-
2
-
-
0019723109
-
Tricyclic antidepressants induce sphingomyelinase deficiency in fibroblast and neuroblastoma cell cultures
-
Albouz, S., Hauw, J. J., Berwald-Netter, Y., Boutry, J. M., Bourdon, R., and Baumann, N. (1981). Tricyclic antidepressants induce sphingomyelinase deficiency in fibroblast and neuroblastoma cell cultures. Biomedicine 35, 218-220.
-
(1981)
Biomedicine
, vol.35
, pp. 218-220
-
-
Albouz, S.1
Hauw, J.J.2
Berwald-Netter, Y.3
Boutry, J.M.4
Bourdon, R.5
Baumann, N.6
-
3
-
-
0020611511
-
Effect of tricyclic antidepressants on sphingomyelinase and other sphingolipid hydrolases in C6 cultured glioma cells
-
Albouz, S., Vanier, M. T., Hauw, J. J., Le Saux, F., Boutry, J. M., and Baumann, N. (1983). Effect of tricyclic antidepressants on sphingomyelinase and other sphingolipid hydrolases in C6 cultured glioma cells. Neurosci. Lett. 36, 311-315.
-
(1983)
Neurosci. Lett.
, vol.36
, pp. 311-315
-
-
Albouz, S.1
Vanier, M.T.2
Hauw, J.J.3
Le Saux, F.4
Boutry, J.M.5
Baumann, N.6
-
4
-
-
84923820273
-
Damage control: Cellular mechanisms of plasma membrane repair
-
Andrews, N. W., Almeida, P. E., and Corrotte, M. (2014). Damage control: cellular mechanisms of plasma membrane repair. Trends Cell Biol. 24, 734-742.
-
(2014)
Trends Cell Biol.
, vol.24
, pp. 734-742
-
-
Andrews, N.W.1
Almeida, P.E.2
Corrotte, M.3
-
5
-
-
77952943373
-
Small molecule inhibitors of acid sphingomyelinase
-
Arenz, C. (2010). Small molecule inhibitors of acid sphingomyelinase. Cell. Physiol. Biochem. 26, 1-8.
-
(2010)
Cell. Physiol. Biochem.
, vol.26
, pp. 1-8
-
-
Arenz, C.1
-
6
-
-
0034681122
-
Enzymatic reduction of disulfide bonds in lysosomes: Characterization of a gamma-interferon-inducible lysosomal thiol reductase (GILT)
-
Arunachalam, B., Phan, U. T., Geuze, H. J., and Cresswell, P. (2000). Enzymatic reduction of disulfide bonds in lysosomes: characterization of a gamma-interferon-inducible lysosomal thiol reductase (GILT). Proc. Natl. Acad. Sci. USA 97, 745-750.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 745-750
-
-
Arunachalam, B.1
Phan, U.T.2
Geuze, H.J.3
Cresswell, P.4
-
7
-
-
0021287299
-
Release of endogenous Zn2+ from brain tissue during activity
-
Assaf, S. Y. and Chung, S. H. (1984). Release of endogenous Zn2+ from brain tissue during activity. Nature 308, 734-736.
-
(1984)
Nature
, vol.308
, pp. 734-736
-
-
Assaf, S.Y.1
Chung, S.H.2
-
8
-
-
0030846557
-
Inflammatory activation of arachidonic acid signaling in murine P388D1 macrophages via sphingomyelin synthesis
-
Balsinde, J., Balboa, M. A., and Dennis, E. A. (1997). Inflammatory activation of arachidonic acid signaling in murine P388D1 macrophages via sphingomyelin synthesis. J. Biol. Chem. 272, 20373-20377.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 20373-20377
-
-
Balsinde, J.1
Balboa, M.A.2
Dennis, E.A.3
-
9
-
-
83755172971
-
Sphingomyelin and sphingomyelin synthase (SMS) in the malignant transformation of glioma cells and in 2-hydroxyoleic acid therapy
-
Barceló-Coblijn, G., Martin, M. L., de Almeida, R. F. M., Noguera-Salvà, M. A., Marcilla-Etxenike, A., Guardiola-Serrano, F., Lüth, A., Kleuser, B., Halver, J. E., and Escribá, P. V. (2011). Sphingomyelin and sphingomyelin synthase (SMS) in the malignant transformation of glioma cells and in 2-hydroxyoleic acid therapy. Proc. Natl. Acad. Sci. USA 108, 19569-19574.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 19569-19574
-
-
Barceló-Coblijn, G.1
Martin, M.L.2
De Almeida, R.F.M.3
Noguera-Salvà, M.A.4
Marcilla-Etxenike, A.5
Guardiola-Serrano, F.6
Lüth, A.7
Kleuser, B.8
Halver, J.E.9
Escribá, P.V.10
-
10
-
-
0344701035
-
Expression of recombinant human acid sphingomyelinase in insect Sf21 cells: Purification, processing and enzymatic characterization
-
Bartelsen, O., Lansmann, S., Nettersheim, M., Lemm, T., Ferlinz, K., and Sandhoff, K. (1998). Expression of recombinant human acid sphingomyelinase in insect Sf21 cells: purification, processing and enzymatic characterization. J. Biotechnol. 63, 29-40.
-
(1998)
J. Biotechnol.
, vol.63
, pp. 29-40
-
-
Bartelsen, O.1
Lansmann, S.2
Nettersheim, M.3
Lemm, T.4
Ferlinz, K.5
Sandhoff, K.6
-
11
-
-
58149306392
-
Sphingolipid metabolizing enzymes as novel therapeutic targets
-
P. J. Quinn and X. Wang, eds. Springer
-
Billich, A. and Baumruker, T. (2008). Sphingolipid metabolizing enzymes as novel therapeutic targets. In: Lipids in Health and Disease, Vol. 49, P. J. Quinn and X. Wang, eds. (Springer), pp. 487-522.
-
(2008)
Lipids in Health and Disease
, vol.49
, pp. 487-522
-
-
Billich, A.1
Baumruker, T.2
-
12
-
-
0018141901
-
Sphingomyelinase in pig and human epidermis
-
Bowser, P. A. and Gray, G. M. (1978). Sphingomyelinase in pig and human epidermis. J. Invest. Dermatol. 70, 331-335.
-
(1978)
J. Invest. Dermatol.
, vol.70
, pp. 331-335
-
-
Bowser, P.A.1
Gray, G.M.2
-
13
-
-
0013881132
-
The metabolism of sphingomyelin
-
Brady, R. O., Kanfer, J. N., Mock, M. B., and Fredrickson, D. S. (1966). The metabolism of sphingomyelin. II. Evidence of an enzymatic deficiency in Niemann-Pick disease. Proc. Natl. Acad. Sci. USA 55, 366-369.
-
(1966)
II. Evidence of an Enzymatic Deficiency in Niemann-pick Disease. Proc. Natl. Acad. Sci. USA
, vol.55
, pp. 366-369
-
-
Brady, R.O.1
Kanfer, J.N.2
Mock, M.B.3
Fredrickson, D.S.4
-
14
-
-
0030059897
-
Intracellular zinc movement and its effect on the carbohydrate metabolism of isolated rat hepatocytes
-
Brand, I. A. and Kleineke, J. (1996). Intracellular zinc movement and its effect on the carbohydrate metabolism of isolated rat hepatocytes. J. Biol. Chem. 271, 1941-1949.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 1941-1949
-
-
Brand, I.A.1
Kleineke, J.2
-
15
-
-
0022311840
-
Whole blood and serum zinc levels in relation to sex and age
-
Buxaderas, S. C. and Farré-Rovira, R. (1985). Whole blood and serum zinc levels in relation to sex and age. Rev. Esp. Fisiol. 41, 463-470.
-
(1985)
Rev. Esp. Fisiol.
, vol.41
, pp. 463-470
-
-
Buxaderas, S.C.1
Farré-Rovira, R.2
-
16
-
-
0021055866
-
The active site of lysosomal sphingomyelinase: Evidence for the involvement of hydrophobic and ionic groups
-
Callahan, J. W., Jones, C. S., Davidson, D. J., and Shankaran, P. (1983). The active site of lysosomal sphingomyelinase: evidence for the involvement of hydrophobic and ionic groups. J. Neurosci. Res. 10, 151-163.
-
(1983)
J. Neurosci. Res.
, vol.10
, pp. 151-163
-
-
Callahan, J.W.1
Jones, C.S.2
Davidson, D.J.3
Shankaran, P.4
-
17
-
-
79958052481
-
Drug targeting of sphingolipid metabolism: Sphingomyelinases and ceramidases
-
Canals, D., Perry, D. M., Jenkins, R. W., and Hannun, Y. A. (2011). Drug targeting of sphingolipid metabolism: sphingomyelinases and ceramidases. Br. J. Pharmacol. 163, 694-712.
-
(2011)
Br. J. Pharmacol.
, vol.163
, pp. 694-712
-
-
Canals, D.1
Perry, D.M.2
Jenkins, R.W.3
Hannun, Y.A.4
-
18
-
-
21444434296
-
UV-C light induces raft-associated acid sphingomyelinase and JNK activation and translocation independently on a nuclear signal
-
Charruyer, A., Grazide, S., Bezombes, C., Müller, S., Laurent, G., and Jaffrézou, J. P. (2005). UV-C light induces raft-associated acid sphingomyelinase and JNK activation and translocation independently on a nuclear signal. J. Biol. Chem. 280, 19196-19204.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 19196-19204
-
-
Charruyer, A.1
Grazide, S.2
Bezombes, C.3
Müller, S.4
Laurent, G.5
Jaffrézou, J.P.6
-
19
-
-
0028095477
-
Apoptotic signaling through CD95 (Fas/Apo-1). Activates an acidic sphingomyelinase
-
Cifone, M. G., De Maria, R., Roncaioli, P., Rippo, M. R., Azuma, M., Lanier, L. L., Santoni, A., and Testi, R. (1994). Apoptotic signaling through CD95 (Fas/Apo-1). activates an acidic sphingomyelinase. J. Exp. Med. 180, 1547-1552.
-
(1994)
J. Exp. Med.
, vol.180
, pp. 1547-1552
-
-
Cifone, M.G.1
De Maria, R.2
Roncaioli, P.3
Rippo, M.R.4
Azuma, M.5
Lanier, L.L.6
Santoni, A.7
Testi, R.8
-
20
-
-
26444438658
-
Role of increased sphingomyelinase activity in apoptosis and organ failure of patients with severe sepsis
-
Claus, R. A., Bunck, A. C., Bockmeyer, C. L., Brunkhorst, F. M., Lösche, W., Kinscherf, R., and Deigner, H.-P. (2005). Role of increased sphingomyelinase activity in apoptosis and organ failure of patients with severe sepsis. FASEB J. 19, 1719-1721.
-
(2005)
FASEB J.
, vol.19
, pp. 1719-1721
-
-
Claus, R.A.1
Bunck, A.C.2
Bockmeyer, C.L.3
Brunkhorst, F.M.4
Lösche, W.5
Kinscherf, R.6
Deigner, H.-P.7
-
21
-
-
0017804664
-
Correlation between the thermotropic behavior of sphingomyelin liposomes and sphingomyelin hydrolysis by sphingomyelinase of Staphylococcus aureus
-
Cohen, R. and Barenholz, Y. (1978). Correlation between the thermotropic behavior of sphingomyelin liposomes and sphingomyelin hydrolysis by sphingomyelinase of Staphylococcus aureus. Biochim. Biophys. Acta 509, 181-187.
-
(1978)
Biochim. Biophys. Acta
, vol.509
, pp. 181-187
-
-
Cohen, R.1
Barenholz, Y.2
-
22
-
-
84884686757
-
Caveolae internalization repairs wounded cells and muscle fibers
-
Corrotte, M., Almeida, P. E., Tam, C., Castro-Gomes, T., Fernandes, M. C., Millis, B. A., Cortez, M., Miller, H., Song, W., Maugel, T. K., et al. (2013). Caveolae internalization repairs wounded cells and muscle fibers. eLife 2, e00926.
-
(2013)
ELife
, vol.2
, pp. e00926
-
-
Corrotte, M.1
Almeida, P.E.2
Tam, C.3
Castro-Gomes, T.4
Fernandes, M.C.5
Millis, B.A.6
Cortez, M.7
Miller, H.8
Song, W.9
Maugel, T.K.10
-
23
-
-
0023444507
-
The tumor promoter tetradecanoylphorbol-13-acetate elicits the redistribution of heavy metals in subcellular fractions of rabbit thymocytes as measured by plasma emission spectroscopy
-
Csermely, P., Fodor, P., and Somogyi, J. (1987). The tumor promoter tetradecanoylphorbol-13-acetate elicits the redistribution of heavy metals in subcellular fractions of rabbit thymocytes as measured by plasma emission spectroscopy. Carcinogenesis 8, 1663-1666.
-
(1987)
Carcinogenesis
, vol.8
, pp. 1663-1666
-
-
Csermely, P.1
Fodor, P.2
Somogyi, J.3
-
24
-
-
84867352935
-
Characterization of secretory sphingomyelinase activity, lipoprotein sphingolipid content and LDL aggregation in ldlr-/-mice fed on a high-fat diet
-
Deevska, G. M., Sunkara, M., Morris, A. J., and Nikolova-Karakashian, M. N. (2012). Characterization of secretory sphingomyelinase activity, lipoprotein sphingolipid content and LDL aggregation in ldlr-/-mice fed on a high-fat diet. Biosci. Rep. 32, 479-490.
-
(2012)
Biosci. Rep.
, vol.32
, pp. 479-490
-
-
Deevska, G.M.1
Sunkara, M.2
Morris, A.J.3
Nikolova-Karakashian, M.N.4
-
25
-
-
84903783256
-
Dysferlin regulates cell membrane repair by facilitating injury-triggered acid sphingomyelinase secretion
-
Defour, A., Van der Meulen, J. H., Bhat, R., Bigot, A., Bashir, R., Nagaraju, K., and Jaiswal, J. K. (2014). Dysferlin regulates cell membrane repair by facilitating injury-triggered acid sphingomyelinase secretion. Cell Death Dis. 5, e1306.
-
(2014)
Cell Death Dis.
, vol.5
, pp. e1306
-
-
Defour, A.1
Van Der Meulen, J.H.2
Bhat, R.3
Bigot, A.4
Bashir, R.5
Nagaraju, K.6
Jaiswal, J.K.7
-
26
-
-
84990860075
-
Genetic convergence of Parkinson's disease and lysosomal storage disorders
-
in press
-
Deng, H., Xiu, X., and Jankovic, J. (2014). Genetic convergence of Parkinson's disease and lysosomal storage disorders. Mol. Neurobiol., in press.
-
(2014)
Mol. Neurobiol.
-
-
Deng, H.1
Xiu, X.2
Jankovic, J.3
-
27
-
-
77954279039
-
Identification and characterization of eight novel SMPD1 mutations causing types A and B Niemann-Pick disease
-
Desnick, J. P., Kim, J., He, X., Wasserstein, M. P., Simonaro, C. M., and Schuchman, E. H. (2010). Identification and characterization of eight novel SMPD1 mutations causing types A and B Niemann-Pick disease. Mol. Med. 16, 316-321.
-
(2010)
Mol. Med.
, vol.16
, pp. 316-321
-
-
Desnick, J.P.1
Kim, J.2
He, X.3
Wasserstein, M.P.4
Simonaro, C.M.5
Schuchman, E.H.6
-
28
-
-
53449098208
-
Acid sphingomyelinase promotes lipoprotein retention within early atheromata and accelerates lesion progression
-
Devlin, C. M., Leventhal, A. R., Kuriakose, G., Schuchman, E. H., Williams, K. J., and Tabas, I. (2008). Acid sphingomyelinase promotes lipoprotein retention within early atheromata and accelerates lesion progression. Arterioscler. Thromb. Vasc. Biol. 28, 1723-1730.
-
(2008)
Arterioscler. Thromb. Vasc. Biol.
, vol.28
, pp. 1723-1730
-
-
Devlin, C.M.1
Leventhal, A.R.2
Kuriakose, G.3
Schuchman, E.H.4
Williams, K.J.5
Tabas, I.6
-
29
-
-
77953142003
-
Improvement in lipid and protein trafficking in Niemann-Pick C1 cells by correction of a secondary enzyme defect
-
Devlin, C., Pipalia, N. H., Liao, X., Schuchman, E. H., Maxfield, F. R., and Tabas, I. (2010). Improvement in lipid and protein trafficking in Niemann-Pick C1 cells by correction of a secondary enzyme defect. Traffic 11, 601-615.
-
(2010)
Traffic
, vol.11
, pp. 601-615
-
-
Devlin, C.1
Pipalia, N.H.2
Liao, X.3
Schuchman, E.H.4
Maxfield, F.R.5
Tabas, I.6
-
30
-
-
0347093304
-
Mannose 6-phosphate receptor-mediated uptake is defective in acid sphingomyelinase-deficient macrophages: Implications for Niemann-Pick disease enzyme replacement therapy
-
Dhami, R. and Schuchman, E. H. (2004). Mannose 6-phosphate receptor-mediated uptake is defective in acid sphingomyelinase-deficient macrophages: implications for Niemann-Pick disease enzyme replacement therapy. J. Biol. Chem. 279, 1526-1532.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 1526-1532
-
-
Dhami, R.1
Schuchman, E.H.2
-
31
-
-
84870526451
-
Functional consequences of sphingomyelinase-induced changes in erythrocyte membrane structure
-
Dinkla, S., Wessels, K., Verdurmen, W. P. R., Tomelleri, C., Cluitmans, J. C. A., Fransen, J., Fuchs, B., Schiller, J., Joosten, I., Brock, R., et al. (2012). Functional consequences of sphingomyelinase-induced changes in erythrocyte membrane structure. Cell Death Dis. 3, e410.
-
(2012)
Cell Death Dis.
, vol.3
, pp. e410
-
-
Dinkla, S.1
Wessels, K.2
Verdurmen, W.P.R.3
Tomelleri, C.4
Cluitmans, J.C.A.5
Fransen, J.6
Fuchs, B.7
Schiller, J.8
Joosten, I.9
Brock, R.10
-
32
-
-
34548316472
-
Secretory sphingomyelinase is upregulated in chronic heart failure: A second messenger system of immune activation relates to body composition, muscular functional capacity, and peripheral blood flow
-
Doehner, W., Bunck, A. C., Rauchhaus, M., von Haehling, S., Brunkhorst, F. M., Cicoira, M., Tschope, C., Ponikowski, P., Claus, R. A., and Anker, S. D. (2007). Secretory sphingomyelinase is upregulated in chronic heart failure: a second messenger system of immune activation relates to body composition, muscular functional capacity, and peripheral blood flow. Eur. Heart J. 28, 821-828.
-
(2007)
Eur. Heart J.
, vol.28
, pp. 821-828
-
-
Doehner, W.1
Bunck, A.C.2
Rauchhaus, M.3
Von Haehling, S.4
Brunkhorst, F.M.5
Cicoira, M.6
Tschope, C.7
Ponikowski, P.8
Claus, R.A.9
Anker, S.D.10
-
33
-
-
84916203333
-
Re-configuration of sphingolipid metabolism by oncogenic transformation
-
Don, A. S., Lim, X. Y., and Couttas, T. A. (2014). Re-configuration of sphingolipid metabolism by oncogenic transformation. Biomolecules 4, 315-353.
-
(2014)
Biomolecules
, vol.4
, pp. 315-353
-
-
Don, A.S.1
Lim, X.Y.2
Couttas, T.A.3
-
34
-
-
0019493332
-
An enzymatic assay for available zinc in plasma and serum
-
Donangelo, C. M. and Chang, G. W. (1981). An enzymatic assay for available zinc in plasma and serum. Clin. Chim. Acta 113, 201-206.
-
(1981)
Clin. Chim. Acta
, vol.113
, pp. 201-206
-
-
Donangelo, C.M.1
Chang, G.W.2
-
35
-
-
35548958684
-
The source of dietary fatty acids alters the activity of secretory sphingomyelinase in the rat
-
Drachmann, T., Mathiessen, J. H., Pedersen, M. H., and Hellgren, L. I. (2007). The source of dietary fatty acids alters the activity of secretory sphingomyelinase in the rat. Eur. J. Lipid Sci. Technol. 109, 1003-1009.
-
(2007)
Eur. J. Lipid Sci. Technol.
, vol.109
, pp. 1003-1009
-
-
Drachmann, T.1
Mathiessen, J.H.2
Pedersen, M.H.3
Hellgren, L.I.4
-
37
-
-
0021827237
-
The effect of detergents on immunoprecipitability of lysosomal sphingomyelinase
-
Driessen, M., Weitz, G., Brouwer-Kelder, E. M., Donker-Koopman, W. E., Bastiaannet, J., Sandhoff, K., Barranger, J. A., Tager, J. M., and Schram, A. W. (1985). The effect of detergents on immunoprecipitability of lysosomal sphingomyelinase. Biochim. Biophys. Acta 841, 97-102.
