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Volumn 4, Issue 1, 2009, Pages

Are animal models predictive for humans?

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; FORECASTING; HUMAN; REVIEW;

EID: 60949086792     PISSN: None     EISSN: 17475341     Source Type: Journal    
DOI: 10.1186/1747-5341-4-2     Document Type: Review
Times cited : (528)

References (87)
  • 5
    • 60949102362 scopus 로고    scopus 로고
    • Xceleron http://www.xceleron.com/metadot/index.pl
    • Xceleron
  • 10
    • 20444386552 scopus 로고    scopus 로고
    • Gender in the pharmacy: Does it matter?
    • 10.1126/science.308.5728.1572 15947169
    • Kaiser J Gender in the pharmacy: Does it matter? Science 2005, 308:1572. 10.1126/science.308.5728.1572 15947169
    • (2005) Science , vol.308 , pp. 1572
    • Kaiser, J.1
  • 11
    • 35948990020 scopus 로고    scopus 로고
    • Blue's clues
    • 10.1038/nm1107-1272 17987010
    • Willyard C Blue's clues Nat Med 2007, 13:1272-1273. 10.1038/nm1107-1272 17987010
    • (2007) Nat Med , vol.13 , pp. 1272-1273
    • Willyard, C.1
  • 12
    • 33846781619 scopus 로고    scopus 로고
    • Cancer research. Probing the roots of race and cancer
    • 10.1126/science.315.5812.592 17272699
    • Couzin J Cancer research. Probing the roots of race and cancer Science 2007, 315:592-594. 10.1126/science.315.5812.592 17272699
    • (2007) Science , vol.315 , pp. 592-594
    • Couzin, J.1
  • 13
    • 20444409455 scopus 로고    scopus 로고
    • Sex and the suffering brain
    • 10.1126/science.308.5728.1574 15947170
    • Holden C Sex and the suffering brain Science 2005, 308:1574. 10.1126/ science.308.5728.1574 15947170
    • (2005) Science , vol.308 , pp. 1574
    • Holden, C.1
  • 14
    • 31344446216 scopus 로고    scopus 로고
    • Rational Prediction
    • Curd M, Cover J, Norton
    • Salmon W Rational Prediction Philosophy of Science Curd M, Cover J, Norton 1998:433-444.
    • (1998) Philosophy of Science , pp. 433-444
    • Salmon, W.1
  • 15
    • 20844432908 scopus 로고    scopus 로고
    • Can cell systems biology rescue drug discovery?
    • 10.1038/nrd1754 15915152
    • Butcher EC Can cell systems biology rescue drug discovery? Nat Rev Drug Discov 2005, 4:461-467. 10.1038/nrd1754 15915152
    • (2005) Nat Rev Drug Discov , vol.4 , pp. 461-467
    • Butcher, E.C.1
  • 16
    • 0037313517 scopus 로고    scopus 로고
    • Modern biomedical research: An internally self-consistent universe with little contact with medical reality?
    • 10.1038/nrd1012 12563306
    • Horrobin DF Modern biomedical research: An internally self-consistent universe with little contact with medical reality? Nat Rev Drug Discov 2003, 2:151-154. 10.1038/nrd1012 12563306
    • (2003) Nat Rev Drug Discov , vol.2 , pp. 151-154
    • Horrobin, D.F.1
  • 17
    • 1442311168 scopus 로고    scopus 로고
    • Where is the evidence that animal research benefits humans?
    • 351856 14988196 10.1136/bmj.328.7438.514
    • Pound P Ebrahim S Sandercock P Bracken MB Roberts I Where is the evidence that animal research benefits humans? BMJ 2004, 328:514-517. 351856 14988196 10.1136/bmj.328.7438.514
    • (2004) BMJ , vol.328 , pp. 514-517
    • Pound, P.1    Ebrahim, S.2    Sandercock, P.3    Bracken, M.B.4    Roberts, I.5
  • 18
    • 23844432878 scopus 로고    scopus 로고
    • The time is now
    • Ediorial 10.1038/nrd1817 16106580
    • Ediorial The time is now Nat Rev Drug Discov 2005, 4:613. 10.1038/ nrd1817 16106580
    • (2005) Nat Rev Drug Discov , vol.4 , pp. 613
  • 19
    • 23844474716 scopus 로고    scopus 로고
    • The ultimate model organism: Progress in experimental medicine
    • 10.1038/nrd1800 16056389
    • Littman BH Williams SA The ultimate model organism: Progress in experimental medicine Nat Rev Drug Discov 2005, 4:631-638. 10.1038/ nrd1800 16056389
    • (2005) Nat Rev Drug Discov , vol.4 , pp. 631-638
    • Littman, B.H.1    Williams, S.A.2
  • 20
    • 60949103526 scopus 로고    scopus 로고
    • Microdoses of Excitement over AMS, 'Phase 0' Trials
    • Uehling M Microdoses of Excitement over AMS, 'Phase 0' Trials Bio-IT World 2006, 2006:.
