Extracellular vesicles in physiological and pathological conditions

Blood Reviews

Volumn 27, Issue 1, 2013, Pages 31-39

  Yuana, Yuana ^a   Sturk, Auguste ^a   Nieuwland, Rienk ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Atomic force microscopy; Biomarker; Cell communication; Exosome based therapy; Exosomes; Microparticles; Microvesicles; Nano particle tracking analysis; Transmission electron microscopy

Indexed keywords

BIOLOGICAL MARKER; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NANOPARTICLE; VASCULOTROPIN RECEPTOR 3;

ANGIOGENESIS; APOPTOSIS; ARTICLE; ATOMIC FORCE MICROSCOPY; AUTOIMMUNITY; BIOGENESIS; BODY FLUID; CELL ACTIVATION; CELL COMMUNICATION; CELL SURVIVAL; CELL VACUOLE; CEREBROSPINAL FLUID; CYTOSOL; ENDOTHELIUM CELL; EXOSOME; EXTRACELLULAR VESICLE; FLOW CYTOMETRY; HOST RESISTANCE; HUMAN; IMMUNE RESPONSE; INFLAMMATION; LYSOSOME; MEMBRANE MICROPARTICLE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SYNOVIAL FLUID; TRANSMISSION ELECTRON MICROSCOPY;

BLOOD COAGULATION; BODY FLUIDS; CELL COMMUNICATION; CELL SURVIVAL; CYTOSOL; ENDOTHELIAL CELLS; EXOCYTOSIS; EXOSOMES; EXTRACELLULAR SPACE; HOMEOSTASIS; HUMANS; INFLAMMATION; LYMPHOCYTES; MULTIVESICULAR BODIES; NEOVASCULARIZATION, PHYSIOLOGIC;

EID: 84872149261     PISSN: 0268960X     EISSN: 15321681     Source Type: Journal    
DOI: 10.1016/j.blre.2012.12.002     Document Type: Article

References (141)

1. Lee E.Y., Choi D.Y., Kim D.K., Kim J.W., Park J.O., Kim S., et al. Gram-positive bacteria produce membrane vesicles: proteomics-based characterization of Staphylococcus aureus-derived membrane vesicles. Proteomics 2009, 9(24):5425-5436.
2. Deatherage B.L., Cookson B.T. Membrane vesicle release in bacteria, eukaryotes, and archaea: a conserved yet underappreciated aspect of microbial life. Infect Immun 2012, 80(6):1948-1957.
3. Van Der Pol E., Boing A.N., Harrison P., Sturk A., Nieuwland R. Classification, functions, and clinical relevance of extracellular vesicles. Pharmacol Rev 2012, 64(3):676-705.
4. Gyorgy B., Szabo T.G., Pasztoi M., Pal Z., Misjak P., Aradi B., et al. Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles. Cell Mol Life Sci 2011, 68(16):2667-2688.
5. Zwaal R.F., Schroit A.J. Pathophysiologic implications of membrane phospholipid asymmetry in blood cells. Blood 1997, 89(4):1121-1132.
6. Thery C., Zitvogel L., Amigorena S. Exosomes: composition, biogenesis and function. Nat Rev Immunol 2002, 2(8):569-579.
7. Flaumenhaft R. Formation and fate of platelet microparticles. Blood Cells Mol Dis 2006, 36(2):182-187.
8. Zwaal R.F., Comfurius P., Bevers E.M. Surface exposure of phosphatidylserine in pathological cells. Cell Mol Life Sci 2005, 62(9):971-988.
9. Frey B., Gaipl U.S. The immune functions of phosphatidylserine in membranes of dying cells and microvesicles. Semin Immunopathol 2011, 33(5):497-516.
10. Safaei R., Larson B.J., Cheng T.C., Gibson M.A., Otani S., Naerdemann W., et al. Abnormal lysosomal trafficking and enhanced exosomal export of cisplatin in drug-resistant human ovarian carcinoma cells. Mol Cancer Ther 2005, 4(10):1595-1604.
11. Shedden K., Xie X.T., Chandaroy P., Chang Y.T., Rosania G.R. Expulsion of small molecules in vesicles shed by cancer cells: association with gene expression and chemosensitivity profiles. Cancer Res 2003, 63(15):4331-4337.
