The structure and catalytic mechanism of human sphingomyelin phosphodiesterase like 3a--an acid sphingomyelinase homologue with a novel nucleotide hydrolase activity

The FEBS journal

Volumn 283, Issue 6, 2016, Pages 1107-1123

  Lim, Sing M ei ^a   Yeung, Kit ^a   Trésaugues, Lionel ^a   Ling, Teo H siang ^a   Nordlund, Pär ^a  

^a INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

Author keywords

acid sphingomyelinase like; binuclear metallophosphodiesterase; calcineurin like phosphodiesterase; Niemann Pick disease; nucleotide hydrolase

Indexed keywords

CYTIDINE PHOSPHATE; DISULFIDE; MUTANT PROTEIN; SMPDL3A PROTEIN, HUMAN; SPHINGOMYELIN PHOSPHODIESTERASE; ZINC;

AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; CONSERVED SEQUENCE; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; GLYCOSYLATION; HUMAN; METABOLISM; MOLECULAR GENETICS; NIEMANN PICK DISEASE; PHYLOGENY; POINT MUTATION; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY; STATIC ELECTRICITY; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; CATALYTIC DOMAIN; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; CYTIDINE MONOPHOSPHATE; DISULFIDES; GLYCOSYLATION; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; NIEMANN-PICK DISEASES; PHYLOGENY; POINT MUTATION; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; SPHINGOMYELIN PHOSPHODIESTERASE; STATIC ELECTRICITY; SUBSTRATE SPECIFICITY; ZINC;

EID: 84982076340     PISSN: None     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.13655     Document Type: Article

References (0)