Biogenesis and functions of exosomes and extracellular vesicles

Methods in Molecular Biology

Volumn 1448, Issue , 2016, Pages 201-216

  Dreyer, Florian ^a   Baur, Andreas ^a  

^a NONE

Author keywords

Biomarker; ESCRT; Exosomes; Extracellular vesicles; HIV

Indexed keywords

BIOLOGICAL MARKER;

BIOGENESIS; CELL COMPOSITION; CELL FUNCTION; EXOSOME; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; NEOPLASM; NONHUMAN; PATHOPHYSIOLOGY; PHASE 1 CLINICAL TRIAL (TOPIC); GENETICS; METABOLISM; PATHOLOGY;

EXOSOMES; EXTRACELLULAR VESICLES; HIV INFECTIONS; HUMANS; NEOPLASMS;

EID: 84979201265     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4939-3753-0_15     Document Type: Chapter

References (81)

1. Skog J et al (2008) Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol 10:1470-1476
2. Muratori C et al (2009) Massive secretion by T cells is caused by HIV Nef in infected cells and by Nef transfer to bystander cells. Cell Host Microbe 6:218-230
3. Bollati V et al (2014) Susceptibility to particle health effects, miRNA and exosomes: rationale and study protocol of the SPHERE study. BMC Public Health 14:1137
4. Trams EG et al (1981) Exfoliation of membrane ecto-enzymes in the form of microvesicles. Biochim Biophys Acta 645:63-70
5. Harding C, Heuser J, Stahl P (1983) Receptormediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes. J Cell Biol 97:329-339
6. Pan BT et al (1985) Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes. J Cell Biol 101:942-948
7. Skokos D et al (2001) Mast cell-dependent B and T lymphocyte activation is mediated by the secretion of immunologically active exosomes. J Immunol 166:868-876
8. Wolfers J et al (2001) Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming. Nat Med 7:297-303
9. Kadiu I et al (2012) Biochemical and biologic characterization of exosomes and microvesicles as facilitators of HIV-1 infection in macrophages. J Immunol 189:744-754
10. Li J et al (2013) Exosomes mediate the cell-tocell transmission of IFN-alpha-induced antiviral activity. Nat Immunol 14:793-803
11. Chatila TA, Williams CB (2014) Regulatory T cells: exosomes deliver tolerance. Immunity 41:3-5
12. Poteryaev D et al (2010) Identification of the switch in early-to-late endosome transition. Cell 141:497-508
13. Thery C, Zitvogel L, Amigorena S (2002) Exosomes: composition, biogenesis and function. Nat Rev Immunol 2:569-579
14. Williams RL, Urbe S (2007) The emerging shape of the ESCRT machinery. Nat Rev Mol Cell Biol 8:355-368
15. Rusten TE, Vaccari T, Stenmark H (2012) Shaping development with ESCRTs. Nat Cell Biol 14:38-45
16. Hurley JH, Hanson PI (2010) Membrane budding and scission by the ESCRT machinery: it’s all in the neck. Nat Rev Mol Cell Biol 11:556-566
17. Robbins PD, Morelli AE (2014) Regulation of immune responses by extracellular vesicles. Nat Rev Immunol 14:195-208
18. Trajkovic K et al (2008) Ceramide triggers budding of exosome vesicles into multivesicular endosomes. Science 319:1244-1247
19. Wu BX, Clarke CJ, Hannun YA (2010) Mammalian neutral sphingomyelinases: regulation and roles in cell signaling responses. Neuromolecular Med 12:320-330
20. Kharaziha P et al (2012) Tumor cell-derived exosomes: a message in a bottle. Biochim Biophys Acta 1826:103-111
21. Ostrowski M et al (2010) Rab27a and Rab27b control different steps of the exosome secretion pathway. Nat Cell Biol 12:19-30; sup pp 11-13
22. Hsu C et al (2010) Regulation of exosome secretion by Rab35 and its GTPase-activating proteins TBC1D10A-C. J Cell Biol 189:223-232
23. Fader CM et al (2009) TI-VAMP/VAMP7 and VAMP3/cellubrevin: two v-SNARE proteins involved in specific steps of the autophagy/ multivesicular body pathways. Biochim Biophys Acta 1793:1901-1916
24. Zitvogel L et al (1998) Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes. Nat Med 4:594-600
