Air pollution and brain damage

Toxicologic Pathology

Volumn 30, Issue 3, 2002, Pages 373-389

  Calderón Garcidueñas, Lilian ^a   Azzarelli, Biagio ^a   Acuna, Hilda ^a   Garcia, Raquel ^a   Gambling, Todd M ^a   Osnaya, Norma ^a   Monroy, Sylvia ^a   Tizapantzi, Maria Del Rosario ^a   Carson, Johnny L ^a   Villarreal Calderon, Anna ^a   Rewcastle, Barry ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Air pollution; Alzheimer's; BBB; Canines; iNOS; Mexico City; Nasal epithelia; NF B

Indexed keywords

APOLIPOPROTEIN E; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE;

ADOLESCENT; AGED; AIR POLLUTION; ALZHEIMER DISEASE; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CELL; BRAIN CORTEX; BRAIN INJURY; CONTROLLED STUDY; DEGENERATIVE DISEASE; DOG; ELECTRON MICROSCOPY; GENE EXPRESSION; GLIA; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LIPID STORAGE; MEXICO; MICROSCOPY; NERVE CELL DEGENERATION; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; NEWBORN; NONHUMAN; NOSE MUCOSA; OLFACTORY EPITHELIUM; PERICYTE; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM; SMOOTH MUSCLE FIBER; URBAN AREA; WHITE MATTER; AIR POLLUTANT; ANIMAL; BRAIN DISEASE; CHEMICALLY INDUCED DISORDER; COMPARATIVE STUDY; DRUG EFFECT; FEMALE; LUNG; MALE; METABOLISM; NERVE CELL; OLFACTORY BULB; ULTRASTRUCTURE; VASCULARIZATION;

AIR POLLUTANTS; ANIMAL; APOPTOSIS; BLOOD-BRAIN BARRIER; BRAIN DISEASES; CEREBRAL CORTEX; COMPARATIVE STUDY; DOGS; FEMALE; LUNG; MALE; MEXICO; NASAL MUCOSA; NEUROGLIA; NEURONS; NF-KAPPA B; NITRIC-OXIDE SYNTHASE; OLFACTORY BULB; OLFACTORY MUCOSA; SUPPORT, U.S. GOV'T, P.H.S.; ANIMALS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II;

ANIMALIA; CANIS FAMILIARIS;

EID: 0036001304     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1080/01926230252929954     Document Type: Article

References (116)