-
(1985)
Biochim. Biophys. Acta
, vol.841
, pp. 97-102
-
-
Driessen, M.1
Weitz, G.2
Brouwer-Kelder, E.M.3
Donker-Koopman, W.E.4
Bastiaannet, J.5
Sandhoff, K.6
Barranger, J.A.7
Tager, J.M.8
Schram, A.W.9
-
38
-
-
0142074218
-
Plasma ceramide and lysophosphatidylcholine inversely correlate with mortality in sepsis patients
-
Drobnik, W., Liebisch, G., Audebert, F. X., Fröhlich, D., Glück, T., Vogel, P., Rothe, G., and Schmitz, G. (2003). Plasma ceramide and lysophosphatidylcholine inversely correlate with mortality in sepsis patients. J. Lipid Res. 44, 754-761.
-
(2003)
J. Lipid Res.
, vol.44
, pp. 754-761
-
-
Drobnik, W.1
Liebisch, G.2
Audebert, F.X.3
Fröhlich, D.4
Glück, T.5
Vogel, P.6
Rothe, G.7
Schmitz, G.8
-
39
-
-
33748664357
-
TRAIL activates acid sphingomyelinase via a redox mechanism and releases ceramide to trigger apoptosis
-
Dumitru, C. A. and Gulbins, E. (2006). TRAIL activates acid sphingomyelinase via a redox mechanism and releases ceramide to trigger apoptosis. Oncogene 25, 5612-5625.
-
(2006)
Oncogene
, vol.25
, pp. 5612-5625
-
-
Dumitru, C.A.1
Gulbins, E.2
-
40
-
-
78649796983
-
Pathology and current treatment of neurodegenerative sphingolipidoses
-
Eckhardt, M. (2010). Pathology and current treatment of neurodegenerative sphingolipidoses. Neuromolecular. Med. 12, 362-382.
-
(2010)
Neuromolecular. Med.
, vol.12
, pp. 362-382
-
-
Eckhardt, M.1
-
41
-
-
78751622827
-
Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1 receptosomes
-
Edelmann, B., Bertsch, U., Tchikov, V., Winoto-Morbach, S., Perrotta, C., Jakob, M., Adam-Klages, S., Kabelitz, D., and Schütze, S. (2011). Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1 receptosomes. EMBO J. 30, 379-394.
-
(2011)
EMBO J.
, vol.30
, pp. 379-394
-
-
Edelmann, B.1
Bertsch, U.2
Tchikov, V.3
Winoto-Morbach, S.4
Perrotta, C.5
Jakob, M.6
Adam-Klages, S.7
Kabelitz, D.8
Schütze, S.9
-
42
-
-
0021077509
-
Carboxyl-terminal proteolytic processing during biosynthesis of the lysosomal enzymes β-glucuronidase and cathepsin D
-
Erickson, A. H. and Blobel, G. (1983). Carboxyl-terminal proteolytic processing during biosynthesis of the lysosomal enzymes β-glucuronidase and cathepsin D. Biochemistry 22, 5201-5205.
-
(1983)
Biochemistry
, vol.22
, pp. 5201-5205
-
-
Erickson, A.H.1
Blobel, G.2
-
43
-
-
0028136956
-
Occurrence of two molecular forms of human acid sphingomyelinase
-
Ferlinz, K., Hurwitz, R., Vielhaber, G., Suzuki, K., and Sandhoff, K. (1994). Occurrence of two molecular forms of human acid sphingomyelinase. Biochem. J. 301, 855-862.
-
(1994)
Biochem. J.
, vol.301
, pp. 855-862
-
-
Ferlinz, K.1
Hurwitz, R.2
Vielhaber, G.3
Suzuki, K.4
Sandhoff, K.5
-
44
-
-
0031020869
-
Functional characterization of the N-glycosylation sites of human acid sphingomyelinase by sitedirected mutagenesis
-
Ferlinz, K., Hurwitz, R., Moczall, H., Lansmann, S., Schuchman, E. H., and Sandhoff, K. (1997). Functional characterization of the N-glycosylation sites of human acid sphingomyelinase by sitedirected mutagenesis. Eur. J. Biochem. 243, 511-517.
-
(1997)
Eur. J. Biochem.
, vol.243
, pp. 511-517
-
-
Ferlinz, K.1
Hurwitz, R.2
Moczall, H.3
Lansmann, S.4
Schuchman, E.H.5
Sandhoff, K.6
-
45
-
-
79956075012
-
Trypanosoma cruzi subverts the sphingomyelinase-mediated plasma membrane repair pathway for cell invasion
-
Fernandes, M. C., Cortez, M., Flannery, A. R., Tam, C., Mortara, R. A., and Andrews, N. W. (2011). Trypanosoma cruzi subverts the sphingomyelinase-mediated plasma membrane repair pathway for cell invasion. J. Exp. Med. 208, 909-921.
-
(2011)
J. Exp. Med.
, vol.208
, pp. 909-921
-
-
Fernandes, M.C.1
Cortez, M.2
Flannery, A.R.3
Tam, C.4
Mortara, R.A.5
Andrews, N.W.6
-
46
-
-
84859409865
-
Increased ceramide in brains with Alzheimer's and other neurodegenerative diseases
-
Filippov, V., Song, M. A., Zhang, K., Vinters, H. V., Tung, S., Kirsch, W. M., Yang, J., and Duerksen-Hughes, P. J. (2012). Increased ceramide in brains with Alzheimer's and other neurodegenerative diseases. J. Alzheimers Dis. 29, 537-547.
-
(2012)
J. Alzheimers Dis.
, vol.29
, pp. 537-547
-
-
Filippov, V.1
Song, M.A.2
Zhang, K.3
Vinters, H.V.4
Tung, S.5
Kirsch, W.M.6
Yang, J.7
Duerksen-Hughes, P.J.8
-
47
-
-
84884126614
-
Rare lysosomal enzyme gene SMPD1 variant (p. R591C). Associates with Parkinson's disease
-
Foo, J. N., Liany, H., Bei, J. X., Yu, X. Q., Liu, J., Au, W. L., Prakash, K. M., Tan, L. C., and Tan, E. K. (2013). Rare lysosomal enzyme gene SMPD1 variant (p. R591C). associates with Parkinson's disease. Neurobiol. Aging 34, 2890-2895.
-
(2013)
Neurobiol. Aging
, vol.34
, pp. 2890-2895
-
-
Foo, J.N.1
Liany, H.2
Bei, J.X.3
Yu, X.Q.4
Liu, J.5
Au, W.L.6
Prakash, K.M.7
Tan, L.C.8
Tan, E.K.9
-
49
-
-
17744391643
-
Chromogenic assay for the activity of sphingomyelinase from Bacillus cereus and its application to the enzymatic hydrolysis of lysophospholipids
-
Fujii, S., Yoshida, A., Sakurai, S., Morita, M., Tsukamoto, K., Ikezawa, H., and Ikeda, K. (2004). Chromogenic assay for the activity of sphingomyelinase from Bacillus cereus and its application to the enzymatic hydrolysis of lysophospholipids. Biol. Pharm. Bull. 27, 1725-1729.
-
(2004)
Biol. Pharm. Bull.
, vol.27
, pp. 1725-1729
-
-
Fujii, S.1
Yoshida, A.2
Sakurai, S.3
Morita, M.4
Tsukamoto, K.5
Ikezawa, H.6
Ikeda, K.7
-
50
-
-
84878911804
-
The p. L302P mutation in the lysosomal enzyme gene SMPD1 is a risk factor for Parkinson disease
-
Gan-Or, Z., Ozelius, L. J., Bar-Shira, A., Saunders-Pullman, R., Mirelman, A., Kornreich, R., Gana-Weisz, M., Raymond, D., Rozenkrantz, L., Deik, A., et al. (2013). The p. L302P mutation in the lysosomal enzyme gene SMPD1 is a risk factor for Parkinson disease. Neurology 80, 1606-1610.
-
(2013)
Neurology
, vol.80
, pp. 1606-1610
-
-
Gan-Or, Z.1
Ozelius, L.J.2
Bar-Shira, A.3
Saunders-Pullman, R.4
Mirelman, A.5
Kornreich, R.6
Gana-Weisz, M.7
Raymond, D.8
Rozenkrantz, L.9
Deik, A.10
-
51
-
-
78049518892
-
An overview of sphingolipid metabolism: From synthesis to breakdown
-
Gault, C. R., Obeid, L. M., and Hannun, Y. A. (2010). An overview of sphingolipid metabolism: from synthesis to breakdown. Adv. Exp. Med. Biol. 688, 1-23.
-
(2010)
Adv. Exp. Med. Biol.
, vol.688
, pp. 1-23
-
-
Gault, C.R.1
Obeid, L.M.2
Hannun, Y.A.3
-
52
-
-
11144354259
-
PAF-mediated pulmonary edema: A new role for acid sphingomyelinase and ceramide
-
Göggel, R., Winoto-Morbach, S., Vielhaber, G., Imai, Y., Lindner, K., Brade, L., Brade, H., Ehlers, S., Slutsky, A. S., Schütze, S., et al. (2004). PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide. Nat. Med. 10, 155-160.
-
(2004)
Nat. Med.
, vol.10
, pp. 155-160
-
-
Göggel, R.1
Winoto-Morbach, S.2
Vielhaber, G.3
Imai, Y.4
Lindner, K.5
Brade, L.6
Brade, H.7
Ehlers, S.8
Slutsky, A.S.9
Schütze, S.10
-
53
-
-
0037201939
-
Sphingomyelinases: Enzymology and membrane activity
-
Goni, F. M. and Alonso, A. (2002). Sphingomyelinases: enzymology and membrane activity. FEBS Lett. 531, 38-46.
-
(2002)
FEBS Lett.
, vol.531
, pp. 38-46
-
-
Goni, F.M.1
Alonso, A.2
-
54
-
-
0141563667
-
2+-dependent sphingomyelinase activity in the serum of patients with type 2 diabetes is elevated
-
2+-dependent sphingomyelinase activity in the serum of patients with type 2 diabetes is elevated. Horm. Metab. Res. 35, 506-507.
-
(2003)
Horm. Metab. Res.
, vol.35
, pp. 506-507
-
-
Górska, M.1
Baranczuk, E.2
Dobrzyn, A.3
-
55
-
-
85045312625
-
Elevated plasma ceramides in depression
-
Gracia-Garcia, P., Rao, V., Haughey, N. J., Ratnam Banduru, V. V., Smith, G., Rosenberg, P. B., Lobo, A., Lyketsos, C. G., and Mielke, M. M. (2011). Elevated plasma ceramides in depression. J. Neuropsychiatry Clin. Neurosci. 23, 215-218.
-
(2011)
J. Neuropsychiatry Clin. Neurosci.
, vol.23
, pp. 215-218
-
-
Gracia-Garcia, P.1
Rao, V.2
Haughey, N.J.3
Ratnam Banduru, V.V.4
Smith, G.5
Rosenberg, P.B.6
Lobo, A.7
Lyketsos, C.G.8
Mielke, M.M.9
-
56
-
-
84899790279
-
Serum acid sphingomyelinase is upregulated in chronic hepatitis C infection and non alcoholic fatty liver disease
-
Grammatikos, G., Mühle, C., Ferreiros, N., Schroeter, S., Bogdanou, D., Schwalm, S., Hintereder, G., Kornhuber, J., Zeuzem, S., Sarrazin, C., et al. (2014). Serum acid sphingomyelinase is upregulated in chronic hepatitis C infection and non alcoholic fatty liver disease. Biochim. Biophys. Acta 1841, 1012-1020.
-
(2014)
Biochim. Biophys. Acta
, vol.1841
, pp. 1012-1020
-
-
Grammatikos, G.1
Mühle, C.2
Ferreiros, N.3
Schroeter, S.4
Bogdanou, D.5
Schwalm, S.6
Hintereder, G.7
Kornhuber, J.8
Zeuzem, S.9
Sarrazin, C.10
-
57
-
-
0030775369
-
Acidic sphingomyelinase mediates entry of N. Gonorrhoeae into nonphagocytic cells
-
Grassmé, H., Gulbins, E., Brenner, B., Ferlinz, K., Sandhoff, K., Harzer, K., Lang, F., and Meyer, T. F. (1997). Acidic sphingomyelinase mediates entry of N. gonorrhoeae into nonphagocytic cells. Cell 91, 605-615.
-
(1997)
Cell
, vol.91
, pp. 605-615
-
-
Grassmé, H.1
Gulbins, E.2
Brenner, B.3
Ferlinz, K.4
Sandhoff, K.5
Harzer, K.6
Lang, F.7
Meyer, T.F.8
-
58
-
-
0034809593
-
Molecular mechanisms of ceramide-mediated CD95 clustering
-
Grassmé, H., Schwarz, H., and Gulbins, E. (2001). Molecular mechanisms of ceramide-mediated CD95 clustering. Biochem. Biophys. Res. Commun. 284, 1016-1030.
-
(2001)
Biochem. Biophys. Res. Commun.
, vol.284
, pp. 1016-1030
-
-
Grassmé, H.1
Schwarz, H.2
Gulbins, E.3
-
59
-
-
0142095498
-
Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts
-
Grassmé, H., Jendrossek, V., Riehle, A., von Kürthy, G., Berger, J., Schwarz, H., Weller, M., Kolesnick, R., and Gulbins, E. (2003). Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts. Nat. Med. 9, 322-330.
-
(2003)
Nat. Med.
, vol.9
, pp. 322-330
-
-
Grassmé, H.1
Jendrossek, V.2
Riehle, A.3
Von Kürthy, G.4
Berger, J.5
Schwarz, H.6
Weller, M.7
Kolesnick, R.8
Gulbins, E.9
-
60
-
-
22544476850
-
Rhinoviruses infect human epithelial cells via ceramide-enriched membrane platforms
-
Grassmé, H., Riehle, A., Wilker, B., and Gulbins, E. (2005). Rhinoviruses infect human epithelial cells via ceramide-enriched membrane platforms. J. Biol. Chem. 280, 26256-26262.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 26256-26262
-
-
Grassmé, H.1
Riehle, A.2
Wilker, B.3
Gulbins, E.4
-
61
-
-
33646806481
-
Sphingomyelinase-to-LDL molar ratio determines low density lipoprotein aggregation size: Biological significance
-
Guarino, A. J., Tulenko, T. N., and Wrenn, S. P. (2006). Sphingomyelinase-to-LDL molar ratio determines low density lipoprotein aggregation size: biological significance. Chem. Phys. Lipids 142, 33-42.
-
(2006)
Chem. Phys. Lipids
, vol.142
, pp. 33-42
-
-
Guarino, A.J.1
Tulenko, T.N.2
Wrenn, S.P.3
-
62
-
-
0033924879
-
Measurement of sphingomyelinase activity
-
Gulbins, E. and Kolesnick, R. (2000). Measurement of sphingomyelinase activity. Methods Enzymol. 322, 382-388.
-
(2000)
Methods Enzymol.
, vol.322
, pp. 382-388
-
-
Gulbins, E.1
Kolesnick, R.2
-
63
-
-
84880269973
-
Acid sphingomyelinase/ceramide system mediates effects of antidepressant drugs
-
Gulbins, E., Palmada, M., Reichel, M., Lüth, A., Böhmer, C., Amato, D., Müller, C. P., Tischbirek, C. H., Groemer, T. W., Tabatabai, G., et al. (2013). Acid sphingomyelinase/ceramide system mediates effects of antidepressant drugs. Nat. Med. 19, 934-938.
-
(2013)
Nat. Med.
, vol.19
, pp. 934-938
-
-
Gulbins, E.1
Palmada, M.2
Reichel, M.3
Lüth, A.4
Böhmer, C.5
Amato, D.6
Müller, C.P.7
Tischbirek, C.H.8
Groemer, T.W.9
Tabatabai, G.10
-
64
-
-
44949199208
-
Sphingomyelin functions as a novel receptor for Helicobacter pylori VacA
-
Gupta, V. R., Patel, H. K., Kostolansky, S. S., Ballivian, R. A., Eichberg, J., and Blanke, S. R. (2008). Sphingomyelin functions as a novel receptor for Helicobacter pylori VacA. PLoS Pathog. 4, e1000073.
-
(2008)
PLoS Pathog.
, vol.4
, pp. e1000073
-
-
Gupta, V.R.1
Patel, H.K.2
Kostolansky, S.S.3
Ballivian, R.A.4
Eichberg, J.5
Blanke, S.R.6
-
65
-
-
0030784482
-
Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation
-
Haimovitz-Friedman, A., Cordon-Cardo, C., Bayoumy, S., Garzotto, M., McLoughlin, M., Gallily, R., Edwards, C. K., III, Schuchman, E. H., Fuks, Z., and Kolesnick, R. (1997). Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation. J. Exp. Med. 186, 1831-1841.
-
(1997)
J. Exp. Med.
, vol.186
, pp. 1831-1841
-
-
Haimovitz-Friedman, A.1
Cordon-Cardo, C.2
Bayoumy, S.3
Garzotto, M.4
McLoughlin, M.5
Gallily, R.6
Edwards, C.K.I.7
Schuchman, E.H.8
Fuks, Z.9
Kolesnick, R.10
-
66
-
-
84924078661
-
Altered blood sphingolipidomics and elevated plasma inflammatory cytokines in combat veterans with post-traumatic stress disorder
-
Hammad, S. M., Truman, J. P., Al Gadban, M. M., Smith, K. J., Twal, W. O., and Hamner, M. B. (2012). Altered blood sphingolipidomics and elevated plasma inflammatory cytokines in combat veterans with post-traumatic stress disorder. Neurobiol. Lipids 10, 2.
-
(2012)
Neurobiol. Lipids
, vol.10
, pp. 2
-
-
Hammad, S.M.1
Truman, J.P.2
Al Gadban, M.M.3
Smith, K.J.4
Twal, W.O.5
Hamner, M.B.6
-
67
-
-
0015698370
-
Letters: A simple sphingomyelinase determination for Niemann-Pick disease: Differential diagnosis of types A, B and C
-
Harzer, K. and Benz, H. U. (1973). Letters: a simple sphingomyelinase determination for Niemann-Pick disease: differential diagnosis of types A, B and C. J. Neurochem. 21, 999-1001.
-
(1973)
J. Neurochem.
, vol.21
, pp. 999-1001
-
-
Harzer, K.1
Benz, H.U.2
-
68
-
-
0026584007
-
The early and late processing of lysosomal enzymes: Proteolysis and compartmentation
-
Hasilik, A. (1992). The early and late processing of lysosomal enzymes: proteolysis and compartmentation. Experientia 48, 130-151.
-
(1992)
Experientia
, vol.48
, pp. 130-151
-
-
Hasilik, A.1
-
69
-
-
0034604554
-
Acid sphingomyelinase is involved in CEACAM receptor-mediated phagocytosis of Neisseria gonorrhoeae
-
Hauck, C. R., Grassmé, H., Bock, J., Jendrossek, V., Ferlinz, K., Meyer, T. F., and Gulbins, E. (2000). Acid sphingomyelinase is involved in CEACAM receptor-mediated phagocytosis of Neisseria gonorrhoeae. FEBS Lett. 478, 260-266.
-
(2000)
FEBS Lett.
, vol.478
, pp. 260-266
-
-
Hauck, C.R.1
Grassmé, H.2
Bock, J.3
Jendrossek, V.4
Ferlinz, K.5
Meyer, T.F.6
Gulbins, E.7
-
71
-
-
0032974462
-
Characterization of human acid sphingomyelinase purified from the media of overexpressing Chinese hamster ovary cells
-
He, X., Miranda, S. R., Xiong, X., Dagan, A., Gatt, S., and Schuchman, E. H. (1999). Characterization of human acid sphingomyelinase purified from the media of overexpressing Chinese hamster ovary cells. Biochim. Biophys. Acta 1432, 251-264.
-
(1999)
Biochim. Biophys. Acta
, vol.1432
, pp. 251-264
-
-
He, X.1
Miranda, S.R.2
Xiong, X.3
Dagan, A.4
Gatt, S.5
Schuchman, E.H.6
-
72
-
-
0037334121
-
A fluorescence-based, high-performance liquid chromatographic assay to determine acid sphingomyelinase activity and diagnose types A and B Niemann-Pick disease
-
He, X., Chen, F., Dagan, A., Gatt, S., and Schuchman, E. H. (2003). A fluorescence-based, high-performance liquid chromatographic assay to determine acid sphingomyelinase activity and diagnose types A and B Niemann-Pick disease. Anal. Biochem. 314, 116-120.
-
(2003)
Anal. Biochem.