    • (2006) Bio-IT World 2006 , vol.2006
    • Uehling, M.1
  • 21
    • 33947595809 scopus 로고    scopus 로고
    • Healthy animals and animal models of human disease(s) in safety assessment of human pharmaceuticals, including therapeutic antibodies
    • 10.1016/j.drudis.2007.02.018 17395094
    • Dixit R Boelsterli U Healthy animals and animal models of human disease(s) in safety assessment of human pharmaceuticals, including therapeutic antibodies Drug Discovery Today 2007, 12:336-342. 10.1016/ j.drudis.2007.02.018 17395094
    • (2007) Drug Discovery Today , vol.12 , pp. 336-342
    • Dixit, R.1    Boelsterli, U.2
  • 25
    • 47049103115 scopus 로고    scopus 로고
    • The beginning of the end for chimpanzee experiments?
    • 2432070 18518999 10.1186/1747-5341-3-16
    • Knight A The beginning of the end for chimpanzee experiments? Philos Ethics Humanit Med 2008, 3:16. 2432070 18518999 10.1186/1747-5341-3-16
    • (2008) Philos Ethics Humanit Med , vol.3 , pp. 16
    • Knight, A.1
  • 26
    • 34248404066 scopus 로고    scopus 로고
    • Evolution and medicine: The long reach of "Dr. Darwin"
    • 1852567 17407602 10.1186/1747-5341-2-4
    • Shanks N Pyles RA Evolution and medicine: The long reach of "Dr. Darwin" Philos Ethics Humanit Med 2007, 2:4. 1852567 17407602 10.1186/1747-5341-2-4
    • (2007) Philos Ethics Humanit Med , vol.2 , pp. 4
    • Shanks, N.1    Pyles, R.A.2
  • 27
    • 40649116964 scopus 로고    scopus 로고
    • Darwinian perspective: Right premises, questionable conclusion. A commentary on Niall Shanks and Rebecca Pyles' "evolution and medicine: The long reach of "Dr. Darwin""
    • 2265736 18269763 10.1186/1747-5341-3-6
    • Vineis P Melnick R A Darwinian perspective: Right premises, questionable conclusion. A commentary on Niall Shanks and Rebecca Pyles' "evolution and medicine: The long reach of "Dr. Darwin"" Philos Ethics Humanit Med 2008, 3:6. 2265736 18269763 10.1186/1747-5341-3-6
    • (2008) Philos Ethics Humanit Med , vol.3 , pp. 6
    • Vineis, P.1    Melnick, R.2
  • 28
    • 60949092399 scopus 로고    scopus 로고
    • Debate title: Animals are predictive for humans http://video.google.com/ videoplay?docid=-8464924004908818871&q=madison+debate+ animal&total=5&start=0&num=30&so=0&type= search&plindex=0
    • Debate Title: Animals Are Predictive for Humans
  • 30
    • 33749333727 scopus 로고    scopus 로고
    • Mouse models of brain tumors and their applications in preclinical trials
    • 10.1158/1078-0432.CCR-06-0438 17000661
    • Fomchenko EI Holland EC Mouse models of brain tumors and their applications in preclinical trials Clin Cancer Res 2006, 12:5288-5297. 10.1158/1078-0432.CCR-06-0438 17000661
    • (2006) Clin Cancer Res , vol.12 , pp. 5288-5297
    • Fomchenko, E.I.1    Holland, E.C.2
  • 32
    • 60949109233 scopus 로고    scopus 로고
    • Staff Of Mice... and Humans
    • Staff Of Mice... and Humans Drug Discovery and Development 2008, 11:16-20.
