Hydroxytyrosol mildly improve cognitive function independent of APP processing in APP/PS1 mice

Molecular Nutrition and Food Research

Volumn 60, Issue 11, 2016, Pages 2331-2342

  Peng, Yunhua ^a   Hou, Chen ^a   Yang, Ziqi ^a   Li, Caixia ^a   Jia, Liyan ^a   Liu, Jing ^a   Tang, Ying ^a   Shi, Le ^a   Li, Yongqin ^b   Long, Jiangang ^a   Liu, Jiankang ^a  

^a XI'AN JIAOTONG UNIVERSITY   (China)

^b THIRD MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Alzheimer's disease; Cognitive function; Hydroxytyrosol; Inflammation; Mediterranean diet; Oxidative stress

Indexed keywords

3,4-DIHYDROXYPHENYLETHANOL; AMYLOID BETA PROTEIN; PHENETHYL ALCOHOL;

AGING; ALZHEIMER DISEASE; ANALOGS AND DERIVATIVES; ANIMAL; BRAIN; CHEMISTRY; COGNITION; DISEASE MODEL; DRUG EFFECTS; MEDITERRANEAN DIET; METABOLISM; MITOCHONDRION; MOUSE; OLIVE TREE; OXIDATIVE STRESS; TRANSGENIC MOUSE;

AGING; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; BRAIN; COGNITION; DIET, MEDITERRANEAN; DISEASE MODELS, ANIMAL; MICE; MICE, TRANSGENIC; MITOCHONDRIA; OLEA; OXIDATIVE STRESS; PHENYLETHYL ALCOHOL;

EID: 84979307934     PISSN: 16134125     EISSN: 16134133     Source Type: Journal    
DOI: 10.1002/mnfr.201600332     Document Type: Article

References (43)