12. Mathivanan S., Ji H., Simpson R.J. Exosomes: extracellular organelles important in intercellular communication. J Proteomics 2010, 73(10):1907-1920.
13. Tesselaar M.E., Romijn F.P., van der Linden I.K., Prins F.A., Bertina R.M., Osanto S. Microparticle-associated tissue factor activity: a link between cancer and thrombosis?. J Thromb Haemost 2007, 5(3):520-527.
14. Zwicker J.I., Liebman H.A., Neuberg D., Lacroix R., Bauer K.A., Furie B.C., et al. Tumor-derived tissue factor-bearing microparticles are associated with venous thromboembolic events in malignancy. Clin Cancer Res 2009, 15(22):6830-6840.
15. Langer F., Spath B., Haubold K., Holstein K., Marx G., Wierecky J., et al. Tissue factor procoagulant activity of plasma microparticles in patients with cancer-associated disseminated intravascular coagulation. Ann Hematol 2008, 87(6):451-457.
16. VanWijk M.J., VanBavel E., Sturk A., Nieuwland R. Microparticles in cardiovascular diseases. Cardiovasc Res 2003, 59(2):277-287.
17. Shantsila E., Kamphuisen P.W., Lip G.Y. Circulating microparticles in cardiovascular disease: implications for atherogenesis and atherothrombosis. J Thromb Haemost 2010, 8(11):2358-2368.
18. Berckmans R.J., Nieuwland R., Tak P.P., Boing A.N., Romijn F.P., Kraan M.C., et al. Cell-derived microparticles in synovial fluid from inflamed arthritic joints support coagulation exclusively via a factor VII-dependent mechanism. Arthritis Rheum 2002, 46(11):2857-2866.
19. Knijff-Dutmer E.A., Koerts J., Nieuwland R., Kalsbeek-Batenburg E.M., van de Laar M.A. Elevated levels of platelet microparticles are associated with disease activity in rheumatoid arthritis. Arthritis Rheum 2002, 46(6):1498-1503.
20. Heijnen H.F., Schiel A.E., Fijnheer R., Geuze H.J., Sixma J.J. Activated platelets release two types of membrane vesicles: microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and alpha-granules. Blood 1999, 94(11):3791-3799.
21. Van Der Pol E., Hoekstra A.G., Sturk A., Otto C., Van Leeuwen T.G., Nieuwland R. Optical and non-optical methods for detection and characterization of microparticles and exosomes. J Thromb Haemost 2010, 8(12):2596-2607.
22. Aras O., Shet A., Bach R.R., Hysjulien J.L., Slungaard A., Hebbel R.P., et al. Induction of microparticle- and cell-associated intravascular tissue factor in human endotoxemia. Blood 2004, 103(12):4545-4553.
23. Salzer U., Hinterdorfer P., Hunger U., Borken C., Prohaska R. Ca(++)-dependent vesicle release from erythrocytes involves stomatin-specific lipid rafts, synexin (annexin VII), and sorcin. Blood 2002, 99(7):2569-2577.
24. Del C.I., Shrimpton C.N., Thiagarajan P., Lopez J.A. Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation. Blood 2005, 106(5):1604-1611.
25. Salzer U., Zhu R., Luten M., Isobe H., Pastushenko V., Perkmann T., et al. Vesicles generated during storage of red cells are rich in the lipid raft marker stomatin. Transfusion 2008, 48(3):451-462.
26. Duijvesz D., Luider T., Bangma C.H., Jenster G. Exosomes as biomarker treasure chests for prostate cancer. Eur Urol 2011, 59(5):823-831.
27. Bernimoulin M., Waters E.K., Foy M., Steele B.M., Sullivan M., Falet H., et al. Differential stimulation of monocytic cells results in distinct populations of microparticles. J Thromb Haemost 2009, 7(6):1019-1028.
28. Jimenez J.J., Jy W., Mauro L.M., Soderland C., Horstman L.L., Ahn Y.S. Endothelial cells release phenotypically and quantitatively distinct microparticles in activation and apoptosis. Thromb Res 2003, 109(4):175-180.
29. Valenti R., Huber V., Filipazzi P., Pilla L., Sovena G., Villa A., et al. Human tumor-released microvesicles promote the differentiation of myeloid cells with transforming growth factor-beta-mediated suppressive activity on T lymphocytes. Cancer Res 2006, 66(18):9290-9298.