    • (2008) Drug Discovery and Development , vol.11 , pp. 16-20
  • 34
    • 33846424676 scopus 로고    scopus 로고
    • Metabolic and non-metabolic factors determining troglitazone hepatotoxicity: A review
    • 10.2133/dmpk.21.347 17072088
    • Masubuchi Y Metabolic and non-metabolic factors determining troglitazone hepatotoxicity: A review Drug Metab Pharmacokinet 2006, 21:347-356. 10.2133/dmpk.21.347 17072088
    • (2006) Drug Metab Pharmacokinet , vol.21 , pp. 347-356
    • Masubuchi, Y.1
  • 35
    • 6044267892 scopus 로고    scopus 로고
    • Failing the public health - Rofecoxib, Merck, and the FDA
    • 10.1056/NEJMp048286 15470193
    • Topol EJ Failing the public health - rofecoxib, Merck, and the FDA N Engl J Med 2004, 351:1707-1709. 10.1056/NEJMp048286 15470193
    • (2004) N Engl J Med , vol.351 , pp. 1707-1709
    • Topol, E.J.1
  • 36
    • 0001936586 scopus 로고
    • Clinical Toxicity - Could it have been predicted? Post-marketing experience
    • Lumley CE, Walker S Lancaster, Quay
    • Heywood R Clinical Toxicity - Could it have been predicted? Post-marketing experience Animal Toxicity Studies: Their Relevance for Man Lumley CE, Walker S Lancaster, Quay 1990 57 67
    • (1990) Animal Toxicity Studies: Their Relevance for Man , pp. 57-67
    • Heywood, R.1
  • 38
    • 0002280017 scopus 로고
    • The duration of toxicity studies required to support repeated dosing in clinical investigation - A toxicologists opinion
    • Boston/UK: Kluwer Parkinson CNM, Lumley C, Walker SR
    • Igarashi T The duration of toxicity studies required to support repeated dosing in clinical investigation - A toxicologists opinion CMR Workshop: The Timing of Toxicological Studies to Support Clinical Trials Boston/ UK: Kluwer Parkinson CNM, Lumley C, Walker SR 1994:67-74.
    • (1994) CMR Workshop: The Timing of Toxicological Studies to Support Clinical Trials , pp. 67-74
    • Igarashi, T.1
  • 39
    • 54849419114 scopus 로고    scopus 로고
    • The Delicate Toxicity Balance in Drug Discovery
    • 12535578
    • Sankar U The Delicate Toxicity Balance in Drug Discovery The Scientist 2005, 19:32. 12535578
    • (2005) The Scientist , vol.19 , pp. 32
    • Sankar, U.1
  • 40
    • 0022806748 scopus 로고
    • Response of experimental animals to human carcinogens: An analysis based upon the IARC Monographs programme
    • 10.1093/carcin/7.11.1853 3769134
    • Wilbourn J Haroun L Heseltine E Kaldor J Partensky C Vainio H Response of experimental animals to human carcinogens: An analysis based upon the IARC Monographs programme Carcinogenesis 1986, 7:1853-1863. 10.1093/ carcin/7.11.1853 3769134
    • (1986) Carcinogenesis , vol.7 , pp. 1853-1863
    • Wilbourn, J.1    Haroun, L.2    Heseltine, E.3    Kaldor, J.4    Partensky, C.5    Vainio, H.6
  • 41
    • 0034039895 scopus 로고    scopus 로고
    • Laboratory animal tests and human cancer
    • 10.1081/DMR-100100565 10774768
    • Rall DP Laboratory animal tests and human cancer Drug Metab Rev 2000, 32:119-128. 10.1081/DMR-100100565 10774768
    • (2000) Drug Metab Rev , vol.32 , pp. 119-128
    • Rall, D.P.1
  • 43
    • 33644850151 scopus 로고    scopus 로고
    • Animal carcinogenicity studies: 1. Poor human predictivity
    • 16522147
    • Knight A Bailey J Balcombe J Animal carcinogenicity studies: 1. Poor human predictivity Altern Lab Anim 2006, 34:19-27. 16522147
    • (2006) Altern Lab Anim , vol.34 , pp. 19-27
    • Knight, A.1    Bailey, J.2    Balcombe, J.3
  • 44
    • 0006536579 scopus 로고    scopus 로고
    • Evaluation of carcinogenic risk to humans: The experience of IARC
    • Washington, DC: Taylor and Francis Iversen
    • Tomatis L Wilbourn L Evaluation of carcinogenic risk to humans: The experience of IARC New Frontiers in Cancer Causation Washington, DC: Taylor and Francis Iversen 2003:371-387.
