Crystal structure of mammalian acid sphingomyelinase

Nature Communications

Volumn 7, Issue , 2016, Pages

  Gorelik, Alexei ^a   Illes, Katalin ^a   Heinz, Leonhard X ^b,c   Superti Furga, Giulio ^b,c   Nagar, Bhushan ^a  

^a MCGILL UNIVERSITY   (Canada)

^b ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

SPHINGOLIPID ACTIVATOR PROTEIN; SPHINGOMYELIN PHOSPHODIESTERASE; ENZYME INHIBITOR; MEMBRANE LIPID;

CANCER; CATALYSIS; CRYSTAL STRUCTURE; ENZYME; ENZYME ACTIVITY; GENETIC ANALYSIS; INHIBITION; INHIBITOR; MAMMAL; MUTATION; NERVOUS SYSTEM DISORDER; PROTEIN;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; DISULFIDE BOND; ENDOPLASMIC RETICULUM; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME STRUCTURE; GENE MUTATION; GLYCOSYLATION; MISSENSE MUTATION; MOLECULAR DOCKING; NONHUMAN; PICK PRESENILE DEMENTIA; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; ANIMAL; CHEMISTRY; ENZYME ASSAY; ENZYME SPECIFICITY; GENETICS; HUMAN; HYDROLYSIS; ISOLATION AND PURIFICATION; MAMMAL; METABOLISM; MOLECULAR MODEL; MOUSE; MUTATION; NIEMANN PICK DISEASE; PROTEIN SECONDARY STRUCTURE; STATIC ELECTRICITY; X RAY CRYSTALLOGRAPHY;

MAMMALIA;

ANIMALS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENZYME ASSAYS; ENZYME INHIBITORS; HUMANS; HYDROLYSIS; MAMMALS; MEMBRANE LIPIDS; MICE; MODELS, MOLECULAR; MOLECULAR DOCKING SIMULATION; MUTATION; NIEMANN-PICK DISEASES; PROTEIN STRUCTURE, SECONDARY; SAPOSINS; SPHINGOMYELIN PHOSPHODIESTERASE; STATIC ELECTRICITY; SUBSTRATE SPECIFICITY;

EID: 84979645672     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms12196     Document Type: Article

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