25. Bhatnagar S et al (2007) Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo. Blood 110:3234-3244
26. Raposo G et al (1997) Accumulation of major histocompatibility complex class II molecules in mast cell secretory granules and their release upon degranulation. Mol Biol Cell 8: 2631-2645
27. Blanchard N et al (2002) TCR activation of human T cells induces the production of exosomes bearing the TCR/CD3/zeta complex. J Immunol 168:3235-3241
28. Buschow SI et al (2009) MHC II in dendritic cells is targeted to lysosomes or T cell-induced exosomes via distinct multivesicular body pathways. Traffic 10:1528-1542
29. Nolte-’t Hoen EN et al (2009) Activated T cells recruit exosomes secreted by dendritic cells via LFA-1. Blood 113:1977-1981
30. Muntasell A et al (2007) T cell-induced secretion of MHC class II-peptide complexes on B cell exosomes. EMBO J 26:4263-4272
31. Lespagnol A et al (2008) Exosome secretion, including the DNA damage-induced p53-dependent secretory pathway, is severely compromised in TSAP6/Steap3-null mice. Cell Death Differ 15:1723-1733
32. Yu X, Harris SL, Levine AJ (2006) The regulation of exosome secretion: a novel function of the p53 protein. Cancer Res 66:4795-4801
33. Deolindo P, Evans-Osses I, Ramirez MI (2013) Microvesicles and exosomes as vehicles between protozoan and host cell communication. Biochem Soc Trans 41:252-257
34. Cocucci E, Racchetti G, Meldolesi J (2009) Shedding microvesicles: artefacts no more. Trends Cell Biol 19:43-51
35. Conde D et al (2005) Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation. Blood 106:1604-1611
36. Quesenberry PJ, Aliotta JM (2010) Cellular phenotype switching and microvesicles. Adv Drug Deliv Rev 62:1141-1148
37. Cocucci E et al (2007) Enlargeosome traffic: exocytosis triggered by various signals is followed by endocytosis, membrane shedding or both. Traffic 8:742-757
38. Balaj L et al (2011) Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences. Nat Commun 2:180
39. Gutierrez-Vazquez C et al (2013) Transfer of extracellular vesicles during immune cell-cell interactions. Immunol Rev 251:125-142
40. Thery C et al (1999) Molecular characterization of dendritic cell-derived exosomes. Selective accumulation of the heat shock protein hsc73. J Cell Biol 147:599-610
41. Mittelbrunn M et al (2011) Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells. Nat Commun 2:282
42. Hessvik NP et al (2012) Profiling of microRNAs in exosomes released from PC-3 prostate cancer cells. Biochim Biophys Acta 1819: 1154-1163
43. Li CC et al (2013) Glioma microvesicles carry selectively packaged coding and non-coding RNAs which alter gene expression in recipient cells. RNA Biol 10:1333-1344
44. Gezer U et al (2014) Long non-coding RNAs with low expression levels in cells are enriched in secreted exosomes. Cell Biol Int 38: 1076-1079
45. Shen B et al (2011) Protein targeting to exosomes/ microvesicles by plasma membrane anchors. J Biol Chem 286:14383-14395
46. Melo SA et al (2014) Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis. Cancer Cell 26:707-721
47. Villarroya-Beltri C et al (2013) Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs. Nat Commun 4:2980
48. Koppers-Lalic D et al (2014) Nontemplated nucleotide additions distinguish the small RNA composition in cells from exosomes. Cell Rep 8:1649-1658
49. Squadrito ML et al (2014) Endogenous RNAs modulate microRNA sorting to exosomes and transfer to acceptor cells. Cell Rep 8:1432-1446
50. Yuana Y et al (2013) Extracellular vesicles in physiological and pathological conditions. Blood Rev 27:31-39
51. Peinado H et al (2012) Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med 18:883-891
52. Alvarez-Erviti L et al (2011) Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat Biotechnol 29:341-345
53. Thery C, Ostrowski M, Segura E (2009) Membrane vesicles as conveyors of immune responses. Nat Rev Immunol 9:581-593