    • (2003) New Frontiers in Cancer Causation , pp. 371-387
    • Tomatis, L.1    Wilbourn, L.2
  • 47
    • 0034036134 scopus 로고    scopus 로고
    • Using the NTP database to assess the value of rodent carcinogenicity studies for determining human cancer risk
    • 10.1081/DMR-100100570 10774773
    • Haseman JK Using the NTP database to assess the value of rodent carcinogenicity studies for determining human cancer risk Drug Metab Rev 2000, 32:169-186. 10.1081/DMR-100100570 10774773
    • (2000) Drug Metab Rev , vol.32 , pp. 169-186
    • Haseman, J.K.1
  • 48
    • 0031830786 scopus 로고    scopus 로고
    • What do animal cancer tests tell us about human cancer risk?: Overview of analyses of the carcinogenic potency database
    • 10.3109/03602539808996318 9606609
    • Gold LS Slone TH Ames BN What do animal cancer tests tell us about human cancer risk?: Overview of analyses of the carcinogenic potency database Drug Metab Rev 1998, 30:359-404. 10.3109/03602539808996318 9606609
    • (1998) Drug Metab Rev , vol.30 , pp. 359-404
    • Gold, L.S.1    Slone, T.H.2    Ames, B.N.3
  • 53
    • 0002854983 scopus 로고
    • Comparative Aspects of Detoxification in Mammals
    • New York: Academic Press Jakoby W
    • Caldwell J Comparative Aspects of Detoxification in Mammals Enzymatic Basis of Detoxification New York: Academic Press Jakoby W 1980. 1
    • (1980) Enzymatic Basis of Detoxification , vol.1
    • Caldwell, J.1
  • 54
    • 0014108381 scopus 로고
    • Comparative pharmacology in relation to teratogenesis
    • 5339261
    • Runner MN Comparative pharmacology in relation to teratogenesis Fed Proc 1967, 26:1131-1136. 5339261
    • (1967) Fed Proc , vol.26 , pp. 1131-1136
    • Runner, M.N.1
  • 55
    • 0020356653 scopus 로고
    • Animal virus screens for potential teratogens. I. Poxvirus morphogenesis
    • 10.1002/1520-6866(1990)2:3/4<361::AID-TCM1770020318>3.0.CO;2-I 6130636
    • Keller SJ Smith MK Animal virus screens for potential teratogens. I. Poxvirus morphogenesis Teratog Carcinog Mutagen 1982, 2:361-374. 10.1002/ 1520-6866(1990)2:3/4<361::AID-TCM1770020318>3.0.CO;2-I 6130636
    • (1982) Teratog Carcinog Mutagen , vol.2 , pp. 361-374
    • Keller, S.J.1    Smith, M.K.2
  • 56
    • 84883839686 scopus 로고
    • Effects of Parental Thalidomide Treatment on Gestation and Fetal Development
    • 14089666
    • Staples RE Holtkamp DE Effects of Parental Thalidomide Treatment on Gestation and Fetal Development Exp Mol Pathol 1963, 26:81-106. 14089666
    • (1963) Exp Mol Pathol , vol.26 , pp. 81-106
    • Staples, R.E.1    Holtkamp, D.E.2
  • 57
    • 0026621257 scopus 로고
    • Problems and opportunities in toxicity testing arising from species differences in xenobiotic metabolism
    • (Spec No) 10.1016/0378-4274(92)90244-E
    • Caldwell J Problems and opportunities in toxicity testing arising from species differences in xenobiotic metabolism Toxicol Lett 1992, 64-65(Spec No):651-659. 10.1016/0378-4274(92)90244-E
    • (1992) Toxicol Lett , vol.64-65 , pp. 651-659
    • Caldwell, J.1
  • 58
    • 36448954646 scopus 로고    scopus 로고
    • Are animal models as good as we think?