, vol.314
, pp. 116-120
-
-
He, X.1
Chen, F.2
Dagan, A.3
Gatt, S.4
Schuchman, E.H.5
-
73
-
-
0037244775
-
Lipids as a target for drugs modulating multidrug resistance of cancer cells
-
Hendrich, A. B. and Michalak, K. (2003). Lipids as a target for drugs modulating multidrug resistance of cancer cells. Curr. Drug Targets 4, 23-30.
-
(2003)
Curr. Drug Targets
, vol.4
, pp. 23-30
-
-
Hendrich, A.B.1
Michalak, K.2
-
74
-
-
84876074448
-
Targeting the ceramide system in cancer
-
Henry, B., Möller, C., Dimanche-Boitrel, M. T., Gulbins, E., and Becker, K. A. (2013). Targeting the ceramide system in cancer. Cancer Lett. 332, 286-294.
-
(2013)
Cancer Lett.
, vol.332
, pp. 286-294
-
-
Henry, B.1
Möller, C.2
Dimanche-Boitrel, M.T.3
Gulbins, E.4
Becker, K.A.5
-
75
-
-
0034595643
-
Sphingomyelinase activity associated with human plasma low density lipoprotein
-
Holopainen, J. M., Medina, O. P., Metso, A. J., and Kinnunen, P. K. J. (2000). Sphingomyelinase activity associated with human plasma low density lipoprotein. J. Biol. Chem. 275, 16484-16489.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 16484-16489
-
-
Holopainen, J.M.1
Medina, O.P.2
Metso, A.J.3
Kinnunen, P.K.J.4
-
76
-
-
0029012443
-
Acid sphingomyelinase deficient mice: A model of types A and B Niemann-Pick disease
-
Horinouchi, K., Erlich, S., Perl, D. P., Ferlinz, K., Bisgaier, C. L., Sandhoff, K., Desnick, R. J., Stewart, C. L., and Schuchman, E. H. (1995). Acid sphingomyelinase deficient mice: a model of types A and B Niemann-Pick disease. Nat. Genet. 10, 288-293.
-
(1995)
Nat. Genet.
, vol.10
, pp. 288-293
-
-
Horinouchi, K.1
Erlich, S.2
Perl, D.P.3
Ferlinz, K.4
Bisgaier, C.L.5
Sandhoff, K.6
Desnick, R.J.7
Stewart, C.L.8
Schuchman, E.H.9
-
77
-
-
0028468309
-
The tricyclic antidepressants desipramine causes proteolytic degradation of lysosomal sphingomyelinase in human fibroblasts
-
Hurwitz, R., Ferlinz, K., and Sandhoff, K. (1994a). The tricyclic antidepressants desipramine causes proteolytic degradation of lysosomal sphingomyelinase in human fibroblasts. Biol. Chem. Hoppe Seyler 375, 447-450.
-
(1994)
Biol. Chem. Hoppe Seyler
, vol.375
, pp. 447-450
-
-
Hurwitz, R.1
Ferlinz, K.2
Sandhoff, K.3
-
78
-
-
0027984782
-
Processing of human acid sphingomyelinase in normal and I-cell fibroblasts
-
Hurwitz, R., Ferlinz, K., Vielhaber, G., Moczall, H., and Sandhoff, K. (1994b). Processing of human acid sphingomyelinase in normal and I-cell fibroblasts. J. Biol. Chem. 269, 5440-5445.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 5440-5445
-
-
Hurwitz, R.1
Ferlinz, K.2
Vielhaber, G.3
Moczall, H.4
Sandhoff, K.5
-
79
-
-
0026497446
-
Overexpression of human α-galactosidase A results in its intracellular aggregation, crystallization in lysosomes, and selective secretion
-
Ioannou, Y. A., Bishop, D. F., and Desnick, R. J. (1992). Overexpression of human α-galactosidase A results in its intracellular aggregation, crystallization in lysosomes, and selective secretion. J. Cell Biol. 119, 1137-1150.
-
(1992)
J. Cell Biol.
, vol.119
, pp. 1137-1150
-
-
Ioannou, Y.A.1
Bishop, D.F.2
Desnick, R.J.3
-
80
-
-
0033918950
-
Sindbis virus entry into cells triggers apoptosis by activating sphingomyelinase, leading to the release of ceramide
-
Jan, J. T., Chatterjee, S., and Griffin, D. E. (2000). Sindbis virus entry into cells triggers apoptosis by activating sphingomyelinase, leading to the release of ceramide. J. Virol. 74, 6425-6432.
-
(2000)
J. Virol.
, vol.74
, pp. 6425-6432
-
-
Jan, J.T.1
Chatterjee, S.2
Griffin, D.E.3
-
81
-
-
84872478057
-
Hyperresponsiveness of mice deficient in plasma-secreted sphingomyelinase reveals its pivotal role in early phase of host response
-
Jbeily, N., Suckert, I., Gonnert, F. A., Acht, B., Bockmeyer, C. L., Grossmann, S. D., Blaess, M. F., Lueth, A., Deigner, H. P., Bauer, M., et al. (2013). Hyperresponsiveness of mice deficient in plasma-secreted sphingomyelinase reveals its pivotal role in early phase of host response. J. Lipid Res. 54, 410-424.
-
(2013)
J. Lipid Res.
, vol.54
, pp. 410-424
-
-
Jbeily, N.1
Suckert, I.2
Gonnert, F.A.3
Acht, B.4
Bockmeyer, C.L.5
Grossmann, S.D.6
Blaess, M.F.7
Lueth, A.8
Deigner, H.P.9
Bauer, M.10
-
82
-
-
62749184862
-
Roles and regulation of secretory and lysosomal acid sphingomyelinase
-
Jenkins, R. W., Canals, D., and Hannun, Y. A. (2009). Roles and regulation of secretory and lysosomal acid sphingomyelinase. Cell. Signal. 21, 836-846.
-
(2009)
Cell. Signal.
, vol.21
, pp. 836-846
-
-
Jenkins, R.W.1
Canals, D.2
Hannun, Y.A.3
-
83
-
-
78149261495
-
Regulated secretion of acid sphingomyelinase: Implications for selectivity of ceramide formation
-
Jenkins, R. W., Canals, D., Idkowiak-Baldys, J., Simbari, F., Roddy, P., Perry, D. M., Kitatani, K., Luberto, C., and Hannun, Y. A. (2010). Regulated secretion of acid sphingomyelinase: implications for selectivity of ceramide formation. J. Biol. Chem. 285, 35706-35718.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 35706-35718
-
-
Jenkins, R.W.1
Canals, D.2
Idkowiak-Baldys, J.3
Simbari, F.4
Roddy, P.5
Perry, D.M.6
Kitatani, K.7
Luberto, C.8
Hannun, Y.A.9
-
84
-
-
79953865281
-
Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase
-
Jenkins, R. W., Clarke, C. J., Canals, D., Snider, A. J., Gault, C. R., Heffernan-Stroud, L., Wu, B. X., Simbari, F., Roddy, P., Kitatani, K., et al. (2011a). Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase. J. Biol. Chem. 286, 13292-13303.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 13292-13303
-
-
Jenkins, R.W.1
Clarke, C.J.2
Canals, D.3
Snider, A.J.4
Gault, C.R.5
Heffernan-Stroud, L.6
Wu, B.X.7
Simbari, F.8
Roddy, P.9
Kitatani, K.10
-
85
-
-
79952809986
-
A novel mechanism of lysosomal acid sphingomyelinase maturation - Requirement for carboxy-terminal proteolytic processing
-
Jenkins, R. W., Idkowiak-Baldys, J., Simbari, F., Canals, D., Roddy, P., Riner, C. D., Clarke, C. J., and Hannun, Y. A. (2011b). A novel mechanism of lysosomal acid sphingomyelinase maturation - requirement for carboxy-terminal proteolytic processing. J. Biol. Chem. 286, 3777-3788.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 3777-3788
-
-
Jenkins, R.W.1
Idkowiak-Baldys, J.2
Simbari, F.3
Canals, D.4
Roddy, P.5
Riner, C.D.6
Clarke, C.J.7
Hannun, Y.A.8
-
86
-
-
84886289791
-
Evaluation of the role of secretory sphingomyelinase and bioactive sphingolipids as biomarkers in hemophagocytic lymphohistiocytosis
-
Jenkins, R. W., Clarke, C. J., Lucas, J. T., Jr., Shabbir, M., Wu, B. X., Simbari, F., Mueller, J., Hannun, Y. A., Lazarchick, J., and Shirai, K. (2013). Evaluation of the role of secretory sphingomyelinase and bioactive sphingolipids as biomarkers in hemophagocytic lymphohistiocytosis. Am. J. Hematol. 88, E265-E272.
-
(2013)
Am. J. Hematol.
, vol.88
, pp. E265-E272
-
-
Jenkins, R.W.1
Clarke, C.J.2
Lucas, J.T.3
Shabbir, M.4
Wu, B.X.5
Simbari, F.6
Mueller, J.7
Hannun, Y.A.8
Lazarchick, J.9
Shirai, K.10
-
87
-
-
0032520147
-
Increased sphingomyelin content of plasma lipoproteins in apolipoprotein E knockout mice reflects combined production and catabolic defects and enhances reactivity with mammalian sphingomyelinase
-
Jeong, T., Schissel, S. L., Tabas, I., Pownall, H. J., Tall, A. R., and Jiang, X. (1998). Increased sphingomyelin content of plasma lipoproteins in apolipoprotein E knockout mice reflects combined production and catabolic defects and enhances reactivity with mammalian sphingomyelinase. J. Clin. Invest. 101, 905-912.
-
(1998)
J. Clin. Invest.
, vol.101
, pp. 905-912
-
-
Jeong, T.1
Schissel, S.L.2
Tabas, I.3
Pownall, H.J.4
Tall, A.R.5
Jiang, X.6
-
88
-
-
0032584078
-
The glutathione redox couple modulates zinc transfer from metallothionein to zincdepleted sorbitol dehydrogenase
-
Jiang, L. J., Maret, W., and Vallee, B. L. (1998). The glutathione redox couple modulates zinc transfer from metallothionein to zincdepleted sorbitol dehydrogenase. Proc. Natl. Acad. Sci. USA 95, 3483-3488.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 3483-3488
-
-
Jiang, L.J.1
Maret, W.2
Vallee, B.L.3
-
89
-
-
34250104099
-
The subunit of human sphingomyelinase is not the same size in all tissues: Studies with a polyclonal rabbit serum
-
Jobb, E. and Callahan, J. W. (1987). The subunit of human sphingomyelinase is not the same size in all tissues: studies with a polyclonal rabbit serum. J. Inher. Metab. Dis. 10(Suppl. 2), 326-328.
-
(1987)
J. Inher. Metab. Dis.
, vol.10
, pp. 326-328
-
-
Jobb, E.1
Callahan, J.W.2
-
90
-
-
0019567332
-
Purification of sphingomyelinase to apparent homogeneity by using hydrophobic chromatography
-
Jones, C. S., Shankaran, P., and Callahan, J. W. (1981). Purification of sphingomyelinase to apparent homogeneity by using hydrophobic chromatography. Biochem. J. 195, 373-382.
-
(1981)
Biochem. J.
, vol.195
, pp. 373-382
-
-
Jones, C.S.1
Shankaran, P.2
Callahan, J.W.3
-
91
-
-
0020711234
-
Studies on the structure of sphingomyelinase. Amino acid composition and heterogeneity on isoelectric focusing
-
Jones, C. S., Shankaran, P., Davidson, D. J., Poulos, A., and Callahan, J. W. (1983). Studies on the structure of sphingomyelinase. Amino acid composition and heterogeneity on isoelectric focusing. Biochem. J. 209, 291-297.
-
(1983)
Biochem. J.
, vol.209
, pp. 291-297
-
-
Jones, C.S.1
Shankaran, P.2
Davidson, D.J.3
Poulos, A.4
Callahan, J.W.5
-
92
-
-
84866661779
-
ASM-3 Acid sphingomyelinase functions as a positive regulator of the DAF-2/AGE-1 signaling pathway and serves as a novel anti-aging target
-
Kim, Y. and Sun, H. (2012). ASM-3 Acid sphingomyelinase functions as a positive regulator of the DAF-2/AGE-1 signaling pathway and serves as a novel anti-aging target. PLoS One 7, e45890.
-
(2012)
PLoS One
, vol.7
, pp. e45890
-
-
Kim, Y.1
Sun, H.2
-
93
-
-
0036006942
-
Sphingomyelinase activity of LDL: A link between atherosclerosis, ceramide, and apoptosis?
-
Kinnunen, P. K. and Holopainen, J. M. (2002). Sphingomyelinase activity of LDL: a link between atherosclerosis, ceramide, and apoptosis? Trends Cardiovasc. Med. 12, 37-42.
-
(2002)
Trends Cardiovasc. Med.
, vol.12
, pp. 37-42
-
-
Kinnunen, P.K.1
Holopainen, J.M.2
-
94
-
-
84860909607
-
Elevated active secretory sphingomyelinase in antineutrophil cytoplasmic antibody-associated primary systemic vasculitis
-
Kiprianos, A. P., Morgan, M. D., Little, M. A., Harper, L., Bacon, P. A., and Young, S. P. (2012). Elevated active secretory sphingomyelinase in antineutrophil cytoplasmic antibody-associated primary systemic vasculitis. Ann. Rheum. Dis. 71, 1100-1102.
-
(2012)
Ann. Rheum. Dis.
, vol.71
, pp. 1100-1102
-
-
Kiprianos, A.P.1
Morgan, M.D.2
Little, M.A.3
Harper, L.4
Bacon, P.A.5
Young, S.P.6
-
95
-
-
75749102680
-
Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology
-
Kirkegaard, T., Roth, A. G., Petersen, N. H. T., Mahalka, A. K., Olsen, O. D., Moilanen, I., Zylicz, A., Knudsen, J., Sandhoff, K., Arenz, C., et al. (2010). Hsp70 stabilizes lysosomes and reverts Niemann-Pick disease-associated lysosomal pathology. Nature 463, 549-553.
-
(2010)
Nature
, vol.463
, pp. 549-553
-
-
Kirkegaard, T.1
Roth, A.G.2
Petersen, N.H.T.3
Mahalka, A.K.4
Olsen, O.D.5
Moilanen, I.6
Zylicz, A.7
Knudsen, J.8
Sandhoff, K.9
Arenz, C.10
-
96
-
-
84880410237
-
Increase in secretory sphingomyelinase activity and specific ceramides in the aorta of apolipoprotein E knockout mice during aging
-
Kobayashi, K., Nagata, E., Sasaki, K., Harada-Shiba, M., Kojo, S., and Kikuzaki, H. (2013). Increase in secretory sphingomyelinase activity and specific ceramides in the aorta of apolipoprotein E knockout mice during aging. Biol. Pharm. Bull. 36, 1192-1196.
-
(2013)
Biol. Pharm. Bull.
, vol.36
, pp. 1192-1196
-
-
Kobayashi, K.1
Nagata, E.2
Sasaki, K.3
Harada-Shiba, M.4
Kojo, S.5
Kikuzaki, H.6
-
97
-
-
25444443570
-
Principles of lysosomal membrane digestion: Stimulation of sphingolipid degradation by sphingolipid activator proteins and anionic lysosomal lipids
-
Kolter, T. and Sandhoff, K. (2005). Principles of lysosomal membrane digestion: stimulation of sphingolipid degradation by sphingolipid activator proteins and anionic lysosomal lipids. Annu. Rev. Cell Dev. Biol. 21, 81-103.
-
(2005)
Annu. Rev. Cell Dev. Biol.
, vol.21
, pp. 81-103
-
-
Kolter, T.1
Sandhoff, K.2
-
98
-
-
17544390315
-
Phosphatidylinositol-3, 5-bisphosphate is a potent and selective inhibitor of acid sphingomyelinase
-
Kölzer, M., Arenz, C., Ferlinz, K., Werth, N., Schulze, H., Klingenstein, R., and Sandhoff, K. (2003). Phosphatidylinositol-3, 5-bisphosphate is a potent and selective inhibitor of acid sphingomyelinase. Biol. Chem. 384, 1293-1298.
-
(2003)
Biol. Chem.
, vol.384
, pp. 1293-1298
-
-
Kölzer, M.1
Arenz, C.2
Ferlinz, K.3
Werth, N.4
Schulze, H.5
Klingenstein, R.6
Sandhoff, K.7
-
99
-
-
12144281320
-
Functional characterization of the postulated intramolecular sphingolipid activator protein domain of human acid sphingomyelinase
-
Kölzer, M., Ferlinz, K., Bartelsen, O., Hoops, S. L., Lang, F., and Sandhoff, K. (2004a). Functional characterization of the postulated intramolecular sphingolipid activator protein domain of human acid sphingomyelinase. Biol. Chem. 385, 1193-1195.
-
(2004)
Biol. Chem.
, vol.385
, pp. 1193-1195
-
-
Kölzer, M.1
Ferlinz, K.2
Bartelsen, O.3
Hoops, S.L.4
Lang, F.5
Sandhoff, K.6
-
100
-
-
0442323490
-
Interactions of acid sphingomyelinase and lipid bilayers in the presence of the tricyclic antidepressant desipramine
-
Kölzer, M., Werth, N., and Sandhoff, K. (2004b). Interactions of acid sphingomyelinase and lipid bilayers in the presence of the tricyclic antidepressant desipramine. FEBS Lett. 559, 96-98.
-
(2004)
FEBS Lett.
, vol.559
, pp. 96-98
-
-
Kölzer, M.1
Werth, N.2
Sandhoff, K.3
-
101
-
-
0023507407
-
Trafficking of lysosomal enzymes
-
Kornfeld, S. (1987). Trafficking of lysosomal enzymes. FASEB J. 1, 462-468.
-
(1987)
FASEB J.
, vol.1
, pp. 462-468
-
-
Kornfeld, S.1
-
102
-
-
38349158920
-
Identification of new functional inhibitors of acid sphingomyelinase using a structureproperty-activity relation model
-
Kornhuber, J., Tripal, P., Reichel, M., Terfloth, L., Bleich, S., Wiltfang, J., and Gulbins, E. (2008). Identification of new functional inhibitors of acid sphingomyelinase using a structureproperty-activity relation model. J. Med. Chem. 51, 219-237.
-
(2008)
J. Med. Chem.
, vol.51
, pp. 219-237
-
-
Kornhuber, J.1
Tripal, P.2
Reichel, M.3
Terfloth, L.4
Bleich, S.5
Wiltfang, J.6
Gulbins, E.7
-
103
-
-
77952908473
-
Functional inhibitors of acid sphingomyelinase (FIASMAs).: A novel pharmacological group of drugs with broad clinical applications
-
Kornhuber, J., Tripal, P., Reichel, M., Mühle, C., Rhein, C., Muehlbacher, M., Groemer, T. W., and Gulbins, E. (2010). Functional inhibitors of acid sphingomyelinase (FIASMAs).: a novel pharmacological group of drugs with broad clinical applications. Cell. Physiol. Biochem. 26, 9-20.
-
(2010)
Cell. Physiol. Biochem.
, vol.26
, pp. 9-20
-
-
Kornhuber, J.1
Tripal, P.2
Reichel, M.3
Mühle, C.4
Rhein, C.5
Muehlbacher, M.6
Groemer, T.W.7
Gulbins, E.8
-
104
-
-
80052314330
-
Identification of novel functional inhibitors of acid sphingomyelinase
-
Kornhuber, J., Muehlbacher, M., Trapp, S., Pechmann, S., Friedl, A., Reichel, M., Mühle, C., Terfloth, L., Groemer, T. W., Spitzer, G. M., et al. (2011). Identification of novel functional inhibitors of acid sphingomyelinase. PLoS One 6, e23852.
-
(2011)
PLoS One
, vol.6
, pp. e23852
-
-
Kornhuber, J.1
Muehlbacher, M.2
Trapp, S.3
Pechmann, S.4
Friedl, A.5
Reichel, M.6
Mühle, C.7
Terfloth, L.8
Groemer, T.W.9
Spitzer, G.M.10
-
105
-
-
84901774687
-
The ceramide system as a novel antidepressant target
-
Kornhuber, J., Müller, C. P., Becker, K. A., Reichel, M., and Gulbins, E. (2014). The ceramide system as a novel antidepressant target. Trends Pharmacol. Sci. 35, 293-304.
-
(2014)
Trends Pharmacol. Sci.
, vol.35
, pp. 293-304
-
-
Kornhuber, J.1
Müller, C.P.2
Becker, K.A.3
Reichel, M.4
Gulbins, E.5
-
106
-
-
84911401050
-
Acid sphingomyelinase serum activity predicts mortality in intensive care unit patients after systemic inflammation: A prospective cohort study
-
Kott, M., Elke, G., Reinicke, M., Winoto-Morbach, S., Schädler, D., Zick, G., Frerichs, U., Weiler, N., and Schütze, S. (2014). Acid sphingomyelinase serum activity predicts mortality in intensive care unit patients after systemic inflammation: a prospective cohort study. PLoS One 9, e112323.
