Preventive effect of silymarin in cerebral ischemia-reperfusion-induced brain injury in rats possibly through impairing NF-κB and STAT-1 activation

Phytomedicine

Volumn 17, Issue 12, 2010, Pages 963-973

  Hou, Yu Chang ^b,c   Liou, Kuo Tong ^e   Chern, Chang Ming ^f   Wang, Yea Hwey ^f   Liao, Jyh Fei ^f   Chang, Shiou ^g   Chou, Yuan Hwa ^f   Shen, Yuh Chiang ^a,d  

^a NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

^b YUANPEI UNIVERSITY   (Taiwan)

^c CHUNG YUAN CHRISTIAN UNIVERSITY   (Taiwan)

^d NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^e CHINESE CULTURE UNIVERSITY   (Taiwan)

^f NATIONAL YANG MING UNIVERSITY   (Taiwan)

^g TAOYUAN GENERAL HOSPITAL   (Taiwan)

Author keywords

Cerebral ischemia reperfusional (CI R) injury; Cytokine; Inducible nitric oxide synthase (iNOS); Nuclear factor kappa B (NF B); Signal transducer and activator of transcription 1 (STAT 1); Silymarin

Indexed keywords

CYCLOOXYGENASE 2; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; MYELOPEROXIDASE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; SILIBININ; SILYMARIN; STAT1 PROTEIN; SUPEROXIDE; TROLOX C; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INFARCTION; BRAIN INJURY; BRAIN ISCHEMIA; CONTROLLED STUDY; CYTOKINE PRODUCTION; INFLAMMATION; LIPID PEROXIDATION; MALE; NITROSATIVE STRESS; NITROSYLATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; STROKE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; ANTIOXIDANTS; BIOLOGICAL MARKERS; BRAIN INFARCTION; BRAIN ISCHEMIA; CYTOKINES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; LIPID PEROXIDATION; MALE; MICROGLIA; MILK THISTLE; NF-KAPPA B; OXIDATIVE STRESS; PHYTOTHERAPY; PLANT EXTRACTS; PROTEIN CARBONYLATION; RATS; RATS, LONG-EVANS; REPERFUSION INJURY; SILYMARIN; STAT1 TRANSCRIPTION FACTOR; TRANSCRIPTIONAL ACTIVATION;

ANIMALIA; RATTUS; SILYBUM MARIANUM;

EID: 77956569078     PISSN: 09447113     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.phymed.2010.03.012     Document Type: Article

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