30. Skog J., Wurdinger T., van R.S., Meijer D.H., Gainche L., Sena-Esteves M., et al. Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol 2008, 10(12):1470-1476.
31. Piccin A., Murphy W.G., Smith O.P. Circulating microparticles: pathophysiology and clinical implications. Blood Rev 2007, 21(3):157-171.
32. Satta N., Toti F., Fressinaud E., Meyer D., Freyssinet J.M. Scott syndrome: an inherited defect of the procoagulant activity of platelets. Platelets 1997, 8(2-3):117-124.
33. Connor D.E., Exner T., Ma D.D., Joseph J.E. The majority of circulating platelet-derived microparticles fail to bind annexin V, lack phospholipid-dependent procoagulant activity and demonstrate greater expression of glycoprotein Ib. Thromb Haemost 2010, 103(5):1044-1052.
34. Perez-Pujol S., Marker P.H., Key N.S. Platelet microparticles are heterogeneous and highly dependent on the activation mechanism: studies using a new digital flow cytometer. Cytometry A 2007, 71(1):38-45.
35. Ayers L., Kohler M., Harrison P., Sargent I., Dragovic R., Schaap M., et al. Measurement of circulating cell-derived microparticles by flow cytometry: sources of variability within the assay. Thromb Res 2011, 127(4):370-377.
36. Pant S., Hilton H., Burczynski M.E. The multifaceted exosome: biogenesis, role in normal and aberrant cellular function, and frontiers for pharmacological and biomarker opportunities. Biochem Pharmacol 2012, 83(11):1484-1494.
37. Record M., Subra C., Silvente-Poirot S., Poirot M. Exosomes as intercellular signalosomes and pharmacological effectors. Biochem Pharmacol 2011, 81(10):1171-1182.
38. Bellingham S.A., Guo B.B., Coleman B.M., Hill A.F. Exosomes: vehicles for the transfer of toxic proteins associated with neurodegenerative diseases?. Front Physiol 2012, 3:124.
39. Trajkovic K., Hsu C., Chiantia S., Rajendran L., Wenzel D., Wieland F., et al. Ceramide triggers budding of exosome vesicles into multivesicular endosomes. Science 2008, 319(5867):1244-1247.
40. Lasser C., Eldh M., Lotvall J. Isolation and characterization of RNA-containing exosomes. J Vis Exp 2012, 59:e3037.
41. Thery C., Ostrowski M., Segura E. Membrane vesicles as conveyors of immune responses. Nat Rev Immunol 2009, 9(8):581-593.
42. Taylor D.D., Gercel-Taylor C. Exosomes/microvesicles: mediators of cancer-associated immunosuppressive microenvironments. Semin Immunopathol 2011, 33(5):441-454.
43. Savina A., Furlan M., Vidal M., Colombo M.I. Exosome release is regulated by a calcium-dependent mechanism in K562 cells. J Biol Chem 2003, 278(22):20083-20090.
44. Burnier L., Fontana P., Kwak B.R., Angelillo-Scherrer A. Cell-derived microparticles in haemostasis and vascular medicine. Thromb Haemost 2009, 101(3):439-451.
45. Nieuwland R., Berckmans R.J., McGregor S., Boing A.N., Romijn F.P., Westendorp R.G., et al. Cellular origin and procoagulant properties of microparticles in meningococcal sepsis. Blood 2000, 95(3):930-935.
46. Lasser C., Alikhani V.S., Ekstrom K., Eldh M., Paredes P.T., Bossios A., et al. Human saliva, plasma and breast milk exosomes contain RNA: uptake by macrophages. J Transl Med 2011, 9:9.
47. Vlassov A.V., Magdaleno S., Setterquist R., Conrad R. Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials. Biochim Biophys Acta 2012, 1820(7):940-948.
48. Keller S., Rupp C., Stoeck A., Runz S., Fogel M., Lugert S., et al. CD24 is a marker of exosomes secreted into urine and amniotic fluid. Kidney Int 2007, 72(9):1095-1102.
49. Pisitkun T., Shen R.F., Knepper M.A. Identification and proteomic profiling of exosomes in human urine. Proc Natl Acad Sci U S A 2004, 101(36):13368-13373.
50. Miranda K.C., Bond D.T., McKee M., Skog J., Paunescu T.G., Da S.N., et al. Nucleic acids within urinary exosomes/microvesicles are potential biomarkers for renal disease. Kidney Int 2010, 78(2):191-199.