-
(2014)
PLoS One
, vol.9
, pp. e112323
-
-
Kott, M.1
Elke, G.2
Reinicke, M.3
Winoto-Morbach, S.4
Schädler, D.5
Zick, G.6
Frerichs, U.7
Weiler, N.8
Schütze, S.9
-
107
-
-
54049133277
-
The molecular neurobiology of depression
-
Krishnan, V. and Nestler, E. J. (2008). The molecular neurobiology of depression. Nature 455, 894-902.
-
(2008)
Nature
, vol.455
, pp. 894-902
-
-
Krishnan, V.1
Nestler, E.J.2
-
108
-
-
84857064428
-
The efficacy of zinc supplementation in depression: Systematic review of randomised controlled trials
-
Lai, J., Moxey, A., Nowak, G., Vashum, K., Bailey, K., and McEvoy, M. (2012). The efficacy of zinc supplementation in depression: systematic review of randomised controlled trials. J. Affect. Disord. 136, e31-e39.
-
(2012)
J. Affect. Disord.
, vol.136
, pp. e31-e39
-
-
Lai, J.1
Moxey, A.2
Nowak, G.3
Vashum, K.4
Bailey, K.5
McEvoy, M.6
-
109
-
-
33846985938
-
Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide
-
Lang, P. A., Schenck, M., Nicolay, J. P., Becker, J. U., Kempe, D. S., Lupescu, A., Koka, S., Eisele, K., Klarl, B. A., Rübben, H., et al. (2007). Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide. Nat. Med. 13, 164-170.
-
(2007)
Nat. Med.
, vol.13
, pp. 164-170
-
-
Lang, P.A.1
Schenck, M.2
Nicolay, J.P.3
Becker, J.U.4
Kempe, D.S.5
Lupescu, A.6
Koka, S.7
Eisele, K.8
Klarl, B.A.9
Rübben, H.10
-
110
-
-
0032952029
-
Transcription factors Sp1 and AP-2 mediate induction of acid sphingomyelinase during monocytic differentiation
-
Langmann, T., Buechler, C., Ries, S., Schaeffler, A., Aslanidis, C., Schuierer, M., Weiler, M., Sandhoff, K., de Jong, P. J., and Schmitz, G. (1999). Transcription factors Sp1 and AP-2 mediate induction of acid sphingomyelinase during monocytic differentiation. J. Lipid Res. 40, 870-880.
-
(1999)
J. Lipid Res.
, vol.40
, pp. 870-880
-
-
Langmann, T.1
Buechler, C.2
Ries, S.3
Schaeffler, A.4
Aslanidis, C.5
Schuierer, M.6
Weiler, M.7
Sandhoff, K.8
De Jong, P.J.9
Schmitz, G.10
-
111
-
-
0030590887
-
Purification of acid sphingomyelinase from human placenta: Characterization and N-terminal sequence
-
Lansmann, S., Ferlinz, K., Hurwitz, R., Bartelsen, O., Glombitza, G., and Sandhoff, K. (1996). Purification of acid sphingomyelinase from human placenta: characterization and N-terminal sequence. FEBS Lett. 399, 227-231.
-
(1996)
FEBS Lett.
, vol.399
, pp. 227-231
-
-
Lansmann, S.1
Ferlinz, K.2
Hurwitz, R.3
Bartelsen, O.4
Glombitza, G.5
Sandhoff, K.6
-
112
-
-
0344643423
-
Human acid sphingomyelinase
-
Lansmann, S., Schuette, C. G., Bartelsen, O., Hoernschemeyer, J., Linke, T., Weisgerber, J., and Sandhoff, K. (2003). Human acid sphingomyelinase. Eur. J. Biochem. 270, 1076-1088.
-
(2003)
Eur. J. Biochem.
, vol.270
, pp. 1076-1088
-
-
Lansmann, S.1
Schuette, C.G.2
Bartelsen, O.3
Hoernschemeyer, J.4
Linke, T.5
Weisgerber, J.6
Sandhoff, K.7
-
113
-
-
0038620213
-
Compound heterozygosity at the sphingomyelin phosphodiesterase-1 (SMPD1). Gene is associated with low HDL cholesterol
-
Lee, C. Y., Krimbou, L., Vincent, J., Bernard, C., Larramée, P., Genest, J., Jr., and Marcil, M. (2003). Compound heterozygosity at the sphingomyelin phosphodiesterase-1 (SMPD1). gene is associated with low HDL cholesterol. Hum. Genet. 112, 552-562.
-
(2003)
Hum. Genet.
, vol.112
, pp. 552-562
-
-
Lee, C.Y.1
Krimbou, L.2
Vincent, J.3
Bernard, C.4
Larramée, P.5
Genest, J.6
Marcil, M.7
-
114
-
-
84905111905
-
Acid sphingomyelinase modulates the autophagic process by controlling lysosomal biogenesis in Alzheimer's disease
-
Lee, J. K., Jin, H. K., Park, M. H., Kim, B. R., Lee, P. H., Nakauchi, H., Carter, J. E., He, X., Schuchman, E. H., and Bae, J. S. (2014). Acid sphingomyelinase modulates the autophagic process by controlling lysosomal biogenesis in Alzheimer's disease. J. Exp. Med. 211, 1551-1570.
-
(2014)
J. Exp. Med.
, vol.211
, pp. 1551-1570
-
-
Lee, J.K.1
Jin, H.K.2
Park, M.H.3
Kim, B.R.4
Lee, P.H.5
Nakauchi, H.6
Carter, J.E.7
He, X.8
Schuchman, E.H.9
Bae, J.S.10
-
115
-
-
79959708514
-
Adeno-associated virus-mediated expression of acid sphingomyelinase decreases atherosclerotic lesion formation in apolipoprotein E-/-mice
-
Leger, A. J., Mosquea, L. M., Li, L., Chuang, W., Pacheco, J., Taylor, K., Luo, Z., Piepenhagen, P., Ziegler, R., Moreland, R., et al. (2011). Adeno-associated virus-mediated expression of acid sphingomyelinase decreases atherosclerotic lesion formation in apolipoprotein E-/-mice. J. Gene Med. 13, 324-332.
-
(2011)
J. Gene Med.
, vol.13
, pp. 324-332
-
-
Leger, A.J.1
Mosquea, L.M.2
Li, L.3
Chuang, W.4
Pacheco, J.5
Taylor, K.6
Luo, Z.7
Piepenhagen, P.8
Ziegler, R.9
Moreland, R.10
-
116
-
-
33644558004
-
Zinc: The new antidepressant?
-
Levenson, C. W. (2006). Zinc: the new antidepressant? Nutr. Rev. 64, 39-42.
-
(2006)
Nutr. Rev.
, vol.64
, pp. 39-42
-
-
Levenson, C.W.1
-
117
-
-
84864807841
-
Oxidative stress triggers Ca-dependent lysosome trafficking and activation of acid sphingomyelinase
-
Li, X., Gulbins, E., and Zhang, Y. (2012). Oxidative stress triggers Ca-dependent lysosome trafficking and activation of acid sphingomyelinase. Cell. Physiol. Biochem. 30, 815-826.
-
(2012)
Cell. Physiol. Biochem.
, vol.30
, pp. 815-826
-
-
Li, X.1
Gulbins, E.2
Zhang, Y.3
-
118
-
-
0032486480
-
Caenorhabditis elegans contains two distinct acid sphingomyelinases
-
Lin, X., Hengartner, M. O., and Kolesnick, R. (1998). Caenorhabditis elegans contains two distinct acid sphingomyelinases. J. Biol. Chem. 273, 14374-14379.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 14374-14379
-
-
Lin, X.1
Hengartner, M.O.2
Kolesnick, R.3
-
119
-
-
0035077616
-
Stimulation of acid sphingomyelinase activity by lysosomal lipids and sphingolipid activator proteins
-
Linke, T., Wilkening, G., Lansmann, S., Moczall, H., Bartelsen, O., Weisgerber, J., and Sandhoff, K. (2001). Stimulation of acid sphingomyelinase activity by lysosomal lipids and sphingolipid activator proteins. Biol. Chem. 382, 283-290.
-
(2001)
Biol. Chem.
, vol.382
, pp. 283-290
-
-
Linke, T.1
Wilkening, G.2
Lansmann, S.3
Moczall, H.4
Bartelsen, O.5
Weisgerber, J.6
Sandhoff, K.7
-
120
-
-
0016705095
-
The metal ion dependence of phospholipase C from Bacillus cereus
-
Little, C. and Otnäss, A. B. (1975). The metal ion dependence of phospholipase C from Bacillus cereus. Biochim. Biophys. Acta 391, 326-333.
-
(1975)
Biochim. Biophys. Acta
, vol.391
, pp. 326-333
-
-
Little, C.1
Otnäss, A.B.2
-
121
-
-
33847077669
-
Surface tension induced by sphingomyelin to ceramide conversion in lipid membranes
-
López-Montero, I., Vélez, M., and Devaux, P. F. (2007). Surface tension induced by sphingomyelin to ceramide conversion in lipid membranes. Biochim. Biophys. Acta 1768, 553-561.
-
(2007)
Biochim. Biophys. Acta
, vol.1768
, pp. 553-561
-
-
López-Montero, I.1
Vélez, M.2
Devaux, P.F.3
-
122
-
-
77953868426
-
Niemann-Pick type C pathogenesis and treatment: From statins to sugars
-
Madra, M. and Sturley, S. L. (2010). Niemann-Pick type C pathogenesis and treatment: from statins to sugars. Clin. Lipidol. 5, 387-395.
-
(2010)
Clin. Lipidol.
, vol.5
, pp. 387-395
-
-
Madra, M.1
Sturley, S.L.2
-
123
-
-
81055156778
-
Phagocytosis of IgG-coated polystyrene beads by macrophages induces and requires high membrane order
-
Magenau, A., Benzing, C., Proschogo, N., Don, A. S., Hejazi, L., Karunakaran, D., Jessup, W., and Gaus, K. (2011). Phagocytosis of IgG-coated polystyrene beads by macrophages induces and requires high membrane order. Traffic 12, 1730-1743.
-
(2011)
Traffic
, vol.12
, pp. 1730-1743
-
-
Magenau, A.1
Benzing, C.2
Proschogo, N.3
Don, A.S.4
Hejazi, L.5
Karunakaran, D.6
Jessup, W.7
Gaus, K.8
-
124
-
-
0029125587
-
Macrophage uptake of oxidized LDL inhibits lysosomal sphingomyelinase, thus causing the accumulation of unesterified cholesterol-sphingomyelin-rich particles in the lysosomes. A possible role for 7-ketocholesterol
-
Maor, I., Mandel, H., and Aviram, M. (1995). Macrophage uptake of oxidized LDL inhibits lysosomal sphingomyelinase, thus causing the accumulation of unesterified cholesterol-sphingomyelin-rich particles in the lysosomes. A possible role for 7-ketocholesterol. Arterioscler. Thromb. Vasc. Biol. 15, 1378-1387.
-
(1995)
Arterioscler. Thromb. Vasc. Biol.
, vol.15
, pp. 1378-1387
-
-
Maor, I.1
Mandel, H.2
Aviram, M.3
-
125
-
-
0032512723
-
Human vascular endothelial cells are a rich and regulatable source of secretory sphingomyelinase. Implications for early atherogenesis and ceramidemediated cell signaling
-
Marathe, S., Schissel, S. L., Yellin, M. J., Beatini, N., Mintzer, R., Williams, K. J., and Tabas, I. (1998). Human vascular endothelial cells are a rich and regulatable source of secretory sphingomyelinase. Implications for early atherogenesis and ceramidemediated cell signaling. J. Biol. Chem. 273, 4081-4088.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 4081-4088
-
-
Marathe, S.1
Schissel, S.L.2
Yellin, M.J.3
Beatini, N.4
Mintzer, R.5
Williams, K.J.6
Tabas, I.7
-
126
-
-
0032725610
-
Sphingomyelinase, an enzyme implicated in atherogenesis, is present in atherosclerotic lesions and binds to specific components of the subendothelial extracellular matrix
-
Marathe, S., Kuriakose, G., Williams, K. J., and Tabas, I. (1999). Sphingomyelinase, an enzyme implicated in atherogenesis, is present in atherosclerotic lesions and binds to specific components of the subendothelial extracellular matrix. Arterioscler. Thromb. Vasc. Biol. 19, 2648-2658.
-
(1999)
Arterioscler. Thromb. Vasc. Biol.
, vol.19
, pp. 2648-2658
-
-
Marathe, S.1
Kuriakose, G.2
Williams, K.J.3
Tabas, I.4
-
127
-
-
0033664589
-
Sphingomyelinase converts lipoproteins from apolipoprotein E knockout mice into potent inducers of macrophage foam cell formation
-
Marathe, S., Choi, Y., Leventhal, A. R., and Tabas, I. (2000a). Sphingomyelinase converts lipoproteins from apolipoprotein E knockout mice into potent inducers of macrophage foam cell formation. Arterioscler. Thromb. Vasc. Biol. 20, 2607-2613.
-
(2000)
Arterioscler. Thromb. Vasc. Biol.
, vol.20
, pp. 2607-2613
-
-
Marathe, S.1
Choi, Y.2
Leventhal, A.R.3
Tabas, I.4
-
128
-
-
0034641594
-
Creation of a mouse model for non-neurological (type B). Niemann-Pick disease by stable, low level expression of lysosomal sphingomyelinase in the absence of secretory sphingomyelinase: Relationship between brain intra-lysosomal enzyme activity and central nervous system function
-
Marathe, S., Miranda, S. R. P., Devlin, C., Johns, A., Kuriakose, G., Williams, K. J., Schuchman, E. H., and Tabas, I. (2000b). Creation of a mouse model for non-neurological (type B). Niemann-Pick disease by stable, low level expression of lysosomal sphingomyelinase in the absence of secretory sphingomyelinase: relationship between brain intra-lysosomal enzyme activity and central nervous system function. Hum. Mol. Genet. 9, 1967-1976.
-
(2000)
Hum. Mol. Genet.
, vol.9
, pp. 1967-1976
-
-
Marathe, S.1
Miranda, S.R.P.2
Devlin, C.3
Johns, A.4
Kuriakose, G.5
Williams, K.J.6
Schuchman, E.H.7
Tabas, I.8
-
129
-
-
0024203683
-
The distributions and diffusivities of small ions in chondroitin sulphate, hyaluronate and some proteoglycan solutions
-
Maroudas, A., Weinberg, P. D., Parker, K. H., and Winlove, C. P. (1988). The distributions and diffusivities of small ions in chondroitin sulphate, hyaluronate and some proteoglycan solutions. Biophys. Chem. 32, 257-270.
-
(1988)
Biophys. Chem.
, vol.32
, pp. 257-270
-
-
Maroudas, A.1
Weinberg, P.D.2
Parker, K.H.3
Winlove, C.P.4
-
130
-
-
35648953273
-
Constitutive acid sphingomyelinase enhances early and late macrophage killing of Salmonella enterica serovar Typhimurium
-
McCollister, B. D., Myers, J. T., Jones-Carson, J., Voelker, D. R., and Vázquez-Torres, A. (2007). Constitutive acid sphingomyelinase enhances early and late macrophage killing of Salmonella enterica serovar Typhimurium. Infect. Immun. 75, 5346-5352.
-
(2007)
Infect. Immun.
, vol.75
, pp. 5346-5352
-
-
McCollister, B.D.1
Myers, J.T.2
Jones-Carson, J.3
Voelker, D.R.4
Vázquez-Torres, A.5
-
131
-
-
0024797039
-
Magnesium, zinc, and manganese in atherosclerosis of the aorta
-
Mendis, S. (1989). Magnesium, zinc, and manganese in atherosclerosis of the aorta. Biol. Trace Elem. Res. 22, 251-256.
-
(1989)
Biol. Trace Elem. Res.
, vol.22
, pp. 251-256
-
-
Mendis, S.1
-
132
-
-
0342298681
-
Studies on inflammation: X. The cytological picture of an inflammatory exudate in relation to its hydrogen ion concentration
-
Menkin, V. (1934). Studies on inflammation: X. The cytological picture of an inflammatory exudate in relation to its hydrogen ion concentration. Am. J. Pathol. 10, 193-210.
-
(1934)
Am. J. Pathol.
, vol.10
, pp. 193-210
-
-
Menkin, V.1
-
133
-
-
81855168404
-
Plasma sphingomyelins are associated with cognitive progression in Alzheimer's disease
-
Mielke, M. M., Haughey, N. J., Bandaru, V. V., Weinberg, D. D., Darby, E., Zaidi, N., Pavlik, V., Doody, R. S., and Lyketsos, C. G. (2011). Plasma sphingomyelins are associated with cognitive progression in Alzheimer's disease. J. Alzheimers Dis. 27, 259-269.
-
(2011)
J. Alzheimers Dis.
, vol.27
, pp. 259-269
-
-
Mielke, M.M.1
Haughey, N.J.2
Bandaru, V.V.3
Weinberg, D.D.4
Darby, E.5
Zaidi, N.6
Pavlik, V.7
Doody, R.S.8
Lyketsos, C.G.9
-
134
-
-
84884264199
-
Plasma ceramide and glucosylceramide metabolism is altered in sporadic Parkinson's disease and associated with cognitive impairment: A pilot study
-
Mielke, M. M., Maetzler, W., Haughey, N. J., Bandaru, V. V. R., Savica, R., Deuschle, C., Gasser, T., Hauser, A. K., Gräber-Sultan, S., Schleicher, E., et al. (2013). Plasma ceramide and glucosylceramide metabolism is altered in sporadic Parkinson's disease and associated with cognitive impairment: a pilot study. PLoS One 8, e73094.
-
(2013)
PLoS One
, vol.8
, pp. e73094
-
-
Mielke, M.M.1
Maetzler, W.2
Haughey, N.J.3
Bandaru, V.V.R.4
Savica, R.5
Deuschle, C.6
Gasser, T.7
Hauser, A.K.8
Gräber-Sultan, S.9
Schleicher, E.10
-
135
-
-
0027370515
-
Copper and zinc body levels in inflammation: An overview of the data obtained from animal and human studies
-
Milanino, R., Marrella, M., Gasperini, R., Pasqualicchio, M., and Velo, G. (1993). Copper and zinc body levels in inflammation: an overview of the data obtained from animal and human studies. Agents Actions 39, 195-209.
-
(1993)
Agents Actions
, vol.39
, pp. 195-209
-
-
Milanino, R.1
Marrella, M.2
Gasperini, R.3
Pasqualicchio, M.4
Velo, G.5
-
136
-
-
77951889353
-
Sphingomyelin metabolism at the plasma membrane: Implications for bioactive sphingolipids
-
Milhas, D., Clarke, C. J., and Hannun, Y. A. (2010). Sphingomyelin metabolism at the plasma membrane: implications for bioactive sphingolipids. FEBS Lett. 584, 1887-1894.
-
(2010)
FEBS Lett.
, vol.584
, pp. 1887-1894
-
-
Milhas, D.1
Clarke, C.J.2
Hannun, Y.A.3
-
137
-
-
84863767856
-
Ebolavirus requires acid sphingomyelinase activity and plasma membrane sphingomyelin for infection
-
Miller, M. E., Adhikary, S., Kolokoltsov, A. A., and Davey, R. A. (2012). Ebolavirus requires acid sphingomyelinase activity and plasma membrane sphingomyelin for infection. J. Virol. 86, 7473-7483.
-
(2012)
J. Virol.
, vol.86
, pp. 7473-7483
-
-
Miller, M.E.1
Adhikary, S.2
Kolokoltsov, A.A.3
Davey, R.A.4
-
138
-
-
18144430592
-
A novel high-throughput screening format to identify inhibitors of secreted acid sphingomyelinase
-
Mintzer, R. J., Appell, K. C., Cole, A., Johns, A., Pagila, R., Polokoff, M. A., Tabas, I., Snider, R. M., and Meurer-Ogden, J. A. (2005). A novel high-throughput screening format to identify inhibitors of secreted acid sphingomyelinase. J. Biomol. Screen. 10, 225-234.
-
(2005)
J. Biomol. Screen.
, vol.10
, pp. 225-234
-
-
Mintzer, R.J.1
Appell, K.C.2
Cole, A.3
Johns, A.4
Pagila, R.5
Polokoff, M.A.6
Tabas, I.7
Snider, R.M.8
Meurer-Ogden, J.A.9
-
139
-
-
0033810516
-
Infusion of recombinant human acid sphingomyelinase into Niemann-Pick disease mice leads to visceral, but not neurological, correction of the pathophysiology
-
Miranda, S. R. P., He, X., Simonaro, C. M., Gatt, S., Dagan, A., Desnick, R. J., and Schuchman, E. H. (2000). Infusion of recombinant human acid sphingomyelinase into Niemann-Pick disease mice leads to visceral, but not neurological, correction of the pathophysiology. FASEB J. 14, 1988-1995.
