MitoPark mice mirror the slow progression of key symptoms and L-DOPA response in Parkinson's disease

Genes, Brain and Behavior

Volumn 9, Issue 2, 2010, Pages 173-181

  Galter, D ^a   Pernold, K ^a   Yoshitake, T ^b   Lindqvist, E ^a   Hoffer, B ^c   Kehr, J ^b   Larsson, N G ^d,e   Olson, L ^a  

^a Department of Neuroscience   (United States)

^b Department of Physiology and Pharmacology ^*  (United States)

^c NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^d KAROLINSKA INSTITUTE   (Sweden)

^e MAX PLANCK INSTITUTE FOR BIOLOGY OF AGEING   (Germany)

Author keywords

Cre loxP system; HPLC; Mitochondria; Striatum; Substantia nigra; Tissue specific knock out mice

Indexed keywords

BRAIN MONOAMINE; DOPAMINE; HOMOVANILLIC ACID; LEVODOPA;

AGED; ANIMAL EXPERIMENT; ARTICLE; BEHAVIORAL SCIENCE; BIOCHEMISTRY; BRAIN CORTEX; BRAIN LEVEL; BRAIN TISSUE; CONTROLLED STUDY; CORPUS STRIATUM; CORRELATION ANALYSIS; DETERIORATION; DISEASE COURSE; DOPAMINERGIC NERVE CELL; DOSE RESPONSE; FEMALE; GENETIC MODEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LOCOMOTION; MALE; MESENCEPHALON; MIDDLE AGED; MITOPARK MICE; MOTOR ACTIVITY; MOUSE; NONHUMAN; OLFACTORY BULB; PARKINSON DISEASE; PRIORITY JOURNAL; TRANSGENIC MOUSE; TREATMENT RESPONSE;

ANIMALS; BASE PAIRING; DISEASE PROGRESSION; DNA PRIMERS; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HIGH MOBILITY GROUP PROTEINS; LEVODOPA; MALE; MESENCEPHALON; MICE; MICE, KNOCKOUT; MODELS, GENETIC; MOTOR ACTIVITY; PARKINSON DISEASE; POLYMERASE CHAIN REACTION; POSTURE;

ANIMALIA; MUS;

EID: 77949342539     PISSN: 16011848     EISSN: 1601183X     Source Type: Journal    
DOI: 10.1111/j.1601-183X.2009.00542.x     Document Type: Article

References (23)

