 437–445.
69. Oudin, A., Forsberg, B., Adolfsson, A.N., Lind, N., Modig, L., Nordin, M., Nordin, S., Adolfsson, R., Nilsson, L.G., Traffic-related air pollution and dementia incidence in northern Sweden: a longitudinal study. Environ. Health Perspect. 124:3 (2016), 306–312.
70. Pedata, P., Grella, R., Lamberti, M., Bergamasco, N., Using the Mini-Mental State Examination (MMSE) for preliminary assessment of cognitive impairment in subjects exposed to air pollution with particulate matter. Giornale Italiano di Medicina del Lavoro ed Ergonomia 36:2 (2014), 124–128.
71. Peters, A., Veronesi, B., Calderon-Garciduenas, L., Gehr, P., Chen, L.C., Geiser, M., Reed, W., Rothen-Rutishauser, B., Schurch, S., Schulz, H., Translocation and potential neurological effects of fine and ultrafine particles a critical update. Part Fibre Toxicol., 3, 2006, 13.
72. Petrovitch, H., Ross, G.W., Steinhorn, S.C., Abbott, R.D., Markesbery, W., Davis, D., Nelson, J., Hardman, J., Masaki, K., Vogt, M.R., Launer, L., White, L.R., AD lesions and infarcts in demented and non-demented Japanese-American men. Ann. Neurol. 57:1 (2005), 98–103.
73. Phelan, E.A., Borson, S., Grothaus, L., Balch, S., Larson, E.B., Association of incident dementia with hospitalizations. JAMA 307:2 (2012), 165–172.
74. Plassman, B.L., Langa, K.M., Fisher, G.G., Heeringa, S.G., Weir, D.R., Ofstedal, M.B., Burke, J.R., Hurd, M.D., Potter, G.G., Rodgers, W.L., Steffens, D.C., Willis, R.J., Wallace, R.B., Prevalence of dementia in the United States: the aging, demographics, and memory study. Neuroepidemiology 29:1–2 (2007), 125–132.
75. Plassman, B.L., Langa, K.M., McCammon, R.J., Fisher, G.G., Potter, G.G., Burke, J.R., Steffens, D.C., Foster, N.L., Giordani, B., Unverzagt, F.W., Welsh-Bohmer, K.A., Heeringa, S.G., Weir, D.R., Wallace, R.B., Incidence of dementia and cognitive impairment not dementia in the United States. Ann. Neurol. 70:3 (2011), 418–426.
76. Pope, C.A. 3rd, Burnett, R.T., Thurston, G.D., Thun, M.J., Calle, E.E., Krewski, D., Godleski, J.J., Cardiovascular mortality and long-term exposure to particulate air pollution: epidemiological evidence of general pathophysiological pathways of disease. Circulation 109:1 (2004), 71–77.
77. Pope, C.A. 3rd, Burnett, R.T., Turner, M.C., Cohen, A., Krewski, D., Jerrett, M., Gapstur, S.M., Thun, M.J., Lung cancer and cardiovascular disease mortality associated with ambient air pollution and cigarette smoke: shape of the exposure-response relationships. Environ. Health Perspect. 119:11 (2011), 1616–1621.
78. Power, M.C., Weisskopf, M.G., Alexeeff, S.E., Coull, B.A., Spiro, I.A., Schwartz, J., Exposure to black carbon and cognitive function in a cohort of older men. Epidemiology (Cambridge, Mass.), 22, 2011, S203.
79. Power, M.C., Weisskopf, M.G., Alexeeff, S.E., Coull, B.A., Spiro Iii, A., Schwartz, J., Traffic-Related air pollution and cognitive function in a cohort of older men. Environ. Health Perspect. 119:5 (2011), 682–687.
80. Prince, M., Bryce, R., Albanese, E., Wimo, A., Ribeiro, W., Ferri, C.P., The global prevalence of dementia: a systematic review and metaanalysis. Alzheimer's Dement. 9:1 (2013), 63–75 (e62).
81. Proust-Lima, C., Dartigues, J.F., Jacqmin-Gadda, H., Misuse of the linear mixed model when evaluating risk factors of cognitive decline. Am. J. Epidemiol. 174:9 (2011), 1077–1088.
82. Qiu, C., Fratiglioni, L., A major role for cardiovascular burden in age-related cognitive decline. Nat. Rev. Cardiol. 12:5 (2015), 267–277.
83. Ranft, U., Schikowski, T., Sugiri, D., Krutmann, J., Kramer, U., Long-term exposure to traffic-related particulate matter impairs cognitive function in the elderly. Environ. Res. 109:8 (2009), 1004–1011.
84. Revett, T.J., Baker, G.B., Jhamandas, J., Kar, S., Glutamate system, amyloid ss peptides and tau protein: functional interrelationships and relevance to Alzheimer disease pathology. J. Psychiatry Neurosci. 38:1 (2013), 6–23.