51. Berckmans R.J., Sturk A., van Tienen L.M., Schaap M.C., Nieuwland R. Cell-derived vesicles exposing coagulant tissue factor in saliva. Blood 2011, 117(11):3172-3180.
52. Street J.M., Barran P.E., Mackay C.L., Weidt S., Balmforth C., Walsh T.S., et al. Identification and proteomic profiling of exosomes in human cerebrospinal fluid. J Transl Med 2012, 10:5.
53. Turola E., Furlan R., Bianco F., Matteoli M., Verderio C. Microglial microvesicle secretion and intercellular signaling. Front Physiol 2012, 3:149.
54. Berckmans R.J., Nieuwland R., Kraan M.C., Schaap M.C., Pots D., Smeets T.J., et al. Synovial microparticles from arthritic patients modulate chemokine and cytokine release by synoviocytes. Arthritis Res Ther 2005, 7(3):R536-R544.
55. Zhang H.G., Liu C., Su K., Yu S., Zhang L., Zhang S., et al. A membrane form of TNF-alpha presented by exosomes delays T cell activation-induced cell death. J Immunol 2006, 176(12):7385-7393.
56. Yang C., Mwaikambo B.R., Zhu T., Gagnon C., Lafleur J., Seshadri S., et al. Lymphocytic microparticles inhibit angiogenesis by stimulating oxidative stress and negatively regulating VEGF-induced pathways. Am J Physiol Regul Integr Comp Physiol 2008, 294(2):R467-R476.
57. Wysoczynski M., Ratajczak M.Z. Lung cancer secreted microvesicles: underappreciated modulators of microenvironment in expanding tumors. Int J Cancer 2009, 125(7):1595-1603.
58. Mostefai H.A., Andriantsitohaina R., Martinez M.C. Plasma membrane microparticles in angiogenesis: role in ischemic diseases and in cancer. Physiol Res 2008, 57(3):311-320.
59. Kim H.K., Song K.S., Chung J.H., Lee K.R., Lee S.N. Platelet microparticles induce angiogenesis in vitro. Br J Haematol 2004, 124(3):376-384.
60. Brill A., Dashevsky O., Rivo J., Gozal Y., Varon D. Platelet-derived microparticles induce angiogenesis and stimulate post-ischemic revascularization. Cardiovasc Res 2005, 67(1):30-38.
61. Boulanger C.M., Tedgui A. Dying for attention: microparticles and angiogenesis. Cardiovasc Res 2005, 67(1):1-3.
62. Bonavia R., Inda M.M., Vandenberg S., Cheng S.Y., Nagane M., Hadwiger P., et al. EGFRvIII promotes glioma angiogenesis and growth through the NF-kappaB, interleukin-8 pathway. Oncogene 2012, 31(36):4054-4066.
63. Bussolati B., Grange C., Camussi G. Tumor exploits alternative strategies to achieve vascularization. FASEB J 2011, 25(9):2874-2882.
64. Taraboletti G., D'Ascenzo S., Borsotti P., Giavazzi R., Pavan A., Dolo V. Shedding of the matrix metalloproteinases MMP-2, MMP-9, and MT1-MMP as membrane vesicle-associated components by endothelial cells. Am J Pathol 2002, 160(2):673-680.
65. Janowska-Wieczorek A., Wysoczynski M., Kijowski J., Marquez-Curtis L., Machalinski B., Ratajczak J., et al. Microvesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer. Int J Cancer 2005, 113(5):752-760.
66. Burger J.A., Kipps T.J. CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment. Blood 2006, 107(5):1761-1767.
67. Janowska-Wieczorek A., Marquez-Curtis L.A., Wysoczynski M., Ratajczak M.Z. Enhancing effect of platelet-derived microvesicles on the invasive potential of breast cancer cells. Transfusion 2006, 46(7):1199-1209.
68. Peinado H., Aleckovic M., Lavotshkin S., Matei I., Costa-Silva B., Moreno-Bueno G., et al. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med 2012, 18(6):883-891.
69. Nilsson R.J., Balaj L., Hulleman E., van R.S., Pegtel D.M., Walraven M., et al. Blood platelets contain tumor-derived RNA biomarkers. Blood 2011, 118(13):3680-3683.