1. Bogaerts, V., Theuns J. & Van Broeckhoven, C. (2008) Genetic findings in Parkinson's disease and translation into treatment: a leading role for mitochondria? Genes Brain Behav 7, 129-151.
2. Chiodo, L.A., Bannon, M.J., Grace, A.A., Roth, R.H. & Bunney, B.S. (1984) Evidence for the absence of impulse-regulating somatodendritic and synthesis-modulating nerve terminal autoreceptors on subpopulations of mesocortical DA neurons. Neuroscience 12, 1-16.
3. Coyle, J.T. (1973) The development of catecholaminergic neurons of the central nervous system. Neurosci Res 5, 35-52.
4. Ekstrand, M. & Larsson, N.G. (2002) Breeding and genotyping of Tfam conditional knockout mice. Methods Mol Biol 197, 391-400.
5. Ekstrand, M., Terzioglu, M., Galter, D., Zhu, S., Hofstetter, C., Lindqvist, E., Thams, S., Bergstrand, A., Hansson, F.S., Trifunovic, A., Hoffer, B., Cullheim, S., Mohammed, A.H., Olson, L. & Larsson, N.G. (2007) Progressive parkinsonism in mice with respiratory-chain-deficient DA neurons. Proc Natl Acad Sci U S A 104, 1325-1330.
6. Fujita, M., Shimada, S., Nishimura, T., Uhl, G.R. & Tohyama, M. (1993) Ontogeny of DA transporter mRNA expression in the rat brain. Brain Res Mol Brain Res 19, 222-226.
7. German, D.C., Manaye, K., Smith, W.K., Woodward, D.J. & Saper, C.B. (1989) Midbrain DArgic cell loss in Parkinson's disease: computer visualization. Ann Neurol 26, 507-514.
8. German, D.C., Manaye, K.F., Sonsalla, P.K. & Brooks, B.A. (1992) Midbrain DArgic cell loss in Parkinson's disease and MPTP-induced parkinsonism: sparing of calbindin-D28k-containing cells. Ann N Y Acad Sci 648, 42-62.
9. Haber, S.N., Ryoo, H., Cox, C. & Lu, W. (1995) Subsets of midbrain DArgic neurons in monkeys are distinguished by different levels of mRNA for the DA transporter: comparison with the mRNA for the D2 receptor, tyrosine hydroxylase and calbindin immunoreactivity. J Comp Neurol 362, 400-410.
10. Huebert, N.D., Palfreyman, M.G. & Haegele, K.D. (1983) A comparison of the effects of reversible and irreversible inhibitors of aromatic L-amino acid decarboxylase on the half-life and other pharmacokinetic parameters of oral L-3,4-dihydroxyphenylalanine. Drug Metab Dispos 11, 195-200.
11. Javoy-Agid, F., Ploska, A. & Agid, Y. (1981) Microtopography of tyrosine hydroxylase, glutamic acid decarboxylase, and choline acetyltransferase in the substantia nigra and ventral tegmental area of control and Parkinsonian brains. J Neurochem 37, 1218-1227.
12. Lammel, S., Hetzel, A., Hackel, O., Jones, I., Liss, B. & Roeper, J. (2008) Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic DA system. Neuron 57, 760-773.
13. Larsson, N.G., Wang, J., Wilhelmsson, H., Oldfors, A., Rustin, P., Lewandoski, M., Barsh, G.S. & Clayton, D.A. (1998) Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice. Nat Genet 18, 231-236.
14. Martens, D.J., Whishaw, I.Q., Miklyaeva, E.I. & Pellis, S.M. (1996) Spatio-temporal impairments in limb and body movements during righting in an hemiparkinsonian rat analogue: relevance to axial apraxia in humans. Brain Res 733, 253-262.
15. Miklyaeva, E.I., Castaneda, E. & Whishaw, I.Q. (1994) Skilled reaching deficits in unilateral DA-depleted rats: impairments in movement and posture and compensatory adjustments. J Neurosci 14, 7148-7158.
16. Miklyaeva, E.I., Martens, D.J. & Whishaw, I.Q. (1995) Impairments and compensatory adjustments in spontaneous movement after unilateral DA depletion in rats. Brain Res 681, 23-40.
17. Miklyaeva, E.I., Woodward, N.C., Nikiforov, E.G., Tompkins, G.J., Klassen, F., Ioffe, M.E. & Whishaw, I.Q. (1997) The ground reaction forces of postural adjustments during skilled reaching in unilateral DA-depleted hemiparkinson rats. Behav Brain Res 88, 143-152.
18. Muir, G.D. & Whishaw, I.Q. (1999) Ground reaction forces in locomoting hemi-parkinsonian rats: a definitive test for impairments and compensations. Exp Brain Res 126, 307-314.
19. Schapira, A.H. (2008)Mitochondria in the aetiology and pathogenesis of Parkinson's disease. Lancet Neurol 7, 97-109.
20. Sorensen, L., Ekstrand,M., Silva, J.P., Lindqvist, E., Xu, B., Rustin, P., Olson, L. & Larsson, N.G. (2001) Late-onset cortico-hippocampal neurodepletion attributable to catastrophic failure of oxidative phosphorylation in MILON mice. J Neurosci 21, 8082-8090.
21. Terzioglu, M. & Galter, D. (2008) Parkinson's disease: genetic versus toxin-induced rodent models. FEBS J 275, 1384-1391.
22. Ungerstedt, U. (1971) Postsynaptic supersensitivity after 6-hydroxy-DA induced degeneration of the nigro-striatal DA system. Acta Physiol Scand Suppl 367, 69-93.
23. Yoshitake, T., Iizuka, R., Yoshitake, S., Weikop, P., Muller, W.E., Ogren, S.O. & Kehr, J. (2004) Hypericum perforatum L preferentially increases extracellular DA levels in the rat prefrontal cortex. Br J Pharmacol 142, 414-418.