85. Rivas-Arancibia, S., Hernández-Zimbrón, L., Rodríguez-Martínez, E., Borgonio-Pérez, G., Velumani, V., Durán-Bedolla, J., Chronic exposure to low doses of ozone produces a state of oxidative stress and blood-brain barrier damage in the hippocampus of rat. Adv. Biosci. Biotechnol. 4 (2013), 24–29.
86. Rothwell, P.M., External validity of randomised controlled trials: to whom do the results of this trial apply?. Lancet 365:9453 (2005), 82–93.
87. Sagare, A.P., Bell, R.D., Zlokovic, B.V., Neurovascular dysfunction and faulty amyloid beta-peptide clearance in Alzheimer disease. Cold Spring Harb. Perspect. Med., 2(10), 2012.
88. Sang, N., Yun, Y., Li, H., Hou, L., Han, M., Li, G., SO2 inhalation contributes to the development and progression of ischemic stroke in the brain. Toxicol. Sci. 114:2 (2010), 226–236.
89. Schikowski, T., Vossoughi, M., Vierkötter, A., Schulte, T., Teichert, T., Sugiri, D., Fehsel, K., Tzivian, L., Bae, I.S., Ranft, U., Hoffmann, B., Probst-Hensch, N., Herder, C., Krämer, U., Luckhaus, C., Association of air pollution with cognitive functions and its modification by APOE gene variants in elderly women. Environ. Res. 142 (2015), 10–16.
90. Schneider, J.A., Wilson, R.S., Bienias, J.L., Evans, D.A., Bennett, D.A., Cerebral infarctions and the likelihood of dementia from Alzheimer disease pathology. Neurology 62:7 (2004), 1148–1155.
91. Schneider, J.A., Arvanitakis, Z., Bang, W., Bennett, D.A., Mixed brain pathologies account for most dementia cases in community-dwelling older persons. Neurology 69:24 (2007), 2197–2204.
92. Serrano-Pozo, A., Frosch, M.P., Masliah, E., Hyman, B.T., Neuropathological alterations in Alzheimer disease. Cold Spring Harb. Perspect. Med., 1(1), 2011, a006189.
93. Seshadri, S., Wolf, P.A., Lifetime risk of stroke and dementia: current concepts, and estimates from the Framingham Study. Lancet Neurol. 6:12 (2007), 1106–1114.
94. Shanks, N., Greek, R., Greek, J., Are animal models predictive for humans?. Philos. Ethics Humanit. Med., 4, 2009, 2.
95. Small, B.J., Fratiglioni, L., Viitanen, M., Winblad, B., Backman, L., The course of cognitive impairment in preclinical Alzheimer disease: three- and 6-year follow-up of a population-based sample. Arch. Neurol. 57:6 (2000), 839–844.
96. Smith, K.R., Peel, J.L., Mind the gap. Environ. Health Perspect. 118:12 (2010), 1643–1645.
97. Sperling, R.A., Aisen, P.S., Beckett, L.A., Bennett, D.A., Craft, S., Fagan, A.M., Iwatsubo, T., Jack, C.R. Jr., Kaye, J., Montine, T.J., Park, D.C., Reiman, E.M., Rowe, C.C., Siemers, E., Stern, Y., Yaffe, K., Carrillo, M.C., Thies, B., Morrison-Bogorad, M., Wagster, M.V., Phelps, C.H., Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer's Dement. 7:3 (2011), 280–292.
98. Sun, R., Gu, D., Air pollution, economic development of communities, and health status among the elderly in urban China. Am. J. Epidemiol. 168:11 (2008), 1311–1318.
99. Taylor, D.H. Jr., Ostbye, T., Langa, K.M., Weir, D., Plassman, B.L., The accuracy of medicare claims as an epidemiological tool: the case of dementia revisited. J. Alzheimers Dis. 17:4 (2009), 807–815.
100. Taylor, D.H., Østbye, T., Langa, K.M., Weir, D., Plassman, B.L., The accuracy of medicare claims as an epidemiological tool: the case of dementia revisited. J. Alzheimer's Dis. 17:4 (2009), 807–815.
101. Tonne, C., Elbaz, A., Beevers, S., Singh-Manoux, A., Traffic-related air pollution in relation to cognitive function in older adults. Epidemiology (Cambridge, Mass.) 25:5 (2014), 674–681, 10.1097/EDE.0000000000000144.
102. U.S. Environmental Protection Agency, 2011. The Benefits and Costs of the Clean Air Act from 1990 to 2020 Office of Air and Radiation.
103. Valeri, L., Vanderweele, T.J., Mediation analysis allowing for exposure-mediator interactions and causal interpretation: theoretical assumptions and implementation with SAS and SPSS macros. Psychol. Methods 18:2 (2013), 137–150.
104. VanderWeele, T.J., Vansteelandt, S., Mediation analysis with multiple mediators. Epidemiol. Methods 2:1 (2014), 95–115.