54. Valadi H et al (2007) Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 9:654-659
55. Al-Nedawi K et al (2008) Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells. Nat Cell Biol 10:619-624
56. Montecalvo A et al (2012) Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes. Blood 119:756-766
57. Biro E et al (2003) Human cell-derived microparticles promote thrombus formation in vivo in a tissue factor-dependent manner. J Thromb Haemost 1:2561-2568
58. Zhang B et al (2015) HucMSC-exosome mediated-Wnt4 signaling is required for cutaneous wound healing. Stem Cells 33(7): 2158-2168
59. Taylor DD, Akyol S, Gercel-Taylor C (2006) Pregnancy-associated exosomes and their modulation of T cell signaling. J Immunol 176:1534-1542
60. Saenz-Cuesta M, Osorio-Querejeta I, Otaegui D (2014) Extracellular vesicles in multiple sclerosis: what are they telling us? Front Cell Neurosci 8:100
61. Buzas EI et al (2014) Emerging role of extracellular vesicles in inflammatory diseases. Nat Rev Rheumatol 10:356-364
62. Silverman JM, Reiner NE (2011) Exosomes and other microvesicles in infection biology: organelles with unanticipated phenotypes. Cell Microbiol 13:1-9
63. Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144: 646-674
64. Andreola G et al (2002) Induction of lymphocyte apoptosis by tumor cell secretion of FasLbearing microvesicles. J Exp Med 195: 1303-1316
65. Raisova M et al (2000) Resistance to CD95/ Fas-induced and ceramide-mediated apoptosis of human melanoma cells is caused by a defective mitochondrial cytochrome c release. FEBS Lett 473:27-32
66. Irmler M et al (1997) Inhibition of death receptor signals by cellular FLIP. Nature 388:190-195
67. Delcayre A, Shu H, Le Pecq JB (2005) Dendritic cell-derived exosomes in cancer immunotherapy: exploiting nature’s antigen delivery pathway. Expert Rev Anticancer Ther 5:537-547
68. Naslund TI et al (2013) Dendritic cell-derived exosomes need to activate both T and B cells to induce antitumor immunity. J Immunol 190:2712-2719
69. Sobo-Vujanovic A et al (2014) Dendritic-cell exosomes cross-present Toll-like receptorligands and activate bystander dendritic cells. Cell Immunol 289:119-127
70. Raposo G et al (1996) B lymphocytes secrete antigen-presenting vesicles. J Exp Med 183:1161-1172
71. Morse MA et al (2005) A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer. J Transl Med 3:9
72. Escudier B et al (2005) Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of the first phase I clinical trial. J Transl Med 3:10
73. Viaud S et al (2009) Dendritic cell-derived exosomes promote natural killer cell activation and proliferation: a role for NKG2D ligands and IL-15Ralpha. PLoS One 4:e4942
74. Munich S et al (2012) Dendritic cell exosomes directly kill tumor cells and activate natural killer cells via TNF superfamily ligands. Oncoimmunology 1:1074-1083
75. Lee JH et al (2013) HIV Nef, paxillin, and Pak1/2 regulate activation and secretion of TACE/ADAM10 proteases. Mol Cell 49: 668-679
76. Arenaccio C et al (2014) Exosomes from human immunodeficiency virus type 1 (HIV-1)-infected cells license quiescent CD4+ T lymphocytes to replicate HIV-1 through a Nef-and ADAM17-dependent mechanism. J Virol 88:11529-11539
77. Arenaccio C et al (2014) Cell activation and HIV-1 replication in unstimulated CD4+ T lymphocytes ingesting exosomes from cells expressing defective HIV-1. Retrovirology 11:46
78. Taylor DD, Gercel-Taylor C (2008) MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer. Gynecol Oncol 110:13-21
79. Ogata-Kawata H et al (2014) Circulating exosomal microRNAs as biomarkers of colon cancer. PLoS One 9:e92921
80. Schorey JS, Bhatnagar S (2008) Exosome function: from tumor immunology to pathogen biology. Traffic 9:871-881
81. Azmi AS, Bao B, Sarkar FH (2013) Exosomes in cancer development, metastasis, and drug resistance: a comprehensive review. Cancer Metastasis Rev 32:623-642