1. Alzheimer's-Association, 2014 Alzheimer's disease facts and figures. Alzheimers Dement. 2014, 10, e47–e92.
2. Querfurth, H. W., LaFerla, F. M., Mechanisms of disease. N. Engl. J. Med. 2010, 362, 329–344.
3. Martinez-Lapiscina, E. H., Clavero, P., Toledo, E., San Julian, B. et al., Virgin olive oil supplementation and long-term cognition: the PREDIMED-NAVARRA randomized, trial. J. Nutr. Health Aging 2013, 17, 544–552.
4. Martinez-Lapiscina, E. H., Clavero, P., Toledo, E., Estruch, R. et al., Mediterranean diet improves cognition: the PREDIMED-NAVARRA randomised trial. J. Neurol. Neurosurg. Psychiatry 2013, 84, 1318–1325.
5. Zheng, A., Li, H., Xu, J., Cao, K. et al., Hydroxytyrosol improves mitochondrial function and reduces oxidative stress in the brain of db/db mice: role of AMP-activated protein kinase activation. Br. J. Nutr. 2015, 113, 1667–1676.
6. Liu, J., Peng, Y., Feng, Z., Shi, W. et al., Reloading functionally ameliorates disuse-induced muscle atrophy by reversing mitochondrial dysfunction, and similar benefits are gained by administering a combination of mitochondrial nutrients. Free Radic. Biol. Med. 2014, 69, 116–128.
7. St-Laurent-Thibault, C., Arseneault, M., Longpre, F., Ramassamy, C., Tyrosol and hydroxytyrosol, two main components of olive oil, protect N2a cells against amyloid-beta-induced toxicity. Involvement of the NF-kappaB signaling. Curr. Alzheimer Res. 2011, 8, 543–551.
8. Liu, J., Shen, W., Zhao, B., Wang, Y. et al., Targeting mitochondrial biogenesis for preventing and treating insulin resistance in diabetes and obesity: hope from natural mitochondrial nutrients. Adv. Drug Deliv. Rev. 2009, 61, 1343–1352.
9. St-Laurent-Thibault, C., Arseneault, M., Longpre, F., Ramassamy, C., Tyrosol and hydroxytyrosol two main components of olive oil, protect N2a cells against amyloid–induced toxicity. Involvement of the NF-kB signaling. Curr. Alzheimer Res. 2011, 8, 543–551.
10. Serra, A., Rubió, L., Borràs, X., Macià, A. et al., Distribution of olive oil phenolic compounds in rat tissues after administration of a phenolic extract from olive cake. Mol. Nutr. Food Res. 2012, 56, 486–496.
11. Cabrerizo, S., La Cruz, D., Pedro, J., López-Villodres, J. A. et al., Role of the inhibition of oxidative stress and inflammatory mediators in the neuroprotective effects of hydroxytyrosol in rat brain slices subjected to hypoxia reoxygenation. J. Nutr. Biochem. 2013, 24, 2152–2157.
12. Borchelt, D. R., Ratovitski, T., van Lare, J., Lee, M. K. et al., Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins. Neuron 1997, 19, 939–945.
13. Chen, B., Song, F. Q., Sun, L. L., Lei, L. Y. et al., Improved early postresuscitation EEG activity for animals treated with hypothermia predicted 96 hr neurological outcome and survival in a rat model of cardiac arrest. Biomed. Res. Int. 2013, 2013, 312137.
14. McBride, J., Zhao, X., Munro, N., Jicha, G. et al., Discrimination of mild cognitive impairment and Alzheimer's disease using transfer entropy measures of scalp EEG. J. Healthc. Eng. 2015, 6, 55–70.
15. Gallego-Jutgla, E., Sole-Casals, J., Vialatte, F. B., Dauwels, J. et al., A theta-band EEG based index for early diagnosis of Alzheimer's disease. J. Alzheimers Dis. 2015, 43, 1175–1184.
16. Dauwels, J., Vialatte, F., Cichocki, A., Diagnosis of Alzheimer's disease from EEG signals: where are we standing? Curr. Alzheimer Res. 2010, 7, 487–505.
17. Peng, Y., Liu, J., Tang, Y., Liu, J. et al., High-fat-diet-induced weight gain ameliorates bone loss without exacerbating AβPP processing and cognition in female APP/PS1 mice. Front. Cell. Neurosci. 2014, 8, 225.
18. Long, J., He, P., Shen, Y., Li, R., New evidence of mitochondria dysfunction in the female Alzheimer's disease brain: deficiency of estrogen receptor-β;. J. Alzheimers Dis. 2012, 30, 545–558.
19. Long, J., Wang, X., Gao, H., Liu, Z. et al., Malonaldehyde acts as a mitochondrial toxin: inhibitory effects on respiratory function and enzyme activities in isolated rat liver mitochondria. Life Sci. 2006, 79, 1466–1472.
20. Penttila, M., Partanen, J. V., Soininen, H., Riekkinen, P. J., Quantitative analysis of occipital EEG in different stages of Alzheimer's disease. Electroencephalogr. Clin. Neurophysiol. 1985, 60, 1–6.
21. Wang, J., Ikonen, S., Gurevicius, K., Van Groen, T. et al., Alteration of cortical EEG in mice carrying mutated human APP transgene. Brain Res. 2002, 943, 181–190.