    • 10.1016/j.theriogenology.2007.09.030 17988725
    • Wall RJ Shani M Are animal models as good as we think? Theriogenology 2008, 69:2-9. 10.1016/j.theriogenology.2007.09.030 17988725
    • (2008) Theriogenology , vol.69 , pp. 2-9
    • Wall, R.J.1    Shani, M.2
  • 59
    • 0037713477 scopus 로고    scopus 로고
    • Why have so many drugs with stellar results in laboratory stroke models failed in clinical trials? A theory based on allometric relationships
    • 12853296
    • Curry SH Why have so many drugs with stellar results in laboratory stroke models failed in clinical trials? A theory based on allometric relationships Ann N Y Acad Sci 2003, 993:69-74. discussion 79-81 12853296
    • (2003) Ann N Y Acad Sci , vol.993 , pp. 69-74
    • Curry, S.H.1
  • 62
    • 0019411287 scopus 로고
    • Carcinogen regulation
    • Council_on_Scientific_Affairs 10.1001/jama.246.3.253 7241769
    • Council_on_Scientific_Affairs Carcinogen regulation JAMA 1981, 246:253-256. 10.1001/jama.246.3.253 7241769
    • (1981) JAMA , vol.246 , pp. 253-256
  • 63
    • 77957178396 scopus 로고
    • The lifetime feeding study in mice and rats - An examination of its validity as a bioassay for human carcinogens
    • 10.1016/S0272-0590(83)80174-2 6884625
    • Salsburg D The lifetime feeding study in mice and rats - an examination of its validity as a bioassay for human carcinogens Fundam Appl Toxicol 1983, 3:63-67. 10.1016/S0272-0590(83)80174-2 6884625
    • (1983) Fundam Appl Toxicol , vol.3 , pp. 63-67
    • Salsburg, D.1
  • 65
    • 0020692313 scopus 로고
    • Increased incidence of experimental colon cancer associated with long-term metronidazole therapy
    • 10.1016/0002-9610(83)90168-X 6295197
    • Sloan DA Fleiszer DM Richards GK Murray D Brown RA Increased incidence of experimental colon cancer associated with long-term metronidazole therapy Am J Surg 1983, 145:66-70. 10.1016/0002-9610(83)90168-X 6295197
    • (1983) Am J Surg , vol.145 , pp. 66-70
    • Sloan, D.A.1    Fleiszer, D.M.2    Richards, G.K.3    Murray, D.4    Brown, R.A.5
  • 70
    • 0018895934 scopus 로고
    • Effect of treatment with phenformin, diphenylhydantoin or L-dopa on life span and tumour incidence in C3H/Sn mice
    • 7390164
    • Dilman VM Anisimov VN Effect of treatment with phenformin, diphenylhydantoin or L-dopa on life span and tumour incidence in C3H/Sn mice Gerontology 1980, 26:241-246. 7390164
    • (1980) Gerontology , vol.26 , pp. 241-246
    • Dilman, V.M.1    Anisimov, V.N.2
  • 71
    • 33846822325 scopus 로고
    • Some aromatic amines, hydrazine and related substances, n-nitroso compounds and miscellaneous alkylating agents
    • IARC Lyon
    • IARC Some aromatic amines, hydrazine and related substances, n-nitroso compounds and miscellaneous alkylating agents IARC monograph on the evaluation of carcinogenic risks to humans, Lyon 1974, 4:
    • (1974) IARC Monograph on the Evaluation of Carcinogenic Risks to Humans, Lyon , vol.4
  • 72
    • 26044442246 scopus 로고    scopus 로고
    • Cancer in rodents: Does it tell us about cancer in humans?
    • 10.1038/nrc1715 16195752
    • Anisimov VN Ukraintseva SV Yashin AI Cancer in rodents: Does it tell us about cancer in humans? Nat Rev Cancer 2005, 5:807-819. 10.1038/nrc1715 16195752
    • (2005) Nat Rev Cancer , vol.5 , pp. 807-819
    • Anisimov, V.N.1    Ukraintseva, S.V.2    Yashin, A.I.3
  • 73
    • 0036561908 scopus 로고    scopus 로고
    • Modelling the molecular circuitry of cancer
    • 10.1038/nrc795 12044009
    • Hahn WC Weinberg RA Modelling the molecular circuitry of cancer Nat Rev Cancer 2002, 2:331-341. 10.1038/nrc795 12044009
    • (2002) Nat Rev Cancer , vol.2 , pp. 331-341
    • Hahn, W.C.1    Weinberg, R.A.2
  • 74
    • 1342288971 scopus 로고    scopus 로고
    • Opinion: Comparative biology of mouse versus human cells: Modelling human cancer in mice
    • 10.1038/nrc1235 14737125
    • Rangarajan A Weinberg RA Opinion: Comparative biology of mouse versus human cells: Modelling human cancer in mice Nat Rev Cancer 2003, 3:952-959. 10.1038/nrc1235 14737125
    • (2003) Nat Rev Cancer , vol.3 , pp. 952-959
    • Rangarajan, A.1    Weinberg, R.A.2
  • 75
    • 26044456166 scopus 로고    scopus 로고
    • Age as a risk in multistage carcinogenesis
    • M E: Informa Healthcare. Taylor and Francis group Balducci L, Ershler WB, Lyman GH 2 2004
    • Anisimov VN Age as a risk in multistage carcinogenesis Comprehensive Geriatric Oncology M E: Informa Healthcare. Taylor and Francis group Balducci L, Ershler WB, Lyman GH 2 2004, 75(101):157-178.