-
(2000)
FASEB J.
, vol.14
, pp. 1988-1995
-
-
Miranda, S.R.P.1
He, X.2
Simonaro, C.M.3
Gatt, S.4
Dagan, A.5
Desnick, R.J.6
Schuchman, E.H.7
-
140
-
-
84877066567
-
Characterization of acid sphingomyelinase activity in human cerebrospinal fluid
-
Mühle, C., Huttner, H. B., Walter, S., Reichel, M., Canneva, F., Lewczuk, P., Gulbins, E., and Kornhuber, J. (2013). Characterization of acid sphingomyelinase activity in human cerebrospinal fluid. PLoS One 8, e62912.
-
(2013)
PLoS One
, vol.8
, pp. e62912
-
-
Mühle, C.1
Huttner, H.B.2
Walter, S.3
Reichel, M.4
Canneva, F.5
Lewczuk, P.6
Gulbins, E.7
Kornhuber, J.8
-
141
-
-
84904001337
-
Sex-dependent decrease of sphingomyelinase activity during alcohol withdrawal treatment
-
Mühle, C., Amova, V., Biermann, T., Bayerlein, K., Richter-Schmidinger, T., Kraus, T., Reichel, M., Gulbins, E., and Kornhuber, J. (2014). Sex-dependent decrease of sphingomyelinase activity during alcohol withdrawal treatment. Cell. Physiol. Biochem. 34, 71-81.
-
(2014)
Cell. Physiol. Biochem.
, vol.34
, pp. 71-81
-
-
Mühle, C.1
Amova, V.2
Biermann, T.3
Bayerlein, K.4
Richter-Schmidinger, T.5
Kraus, T.6
Reichel, M.7
Gulbins, E.8
Kornhuber, J.9
-
142
-
-
0037155897
-
Up-regulation of acid sphingomyelinase during retinoic acidinduced myeloid differentiation of NB4, a human acute promyelocytic leukemia cell line
-
Murate, T., Suzuki, M., Hattori, M., Takagi, A., Kojima, T., Tanizawa, T., Asano, H., Hotta, T., Saito, H., Yoshida, S., et al. (2002). Up-regulation of acid sphingomyelinase during retinoic acidinduced myeloid differentiation of NB4, a human acute promyelocytic leukemia cell line. J. Biol. Chem. 277, 9936-9943.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 9936-9943
-
-
Murate, T.1
Suzuki, M.2
Hattori, M.3
Takagi, A.4
Kojima, T.5
Tanizawa, T.6
Asano, H.7
Hotta, T.8
Saito, H.9
Yoshida, S.10
-
143
-
-
0035996576
-
PH Heterogeneity of human and rabbit atherosclerotic plaques; a new insight into detection of vulnerable plaque
-
Naghavi, M., John, R., Naguib, S., Siadaty, M. S., Grasu, R., Kurian, K. C., van Winkle, W. B., Soller, B., Litovsky, S., Madjid, M., et al. (2002). pH Heterogeneity of human and rabbit atherosclerotic plaques; a new insight into detection of vulnerable plaque. Atherosclerosis 164, 27-35.
-
(2002)
Atherosclerosis
, vol.164
, pp. 27-35
-
-
Naghavi, M.1
John, R.2
Naguib, S.3
Siadaty, M.S.4
Grasu, R.5
Kurian, K.C.6
Van Winkle, W.B.7
Soller, B.8
Litovsky, S.9
Madjid, M.10
-
144
-
-
33750613223
-
Cryptosporidium parvum infects human cholangiocytes via sphingolipidenriched membrane microdomains
-
Nelson, J. B., O'Hara, S. P., Small, A. J., Tietz, P. S., Choudhury, A. K., Pagano, R. E., Chen, X. M., and LaRusso, N. F. (2006). Cryptosporidium parvum infects human cholangiocytes via sphingolipidenriched membrane microdomains. Cell. Microbiol. 8, 1932-1945.
-
(2006)
Cell. Microbiol.
, vol.8
, pp. 1932-1945
-
-
Nelson, J.B.1
O'Hara, S.P.2
Small, A.J.3
Tietz, P.S.4
Choudhury, A.K.5
Pagano, R.E.6
Chen, X.M.7
LaRusso, N.F.8
-
145
-
-
0029778534
-
Functional analysis of the glycosylation of murine acid sphingomyelinase
-
Newrzella, D. and Stoffel, W. (1996). Functional analysis of the glycosylation of murine acid sphingomyelinase. J. Biol. Chem. 271, 32089-32095.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 32089-32095
-
-
Newrzella, D.1
Stoffel, W.2
-
146
-
-
33745022321
-
The lysosomal trafficking of acid sphingomyelinase is mediated by sortilin and mannose 6-phosphate receptor
-
Ni, X. and Morales, C. R. (2006). The lysosomal trafficking of acid sphingomyelinase is mediated by sortilin and mannose 6-phosphate receptor. Traffic 7, 889-902.
-
(2006)
Traffic
, vol.7
, pp. 889-902
-
-
Ni, X.1
Morales, C.R.2
-
147
-
-
0035341211
-
The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein
-
Nielsen, M. S., Madsen, P., Christensen, E. I., Nykjaer, A., Gliemann, J., Kasper, D., Pohlmann, R., and Petersen, C. M. (2001). The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein. EMBO J. 20, 2180-2190.
-
(2001)
EMBO J.
, vol.20
, pp. 2180-2190
-
-
Nielsen, M.S.1
Madsen, P.2
Christensen, E.I.3
Nykjaer, A.4
Gliemann, J.5
Kasper, D.6
Pohlmann, R.7
Petersen, C.M.8
-
148
-
-
0030836650
-
The phosphorylation of bovine DNase I Asn-linked oligosaccharides is dependent on specific lysine and arginine residues
-
Nishikawa, A., Gregory, W., Frenz, J., Cacia, J., and Kornfeld, S. (1997). The phosphorylation of bovine DNase I Asn-linked oligosaccharides is dependent on specific lysine and arginine residues. J. Biol. Chem. 272, 19408-19412.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 19408-19412
-
-
Nishikawa, A.1
Gregory, W.2
Frenz, J.3
Cacia, J.4
Kornfeld, S.5
-
149
-
-
77953865510
-
Plasma membrane sphingomyelin hydrolysis increases hippocampal neuron excitability by sphingosine-1-phosphate mediated mechanisms
-
Norman, E., Cutler, R. G., Flannery, R., Wang, Y., and Mattson, M. P. (2010). Plasma membrane sphingomyelin hydrolysis increases hippocampal neuron excitability by sphingosine-1-phosphate mediated mechanisms. J. Neurochem. 114, 430-439.
-
(2010)
J. Neurochem.
, vol.114
, pp. 430-439
-
-
Norman, E.1
Cutler, R.G.2
Flannery, R.3
Wang, Y.4
Mattson, M.P.5
-
150
-
-
0031785063
-
Digestion of ceramide by human milk bile saltstimulated lipase
-
Nyberg, L., Farooqi, A., Bläckberg, L., Duan, R. D., Nilsson, A., and Hernell, O. (1998). Digestion of ceramide by human milk bile saltstimulated lipase. J. Pediatr. Gastroenterol. Nutr. 27, 560-567.
-
(1998)
J. Pediatr. Gastroenterol. Nutr.
, vol.27
, pp. 560-567
-
-
Nyberg, L.1
Farooqi, A.2
Bläckberg, L.3
Duan, R.D.4
Nilsson, A.5
Hernell, O.6
-
151
-
-
84919723483
-
Acid sphingomyelinase activity is regulated by membrane lipids and facilitates cholesterol transfer by NPC2
-
Oninla, V. O., Breiden, B., Babalola, J. O., and Sandhoff, K. (2014). Acid sphingomyelinase activity is regulated by membrane lipids and facilitates cholesterol transfer by NPC2. J. Lipid Res. 55, 2606-2619.
-
(2014)
J. Lipid Res.
, vol.55
, pp. 2606-2619
-
-
Oninla, V.O.1
Breiden, B.2
Babalola, J.O.3
Sandhoff, K.4
-
152
-
-
0032582694
-
Sphingomyelinase induces aggregation and fusion, but phospholipase A2 only aggregation, of low density lipoprotein (LDL). Particles. Two distinct mechanisms leading to increased binding strength of LDL to human aortic proteoglycans
-
Öörni, K., Hakala, J. K., Annila, A., Ala-Korpela, M., and Kovanen, P. T. (1998). Sphingomyelinase induces aggregation and fusion, but phospholipase A2 only aggregation, of low density lipoprotein (LDL). particles. Two distinct mechanisms leading to increased binding strength of LDL to human aortic proteoglycans. J. Biol. Chem. 273, 29127-29134.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 29127-29134
-
-
Öörni, K.1
Hakala, J.K.2
Annila, A.3
Ala-Korpela, M.4
Kovanen, P.T.5
-
153
-
-
23244438374
-
Sphingomyelinase induces aggregation and fusion of small very low-density lipoprotein and intermediate-density lipoprotein particles and increases their retention to human arterial proteoglycans
-
Öörni, K., Posio, P., Ala-Korpela, M., Jauhiainen, M., and Kovanen, P. T. (2005). Sphingomyelinase induces aggregation and fusion of small very low-density lipoprotein and intermediate-density lipoprotein particles and increases their retention to human arterial proteoglycans. Arterioscler. Thromb. Vasc. Biol. 25, 1678-1683.
-
(2005)
Arterioscler. Thromb. Vasc. Biol.
, vol.25
, pp. 1678-1683
-
-
Öörni, K.1
Posio, P.2
Ala-Korpela, M.3
Jauhiainen, M.4
Kovanen, P.T.5
-
154
-
-
0029014350
-
Acid sphingomyelinase-deficient mice mimic the neurovisceral form of human lysosomal storage disease (Niemann-Pick disease)
-
Otterbach, B. and Stoffel, W. (1995). Acid sphingomyelinase-deficient mice mimic the neurovisceral form of human lysosomal storage disease (Niemann-Pick disease). Cell 81, 1053-1061.
-
(1995)
Cell
, vol.81
, pp. 1053-1061
-
-
Otterbach, B.1
Stoffel, W.2
-
155
-
-
84898539271
-
Elevation of ceramide and activation of secretory acid sphingomyelinase in patients with acute coronary syndromes
-
Pan, W., Yu, J., Shi, R., Yan, L., Yang, T., Li, Y., Zhang, Z., Yu, G., Bai, Y., Schuchman, E. H., et al. (2014). Elevation of ceramide and activation of secretory acid sphingomyelinase in patients with acute coronary syndromes. Coron. Artery Dis. 25, 230-235.
-
(2014)
Coron. Artery Dis.
, vol.25
, pp. 230-235
-
-
Pan, W.1
Yu, J.2
Shi, R.3
Yan, L.4
Yang, T.5
Li, Y.6
Zhang, Z.7
Yu, G.8
Bai, Y.9
Schuchman, E.H.10
-
156
-
-
21144457361
-
Acid sphingomyelinase deficiency. Phenotype variability with prevalence of intermediate phenotype in a series of twenty-five Czech and Slovak patients. A multiapproach study
-
Pavlu-Pereira, H., Asfaw, B., Poupctová, H., Ledvinová, J., Sikora, J., Vanier, M. T., Sandhoff, K., Zeman, J., Novotná, Z., Chudoba, D., et al. (2005). Acid sphingomyelinase deficiency. Phenotype variability with prevalence of intermediate phenotype in a series of twenty-five Czech and Slovak patients. A multiapproach study. J. Inherit. Metab. Dis. 28, 203-227.
-
(2005)
J. Inherit. Metab. Dis.
, vol.28
, pp. 203-227
-
-
Pavlu-Pereira, H.1
Asfaw, B.2
Poupctová, H.3
Ledvinová, J.4
Sikora, J.5
Vanier, M.T.6
Sandhoff, K.7
Zeman, J.8
Novotná, Z.9
Chudoba, D.10
-
157
-
-
67449110914
-
Sphingomyelinases: Their regulation and roles in cardiovascular pathophysiology
-
Pavoine, C. and Pecker, F. (2009). Sphingomyelinases: their regulation and roles in cardiovascular pathophysiology. Cardiovasc. Res. 82, 175-183.
-
(2009)
Cardiovasc. Res.
, vol.82
, pp. 175-183
-
-
Pavoine, C.1
Pecker, F.2
-
158
-
-
78650052094
-
Syntaxin 4 is required for acid sphingomyelinase activity and apoptotic function
-
Perrotta, C., Bizzozero, L., Cazzato, D., Morlacchi, S., Assi, E., Simbari, F., Zhang, Y., Gulbins, E., Bassi, M. T., Rosa, P., et al. (2010). Syntaxin 4 is required for acid sphingomyelinase activity and apoptotic function. J. Biol. Chem. 285, 40240-40251.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 40240-40251
-
-
Perrotta, C.1
Bizzozero, L.2
Cazzato, D.3
Morlacchi, S.4
Assi, E.5
Simbari, F.6
Zhang, Y.7
Gulbins, E.8
Bassi, M.T.9
Rosa, P.10
-
159
-
-
14444281750
-
Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography
-
Petersen, C. M., Nielsen, M. S., Nykjaer, A., Jacobsen, L., Tommerup, N., Rasmussen, H. H., Roigaard, H., Gliemann, J., Madsen, P., and Moestrup, S. K. (1997). Molecular identification of a novel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography. J. Biol. Chem. 272, 3599-3605.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 3599-3605
-
-
Petersen, C.M.1
Nielsen, M.S.2
Nykjaer, A.3
Jacobsen, L.4
Tommerup, N.5
Rasmussen, H.H.6
Roigaard, H.7
Gliemann, J.8
Madsen, P.9
Moestrup, S.K.10
-
160
-
-
84883627583
-
Transformation-associated changes in sphingolipid metabolism sensitize cells to lysosomal cell death induced by inhibitors of acid sphingomyelinase
-
Petersen, N. H. T., Olsen, O. D., Groth-Pedersen, L., Ellegaard, A. M., Bilgin, M., Redmer, S., Ostenfeld, M. S., Ulanet, D., Dovmark, T. H., Lønborg, A., et al. (2013). Transformation-associated changes in sphingolipid metabolism sensitize cells to lysosomal cell death induced by inhibitors of acid sphingomyelinase. Cancer Cell 24, 379-393.
-
(2013)
Cancer Cell
, vol.24
, pp. 379-393
-
-
Petersen, N.H.T.1
Olsen, O.D.2
Groth-Pedersen, L.3
Ellegaard, A.M.4
Bilgin, M.5
Redmer, S.6
Ostenfeld, M.S.7
Ulanet, D.8
Dovmark, T.H.9
Lønborg, A.10
-
161
-
-
18844434417
-
Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice
-
Petrache, I., Natarajan, V., Zhen, L., Medler, T. R., Richter, A. T., Cho, C., Hubbard, W. C., Berdyshev, E. V., and Tuder, R. M. (2005). Ceramide upregulation causes pulmonary cell apoptosis and emphysema-like disease in mice. Nat. Med. 11, 491-498.
-
(2005)
Nat. Med.
, vol.11
, pp. 491-498
-
-
Petrache, I.1
Natarajan, V.2
Zhen, L.3
Medler, T.R.4
Richter, A.T.5
Cho, C.6
Hubbard, W.C.7
Berdyshev, E.V.8
Tuder, R.M.9
-
162
-
-
6044238051
-
Acid sphingomyelinase: Identification of nine novel mutations among Italian Niemann Pick type B patients and characterization of in vivo functional in-frame start codon
-
Pittis, M. G., Ricci, V., Guerci, V. I., Marcais, C., Ciana, G., Dardis, A., Gerin, F., Stroppiano, M., Vanier, M. T., Filocamo, M., et al. (2004). Acid sphingomyelinase: identification of nine novel mutations among Italian Niemann Pick type B patients and characterization of in vivo functional in-frame start codon. Hum. Mutat. 24, 186-187.
-
(2004)
Hum. Mutat.
, vol.24
, pp. 186-187
-
-
Pittis, M.G.1
Ricci, V.2
Guerci, V.I.3
Marcais, C.4
Ciana, G.5
Dardis, A.6
Gerin, F.7
Stroppiano, M.8
Vanier, M.T.9
Filocamo, M.10
-
163
-
-
77953491246
-
Proteolysis sensitizes LDL particles to phospholipolysis by secretory phospholipase A2 group V and secretory sphingomyelinase
-
Plihtari, R., Hurt-Camejo, E., Öörni, K., and Kovanen, P. T. (2010). Proteolysis sensitizes LDL particles to phospholipolysis by secretory phospholipase A2 group V and secretory sphingomyelinase. J. Lipid Res. 51, 1801-1809.
-
(2010)
J. Lipid Res.
, vol.51
, pp. 1801-1809
-
-
Plihtari, R.1
Hurt-Camejo, E.2
Öörni, K.3
Kovanen, P.T.4
-
164
-
-
0028353499
-
Acid sphingomyelinase possesses a domain homologous to its activator proteins: Saposins B and D
-
Ponting, C. P. (1994). Acid sphingomyelinase possesses a domain homologous to its activator proteins: saposins B and D. Protein Sci. 3, 359-361.
-
(1994)
Protein Sci.
, vol.3
, pp. 359-361
-
-
Ponting, C.P.1
-
165
-
-
0036239931
-
Human immunodeficiency virus type 1 uses lipid raft-colocalized CD4 and chemokine receptors for productive entry into CD4+ T cells
-
Popik, W., Alce, T. M., and Au, W. C. (2002). Human immunodeficiency virus type 1 uses lipid raft-colocalized CD4 and chemokine receptors for productive entry into CD4+ T cells. J. Virol. 76, 4709-4722.
-
(2002)
J. Virol.
, vol.76
, pp. 4709-4722
-
-
Popik, W.1
Alce, T.M.2
Au, W.C.3
-
166
-
-
84868090810
-
Topical application of phosphatidyl-inositol-3, 5-bisphosphate for acute lung injury in neonatal swine
-
Preuß, S., Omam, F. D., Scheiermann, J., Stadelmann, S., Winoto-Morbach, S., von Bismarck, P., Adam-Klages, S., Knerlich-Lukoschus, F., Lex, D., Wesch, D., et al. (2012). Topical application of phosphatidyl-inositol-3, 5-bisphosphate for acute lung injury in neonatal swine. J. Cell Mol. Med. 16, 2813-2826.
-
(2012)
J. Cell Mol. Med.
, vol.16
, pp. 2813-2826
-
-
Preuß, S.1
Omam, F.D.2
Scheiermann, J.3
Stadelmann, S.4
Winoto-Morbach, S.5
Von Bismarck, P.6
Adam-Klages, S.7
Knerlich-Lukoschus, F.8
Lex, D.9
Wesch, D.10
-
167
-
-
0042858520
-
Activation of human acid sphingomyelinase through modification or deletion of C-terminal cysteine
-
Qiu, H., Edmunds, T., Baker-Malcolm, J., Karey, K. P., Estes, S., Schwarz, C., Hughes, H., and Van Patten, S. M. (2003). Activation of human acid sphingomyelinase through modification or deletion of C-terminal cysteine. J. Biol. Chem. 278, 32744-32752.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 32744-32752
-
-
Qiu, H.1
Edmunds, T.2
Baker-Malcolm, J.3
Karey, K.P.4
Estes, S.5
Schwarz, C.6
Hughes, H.7
Van Patten, S.M.8
-
168
-
-
0025866614
-
Human acid sphingomyelinase from human urine
-
Quintern, L. E. and Sandhoff, K. (1991). Human acid sphingomyelinase from human urine. Methods Enzymol. 197, 536-540.
-
(1991)
Methods Enzymol.
, vol.197
, pp. 536-540
-
-
Quintern, L.E.1
Sandhoff, K.2
-
169
-
-
0023574186
-
Acid sphingomyelinase from human urine: Purification and characterization
-
Quintern, L. E., Weitz, G., Nehrkorn, H., Tager, J. M., Schram, A. W., and Sandhoff, K. (1987). Acid sphingomyelinase from human urine: purification and characterization. Biochim. Biophys. Acta 922, 323-336.
-
(1987)
Biochim. Biophys. Acta
, vol.922
, pp. 323-336
-
-
Quintern, L.E.1
Weitz, G.2
Nehrkorn, H.3
Tager, J.M.4
Schram, A.W.5
Sandhoff, K.6
-
170
-
-
0024550289
-
Proteolytic processing of the β-subunit of the lysosomal enzyme, β-hexosaminidase, in normal human fibroblasts
-
Quon, D. V. K., Proia, R. L., Fowler, A. V., Bleibaum, J., and Neufeld, E. F. (1989). Proteolytic processing of the β-subunit of the lysosomal enzyme, β-hexosaminidase, in normal human fibroblasts. J. Biol. Chem. 264, 3380-3384.