70. Sheldon H., Heikamp E., Turley H., Dragovic R., Thomas P., Oon C.E., et al. New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes. Blood 2010, 116(13):2385-2394.
71. Tatischeff I. Cell-derived microvesicles and antitumoral multidrug resistance. C R Biol 2012, 335(2):103-106.
72. Bebawy M., Combes V., Lee E., Jaiswal R., Gong J., Bonhoure A., et al. Membrane microparticles mediate transfer of P-glycoprotein to drug sensitive cancer cells. Leukemia 2009, 23(9):1643-1649.
73. Bruno S., Grange C., Collino F., Deregibus M.C., Cantaluppi V., Biancone L., et al. Microvesicles derived from mesenchymal stem cells enhance survival in a lethal model of acute kidney injury. PLoS One 2012, 7(3):e33115.
74. Boilard E., Nigrovic P.A., Larabee K., Watts G.F., Coblyn J.S., Weinblatt M.E., et al. Platelets amplify inflammation in arthritis via collagen-dependent microparticle production. Science 2010, 327(5965):580-583.
75. Mause S.F., von H.P., Zernecke A., Koenen R.R., Weber C. Platelet microparticles: a transcellular delivery system for RANTES promoting monocyte recruitment on endothelium. Arterioscler Thromb Vasc Biol 2005, 25(7):1512-1518.
76. Gasser O., Schifferli J.A. Activated polymorphonuclear neutrophils disseminate anti-inflammatory microparticles by ectocytosis. Blood 2004, 104(8):2543-2548.
77. Dalli J., Norling L.V., Renshaw D., Cooper D., Leung K.Y., Perretti M. Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles. Blood 2008, 112(6):2512-2519.
78. Sprague D.L., Elzey B.D., Crist S.A., Waldschmidt T.J., Jensen R.J., Ratliff T.L. Platelet-mediated modulation of adaptive immunity: unique delivery of CD154 signal by platelet-derived membrane vesicles. Blood 2008, 111(10):5028-5036.
79. Wieckowski E.U., Visus C., Szajnik M., Szczepanski M.J., Storkus W.J., Whiteside T.L. Tumor-derived microvesicles promote regulatory T cell expansion and induce apoptosis in tumor-reactive activated CD8+ T lymphocytes. J Immunol 2009, 183(6):3720-3730.
80. Bach R.R. Tissue factor encryption. Arterioscler Thromb Vasc Biol 2006, 26(3):456-461.
81. Simak J., Holada K., Vostal J.G. Release of annexin V-binding membrane microparticles from cultured human umbilical vein endothelial cells after treatment with camptothecin. BMC Cell Biol 2002, 3:11.
82. Sabatier F., Roux V., Anfosso F., Camoin L., Sampol J., gnat-George F. Interaction of endothelial microparticles with monocytic cells in vitro induces tissue factor-dependent procoagulant activity. Blood 2002, 99(11):3962-3970.
83. Brodsky S.V., Malinowski K., Golightly M., Jesty J., Goligorsky M.S. Plasminogen activator inhibitor-1 promotes formation of endothelial microparticles with procoagulant potential. Circulation 2002, 106(18):2372-2378.
84. Yuana Y., Osanto S., Bertina R.M. Use of immuno-magnetic beads for direct capture of nanosized microparticles from plasma. Blood Coagul Fibrinolysis 2012, 23(3):244-250.
85. Henriksson C.E., Klingenberg O., Ovstebo R., Joo G.B., Westvik A.B., Kierulf P. Discrepancy between tissue factor activity and tissue factor expression in endotoxin-induced monocytes is associated with apoptosis and necrosis. Thromb Haemost 2005, 94(6):1236-1244.
86. Giesen P.L., Rauch U., Bohrmann B., Kling D., Roque M., Fallon J.T., et al. Blood-borne tissue factor: another view of thrombosis. Proc Natl Acad Sci U S A 1999, 96(5):2311-2315.
87. Butenas S., Orfeo T., Mann K.G. Tissue factor in coagulation. Which? Where? When?. Arterioscler Thromb Vasc Biol 2009, 29(12):1989-1996.
88. Berckmans R.J., Neiuwland R., Boing A.N., Romijn F.P., Hack C.E., Sturk A. Cell-derived microparticles circulate in healthy humans and support low grade thrombin generation. Thromb Haemost 2001, 85(4):639-646.