1. STAT3 and NF κB activation precedes glial reactivity in the excitotoxically injured young cortex but not in the corresponding distal thalamic nuclei
2. Cell injury and interstitial inflammation in rat lung after inhalation of ozone and urban particles
3. Inflammation and Alzheimer's disease
4. The role of microglia and astrocytes in CNS immune surveillance and immunopathology
5. Measurements of formaldehyde and acetaldehyde in the atmosphere of Mexico City
6. Airborne particles evoke an inflammatory response in human airway epithelium. Activation of transcription factors
7. Incidence of dementia and probable Alzheimer's disease in a general population: The Framingham study
8. Early and rapid de novo synthesis of Alzheimer beta A4-amyloid precursor protein (APP) in activated microglia
9. Amyloid precursor protein (APP) as a microglial acute phase protein
10. The female sex hormone oestrogen as neuroprotectant: Activities at various levels
11. Extrathoracic deposition of inhaled, coarse particles (4.5 um) in children vs adults
12. Inducible endothelial functions in inflammation and coagulation
13. Urban leakage of liquefied petroleum gas and its impact on Mexico City air quality
14. Microglial-produced nitric oxide and reactive oxides mediate neuronal cell death
15. Induction of the lung myofibroblast PDGF receptor system by urban ambient particles from Mexico City
16. Age-related changes in the brain of the dog
17. Are inhaled dust particles harmful for our lungs?
18. Analysis of the change in atmospheric urban formaldehyde and photochemistry activity as a result of using methyl-t-butyl ether (MTBE) as an additive in gasolines in the metropolitan area of Mexico City
19. Environmental causes for sinonasal cancers in pet dogs, and their usefulness as sentinels of indoor cancer risk
20. Canines as sentinel species for assessing chronic exposures to air pollutants: Part 2. Cardiac pathology
21. Exposure to air pollution is associated with lung hyperinflation in healthy children and adolescents in Southwest Mexico City. A Pilot Study
22. Canines as sentinel species for assessing chronic exposures to air pollutants: Part 1. Respiratory pathology
23. Lung damage and cytokine profile in children chronically exposed to air pollutants
24. Histopathological changes of the nasal mucosa in Southwest Metropolitan Mexico City
25. DNA damage in nasal respiratory epithelium from children exposed to urban pollution
26. Nasal epithelium as a sentinel for airborne environmental pollution
27. Ultrastructural nasal pathology in children chronically and sequentially exposed to air pollutants
28. Activated microglia mediate cell injury via a nitric oxide mechanism
29. Oxidized LDL promotes vascular endothelial cell pinocytosis via a prooxidation mechanism
30. 10/TSP ratios in the Mexico City Metropolitan Area: A temporal and spatial approach
31. Ultrastructural features of the blood-brain barrier in biopsy tissue from Alzheimer's disease patients
32. Inhaled concentrated ambient particles are associated with hematologic and bronchioalveolar changes in canines
33. Cerebral ischemia: Gene activation, neuronal injury, and the protective role of antioxidants
34. Multiple sclerosis in Mexico: Hospital cases at the National Institute of Neurology and Neurosurgery, Mexico City
35. Canine as an animal model of human aging and dementia
36. Respiratory tract uptake of inhalants and metabolism of xenobiotics
37. Cerebral hypopeffusion, capillary degeneration, and development of Alzheimer disease
38. Quantitative particle-induced X ray emission imaging of rat olfactory epithelium applied to the permeability of rat epithelium to inhaled aluminum
39. Cytokines and particle-induced inflammatory cell recruitment
40. Particulate air pollution in Mexico City: A collaborative research project
41. Hematopoietic cells differentiate into both microglia and macroglia in the brains of adult mice
42. Metereological factors associated with inhomogeneous ozone concentrations with the Mexico Basin
43. Pulmonary retention of ultrafine and fine particles in rats
44. Particulate-cell interactions and pulmonary cytokine expression
45. Worldwide prevalence and incidence of dementia
46. Campus ozone concentrations related to new blends in gasoline sold in Mexico City. A statistical analysis
47. Concentrated ambient air particles induce mild pulmonary inflammation in healthy human volunteers
48. Microglia and the immune pathology of Alzheimer disease
49. Risk factors for dementia in Parkinson's disease: Effect of education
50. Occupational exposure to metals as risk factors for Parkinson's disease
51. A damaged microcirculation contributes to neuronal cell death in Alzheimer's disease
52. Production of neurotoxic factors by brain endothelium in Alzheimer's disease
53. Histopathology of nasal olfactory mucosa from selected inhalation toxicity studies conducted with volatile chemicals
54. Manganese taken up into the CNS via the olfactory pathway in rats affects astrocytes
55. Interleukin (IL)-10 inhibits IL-6 production in microglia by preventing activation of NF-κB
56. Age-related changes in the of factory system of dogs
57. Histological markers in nasal mucosa of patients with Alzheimer's disease