-
(1989)
J. Biol. Chem.
, vol.264
, pp. 3380-3384
-
-
Quon, D.V.K.1
Proia, R.L.2
Fowler, A.V.3
Bleibaum, J.4
Neufeld, E.F.5
-
171
-
-
0034528837
-
Posttranslational regulation of acid sphingomyelinase in niemann-pick type C1 fibroblasts and free cholesterol-enriched Chinese hamster ovary cells
-
Reagan, J. W., Jr., Hubbert, M. L., and Shelness, G. S. (2000). Posttranslational regulation of acid sphingomyelinase in niemann-pick type C1 fibroblasts and free cholesterol-enriched chinese hamster ovary cells. J. Biol. Chem. 275, 38104-38110.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 38104-38110
-
-
Reagan, J.W.1
Hubbert, M.L.2
Shelness, G.S.3
-
172
-
-
33644869928
-
Dose-related effects of eicosapentaenoic acid on innate immune function in healthy humans: A comparison of young and older men
-
Rees, D., Miles, E. A., Banerjee, T., Wells, S. J., Roynette, C. E., Wahle, K. W. J., and Calder, P. C. (2006). Dose-related effects of eicosapentaenoic acid on innate immune function in healthy humans: a comparison of young and older men. Am. J. Clin. Nutr. 83, 331-342.
-
(2006)
Am. J. Clin. Nutr.
, vol.83
, pp. 331-342
-
-
Rees, D.1
Miles, E.A.2
Banerjee, T.3
Wells, S.J.4
Roynette, C.E.5
Wahle, K.W.J.6
Calder, P.C.7
-
173
-
-
80053231511
-
Activity of secretory sphingomyelinase is increased in plasma of alcohol-dependent patients
-
Reichel, M., Beck, J., Mühle, C., Rotter, A., Bleich, S., Gulbins, E., and Kornhuber, J. (2011). Activity of secretory sphingomyelinase is increased in plasma of alcohol-dependent patients. Alcohol. Clin. Exp. Res. 35, 1852-1859.
-
(2011)
Alcohol. Clin. Exp. Res.
, vol.35
, pp. 1852-1859
-
-
Reichel, M.1
Beck, J.2
Mühle, C.3
Rotter, A.4
Bleich, S.5
Gulbins, E.6
Kornhuber, J.7
-
174
-
-
84903965593
-
The common acid sphingomyelinase polymorphism p. G508R is associated with self-reported allergy
-
Reichel, M., Richter-Schmidinger, T., Mühle, C., Rhein, C., Alexopoulos, P., Schwab, S. G., Gulbins, E., and Kornhuber, J. (2014). The common acid sphingomyelinase polymorphism p. G508R is associated with self-reported allergy. Cell. Physiol. Biochem. 34, 82-91.
-
(2014)
Cell. Physiol. Biochem.
, vol.34
, pp. 82-91
-
-
Reichel, M.1
Richter-Schmidinger, T.2
Mühle, C.3
Rhein, C.4
Alexopoulos, P.5
Schwab, S.G.6
Gulbins, E.7
Kornhuber, J.8
-
175
-
-
0019876873
-
UDP-N-acetylglucosamine: Glycoprotein N-acetylglucosamine-1-phosphotransferase. Proposed enzyme for the phosphorylation of the high mannose oligosaccharide units of lysosomal enzymes
-
Reitman, M. L. and Kornfeld, S. (1981). UDP-N-acetylglucosamine: glycoprotein N-acetylglucosamine-1-phosphotransferase. Proposed enzyme for the phosphorylation of the high mannose oligosaccharide units of lysosomal enzymes. J. Biol. Chem. 256, 4275-4281.
-
(1981)
J. Biol. Chem.
, vol.256
, pp. 4275-4281
-
-
Reitman, M.L.1
Kornfeld, S.2
-
176
-
-
34347405277
-
Saposin B mobilizes lipids from cholesterol-poor and bis (monoacylglycero) phosphate-rich membranes at acidic pH. Unglycosylated patient variant saposin B lacks lipid-extraction capacity
-
Remmel, N., Locatelli-Hoops, S., Breiden, B., Schwarzmann, G., and Sandhoff, K. (2007). Saposin B mobilizes lipids from cholesterol-poor and bis (monoacylglycero) phosphate-rich membranes at acidic pH. Unglycosylated patient variant saposin B lacks lipid-extraction capacity. FEBS J. 274, 3405-3420.
-
(2007)
FEBS J.
, vol.274
, pp. 3405-3420
-
-
Remmel, N.1
Locatelli-Hoops, S.2
Breiden, B.3
Schwarzmann, G.4
Sandhoff, K.5
-
177
-
-
84860444286
-
Functional implications of novel human acid sphingomyelinase splice variants
-
Rhein, C., Tripal, P., Seebahn, A., Konrad, A., Kramer, M., Nagel, C., Kemper, J., Bode, J., Mühle, C., Gulbins, E., et al. (2012). Functional implications of novel human acid sphingomyelinase splice variants. PLoS One 7, e35467.
-
(2012)
PLoS One
, vol.7
, pp. e35467
-
-
Rhein, C.1
Tripal, P.2
Seebahn, A.3
Konrad, A.4
Kramer, M.5
Nagel, C.6
Kemper, J.7
Bode, J.8
Mühle, C.9
Gulbins, E.10
-
178
-
-
84908655582
-
The acid sphingomyelinase sequence variation p. A487V is not associated with decreased levels of enzymatic activity
-
Rhein, C., Naumann, J., Mühle, C., Zill, P., Adli, M., Hegerl, U., Hiemke, C., Mergl, R., Möller, H. J., Reichel, M., et al. (2013). The acid sphingomyelinase sequence variation p. A487V is not associated with decreased levels of enzymatic activity. JIMD Rep 8, 1-6.
-
(2013)
JIMD Rep
, vol.8
, pp. 1-6
-
-
Rhein, C.1
Naumann, J.2
Mühle, C.3
Zill, P.4
Adli, M.5
Hegerl, U.6
Hiemke, C.7
Mergl, R.8
Möller, H.J.9
Reichel, M.10
-
179
-
-
84908619827
-
Secretion of acid sphingomyelinase is affected by its polymorphic signal peptide
-
Rhein, C., Reichel, M., Mühle, C., Rotter, A., Schwab, S. G., and Kornhuber, J. (2014). Secretion of acid sphingomyelinase is affected by its polymorphic signal peptide. Cell. Physiol. Biochem. 34, 1385-1401.
-
(2014)
Cell. Physiol. Biochem.
, vol.34
, pp. 1385-1401
-
-
Rhein, C.1
Reichel, M.2
Mühle, C.3
Rotter, A.4
Schwab, S.G.5
Kornhuber, J.6
-
180
-
-
33845311849
-
Membrane rafts in host-pathogen interactions
-
Riethmüller, J., Riehle, A., Grassmé, H., and Gulbins, E. (2006). Membrane rafts in host-pathogen interactions. Biochim. Biophys. Acta 1758, 2139-2147.
-
(2006)
Biochim. Biophys. Acta
, vol.1758
, pp. 2139-2147
-
-
Riethmüller, J.1
Riehle, A.2
Grassmé, H.3
Gulbins, E.4
-
181
-
-
4344587249
-
PH microdomains in oligodendrocytes
-
Ro, H. A. and Carson, J. H. (2004). pH microdomains in oligodendrocytes. J. Biol. Chem. 279, 37115-37123.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 37115-37123
-
-
Ro, H.A.1
Carson, J.H.2
-
182
-
-
84891654950
-
Lipid-modifying enzymes in human tear fluid and corneal epithelial stress response
-
Robciuc, A., Rantamäki, A. H., Jauhiainen, M., and Holopainen, J. M. (2014). Lipid-modifying enzymes in human tear fluid and corneal epithelial stress response. Invest. Ophthalmol. Vis. Sci. 55, 16-24.
-
(2014)
Invest. Ophthalmol. Vis. Sci.
, vol.55
, pp. 16-24
-
-
Robciuc, A.1
Rantamäki, A.H.2
Jauhiainen, M.3
Holopainen, J.M.4
-
183
-
-
0033994563
-
Characterization of sphingomyelinase activity released by thrombin-stimulated platelets
-
Romiti, E., Vasta, V., Meacci, E., Farnararo, M., Linke, T., Ferlinz, K., Sandhoff, K., and Bruni, P. (2000). Characterization of sphingomyelinase activity released by thrombin-stimulated platelets. Mol. Cell Biochem. 205, 75-81.
-
(2000)
Mol. Cell Biochem.
, vol.205
, pp. 75-81
-
-
Romiti, E.1
Vasta, V.2
Meacci, E.3
Farnararo, M.4
Linke, T.5
Ferlinz, K.6
Sandhoff, K.7
Bruni, P.8
-
184
-
-
70349995082
-
Potent and selective inhibition of acid sphingomyelinase by bisphosphonates
-
Roth, A. G., Drescher, D., Yang, Y., Redmer, S., Uhlig, S., and Arenz, C. (2009a). Potent and selective inhibition of acid sphingomyelinase by bisphosphonates. Angew. Chem. Int. Ed. Engl. 48, 7560-7563.
-
(2009)
Angew. Chem. Int. Ed. Engl.
, vol.48
, pp. 7560-7563
-
-
Roth, A.G.1
Drescher, D.2
Yang, Y.3
Redmer, S.4
Uhlig, S.5
Arenz, C.6
-
185
-
-
70350536352
-
Potent inhibition of acid sphingomyelinase by phosphoinositide analogues
-
Roth, A. G., Redmer, S., and Arenz, C. (2009b). Potent inhibition of acid sphingomyelinase by phosphoinositide analogues. Chem-BioChem 10, 2367-2374.
-
(2009)
Chem-BioChem
, vol.10
, pp. 2367-2374
-
-
Roth, A.G.1
Redmer, S.2
Arenz, C.3
-
186
-
-
76449107820
-
Development of carbohydrate-derived inhibitors of acid sphingomyelinase
-
Roth, A. G., Redmer, S., and Arenz, C. (2010). Development of carbohydrate-derived inhibitors of acid sphingomyelinase. Bioorg. Med. Chem. 18, 939-944.
-
(2010)
Bioorg. Med. Chem.
, vol.18
, pp. 939-944
-
-
Roth, A.G.1
Redmer, S.2
Arenz, C.3
-
187
-
-
22544470314
-
Caspase-dependent and -independent activation of acid sphingomyelinase signaling
-
Rotolo, J. A., Zhang, J., Donepudi, M., Lee, H., Fuks, Z., and Kolesnick, R. (2005). Caspase-dependent and -independent activation of acid sphingomyelinase signaling. J. Biol. Chem. 280, 26425-26434.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 26425-26434
-
-
Rotolo, J.A.1
Zhang, J.2
Donepudi, M.3
Lee, H.4
Fuks, Z.5
Kolesnick, R.6
-
188
-
-
0020263020
-
Acid sphingomyelinase of human placenta: Purification, properties, and 125iodine labeling
-
Sakuragawa, N. (1982). Acid sphingomyelinase of human placenta: purification, properties, and 125iodine labeling. J. Biochem. 92, 637-646.
-
(1982)
J. Biochem.
, vol.92
, pp. 637-646
-
-
Sakuragawa, N.1
-
189
-
-
0021919863
-
Effects of dimethylsulfoxide on sphingomyelinase in cultured human fibroblasts and correction of sphingomyelinase deficiency in fibroblasts from Niemann-Pick patients
-
Sakuragawa, N., Sato, M., Yoshida, Y., Kamo, I., Arima, M., and Satoyoshi, E. (1985). Effects of dimethylsulfoxide on sphingomyelinase in cultured human fibroblasts and correction of sphingomyelinase deficiency in fibroblasts from Niemann-Pick patients. Biochem. Biophys. Res. Commun. 126, 756-762.
-
(1985)
Biochem. Biophys. Res. Commun.
, vol.126
, pp. 756-762
-
-
Sakuragawa, N.1
Sato, M.2
Yoshida, Y.3
Kamo, I.4
Arima, M.5
Satoyoshi, E.6
-
190
-
-
0042528720
-
Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants
-
Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O. et al. (2003). Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301, 805-809.
-
(2003)
Science
, vol.301
, pp. 805-809
-
-
Santarelli, L.1
Saxe, M.2
Gross, C.3
Surget, A.4
Battaglia, F.5
Dulawa, S.6
Weisstaub, N.7
Lee, J.8
Duman, R.9
Arancio, O.10
-
191
-
-
27744607641
-
Elevated sphingomyelinase activity and ceramide concentration in serum of patients undergoing high dose spatially fractionated radiation treatment: Implications for endothelial apoptosis
-
Sathishkumar, S., Boyanovsky, B., Karakashian, A. A., Rozenova, K., Giltiay, N. V., Kudrimoti, M., Mohiuddin, M., Ahmed, M. M., and Nikolova-Karakashian, M. (2005). Elevated sphingomyelinase activity and ceramide concentration in serum of patients undergoing high dose spatially fractionated radiation treatment: implications for endothelial apoptosis. Cancer Biol. Ther. 4, 979-986.
-
(2005)
Cancer Biol. Ther.
, vol.4
, pp. 979-986
-
-
Sathishkumar, S.1
Boyanovsky, B.2
Karakashian, A.A.3
Rozenova, K.4
Giltiay, N.V.5
Kudrimoti, M.6
Mohiuddin, M.7
Ahmed, M.M.8
Nikolova-Karakashian, M.9
-
192
-
-
0023766418
-
Effects of dimethylsulfoxide on sphingomyelinase activities in normal and Niemann-Pick type A, B and C fibroblasts
-
Sato, M., Yoshida, Y., Sakuragawa, N., and Arima, M. (1988). Effects of dimethylsulfoxide on sphingomyelinase activities in normal and Niemann-Pick type A, B and C fibroblasts. Biochim. Biophys. Acta 962, 59-65.
-
(1988)
Biochim. Biophys. Acta
, vol.962
, pp. 59-65
-
-
Sato, M.1
Yoshida, Y.2
Sakuragawa, N.3
Arima, M.4
-
193
-
-
10044250982
-
Astroglial expression of ceramide in Alzheimer's disease brains: A role during neuronal apoptosis
-
Satoi, H., Tomimoto, H., Ohtani, R., Kitano, T., Kondo, T., Watanabe, M., Oka, N., Akiguchi, I., Furuya, S., Hirabayashi, Y., et al. (2005). Astroglial expression of ceramide in Alzheimer's disease brains: a role during neuronal apoptosis. Neuroscience 130, 657-666.
-
(2005)
Neuroscience
, vol.130
, pp. 657-666
-
-
Satoi, H.1
Tomimoto, H.2
Ohtani, R.3
Kitano, T.4
Kondo, T.5
Watanabe, M.6
Oka, N.7
Akiguchi, I.8
Furuya, S.9
Hirabayashi, Y.10
-
195
-
-
0030806148
-
Change of zinc distribution in rat brain with increasing age
-
Sawashita, J., Takeda, A., and Okada, S. (1997). Change of zinc distribution in rat brain with increasing age. Brain Res. Dev. Brain Res. 102, 295-298.
-
(1997)
Brain Res. Dev. Brain Res.
, vol.102
, pp. 295-298
-
-
Sawashita, J.1
Takeda, A.2
Okada, S.3
-
196
-
-
0029666484
-
2+-stimulated sphingomyelinase is secreted by many cell types and is a product of the acid sphingomyelinase gene
-
2+-stimulated sphingomyelinase is secreted by many cell types and is a product of the acid sphingomyelinase gene. J. Biol. Chem. 271, 18431-18436.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 18431-18436
-
-
Schissel, S.L.1
Schuchman, E.H.2
Williams, K.J.3
Tabas, I.4
-
197
-
-
0029762320
-
Rabbit aorta and human atherosclerotic lesions hydrolyze the sphingomyelin of retained low-density lipoprotein. Proposed role for arterial-wall sphingomyelinase in subendothelial retention and aggregation of atherogenic lipoproteins
-
Schissel, S. L., Tweedie-Hardman, J., Rapp, J. H., Graham, G., Williams, K. J., and Tabas, I. (1996b). Rabbit aorta and human atherosclerotic lesions hydrolyze the sphingomyelin of retained low-density lipoprotein. Proposed role for arterial-wall sphingomyelinase in subendothelial retention and aggregation of atherogenic lipoproteins. J. Clin. Invest. 98, 1455-1464.
-
(1996)
J. Clin. Invest.
, vol.98
, pp. 1455-1464
-
-
Schissel, S.L.1
Tweedie-Hardman, J.2
Rapp, J.H.3
Graham, G.4
Williams, K.J.5
Tabas, I.6
-
198
-
-
0032579258
-
Secretory sphingomyelinase, a product of the acid sphingomyelinase gene, can hydrolyze atherogenic lipoproteins at neutral pH. Implications for atherosclerotic lesion development
-
Schissel, S. L., Jiang, X., Tweedie-Hardman, J., Jeong, T., Camejo, E. H., Najib, J., Rapp, J. H., Williams, K. J., and Tabas, I. (1998a). Secretory sphingomyelinase, a product of the acid sphingomyelinase gene, can hydrolyze atherogenic lipoproteins at neutral pH. Implications for atherosclerotic lesion development. J. Biol. Chem. 273, 2738-2746.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 2738-2746
-
-
Schissel, S.L.1
Jiang, X.2
Tweedie-Hardman, J.3
Jeong, T.4
Camejo, E.H.5
Najib, J.6
Rapp, J.H.7
Williams, K.J.8
Tabas, I.9
-
199
-
-
0032540959
-
The cellular trafficking and zinc dependence of secretory and lysosomal sphingomyelinase, two products of the acid sphingomyelinase gene
-
Schissel, S. L., Keesler, G. A., Schuchman, E. H., Williams, K. J., and Tabas, I. (1998b). The cellular trafficking and zinc dependence of secretory and lysosomal sphingomyelinase, two products of the acid sphingomyelinase gene. J. Biol. Chem. 273, 18250-18259.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 18250-18259
-
-
Schissel, S.L.1
Keesler, G.A.2
Schuchman, E.H.3
Williams, K.J.4
Tabas, I.5
-
200
-
-
0014083339
-
Sphingomyelinase in normal human spleens and in spleens from subjects with Niemann-Pick disease
-
Schneider, P. B. and Kennedy, E. P. (1967). Sphingomyelinase in normal human spleens and in spleens from subjects with Niemann-Pick disease. J. Lipid Res. 8, 202-209.
-
(1967)
J. Lipid Res.
, vol.8
, pp. 202-209
-
-
Schneider, P.B.1
Kennedy, E.P.2
-
201
-
-
48749133600
-
Acid sphingomyelinase is required for efficient phagolysosomal fusion
-
Schramm, M., Herz, J., Haas, A., Krönke, M., and Utermöhlen, O. (2008). Acid sphingomyelinase is required for efficient phagolysosomal fusion. Cell Microbiol. 10, 1839-1853.
-
(2008)
Cell Microbiol.
, vol.10
, pp. 1839-1853
-
-
Schramm, M.1
Herz, J.2
Haas, A.3
Krönke, M.4
Utermöhlen, O.5
-
202
-
-
35248814255
-
The pathogenesis and treatment of acid sphingomyelinase-deficient Niemann-Pick disease
-
Schuchman, E. H. (2007). The pathogenesis and treatment of acid sphingomyelinase-deficient Niemann-Pick disease. J. Inherit. Metab. Dis. 30, 654-663.
-
(2007)
J. Inherit. Metab. Dis.
, vol.30
, pp. 654-663
-
-
Schuchman, E.H.1
-
203
-
-
77951893147
-
Acid sphingomyelinase, cell membranes and human disease: Lessons from Niemann-Pick disease
-
Schuchman, E. H. (2010). Acid sphingomyelinase, cell membranes and human disease: lessons from Niemann-Pick disease. FEBS Lett. 584, 1895-1900.
-
(2010)
FEBS Lett.
, vol.584
, pp. 1895-1900
-
-
Schuchman, E.H.1
-
204
-
-
0031291717
-
Niemann-Pick disease: Mutation update, genotype/phenotype correlations, and prospects for genetic testing
-
Schuchman, E. H. and Miranda, S. R. P. (1997). Niemann-Pick disease: mutation update, genotype/phenotype correlations, and prospects for genetic testing. Genet. Test. 1, 13-19.
-
(1997)
Genet. Test.
, vol.1
, pp. 13-19
-
-
Schuchman, E.H.1
Miranda, S.R.P.2
-
205
-
-
0025819971
-
Human acid sphingomyelinase. Isolation, nucleotide sequence and expression of the full-length and alternatively spliced cDNAs
-
Schuchman, E. H., Suchi, M., Takahashi, T., Sandhoff, K., and Desnick, R. J. (1991). Human acid sphingomyelinase. Isolation, nucleotide sequence and expression of the full-length and alternatively spliced cDNAs. J. Biol. Chem. 266, 8531-8539.