    • (2004) Comprehensive Geriatric Oncology , Issue.101 , pp. 75-101
    • Anisimov, V.N.1
  • 76
    • 60949110532 scopus 로고    scopus 로고
    • Basic Issues in the Use of Animals in Health Research
    • American Psychological Association Carroll ME, Overmier JB
    • Overmier JB Carroll ME Basic Issues in the Use of Animals in Health Research Animal Research and Human Health American Psychological Association Carroll ME, Overmier JB 2001:5.
    • (2001) Animal Research and Human Health , pp. 5
    • Overmier, J.B.1    Carroll, M.E.2
  • 77
    • 60949111017 scopus 로고    scopus 로고
    • 2 Top Diet Drugs Are Recalled Amid Reports of Heart Defects
    • New York
    • Kolata G 2 Top Diet Drugs Are Recalled Amid Reports of Heart Defects New York Times. New York 1997.
    • (1997) New York Times
    • Kolata, G.1
  • 79
    • 60949096382 scopus 로고    scopus 로고
    • Animals and Medicine: Do Animal Experiments Predict Human Response?
    • Shanks N Greek R Nobis N Greek J Animals and Medicine: Do Animal Experiments Predict Human Response? Skeptic 2007, 13:44-51.
    • (2007) Skeptic , vol.13 , pp. 44-51
    • Shanks, N.1    Greek, R.2    Nobis, N.3    Greek, J.4
  • 80
    • 60949104898 scopus 로고    scopus 로고
    • Letter. Animal research wars
    • Conn P Parker J Letter. Animal research wars Skeptic 2007, 13:18-19.
    • (2007) Skeptic , vol.13 , pp. 18-19
    • Conn, P.1    Parker, J.2
  • 81
    • 10044298236 scopus 로고    scopus 로고
    • Reductionism and complexity in molecular biology. Scientists now have the tools to unravel biological and overcome the limitations of reductionism
    • 1299179 15520799 10.1038/sj.embor.7400284
    • Van Regenmortel MH Reductionism and complexity in molecular biology. Scientists now have the tools to unravel biological and overcome the limitations of reductionism EMBO Rep 2004, 5:1016-1020. 1299179 15520799 10.1038/sj.embor.7400284
    • (2004) EMBO Rep , vol.5 , pp. 1016-1020
    • Van Regenmortel, M.H.1
  • 82
    • 10044278501 scopus 로고    scopus 로고
    • A successful form for reductionism
    • Morange M A successful form for reductionism The Biochemist 2001, 23:37-39.
    • (2001) The Biochemist , vol.23 , pp. 37-39
    • Morange, M.1
  • 85
    • 4043123358 scopus 로고    scopus 로고
    • Comparison of differentially expressed genes in T lymphocytes between human autoimmune disease and murine models of autoimmune disease
    • 10.1016/j.clim.2004.03.017 15308114
    • Liu Z Maas K Aune TM Comparison of differentially expressed genes in T lymphocytes between human autoimmune disease and murine models of autoimmune disease Clin Immunol 2004, 112:225-230. 10.1016/ j.clim.2004.03.017 15308114
    • (2004) Clin Immunol , vol.112 , pp. 225-230
    • Liu, Z.1    Maas, K.2    Aune, T.M.3
  • 86
    • 33747516799 scopus 로고    scopus 로고
    • Cancer: Off by a whisker
    • 10.1038/442739a 16915261
    • Dennis C Cancer: Off by a whisker Nature 2006, 442:739-741. 10.1038/ 442739a 16915261
    • (2006) Nature , vol.442 , pp. 739-741
    • Dennis, C.1
  • 87
    • 38849200765 scopus 로고    scopus 로고
    • Transgenic animal models in biomedical research
    • 17172731
    • Houdebine LM Transgenic animal models in biomedical research Methods Mol Biol 2007, 360:163-202. 17172731
    • (2007) Methods Mol Biol , vol.360 , pp. 163-202
    • Houdebine, L.M.1


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