22. Rice, D. M., Buchsbaum, M. S., Starr, A., Auslander, L. et al., Abnormal EEG slow activity in left temporal areas in senile dementia of the Alzheimer type. J. Gerontol. 1990, 45, M145–M151.
23. Singh, B., Parsaik, A. K., Mielke, M. M., Erwin, P. J. et al., Association of mediterranean diet with mild cognitive impairment and Alzheimer's disease: a systematic review and meta-analysis. J. Alzheimers Dis. 2014, 39, 271–282.
24. Psaltopoulou, T., Sergentanis, T. N., Panagiotakos, D. B., Sergentanis, I. N. et al., Mediterranean diet, stroke, cognitive impairment, and depression: a meta-analysis. Ann. Neurol. 2013, 74, 580–591.
25. Christian, M. S., Sharper, V. A., Hoberman, A. M., Seng, J. E. et al., The toxicity profile of hydrolyzed aqueous olive pulp extract. Drug Chem. Toxicol. 2004, 27, 309–330.
26. Medina-Remon, A., Tresserra-Rimbau, A., Pons, A., Tur, J. A. et al., Effects of total dietary polyphenols on plasma nitric oxide and blood pressure in a high cardiovascular risk cohort. The PREDIMED randomized trial. Nutr. Metab. Cardiovasc. Dis. 2015, 25, 60–67.
27. Montedoro, G., Servili, M., Baldioli, M., Miniati, E., Simple and hydrolyzable phenolic compounds in virgin olive oil. 1. Their extraction, separation, and quantitative and semiquantitative evaluation by HPLC. J. Agric. Food Chem. 1992, 40, 1571–1576.
28. Terpstra, A., Differences between humans and mice in efficacy of the body fat lowering effect of conjugated linoleic acid: role of metabolic rate. J. Nutr. 2001, 131, 2067–2068.
29. Ansari, M. A., Scheff, S. W., Oxidative stress in the progression of Alzheimer disease in the frontal cortex. J. Neuropathol. Exp. Neurol. 2010, 69, 155–167.
30. Lee, H.-P., Pancholi, N., Esposito, L., Previll, L. A. et al., Early induction of oxidative stress in mouse model of Alzheimer disease with reduced mitochondrial superoxide dismutase activity. PLoS One 2012, 7, e28033.
31. Wirths, O., Breyhan, H., Marcello, A., Cotel, M. C. et al., Inflammatory changes are tightly associated with neurodegeneration in the brain and spinal cord of the APP/PS1KI mouse model of Alzheimer's disease. Neurobiol. Aging 2010, 31, 747–757.
32. Wyss-Coray, T., Inflammation in Alzheimer disease: driving force, bystander or beneficial response? Nat. Med. 2006, 12, 1005–1015.
33. Heneka, M. T., Kummer, M. P., Stutz, A., Delekate, A. et al., NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice. Nature 2013, 493, 674–678.
34. Shi, J. Q., Zhang, C. C., Sun, X. L., Cheng, X. X. et al., Antimalarial drug artemisinin extenuates amyloidogenesis and neuroinflammation in APPswe/PS1dE9 transgenic mice via inhibition of nuclear factor-kappaB and NLRP3 inflammasome activation. CNS Neurosci. Ther. 2013, 19, 262–268.
35. Campbell, I. L., Abraham, C. R., Masliah, E., Kemper, P. et al., Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6. Proc. Natl. Acad. Sci. USA 1993, 90, 10061–10065.
36. Vukic, V., Callaghan, D., Walker, D., Lue, L. F. et al., Expression of inflammatory genes induced by beta-amyloid peptides in human brain endothelial cells and in Alzheimer's brain is mediated by the JNK-AP1 signaling pathway. Neurobiol. Dis. 2009, 34, 95–106.
37. Sokolova, A., Hill, M. D., Rahimi, F., Warden, L. A. et al., Monocyte chemoattractant protein-1 plays a dominant role in the chronic inflammation observed in Alzheimer's disease. Brain Pathol. 2009, 19, 392–398.
38. Xiang, Z., Ho, L., Valdellon, J., Borchelt, D. et al., Cyclooxygenase (COX)-2 and cell cycle activity in a transgenic mouse model of Alzheimer's disease neuropathology. Neurobiol. Aging 2002, 23, 327–334.
39. Zhou, R. B., Yazdi, A. S., Menu, P., Tschopp, J., A role for mitochondria in NLRP3 inflammasome activation (vol 469, pg 221, 2011). Nature 2011, 469, 221–225.
40. Shimada, K., Crother, T. R., Karlin, J., Dagvadorj, J. et al., Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis. Immunity 2012, 36, 401–414.
41. Kannan, K., Jain, S. K., Oxidative stress and apoptosis. Pathophysiology 2000, 7, 153–163.
42. Bamberger, M. E., Landreth, G. E., Inflammation, apoptosis, and Alzheimer's disease. Neuroscientist 2002, 8, 276–283.
43. Arunsundar, M., Shanmugarajan, T. S., Ravichandran, V., 3, 4-Dihydroxyphenylethanol attenuates spatio-cognitive deficits in an Alzheimer's disease mouse model: modulation of the molecular signals in neuronal survival-apoptotic programs. Neurotox. Res. 2014, 27, 143–155.