-
(1991)
J. Biol. Chem.
, vol.266
, pp. 8531-8539
-
-
Schuchman, E.H.1
Suchi, M.2
Takahashi, T.3
Sandhoff, K.4
Desnick, R.J.5
-
206
-
-
0032489554
-
TNF receptor death domain-associated proteins TRADD and FADD signal activation of acid sphingomyelinase
-
Schwandner, R., Wiegmann, K., Bernardo, K., Kreder, D., and Krönke, M. (1998). TNF receptor death domain-associated proteins TRADD and FADD signal activation of acid sphingomyelinase. J. Biol. Chem. 273, 5916-5922.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 5916-5922
-
-
Schwandner, R.1
Wiegmann, K.2
Bernardo, K.3
Kreder, D.4
Krönke, M.5
-
207
-
-
0018188205
-
An improved and simple micro-method of sphingomyelinase assay in leukocytes and urine
-
Seidel, D., Klenke, J., Fischer, G., and Pilz, H. (1978). An improved and simple micro-method of sphingomyelinase assay in leukocytes and urine. J. Clin. Chem. Clin. Biochem. 16, 407-411.
-
(1978)
J. Clin. Chem. Clin. Biochem.
, vol.16
, pp. 407-411
-
-
Seidel, D.1
Klenke, J.2
Fischer, G.3
Pilz, H.4
-
208
-
-
80052103076
-
Flipping and flopping-lipids on the move
-
Sharom, F. J. (2011). Flipping and flopping-lipids on the move. IUBMB Life 63, 736-746.
-
(2011)
IUBMB Life
, vol.63
, pp. 736-746
-
-
Sharom, F.J.1
-
209
-
-
0023882543
-
Microelectrode studies on the acid microenvironment beneath adherent macrophages and osteoclasts
-
Silver, I. A., Murrills, R. J., and Etherington, D. J. (1988). Microelectrode studies on the acid microenvironment beneath adherent macrophages and osteoclasts. Exp. Cell Res. 175, 266-276.
-
(1988)
Exp. Cell Res.
, vol.175
, pp. 266-276
-
-
Silver, I.A.1
Murrills, R.J.2
Etherington, D.J.3
-
210
-
-
0345320407
-
Sphingolipid metabolism during human platelet activation
-
Simon, C. G., Jr. and Gear, A. R. L. (1999). Sphingolipid metabolism during human platelet activation. Thromb. Res. 94, 13-23.
-
(1999)
Thromb. Res.
, vol.94
, pp. 13-23
-
-
Simon, C.G.J.1
Gear, A.R.L.2
-
211
-
-
0032524380
-
Sphingomyelinase activity in human platelets
-
Simon, C. G., Jr., Chatterjee, S., and Gear, A. R. L. (1998). Sphingomyelinase activity in human platelets. Thromb. Res. 90, 155-161.
-
(1998)
Thromb. Res.
, vol.90
, pp. 155-161
-
-
Simon, C.G.1
Chatterjee, S.2
Gear, A.R.L.3
-
212
-
-
0036914191
-
The demographics and distribution of type B Niemann-Pick disease: Novel mutations lead to new genotype/phenotype correlations
-
Simonaro, C. M., Desnick, R. J., McGovern, M. M., Wasserstein, M. P., and Schuchman, E. H. (2002). The demographics and distribution of type B Niemann-Pick disease: novel mutations lead to new genotype/phenotype correlations. Am. J. Hum. Genet. 71, 1413-1419.
-
(2002)
Am. J. Hum. Genet.
, vol.71
, pp. 1413-1419
-
-
Simonaro, C.M.1
Desnick, R.J.2
McGovern, M.M.3
Wasserstein, M.P.4
Schuchman, E.H.5
-
213
-
-
0025202558
-
Rapid turn-over of plasma membrane sphingomyelin and cholesterol in baby hamster kidney cells after exposure to sphingomyelinase
-
Slotte, J. P., Härmälä, A. S., Jansson, C., and Pörn, M. I. (1990). Rapid turn-over of plasma membrane sphingomyelin and cholesterol in baby hamster kidney cells after exposure to sphingomyelinase. Biochim. Biophys. Acta 1030, 251-257.
-
(1990)
Biochim. Biophys. Acta
, vol.1030
, pp. 251-257
-
-
Slotte, J.P.1
Härmälä, A.S.2
Jansson, C.3
Pörn, M.I.4
-
214
-
-
54049092827
-
The unexpected role of acid sphingomyelinase in cell death and the pathophysiology of common diseases
-
Smith, E. L. and Schuchman, E. H. (2008). The unexpected role of acid sphingomyelinase in cell death and the pathophysiology of common diseases. FASEB J. 22, 3419-3431.
-
(2008)
FASEB J.
, vol.22
, pp. 3419-3431
-
-
Smith, E.L.1
Schuchman, E.H.2
-
215
-
-
84864859102
-
Conformational changes of apoB-100 in SMase-modified LDL mediate formation of large aggregates at acidic pH
-
Sneck, M., Nguyen, S. D., Pihlajamaa, T., Yohannes, G., Riekkola, M. L., Milne, R., Kovanen, P. T., and Öörni, K. (2012). Conformational changes of apoB-100 in SMase-modified LDL mediate formation of large aggregates at acidic pH. J. Lipid Res. 53, 1832-1839.
-
(2012)
J. Lipid Res.
, vol.53
, pp. 1832-1839
-
-
Sneck, M.1
Nguyen, S.D.2
Pihlajamaa, T.3
Yohannes, G.4
Riekkola, M.L.5
Milne, R.6
Kovanen, P.T.7
Öörni, K.8
-
216
-
-
0027420322
-
Captopril inhibits the 72 kDa and 92 kDa matrix metalloproteinases
-
Sorbi, D., Fadly, M., Hicks, R., Alexander, S., and Arbeit, L. (1993). Captopril inhibits the 72 kDa and 92 kDa matrix metalloproteinases. Kidney Int. 44, 1266-1272.
-
(1993)
Kidney Int.
, vol.44
, pp. 1266-1272
-
-
Sorbi, D.1
Fadly, M.2
Hicks, R.3
Alexander, S.4
Arbeit, L.5
-
217
-
-
51249103180
-
Cholesterol displacement by ceramide in sphingomyelin-containing liquid-ordered domains, and generation of gel regions in giant lipidic vesicles
-
Sot, J., Ibarguren, M., Busto, J. V., Montes, L. R., Goñi, F. M., and Alonso, A. (2008). Cholesterol displacement by ceramide in sphingomyelin-containing liquid-ordered domains, and generation of gel regions in giant lipidic vesicles. FEBS Lett. 582, 3230-3236.
-
(2008)
FEBS Lett.
, vol.582
, pp. 3230-3236
-
-
Sot, J.1
Ibarguren, M.2
Busto, J.V.3
Montes, L.R.4
Goñi, F.M.5
Alonso, A.6
-
218
-
-
84887934289
-
Genetics of Parkinson's disease: The yield
-
Spatola, M. and Wider, C. (2014). Genetics of Parkinson's disease: the yield. Parkinsonism Relat. Disord. 20(Suppl 1), S35-S38.
-
(2014)
Parkinsonism Relat. Disord.
, vol.20
, pp. S35-S38
-
-
Spatola, M.1
Wider, C.2
-
219
-
-
0018367734
-
Neutral and acid sphingomyelinases: Somatotopographical distribution in human brain and distribution in rat organs. A possible relationship with the dopamine system
-
Spence, M. W., Burgess, J. K., and Sperker, E. R. (1979). Neutral and acid sphingomyelinases: somatotopographical distribution in human brain and distribution in rat organs. A possible relationship with the dopamine system. Brain Res. 168, 543-551.
-
(1979)
Brain Res.
, vol.168
, pp. 543-551
-
-
Spence, M.W.1
Burgess, J.K.2
Sperker, E.R.3
-
221
-
-
55749095009
-
The role of sphingomyelin in regulating phase coexistence in complex lipid model membranes: Competition between ceramide and cholesterol
-
Staneva, G., Chachaty, C., Wolf, C., Koumanov, K., and Quinn, P. J. (2008). The role of sphingomyelin in regulating phase coexistence in complex lipid model membranes: competition between ceramide and cholesterol. Biochim. Biophys. Acta 1778, 2727-2739.
-
(2008)
Biochim. Biophys. Acta
, vol.1778
, pp. 2727-2739
-
-
Staneva, G.1
Chachaty, C.2
Wolf, C.3
Koumanov, K.4
Quinn, P.J.5
-
222
-
-
60549102443
-
Membrane microdomains: Role of ceramides in the maintenance of their structure and functions
-
Staneva, G., Momchilova, A., Wolf, C., Quinn, P. J., and Koumanov, K. (2009). Membrane microdomains: role of ceramides in the maintenance of their structure and functions. Biochim. Biophys. Acta 1788, 666-675.
-
(2009)
Biochim. Biophys. Acta
, vol.1788
, pp. 666-675
-
-
Staneva, G.1
Momchilova, A.2
Wolf, C.3
Quinn, P.J.4
Koumanov, K.5
-
223
-
-
52049104445
-
A fluorescent glycolipid-binding peptide probe traces cholesterol dependent microdomain-derived trafficking pathways
-
Steinert, S., Lee, E., Tresset, G., Zhang, D., Hortsch, R., Wetzel, R., Hebbar, S., Sundram, J. R., Kesavapany, S., Boschke, E., et al. (2008). A fluorescent glycolipid-binding peptide probe traces cholesterol dependent microdomain-derived trafficking pathways. PLOS One 3, e2933.
-
(2008)
PLOS One
, vol.3
, pp. e2933
-
-
Steinert, S.1
Lee, E.2
Tresset, G.3
Zhang, D.4
Hortsch, R.5
Wetzel, R.6
Hebbar, S.7
Sundram, J.R.8
Kesavapany, S.9
Boschke, E.10
-
224
-
-
84888045691
-
Zinc in depression: A meta-analysis
-
Swardfager, W., Herrmann, N., Mazereeuw, G., Goldberger, K., Harimoto, T., and Lanctôt, K. L. (2013a). Zinc in depression: a meta-analysis. Biol. Psychiatry 74, 872-878.
-
(2013)
Biol. Psychiatry
, vol.74
, pp. 872-878
-
-
Swardfager, W.1
Herrmann, N.2
Mazereeuw, G.3
Goldberger, K.4
Harimoto, T.5
Lanctôt, K.L.6
-
225
-
-
84877091127
-
Potential roles of zinc in the pathophysiology and treatment of major depressive disorder
-
Swardfager, W., Herrmann, N., McIntyre, R. S., Mazereeuw, G., Goldberger, K., Cha, D. S., Schwartz, Y., and Lanctôt, K. L. (2013b). Potential roles of zinc in the pathophysiology and treatment of major depressive disorder. Neurosci. Biobehav. Rev. 37, 911-929.
-
(2013)
Neurosci. Biobehav. Rev.
, vol.37
, pp. 911-929
-
-
Swardfager, W.1
Herrmann, N.2
McIntyre, R.S.3
Mazereeuw, G.4
Goldberger, K.5
Cha, D.S.6
Schwartz, Y.7
Lanctôt, K.L.8
-
226
-
-
0032868934
-
Secretory sphingomyelinase
-
Tabas, I. (1999). Secretory sphingomyelinase. Chem. Phys. Lipids 102, 123-130.
-
(1999)
Chem. Phys. Lipids
, vol.102
, pp. 123-130
-
-
Tabas, I.1
-
227
-
-
37349021003
-
Subendothelial lipoprotein retention as the initiating process in atherosclerosis: Update and therapeutic implications
-
Tabas, I., Williams, K. J., and Borén, J. (2007). Subendothelial lipoprotein retention as the initiating process in atherosclerosis: update and therapeutic implications. Circulation 116, 1832-1844.
-
(2007)
Circulation
, vol.116
, pp. 1832-1844
-
-
Tabas, I.1
Williams, K.J.2
Borén, J.3
-
228
-
-
0034268524
-
Distribution of acid sphingomyelinase in human various body fluids
-
Takahashi, I., Takahashi, T., Abe, T., Watanabe, W., and Takada, G. (2000). Distribution of acid sphingomyelinase in human various body fluids. Tohoku J. Exp. Med. 192, 61-66.
-
(2000)
Tohoku J. Exp. Med.
, vol.192
, pp. 61-66
-
-
Takahashi, I.1
Takahashi, T.2
Abe, T.3
Watanabe, W.4
Takada, G.5
-
229
-
-
0036069179
-
Elevated sphingomyelinase and hypercytokinemia in hemophagocytic lymphohistiocytosis
-
Takahashi, T., Abe, T., Sato, T., Miura, K., Takahashi, I., Yano, M., Watanabe, A., Imashuku, S., and Takada, G. (2002). Elevated sphingomyelinase and hypercytokinemia in hemophagocytic lymphohistiocytosis. J. Pediatr. Hematol. Oncol. 24, 401-404.
-
(2002)
J. Pediatr. Hematol. Oncol.
, vol.24
, pp. 401-404
-
-
Takahashi, T.1
Abe, T.2
Sato, T.3
Miura, K.4
Takahashi, I.5
Yano, M.6
Watanabe, A.7
Imashuku, S.8
Takada, G.9
-
230
-
-
23944502295
-
Acid sphingomyelinase: Relation of 93lysine residue on the ratio of intracellular to secreted enzyme activity
-
Takahashi, I., Takahashi, T., Mikami, T., Komatsu, M., Ohura, T., Schuchman, E. H., and Takada, G. (2005). Acid sphingomyelinase: relation of 93lysine residue on the ratio of intracellular to secreted enzyme activity. Tohoku J. Exp. Med. 206, 333-340.
-
(2005)
Tohoku J. Exp. Med.
, vol.206
, pp. 333-340
-
-
Takahashi, I.1
Takahashi, T.2
Mikami, T.3
Komatsu, M.4
Ohura, T.5
Schuchman, E.H.6
Takada, G.7
-
231
-
-
84912076652
-
Phospholipid flippase activities and substrate specificities of human type IV P-type ATPases localized to the plasma membrane
-
Takatsu, H., Tanaka, G., Segawa, K., Suzuki, J., Nagata, S., Nakayama, K. and Shin, H. W. (2014). Phospholipid flippase activities and substrate specificities of human type IV P-type ATPases localized to the plasma membrane. J. Biol. Chem. 289, 33543-33556.
-
(2014)
J. Biol. Chem.
, vol.289
, pp. 33543-33556
-
-
Takatsu, H.1
Tanaka, G.2
Segawa, K.3
Suzuki, J.4
Nagata, S.5
Nakayama, K.6
Shin, H.W.7
-
232
-
-
0028069937
-
Localization in rat brain of the trace metals, zinc and manganese, after intracerebroventricular injection
-
Takeda, A., Sawashita, J., and Okada, S. (1994). Localization in rat brain of the trace metals, zinc and manganese, after intracerebroventricular injection. Brain Res. 658, 252-254.
-
(1994)
Brain Res.
, vol.658
, pp. 252-254
-
-
Takeda, A.1
Sawashita, J.2
Okada, S.3
-
233
-
-
0028855886
-
Biological half-lives of zinc and manganese in rat brain
-
Takeda, A., Sawashita, J., and Okada, S. (1995). Biological half-lives of zinc and manganese in rat brain. Brain Res. 695, 53-58.
-
(1995)
Brain Res.
, vol.695
, pp. 53-58
-
-
Takeda, A.1
Sawashita, J.2
Okada, S.3
-
234
-
-
77953576191
-
Exocytosis of acid sphingomyelinase by wounded cells promotes endocytosis and plasma membrane repair
-
Tam, C., Idone, V., Devlin, C., Fernandes, M. C., Flannery, A., He, X., Schuchman, E., Tabas, I., and Andrews, N. W. (2010). Exocytosis of acid sphingomyelinase by wounded cells promotes endocytosis and plasma membrane repair. J. Cell Biol. 189, 1027-1038.
-
(2010)
J. Cell Biol.
, vol.189
, pp. 1027-1038
-
-
Tam, C.1
Idone, V.2
Devlin, C.3
Fernandes, M.C.4
Flannery, A.5
He, X.6
Schuchman, E.7
Tabas, I.8
Andrews, N.W.9
-
235
-
-
84893348774
-
2+ and sphingomyelinase in the repair of pore-forming toxin wounds
-
2+ and sphingomyelinase in the repair of pore-forming toxin wounds. J. Vis. Exp. e50531.
-
(2013)
J. Vis. Exp.
, pp. e50531
-
-
Tam, C.1
Flannery, A.R.2
Andrews, N.3
-
236
-
-
32044475128
-
Niemann-Pick type C disease: Novel NPC1 mutations and characterization of the concomitant acid sphingomyelinase deficiency
-
Tamura, H., Takahashi, T., Ban, N., Torisu, H., Ninomiya, H., Takada, G., and Inagaki, N. (2006). Niemann-Pick type C disease: novel NPC1 mutations and characterization of the concomitant acid sphingomyelinase deficiency. Mol. Genet. Metab. 87, 113-121.
-
(2006)
Mol. Genet. Metab.
, vol.87
, pp. 113-121
-
-
Tamura, H.1
Takahashi, T.2
Ban, N.3
Torisu, H.4
Ninomiya, H.5
Takada, G.6
Inagaki, N.7
-
237
-
-
34248221744
-
Neutral sphingomyelinase 2 is palmitoylated on multiple cysteine residues. Role of palmitoylation in subcellular localization
-
Tani, M. and Hannun, Y. A. (2007). Neutral sphingomyelinase 2 is palmitoylated on multiple cysteine residues. Role of palmitoylation in subcellular localization. J. Biol. Chem. 282, 10047-10056.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 10047-10056
-
-
Tani, M.1
Hannun, Y.A.2
-
238
-
-
0026537635
-
Cytosolic pH regulation in mouse macrophages. Proton extrusion by plasma-membrane-localized H+-ATPase
-
Tapper, H. and Sundler, R. (1992). Cytosolic pH regulation in mouse macrophages. Proton extrusion by plasma-membrane-localized H+-ATPase. Biochem. J. 281(Pt 1), 245-250.
-
(1992)
Biochem. J.
, vol.281
, pp. 245-250
-
-
Tapper, H.1
Sundler, R.2
-
239
-
-
84896760494
-
Relative acidic compartment volume as a lysosomal storage disorder-associated biomarker
-
te Vruchte, D., Speak, A. O., Wallom, K. L., Al Eisa N., Smith, D. A., Hendriksz, C. J., Simmons, L., Lachmann, R. H., Cousins, A., Hartung, R., et al. (2014). Relative acidic compartment volume as a lysosomal storage disorder-associated biomarker. J. Clin. Invest. 124, 1320-1328.
-
(2014)
J. Clin. Invest.
, vol.124
, pp. 1320-1328
-
-
Vruchte, T.D.1
Speak, A.O.2
Wallom, K.L.3
Al Eisa, N.4
Smith, D.A.5
Hendriksz, C.J.6
Simmons, L.7
Lachmann, R.H.8
Cousins, A.9
Hartung, R.10
-
240
-
-
2042499658
-
Acid sphingomyelinase and inhibition by phosphate ion: Role of inhibition by phosphatidyl-myoinositol 3, 4, 5-triphosphate in oligodendrocyte cell signaling
-
Testai, F. D., Landek, M. A., Goswami, R., Ahmed, M., and Dawson, G. (2004). Acid sphingomyelinase and inhibition by phosphate ion: role of inhibition by phosphatidyl-myoinositol 3, 4, 5-triphosphate in oligodendrocyte cell signaling. J. Neurochem. 89, 636-644.
-
(2004)
J. Neurochem.
, vol.89
, pp. 636-644
-
-
Testai, F.D.1
Landek, M.A.2
Goswami, R.3
Ahmed, M.4
Dawson, G.5
-
241
-
-
0024474453
-
Correction of sphingomyelinase deficiency in Niemann-Pick type C fibroblasts by removal of lipoprotein fraction from culture media
-
Thomas, G. H., Tuck-Muller, C. M., Miller, C. S., and Reynolds, L. W. (1989). Correction of sphingomyelinase deficiency in Niemann-Pick type C fibroblasts by removal of lipoprotein fraction from culture media. J. Inherit. Metab. Dis. 12, 139-151.
-
(1989)
J. Inherit. Metab. Dis.
, vol.12
, pp. 139-151
-
-
Thomas, G.H.1
Tuck-Muller, C.M.2
Miller, C.S.3
Reynolds, L.W.4
-
242
-
-
40049112564
-
Ceramide triggers budding of exosome vesicles into multivesicular endosomes
-
Trajkovic, K., Hsu, C., Chiantia, S., Rajendran, L., Wenzel, D., Wieland, F., Schwille, P., Brügger, B., and Simons, M. (2008). Ceramide triggers budding of exosome vesicles into multivesicular endosomes. Science 319, 1244-1247.