89. Butenas S., Mann K.G. Active tissue factor in blood?. Nat Med 2004, 10(11):1155-1156.
90. Versteeg H.H., Ruf W. Tissue factor coagulant function is enhanced by protein-disulfide isomerase independent of oxidoreductase activity. J Biol Chem 2007, 282(35):25416-25424.
91. Nieuwland R., Berckmans R.J., Rotteveel-Eijkman R.C., Maquelin K.N., Roozendaal K.J., Jansen P.G., et al. Cell-derived microparticles generated in patients during cardiopulmonary bypass are highly procoagulant. Circulation 1997, 96(10):3534-3541.
92. Biro E., Sturk-Maquelin K.N., Vogel G.M., Meuleman D.G., Smit M.J., Hack C.E., et al. Human cell-derived microparticles promote thrombus formation in vivo in a tissue factor-dependent manner. J Thromb Haemost 2003, 1(12):2561-2568.
93. Shet A.S., Aras O., Gupta K., Hass M.J., Rausch D.J., Saba N., et al. Sickle blood contains tissue factor-positive microparticles derived from endothelial cells and monocytes. Blood 2003, 102(7):2678-2683.
94. van Beers E.J., Schaap M.C., Berckmans R.J., Nieuwland R., Sturk A., van Doormaal F.F., et al. Circulating erythrocyte-derived microparticles are associated with coagulation activation in sickle cell disease. Haematologica 2009, 94(11):1513-1519.
95. Mallat Z., Benamer H., Hugel B., Benessiano J., Steg P.G., Freyssinet J.M., et al. Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes. Circulation 2000, 101(8):841-843.
96. Morel O., Jesel L., Freyssinet J.M., Toti F. Elevated levels of procoagulant microparticles in a patient with myocardial infarction, antiphospholipid antibodies and multifocal cardiac thrombosis. Thromb J 2005, 3:15.
97. Trappenburg M.C., van S.M., Marchetti M., Spronk H.M., ten C.H., Leyte A., et al. Elevated procoagulant microparticles expressing endothelial and platelet markers in essential thrombocythemia. Haematologica 2009, 94(7):911-918.
98. Tesselaar M.E., Romijn F.P., van der Linden I.K., Bertina R.M., Osanto S. Microparticle-associated tissue factor activity in cancer patients with and without thrombosis. J Thromb Haemost 2009, 7(8):1421-1423.
99. Darbousset R., Thomas G.M., Mezouar S., Frere C., Bonier R., Mackman N., et al. Tissue factor-positive neutrophils bind to injured endothelial wall and initiate thrombus formation. Blood 2012, 120(10):2133-2143.
100. Davila M., Amirkhosravi A., Coll E., Desai H., Robles L., Colon J., et al. Tissue factor-bearing microparticles derived from tumor cells: impact on coagulation activation. J Thromb Haemost 2008, 6(9):1517-1524.
101. van den Goor J., Saxby B., Tijssen J., Wesnes K., de M.B., Nieuwland R. Improvement of cognitive test performance in patients undergoing primary CABG and other CPB-assisted cardiac procedures. Perfusion 2008, 23(5):267-273.
102. Baj-Krzyworzeka M., Szatanek R., Weglarczyk K., Baran J., Urbanowicz B., Branski P., et al. Tumour-derived microvesicles carry several surface determinants and mRNA of tumour cells and transfer some of these determinants to monocytes. Cancer Immunol Immunother 2006, 55(7):808-818.
103. Baj-Krzyworzeka M., Baran J., Weglarczyk K., Szatanek R., Szaflarska A., Siedlar M., et al. Tumour-derived microvesicles (TMV) mimic the effect of tumour cells on monocyte subpopulations. Anticancer Res 2010, 30(9):3515-3519.
104. Herrmann M., Voll R.E., Zoller O.M., Hagenhofer M., Ponner B.B., Kalden J.R. Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus. Arthritis Rheum 1998, 41(7):1241-1250.
105. Lima L.G., Chammas R., Monteiro R.Q., Moreira M.E., Barcinski M.A. Tumor-derived microvesicles modulate the establishment of metastatic melanoma in a phosphatidylserine-dependent manner. Cancer Lett 2009, 283(2):168-175.
106. Boing A.N., Hau C.M., Sturk A., Nieuwland R. Platelet microparticles contain active caspase 3. Platelets 2008, 19(2):96-103.