105. Vanderweele, T.J., Arah, O.A., Bias formulas for sensitivity analysis of unmeasured confounding for general outcomes, treatments, and confounders. Epidemiol. (Cambridge, Mass.) 22:1 (2011), 42–52.
106. Ward, A., Tardiff, S., Dye, C., Arrighi, H.M., Rate of conversion from prodromal Alzheimer's disease to Alzheimer's dementia: a systematic review of the literature. Dement. Geriatric Cognit. Disord. Extra 3:1 (2013), 320–332.
107. Weisskopf, M.G., Sparrow, D., Hu, H., Power, M.C., Biased exposure-health effect estimates from selection in cohort studies: are environmental studies at particular risk?. Environ. Health Perspect. 123:11 (2015), 1113–1122.
108. Wellenius, G.A., Boyle, L.D., Coull, B.A., Milberg, W.P., Gryparis, A., Schwartz, J., Mittleman, M.A., Lipsitz, L.A., Residential proximity to nearest major roadway and cognitive function in community-dwelling seniors: results from the MOBILIZE Boston Study. J. Am. Geriatr. Soc. 60:11 (2012), 2075–2080.
109. Wellenius, G.A., Burger, M.R., Coull, B.A., Schwartz, J., Suh, H.H., Koutrakis, P., Schlaug, G., Gold, D.R., Mittleman, M.A., Ambient air pollution and the risk of acute ischemic stroke. Arch. Intern. Med. 172:3 (2012), 229–234.
110. Wen, M., Gu, D., Air pollution shortens life expectancy and health expectancy for older adults: the case of China. J. Gerontol. Ser. A: Biol. Sci. Med. Sci. 7:11 (2012), 1219–1229.
111. Weng, S.W., Lin, Y.T., Hwang, B.F., Air pollution and Alzheimer's disease: a population-based prospective cohort study in Taiwan. Epidemiology (Cambridge, Mass.), 23(5), 2012, S143.
112. Weuve, J., Puett, R.C., Schwartz, J., Yanosky, J.D., Laden, F., Grodstein, F., Exposure to particulate air pollution and cognitive decline in older women. Arch. Intern. Med. 172:3 (2012), 219–227.
113. Weuve, J., Hebert, L.E., Scherr, P.A., Evans, D.A., Deaths in the United States among persons with Alzheimer's disease (2010–2050). Alzheimers Dement. 10:2 (2014), e40–46.
114. Weuve, J., Proust-Lima, C., Power, M.C., Gross, A.L., Hofer, S.M., Thiebaut, R., Chene, G., Glymour, M.M., Dufouil, C., Initiative, M., Guidelines for reporting methodological challenges and evaluating potential bias in dementia research. Alzheimers Dement. 11:9 (2015), 1098–1109.
115. Weuve, J., Kaufman, J.D., Szpiro, A.A., Curl, C., Puett, R.C., Beck, T., Evans, D.A., Mendes de Leon, C.F., Exposure to traffic-related air pollution in relation to progression in physical disability among older adults. Environ. Health Perspect. 124 (2016), 1000–1008.
116. Weuve, J., Invited commentary: how exposure to air pollution may shape dementia risk, and what epidemiology can say about it. Am. J. Epidemiol 180:4 (2014), 367–371.
117. Wilker, E.H., Preis, S.R., Beiser, A.S., Wolf, P.A., Au, R., Kloog, I., Li, W., Schwartz, J., Koutrakis, P., DeCarli, C., Seshadri, S., Mittleman, M.A., Long-term exposure to fine particulate matter, residential proximity to major roads and measures of brain structure. Stroke 46:5 (2015), 1161–1166.
118. Wilson, R.S., Leurgans, S.E., Boyle, P.A., Bennett, D.A., Cognitive decline in prodromal Alzheimer disease and mild cognitive impairment. Arch. Neurol. 68:3 (2011), 351–356.
119. Wilson, R.S., Weir, D.R., Leurgans, S.E., Evans, D.A., Hebert, L.E., Langa, K.M., Plassman, B.L., Small, B.J., Bennett, D.A., Sources of variability in estimates of the prevalence of Alzheimer's disease in the United States. Alzheimer's Dement. 7:1 (2011), 74–79.
120. Woodruff-Pak, D.S., Animal models of Alzheimer's disease: therapeutic implications. J. Alzheimer's Dis. 15:4 (2008), 507–521.
121. Wyss-Coray, T., Rogers, J., Inflammation in Alzheimer disease-a brief review of the basic science and clinical literature. Cold Spring Harb. Perspect. Med., 2(1), 2012, a006346.
122. Zawia, N.H., Lahiri, D.K., Cardozo-Pelaez, F., Epigenetics, oxidative stress, and Alzheimer disease. Free Radic. Biol. Med. 46:9 (2009), 1241–1249.
123. Zeng, Y., Gu, D., Purser, J., Hoenig, H., Christakis, N., Associations of environmental factors with elderly health and mortality in China. Am. J. Public Health 100:2 (2010), 298–305.