-
(2008)
Science
, vol.319
, pp. 1244-1247
-
-
Trajkovic, K.1
Hsu, C.2
Chiantia, S.3
Rajendran, L.4
Wenzel, D.5
Wieland, F.6
Schwille, P.7
Brügger, B.8
Simons, M.9
-
243
-
-
51849153232
-
Quantitative modeling of selective lysosomal targeting for drug design
-
Trapp, S., Rosania, G. R., Horobin, R. W., and Kornhuber, J. (2008). Quantitative modeling of selective lysosomal targeting for drug design. Eur. Biophys. J. 37, 1317-1328.
-
(2008)
Eur. Biophys. J.
, vol.37
, pp. 1317-1328
-
-
Trapp, S.1
Rosania, G.R.2
Horobin, R.W.3
Kornhuber, J.4
-
244
-
-
84859313174
-
Differential regulation of acid sphingomyelinase in macrophages stimulated with oxidized low-density lipoprotein (LDL) and oxidized LDL immune complexes: Role in phagocytosis and cytokine release
-
Truman, J. P., Al Gadban, M. M., Smith, K. J., Jenkins, R. W., Mayroo, N., Virella, G., Lopes-Virella, M. F., Bielawska, A., Hannun, Y. A., and Hammad, S. M. (2012). Differential regulation of acid sphingomyelinase in macrophages stimulated with oxidized low-density lipoprotein (LDL) and oxidized LDL immune complexes: role in phagocytosis and cytokine release. Immunology 136, 30-45.
-
(2012)
Immunology
, vol.136
, pp. 30-45
-
-
Truman, J.P.1
Al Gadban, M.M.2
Smith, K.J.3
Jenkins, R.W.4
Mayroo, N.5
Virella, G.6
Lopes-Virella, M.F.7
Bielawska, A.8
Hannun, Y.A.9
Hammad, S.M.10
-
245
-
-
0345505643
-
Severe impairment in early host defense against Listeria monocytogenes in mice deficient in acid sphingomyelinase
-
Utermöhlen, O., Karow, U., Löhler, J., and Krönke, M. (2003). Severe impairment in early host defense against Listeria monocytogenes in mice deficient in acid sphingomyelinase. J. Immunol. 170, 2621-2628.
-
(2003)
J. Immunol.
, vol.170
, pp. 2621-2628
-
-
Utermöhlen, O.1
Karow, U.2
Löhler, J.3
Krönke, M.4
-
246
-
-
38549173564
-
Membrane lipids: Where they are and how they behave
-
van Meer, G., Voelker, D. R., and Feigenson, G. W. (2008). Membrane lipids: where they are and how they behave. Nat. Rev. Mol. Cell Biol. 9, 112-124.
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 112-124
-
-
Van Meer, G.1
Voelker, D.R.2
Feigenson, G.W.3
-
247
-
-
0025025442
-
The cysteine switch: A principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family
-
Van Wart, H. E. and Birkedal-Hansen, H. (1990). The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene family. Proc. Natl. Acad. Sci. USA 87, 5578-5582.
-
(1990)
Proc. Natl. Acad. Sci. USA
, vol.87
, pp. 5578-5582
-
-
Van Wart, H.E.1
Birkedal-Hansen, H.2
-
248
-
-
0023919666
-
Sphingomyelinases in human, bovine and porcine seminal plasma
-
Vanha-Perttula, T. (1988). Sphingomyelinases in human, bovine and porcine seminal plasma. FEBS Lett. 233, 263-267.
-
(1988)
FEBS Lett.
, vol.233
, pp. 263-267
-
-
Vanha-Perttula, T.1
-
249
-
-
0025552614
-
Hydrolases from bovine seminal vesicle, prostate and Cowper's gland
-
Vanha-Perttula, T., Rönkkö, S., and Lahtinen, R. (1990). Hydrolases from bovine seminal vesicle, prostate and Cowper's gland. Andrologia 22(Suppl 1), 10-24.
-
(1990)
Andrologia
, vol.22
, pp. 10-24
-
-
Vanha-Perttula, T.1
Rönkkö, S.2
Lahtinen, R.3
-
250
-
-
0018879888
-
Sphingomyelinase activities of various human tissues in control subjects and in Niemann-Pick disease - Development and evaluation of a microprocedure
-
Vanier, M. T., Revol, A., and Fichet, M. (1980). Sphingomyelinase activities of various human tissues in control subjects and in Niemann-Pick disease - development and evaluation of a microprocedure. Clin. Chim. Acta 106, 257-267.
-
(1980)
Clin. Chim. Acta
, vol.106
, pp. 257-267
-
-
Vanier, M.T.1
Revol, A.2
Fichet, M.3
-
251
-
-
84902163560
-
Dietary zinc is associated with a lower incidence of depression: Findings from two Australian cohorts
-
Vashum, K. P., McEvoy, M., Milton, A. H., McElduff, P., Hure, A., Byles, J., and Attia, J. (2014). Dietary zinc is associated with a lower incidence of depression: findings from two Australian cohorts. J. Affect. Disord. 166, 249-257.
-
(2014)
J. Affect. Disord.
, vol.166
, pp. 249-257
-
-
Vashum, K.P.1
McEvoy, M.2
Milton, A.H.3
McElduff, P.4
Hure, A.5
Byles, J.6
Attia, J.7
-
252
-
-
0032939644
-
Ceramides in phospholipid membranes: Effects on bilayer stability and transition to nonlamellar phases
-
Veiga, M. P., Arrondo, J. L. R., Goñi, F. M., and Alonso, A. (1999). Ceramides in phospholipid membranes: effects on bilayer stability and transition to nonlamellar phases. Biophys. J. 76, 342-350.
-
(1999)
Biophys. J.
, vol.76
, pp. 342-350
-
-
Veiga, M.P.1
Arrondo, J.L.R.2
Goñi, F.M.3
Alonso, A.4
-
253
-
-
77957017688
-
Cationic cell-penetrating peptides induce ceramide formation via acid sphingomyelinase: Implications for uptake
-
Verdurmen, W. P. R., Thanos, M., Ruttekolk, I. R., Gulbins, E., and Brock, R. (2010). Cationic cell-penetrating peptides induce ceramide formation via acid sphingomyelinase: implications for uptake. J. Control. Release 147, 171-179.
-
(2010)
J. Control. Release
, vol.147
, pp. 171-179
-
-
Verdurmen, W.P.R.1
Thanos, M.2
Ruttekolk, I.R.3
Gulbins, E.4
Brock, R.5
-
254
-
-
44449165512
-
Improved pulmonary function by acid sphingomyelinase inhibition in a newborn piglet lavage model
-
von Bismarck, P., Wistädt, C. F., Klemm, K., Winoto-Morbach, S., Uhlig, U., Schütze, S., Adam, D., Lachmann, B., Uhlig, S., and Krause, M. F. (2008). Improved pulmonary function by acid sphingomyelinase inhibition in a newborn piglet lavage model. Am. J. Respir. Crit. Care Med. 177, 1233-1241.
-
(2008)
Am. J. Respir. Crit. Care Med.
, vol.177
, pp. 1233-1241
-
-
Von Bismarck, P.1
Wistädt, C.F.2
Klemm, K.3
Winoto-Morbach, S.4
Uhlig, U.5
Schütze, S.6
Adam, D.7
Lachmann, B.8
Uhlig, S.9
Krause, M.F.10
-
255
-
-
77954898687
-
Golgi-tophagosome transport of acid sphingomyelinase and prosaposin is mediated by sortilin
-
Wähe, A., Kasmapour, B., Schmaderer, C., Liebl, D., Sandhoff, K., Nykjaer, A., Griffiths, G., and Gutierrez, M. G. (2010). Golgi-tophagosome transport of acid sphingomyelinase and prosaposin is mediated by sortilin. J. Cell Sci. 123, 2502-2511.
-
(2010)
J. Cell Sci.
, vol.123
, pp. 2502-2511
-
-
Wähe, A.1
Kasmapour, B.2
Schmaderer, C.3
Liebl, D.4
Sandhoff, K.5
Nykjaer, A.6
Griffiths, G.7
Gutierrez, M.G.8
-
256
-
-
80052098877
-
Mechanistic roles of lipoprotein lipase and sphingomyelinase in low density lipoprotein aggregation
-
Walters, M. J. and Wrenn, S. P. (2011). Mechanistic roles of lipoprotein lipase and sphingomyelinase in low density lipoprotein aggregation. J. Colloid Interface Sci. 363, 268-274.
-
(2011)
J. Colloid Interface Sci.
, vol.363
, pp. 268-274
-
-
Walters, M.J.1
Wrenn, S.P.2
-
257
-
-
0028944481
-
A novel polymorphism in the human acid sphingomyelinase gene due to size variation of the signal peptide region
-
Wan, Q. and Schuchman, E. H. (1995). A novel polymorphism in the human acid sphingomyelinase gene due to size variation of the signal peptide region. Biochim. Biophys. Acta 1270, 207-210.
-
(1995)
Biochim. Biophys. Acta
, vol.1270
, pp. 207-210
-
-
Wan, Q.1
Schuchman, E.H.2
-
258
-
-
33748984649
-
Acid sphingomyelinase deficiency: Prevalence and characterization of an intermediate phenotype of Niemann-Pick disease
-
Wasserstein, M. P., Aron, A., Brodie, S. E., Simonaro, C., Desnick, R. J., and McGovern, M. M. (2006). Acid sphingomyelinase deficiency: prevalence and characterization of an intermediate phenotype of Niemann-Pick disease. J. Pediatr. 149, 554-559.
-
(2006)
J. Pediatr.
, vol.149
, pp. 554-559
-
-
Wasserstein, M.P.1
Aron, A.2
Brodie, S.E.3
Simonaro, C.4
Desnick, R.J.5
McGovern, M.M.6
-
259
-
-
0020760699
-
Partial purification and properties of acid sphingomyelinase from rat liver
-
Watanabe, K., Sakuragawa, N., Arima, M., and Satoyoshi, E. (1983). Partial purification and properties of acid sphingomyelinase from rat liver. J. Lipid Res. 24, 596-603.
-
(1983)
J. Lipid Res.
, vol.24
, pp. 596-603
-
-
Watanabe, K.1
Sakuragawa, N.2
Arima, M.3
Satoyoshi, E.4
-
260
-
-
0014428383
-
The lysosomal localization of sphingolipid hydrolases
-
Weinreb, N. J., Brady, R. O., and Tappel, A. L. (1968). The lysosomal localization of sphingolipid hydrolases. Biochim. Biophys. Acta 159, 141-146.
-
(1968)
Biochim. Biophys. Acta
, vol.159
, pp. 141-146
-
-
Weinreb, N.J.1
Brady, R.O.2
Tappel, A.L.3
-
261
-
-
0020966758
-
Release of sphingomyelin phosphodiesterase (acid sphingomyelinase). By ammonium chloride from CL 1D mouse L-cells and human fibroblasts. Partial purification and characterization of the exported enzymes
-
Weitz, G., Lindl, T., Hinrichs, U., and Sandhoff, K. (1983). Release of sphingomyelin phosphodiesterase (acid sphingomyelinase). by ammonium chloride from CL 1D mouse L-cells and human fibroblasts. Partial purification and characterization of the exported enzymes. Hoppe-Seylers Z. Physiol. Chem. 364, 863-871.
-
(1983)
Hoppe-seylers Z. Physiol. Chem.
, vol.364
, pp. 863-871
-
-
Weitz, G.1
Lindl, T.2
Hinrichs, U.3
Sandhoff, K.4
-
262
-
-
0021951061
-
Soluble sphingomyelinase from human urine as antigen for obtaining anti-sphingomyelinase antibodies
-
Weitz, G., Driessen, M., Brouwer-Kelder, E. M., Sandhoff, K., Barranger, J. A., Tager, J. M., and Schram, A. W. (1985). Soluble sphingomyelinase from human urine as antigen for obtaining anti-sphingomyelinase antibodies. Biochim. Biophys. Acta 838, 92-97.
-
(1985)
Biochim. Biophys. Acta
, vol.838
, pp. 92-97
-
-
Weitz, G.1
Driessen, M.2
Brouwer-Kelder, E.M.3
Sandhoff, K.4
Barranger, J.A.5
Tager, J.M.6
Schram, A.W.7
-
263
-
-
0017122067
-
I-cell disease: Activities of lysosomal enzymes toward natural and synthetic substrates
-
Wenger, D. A., Sattler, M., Clark, C., and Wharton, C. (1976). I-cell disease: activities of lysosomal enzymes toward natural and synthetic substrates. Life. Sci. 19, 413-420.
-
(1976)
Life. Sci.
, vol.19
, pp. 413-420
-
-
Wenger, D.A.1
Sattler, M.2
Clark, C.3
Wharton, C.4
-
264
-
-
12944316607
-
Acute systemic inflammation up-regulates secretory sphingomyelinase in vivo: A possible link between inflammatory cytokines and atherogenesis
-
Wong, M. L., Xie, B., Beatini, N., Phu, P., Marathe, S., Johns, A., Gold, P. W., Hirsch, E., Williams, K. J., Licinio, J., et al. (2000). Acute systemic inflammation up-regulates secretory sphingomyelinase in vivo: a possible link between inflammatory cytokines and atherogenesis. Proc. Natl. Acad. Sci. USA 97, 8681-8686.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 8681-8686
-
-
Wong, M.L.1
Xie, B.2
Beatini, N.3
Phu, P.4
Marathe, S.5
Johns, A.6
Gold, P.W.7
Hirsch, E.8
Williams, K.J.9
Licinio, J.10
-
265
-
-
84897018661
-
The p. L302P mutation in the lysosomal enzyme gene SMPD1 is a risk factor for Parkinson disease
-
Wu, R. M., Lin, C. H., and Lin, H. I. (2014). The p. L302P mutation in the lysosomal enzyme gene SMPD1 is a risk factor for Parkinson disease. Neurology 82, 283.
-
(2014)
Neurology
, vol.82
, pp. 283
-
-
Wu, R.M.1
Lin, C.H.2
Lin, H.I.3
-
266
-
-
84859726313
-
Requirement of translocated lysosomal V1 H+-ATPase for activation of membrane acid sphingomyelinase and raft clustering in coronary endothelial cells
-
Xu, M., Xia, M., Li, X. X., Han, W. Q., Boini, K. M., Zhang, F., Zhang, Y., Ritter, J. K., and Li, P. L. (2012). Requirement of translocated lysosomal V1 H+-ATPase for activation of membrane acid sphingomyelinase and raft clustering in coronary endothelial cells. Mol. Biol. Cell 23, 1546-1557.
-
(2012)
Mol. Biol. Cell
, vol.23
, pp. 1546-1557
-
-
Xu, M.1
Xia, M.2
Li, X.X.3
Han, W.Q.4
Boini, K.M.5
Zhang, F.6
Zhang, Y.7
Ritter, J.K.8
Li, P.L.9
-
267
-
-
0028070703
-
Microbial endoglycosidases for analyses of oligosaccharide chains in glycoproteins
-
Yamamoto, K. (1994). Microbial endoglycosidases for analyses of oligosaccharide chains in glycoproteins. J. Biochem. 116, 229-235.
-
(1994)
J. Biochem.
, vol.116
, pp. 229-235
-
-
Yamamoto, K.1
-
268
-
-
0020317596
-
Acid sphingomyelinase of human brain: Purification to homogeneity
-
Yamanaka, T. and Suzuki, K. (1982). Acid sphingomyelinase of human brain: purification to homogeneity. J. Neurochem. 38, 1753-1764.
-
(1982)
J. Neurochem.
, vol.38
, pp. 1753-1764
-
-
Yamanaka, T.1
Suzuki, K.2
-
269
-
-
84861207340
-
WormBase 2012: More genomes, more data, new website
-
Yook, K., Harris, T. W., Bieri, T., Cabunoc, A., Chan, J., Chen, W. J., Davis, P., de la Cruz, N., Duong, A., Fang, R., et al. (2012). WormBase 2012: more genomes, more data, new website. Nucleic Acids Res. 40, D735-D741.
-
(2012)
Nucleic Acids Res.
, vol.40
, pp. D735-D741
-
-
Yook, K.1
Harris, T.W.2
Bieri, T.3
Cabunoc, A.4
Chan, J.5
Chen, W.J.6
Davis, P.7
De La Cruz, N.8
Duong, A.9
Fang, R.10
-
270
-
-
0022367017
-
Reduction of acid sphingomyelinase activity in human fibroblasts induced by AY-9944 and other cationic amphiphilic drugs
-
Yoshida, Y., Arimoto, K., Sato, M., Sakuragawa, N., Arima, M., and Satoyoshi, E. (1985). Reduction of acid sphingomyelinase activity in human fibroblasts induced by AY-9944 and other cationic amphiphilic drugs. J. Biochem. (Tokyo) 98, 1669-1679.
-
(1985)
J. Biochem. (Tokyo)
, vol.98
, pp. 1669-1679
-
-
Yoshida, Y.1
Arimoto, K.2
Sato, M.3
Sakuragawa, N.4
Arima, M.5
Satoyoshi, E.6
-
271
-
-
84923914371
-
Ceramide is upregulated and associated with mortality in patients with chronic heart failure
-
in press
-
Yu, J., Pan, W., Shi, R., Yang, T., Li, Y., Yu, G., Bai, Y., Schuchman, E. H., He, X., and Zhang, G. (2015). Ceramide is upregulated and associated with mortality in patients with chronic heart failure. Can. J. Cardiol., in press.
-
(2015)
Can. J. Cardiol.
-
-
Yu, J.1
Pan, W.2
Shi, R.3
Yang, T.4
Li, Y.5
Yu, G.6
Bai, Y.7
Schuchman, E.H.8
He, X.9
Zhang, G.10
-
272
-
-
34249657837
-
Activation of acid sphingomyelinase by protein kinase Cd-mediated phosphorylation
-
Zeidan, Y. H. and Hannun, Y. A. (2007a). Activation of acid sphingomyelinase by protein kinase Cd-mediated phosphorylation. J. Biol. Chem. 282, 11549-11561.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 11549-11561
-
-
Zeidan, Y.H.1
Hannun, Y.A.2
-
273
-
-
34547149529
-
Translational aspects of sphingolipid metabolism
-
Zeidan, Y. H. and Hannun, Y. A. (2007b). Translational aspects of sphingolipid metabolism. Trends Mol. Med. 13, 327-336.
-
(2007)
Trends Mol. Med.
, vol.13
, pp. 327-336
-
-
Zeidan, Y.H.1
Hannun, Y.A.2
-
274
-
-
33746917065
-
Acid ceramidase but not acid sphingomyelinase is required for tumor necrosis factor-α-induced PGE2 production
-
Zeidan, Y. H., Pettus, B. J., Elojeimy, S., Taha, T., Obeid, L. M., Kawamori, T., Norris, J. S., and Hannun, Y. A. (2006). Acid ceramidase but not acid sphingomyelinase is required for tumor necrosis factor-α-induced PGE2 production. J. Biol. Chem. 281, 24695-24703.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 24695-24703
-
-
Zeidan, Y.H.1
Pettus, B.J.2
Elojeimy, S.3
Taha, T.4
Obeid, L.M.5
Kawamori, T.6
Norris, J.S.7
Hannun, Y.A.8
-
275
-
-
42449138318
-
Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ceramide pathway
-
Zeidan, Y. H., Jenkins, R. W., and Hannun, Y. A. (2008a). Remodeling of cellular cytoskeleton by the acid sphingomyelinase/ceramide pathway. J. Cell Biol. 181, 335-350.
-
(2008)
J. Cell Biol.
, vol.181
, pp. 335-350
-
-
Zeidan, Y.H.1
Jenkins, R.W.2
Hannun, Y.A.3
-
276
-
-
38049098527
-
A novel role for protein kinase Cδ-mediated phosphorylation of acid sphingomyelinase in UV light-induced mitochondrial injury
-
Zeidan, Y. H., Wu, B. X., Jenkins, R. W., Obeid, L. M., and Hannun, Y. A. (2008b). A novel role for protein kinase Cδ-mediated phosphorylation of acid sphingomyelinase in UV light-induced mitochondrial injury. FASEB J. 22, 183-193.
-
(2008)
FASEB J.
, vol.22
, pp. 183-193
-
-
Zeidan, Y.H.1
Wu, B.X.2
Jenkins, R.W.3
Obeid, L.M.4
Hannun, Y.A.5
-
277
-
-
0031943690
-
Sphingomyelinase treatment induces ATP-independent endocytosis
-
Zha, X., Pierini, L. M., Leopold, P. L., Skiba, P. J., Tabas, I., and Maxfield, F. R. (1998). Sphingomyelinase treatment induces ATP-independent endocytosis. J. Cell Biol. 140, 39-47.
-
(1998)
J. Cell Biol.
, vol.140
, pp. 39-47
-
-
Zha, X.1
Pierini, L.M.2
Leopold, P.L.3
Skiba, P.J.4
Tabas, I.5
Maxfield, F.R.6
|