Sigma 1 receptor activation regulates brain-derived neurotrophic factor through NR2A-CaMKIV-TORC1 pathway to rescue the impairment of learning and memory induced by brain ischaemia/reperfusion

Psychopharmacology

Volumn 232, Issue 10, 2015, Pages 1779-1791

  Xu, Qian ^a   Ji, Xue Fei ^a   Chi, Tian Yan ^a   Liu, Peng ^a   Jin, Ge ^a   Gu, Shao Li ^a   Zou, Li Bo ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Brain ischaemia reperfusion model; Brain derived neurotrophic factor; DTG; Learning and memory; NR2A CaMKIV TORC1; PRE084; Sigma 1 receptor

Indexed keywords

2-(4-MORPHOLINO)ETHYL-1-PHENYLCYCLOHEXANE-1-CARBOXYLATE; BRAIN DERIVED NEUROTROPHIC FACTOR; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE IV; CAMK4 PROTEIN, MOUSE; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MORPHOLINE DERIVATIVE; MULTIPROTEIN COMPLEX; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N-METHYL D-ASPARTATE RECEPTOR SUBTYPE 2A; SIGMA OPIATE RECEPTOR; SIGMA-1 RECEPTOR; TARGET OF RAPAMYCIN KINASE;

AGONISTS; ANIMAL; BRAIN ISCHEMIA; C57BL MOUSE; COMPLICATION; DRUG EFFECTS; FEMALE; MALE; MEMORY; METABOLISM; MOUSE; PHYSIOLOGY; REPERFUSION INJURY;

ANIMALS; BRAIN ISCHEMIA; BRAIN-DERIVED NEUROTROPHIC FACTOR; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 4; FEMALE; MALE; MEMORY; MICE; MICE, INBRED C57BL; MORPHOLINES; MULTIPROTEIN COMPLEXES; RECEPTORS, N-METHYL-D-ASPARTATE; RECEPTORS, SIGMA; REPERFUSION INJURY; TOR SERINE-THREONINE KINASES;

EID: 84939952436     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-014-3809-6     Document Type: Article

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