107. Tait J.F., Smith C. Phosphatidylserine receptors: role of CD36 in binding of anionic phospholipid vesicles to monocytic cells. J Biol Chem 1999, 274(5):3048-3054.
108. Chironi G., Simon A., Hugel B., Del P.M., Gariepy J., Freyssinet J.M., et al. Circulating leukocyte-derived microparticles predict subclinical atherosclerosis burden in asymptomatic subjects. Arterioscler Thromb Vasc Biol 2006, 26(12):2775-2780.
109. Ueba T., Nomura S., Inami N., Nishikawa T., Kajiwara M., Iwata R., et al. Plasma level of platelet-derived microparticles is associated with coronary heart disease risk score in healthy men. J Atheroscler Thromb 2010, 17(4):342-349.
110. Nozaki T., Sugiyama S., Koga H., Sugamura K., Ohba K., Matsuzawa Y., et al. Significance of a multiple biomarkers strategy including endothelial dysfunction to improve risk stratification for cardiovascular events in patients at high risk for coronary heart disease. J Am Coll Cardiol 2009, 54(7):601-608.
111. Janowska-Wieczorek A., Majka M., Kijowski J., Baj-Krzyworzeka M., Reca R., Turner A.R., et al. Platelet-derived microparticles bind to hematopoietic stem/progenitor cells and enhance their engraftment. Blood 2001, 98(10):3143-3149.
112. Baglio S.R., Pegtel D.M., Baldini N. Mesenchymal stem cell secreted vesicles provide novel opportunities in (stem) cell-free therapy. Front Physiol 2012, 3:359.
113. Bruno S., Grange C., Deregibus M.C., Calogero R.A., Saviozzi S., Collino F., et al. Mesenchymal stem cell-derived microvesicles protect against acute tubular injury. J Am Soc Nephrol 2009, 20(5):1053-1067.
114. Kim S.H., Lechman E.R., Bianco N., Menon R., Keravala A., Nash J., et al. Exosomes derived from IL-10-treated dendritic cells can suppress inflammation and collagen-induced arthritis. J Immunol 2005, 174(10):6440-6448.
115. Chaput N., Flament C., Viaud S., Taieb J., Roux S., Spatz A., et al. Dendritic cell derived-exosomes: biology and clinical implementations. J Leukoc Biol 2006, 80(3):471-478.
116. Le Pecq J.B. Dexosomes as a therapeutic cancer vaccine: from bench to bedside. Blood Cells Mol Dis 2005, 35(2):129-135.
117. Altieri S.L., Khan A.N., Tomasi T.B. Exosomes from plasmacytoma cells as a tumor vaccine. J Immunother 2004, 27(4):282-288.
118. Yuana Y., Bertina R.M., Osanto S. Pre-analytical and analytical issues in the analysis of blood microparticles. Thromb Haemost 2011, 105(3):396-408.
119. Lamparski H.G., Metha-Damani A., Yao J.Y., Patel S., Hsu D.H., Ruegg C., et al. Production and characterization of clinical grade exosomes derived from dendritic cells. J Immunol Methods 2002, 270(2):211-226.
120. Zeelenberg I.S., Ostrowski M., Krumeich S., Bobrie A., Jancic C., Boissonnas A., et al. Targeting tumor antigens to secreted membrane vesicles in vivo induces efficient antitumor immune responses. Cancer Res 2008, 68(4):1228-1235.
121. Van Der Pol E., van Gemert M.J., Sturk A., Nieuwland R., Van Leeuwen T.G. Single vs. swarm detection of microparticles and exosomes by flow cytometry. J Thromb Haemost 2012, 10(5):919-930.
122. Tait J.F., Gibson D. Phospholipid binding of annexin V: effects of calcium and membrane phosphatidylserine content. Arch Biochem Biophys 1992, 298(1):187-191.
123. Shi J., Heegaard C.W., Rasmussen J.T., Gilbert G.E. Lactadherin binds selectively to membranes containing phosphatidyl-L-serine and increased curvature. Biochim Biophys Acta 2004, 1667(1):82-90.
124. Nomura S., Shouzu A., Taomoto K., Togane Y., Goto S., Ozaki Y., et al. Assessment of an ELISA kit for platelet-derived microparticles by joint research at many institutes in Japan. J Atheroscler Thromb 2009, 16(6):878-887.
