Crystal structure of saposin B reveals a dimeric shell for lipid binding

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 1, 2003, Pages 38-43

  Ahn, Victoria E ^a   Faull, Kym F ^b   Whitelegge, Julian P ^b   Fluharty, Arvan L ^b   Privé, Gilbert G ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b University of Toronto ^*

Author keywords

[No Author keywords available]

Indexed keywords

ARYLSULFATASE; CELL PROTEIN; SAPOSIN B; UNCLASSIFIED DRUG;

ALPHA HELIX; ARTICLE; COMPLEX FORMATION; CRYSTAL STRUCTURE; CRYSTALLIZATION; EXTRACTION; HYDROPHOBICITY; LIPID MEMBRANE; LYSOSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN LIPID INTERACTION; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; GLYCOPROTEINS; HUMANS; LIPID METABOLISM; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, SECONDARY; SAPOSINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SPHINGOLIPID ACTIVATOR PROTEINS;

EID: 0037422574     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0136947100     Document Type: Article

References (32)

1. Sandhoff, K. & Kolter, T. (1996) Trends Cell Biol. 6, 98-103.
2. Vaccaro, A. M., Salvioli, R., Tatti, M. & Ciaffoni, F. (1999) Neurochem. Res. 24, 307-314.
3. Fluharty, A. L. (1995) Trends Glycosci. Glycotechnol. 7, 167-189.
4. Wilkening, G., Linke, T., Uhlhorn-Dierks, G. & Sandhoff, K. (2000) J. Biol. Chem. 275, 35814-35819.
5. Munford, R. S., Sheppard, P. O. & O'Hara, P. J. (1995) J. Lipid Res. 36, 1653-1663.
6. Zhai, Y. & Saier, M. H., Jr. (2000) Biochim. Biophys. Acta 1469, 87-99.
7. Vaccaro, A. M., Salvioli, R., Barca, A., Tatti, M., Ciaffoni, F., Maras, B., Siciliano, R., Zappacosta, F., Amoresano, A. & Pucci, P. (1995) J. Biol. Chem. 270, 9953-9960.
8. Waring, A. J., Chen, Y., Faull, K. F., Stevens, R., Sherman, M. A. & Fluharty, A. L. (1998) Mol. Genet. Metab. 63, 14-25.
9. Bruhn, H. & Leippe, M. (1999) Biol. Chem. 380, 1001-1007.
10. Whitelegge, J. P., Penn, B., To, T., Johnson, J., Waring, A., Sherman, M., Stevens, R. L., Fluharty, C. B., Faull, K. F. & Fluharty, A. L. (2000) Protein Sci. 9, 1618-1630.
11. Zaltash, S., Palmblad, M., Curstedt, T., Johansson, J. & Persson, B. (2000) Biochim. Biophys. Acta 1466, 179-186.
12. Liepinsh, E., Andersson, M., Ruysschaert, J. M. & Otting, G. (1997) Nat. Struct. Biol. 4, 793-795.
13. Kervinen, J., Tobin, G. J., Costa, J., Waugh, D. S., Wlodawer, A. & Zdanov, A. (1999) EMBO J. 18, 3947-3955.
14. Gonzalez, C., Langdon, G. M., Bruix, M., Galvez, A., Valdivia, E., Maqueda, M. & Rico, M (2000) Proc. Natl. Acad. Sci. USA 97, 11221-11226.
15. Ahn, V. E., Faull, K. F., Whitelegge, J. P., Higginson, J., Fluharty, A. L. & Privé, G. G. (2003) Protein Expression Purif. 27, 186-193.
16. Sharff, A. J., Koronakis, E., Luisi, B. & Koronakis, V. (2000) Acta Crystallogr. D 56, 785-788.
17. Collaborative Computational Project Number 4 (1994) Acta Crystallogr. D 50, 760-763.
18. Smith, G. D., Nagar, B., Rini, J. M., Hauptman, H. A. & Blessing, R. H. (1998) Acta Crystallogr. D 54, 799-804.
19. Jones, T. A., Zou, J. Y., Cowan, S. W. & Kjeldgaard, M. (1991) Acta Crystallogr. A 47, 110-119.
20. Brunger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., et al. (1998) Acta Crystallogr. D 54, 905-921.
21. Kraulis, P. J. (1991) J. Appl. Crystallogr. 24, 946-950.
22. Fluharty, A. L., Katona, Z., Meek, W. E., Frei, K. & Fowler, A. V. (1992) Biochem. Med. Metab. Biol. 47, 66-85.
23. Wynn, C. H. (1986) Biochem. J. 240, 921-924.
24. Murphy, R. C. (2002) Mass Spectrometry of Phospholipids: Tables of Molecular and Product Ions (Illuminat, Denver, CO).
25. Beamer, L. J., Carroll, S. F. & Eisenberg, D. (1997) Science 276, 1861-1864.
26. Wright, C. S., Li, S. C. & Rastinejad, F. (2000) J. Mol. Biol. 304, 411-422.
27. Fluharty, C. B., Johnson, J., Whitelegge, J., Faull, K. F. & Fluharty, A. L. (2001) J. Neurosci. Res. 63, 82-89.
28. Anderson, T. A., Levitt, D. G. & Banaszak, L. J. (1998) Structure (London) 6, 895-909.
29. Schouten, A., Agianian, B., Westerman, J., Kroon, J., Wirtz, K. W. & Gros, P. (2002) EMBO J. 21, 2117-2121.
30. Roderick, S. L., Chan, W. W., Agate, D. S., Olsen, L. R., Vetting, M. W., Rajashankar, K. R. & Cohen, D. E. (2002) Nat. Struct. Biol. 9, 507-511.
31. Vogel, A., Schwarzmann, G. & Sandhoff, K. (1991) Eur. J. Biochem. 200, 591-597.
32. Ponting, C. P. & Russell, R. B. (1995) Trends Biochem. Sci. 20, 179-180.