58. Age-related changes in the prevalence of smell/taste problems among the United States adult population. Results of the 1994 disability supplement to the National Health Interview Survey (NHIS)
59. Induction of endothelial nitric-oxide synthase in rat brain astrocytes by systemic lipopolysaccharide treatment
60. Synergistic neurotoxic effects of combined treatments with cytokines in murine primary mixed neuron/glia cultures
61. Immunocytochemical characteristics of cells and fibers in the nasal mucosa of young and adult macaques
62. Prediction of hourly microenvironmental concentrations of fine particles based on measurements obtained from the Baltimore scripted activity study
63. Respiratory dose of inhaled ultrafine particles in healthy adults
64. Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: Role of microglia
65. Beta-amyloid deposition and neurofibrillary tangle formation in the olfactory bulb in ageing and Atzheimer's disease
66. Olfactory centres in Atzheimer's disease: Olfactory bulb is involved in early Braak's stages
67. Human endothelium as a source of multifunctional cytokines: Molecular regulation and possible role in human disease
68. Intranasal instillation of aflatoxin B, in rats: Bioactivation in the nasal mucosa and neuronal transport to the olfactory bulb
69. Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain
70. Anterior distribution of human olfactory epithelium
71. The nomenclature of cell death: Recommendations of an ad hoc Committee of the Society of Toxicologic Pathologists
72. Free radical activity and proinflammatory effects of particulate air pollution (PM 10) in vivo and in vitro
73. Dementia syndrome and risk factors in adults older than 60 years old residing in Habana
74. Development of the vertebrate main olfactory system
75. Molecular consequences of activated microglia in the brain: Overactivation produces apoptosis
76. Biology of the endothelium
77. NF-κB in neuronal plasticity and neurodegenerative disorders
78. Reactive microglia are positive for HLA-DR in the substancia nigra of Parkinson's and Alzheimer's disease brains
79. Survey of personal exposures to benzene in Mexico City
80. The brain
81. A receptor model for atmospheric aerosols from a southwestem site in Mexico City
82. Nasal dosimetry, lesion distribution and the toxicologic pathologist: A brief review
83. Airflow, gas deposition, and lesion distribution in the nasal passages
84. Immunohistopathology of variations of human olfactory mucosa
85. Inflammatory effects of intratracheal instillation of ultrafine particles in the rabbit: Role of C-fiber and mast cells
86. The first attempt at radioisotopic evaluation of the integrity of the nose-brain barrier
87. A light and electron microscopic study of HLA-DR positive cells in the human cerebral cortex and subcortical white matter
88. Prevalence of Alzheimer's disease and vascular dementia: Association with education. The Rotterdam study
89. Human olfactory mucosa. The influence of age and receptor distribution
90. Apolipoprotein E and Alzheimer's disease. A role in amyloid catabolism
91. Selective upregulation of inducible nitric oxide synthase (iNOS) by lipopolysaccharide (LPS) and cytokines in microglia: In vitro and in vivo studies
92. Animal model of vascular inflammation
93. Personal exposure to elements in Mexico City Air
94. How the blood talks to the brain parenchyma and the paraventricular nucleus of the hypothalamus during systemic inflammatory and infectious stimuli
95. Canine cognitive dysfunction as a model for human age-related cognitive decline, dementia and Alzheimer's disease: Clinical presentation, cognitive testing, pathology and response to 1-deprenyl theraphy
96. Age-specific onset of beta-amyloid in beagle brains
97. Myeloid commitment shift toward monocytopoiesis after thermal injury and sepsis
98. The progression of beta-amyloid deposition in the frontal cortex of the ages canine
99. Centriacinar region inflammatory disease in young individuals: A comparative study of Miami and Los Angeles residents
100. Microglial response to brain injury: A brief synopsis
101. Nitric oxide and blood-brain barrier integrity
102. Senile dementia in aged dogs and the diagnostic standards
103. Volatile organic compounds, poly-cyclic aromatic hydrocarbons and elements in the air of ten urban homes
104. Avances en la investigación de liquenes epifitos como indicadores de contaminación atmosférica en el Valle de México
105. Mutagenicity assessment of airborne particles in Mexico City
106. Ozone and limonene in indoor air: A source of submicron particle exposure
107. Prevalence of Alzheimer's disease and other dementing disorders in an urban community of Beijing, China
108. Sub-population of dogs with severe brain parenchymal beta amyloidosis distinguished with cluster analysis
109. The 1998 Baltimore particulate matter epidemiology-exposure study: Part 1. Comparison of ambient, residential outdoor, indoor and apartment particulate matter monitoring
110. Differential expression of nitric oxide synthases in bacterial meningitis: Role of the inducible isoform for blood-brain barrier breakdown
111. Olfactory dysfunction in Parkinson's disease
112. 2-cell responses and neuropathologies?
113. The leukocytes