125. Yuana Y., Oosterkamp T.H., Bahatyrova S., Ashcroft B., Garcia R.P., Bertina R.M., et al. Atomic force microscopy: a novel approach to the detection of nanosized blood microparticles. J Thromb Haemost 2010, 8(2):315-323.
126. Siedlecki C.A., Wang I.W., Higashi J.M., Kottke-Marchant K., Marchant R.E. Platelet-derived microparticles on synthetic surfaces observed by atomic force microscopy and fluorescence microscopy. Biomaterials 1999, 20(16):1521-1529.
127. Baran J., Baj-Krzyworzeka M., Weglarczyk K., Szatanek R., Zembala M., Barbasz J., et al. Circulating tumour-derived microvesicles in plasma of gastric cancer patients. Cancer Immunol Immunother 2010, 59(6):841-850.
128. Gyorgy B., Modos K., Pallinger E., Paloczi K., Pasztoi M., Misjak P., et al. Detection and isolation of cell-derived microparticles are compromised by protein complexes resulting from shared biophysical parameters. Blood 2011, 117(4):e39-e48.
129. Soo C.Y., Song Y., Zheng Y., Campbell E.C., Riches A.C., Gunn-Moore F., et al. Nanoparticle tracking analysis monitors microvesicle and exosome secretion from immune cells. Immunology 2012, 136(2):192-197.
130. Gercel-Taylor C., Atay S., Tullis R.H., Kesimer M., Taylor D.D. Nanoparticle analysis of circulating cell-derived vesicles in ovarian cancer patients. Anal Biochem 2012, 428(1):44-53.
131. Filipe V., Hawe A., Jiskoot W. Critical evaluation of Nanoparticle Tracking Analysis (NTA) by NanoSight for the measurement of nanoparticles and protein aggregates. Pharm Res 2010, 27(5):796-810.
132. Dragovic R.A., Gardiner C., Brooks A.S., Tannetta D.S., Ferguson D.J., Hole P., et al. Sizing and phenotyping of cellular vesicles using Nanoparticle Tracking Analysis. Nanomedicine 2011, 7(6):780-788.
133. Redman C.W., Tannetta D.S., Dragovic R.A., Gardiner C., Southcombe J.H., Collett G.P., et al. Review: does size matter? Placental debris and the pathophysiology of pre-eclampsia. Placenta 2012, 33(Suppl.):S48-S54.
134. Sharma S., Rasool H.I., Palanisamy V., Mathisen C., Schmidt M., Wong D.T., et al. Structural-mechanical characterization of nanoparticle exosomes in human saliva, using correlative AFM, FESEM, and force spectroscopy. ACS Nano 2010, 4(4):1921-1926.
135. Ashcroft B.A., de S.J., Yuana Y., Osanto S., Bertina R., Kuil M.E. Determination of the size distribution of blood microparticles directly in plasma using atomic force microscopy and microfluidics. Biomed Microdevices 2012, 14(4):641-649.
136. van der Vlist E.J., Nolte-'t Hoen E.N., Stoorvogel W., Arkesteijn G.J., Wauben M.H. Fluorescent labeling of nano-sized vesicles released by cells and subsequent quantitative and qualitative analysis by high-resolution flow cytometry. Nat Protoc 2012, 7(7):1311-1326.
137. Hoen E.N., van der Vlist E.J., Aalberts M., Mertens H.C., Bosch B.J., Bartelink W., et al. Quantitative and qualitative flow cytometric analysis of nanosized cell-derived membrane vesicles. Nanomedicine 2012, 8(5):712-720.
138. Wolf P. The nature and significance of platelet products in human plasma. Br J Haematol 1967, 13(3):269-288.
139. Denzer K., van E.M., Kleijmeer M.J., Jakobson E., de G.C., Geuze H.J. Follicular dendritic cells carry MHC class II-expressing microvesicles at their surface. J Immunol 2000, 165(3):1259-1265.
140. Turiak L., Misjak P., Szabo T.G., Aradi B., Paloczi K., Ozohanics O., et al. Proteomic characterization of thymocyte-derived microvesicles and apoptotic bodies in BALB/c mice. J Proteomics 2011, 74(10):2025-2033.
141. Zomer A., Vendrig T., Hopmans E.S., van E.M., Middeldorp J.M., Pegtel D.M. Exosomes: fit to deliver small RNA. Commun Integr Biol 2010, 3(5):447-450.