Subtoxic alterations in hepatocyte-derived exosomes: An early step in drug-induced liver injury?

Toxicological Sciences

Volumn 151, Issue 2, 2016, Pages 365-375

  Holman, Natalie S ^a,b   Mosedale, Merrie ^a,b   Wolf, Kristina K ^a,c   LeCluyse, Edward L ^a   Watkins, Paul B ^a,b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b University of North Carolina at Chapel Hill   (United States)

^c QPS DMPK Hepatic Biosciences   (United States)

Author keywords

Drug induced liver injury; Exosomes; Liver specific RNA; MiR 122

Indexed keywords

ALBUMIN; MESSENGER RNA; MICRORNA 122; PARACETAMOL; ALB PROTEIN, HUMAN; HUMAN SERUM ALBUMIN; MICRORNA; MIRN122 MICRORNA, HUMAN; MIRN122 MICRORNA, RAT;

ADOLESCENT; ADULT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHILD; EXOSOME; FEMALE; HEPATOCYTE DERIVED EXOSOME; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; LIVER NECROSIS; MALE; MIDDLE AGED; NONHUMAN; PRESCHOOL CHILD; RAT; RNA ANALYSIS; TOXIC HEPATITIS; ANIMAL; DOSE RESPONSE; DRUG EFFECTS; GENETICS; INFANT; LIVER; METABOLISM; NECROSIS; PATHOLOGY; SPRAGUE DAWLEY RAT; TIME FACTOR;

ACETAMINOPHEN; ADOLESCENT; ADULT; AGED; ANIMALS; CHEMICAL AND DRUG INDUCED LIVER INJURY; CHILD, PRESCHOOL; DOSE-RESPONSE RELATIONSHIP, DRUG; EXOSOMES; FEMALE; HEPATOCYTES; HUMANS; INFANT; LIVER; MALE; MICRORNAS; MIDDLE AGED; NECROSIS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SERUM ALBUMIN, HUMAN; TIME FACTORS;

EID: 84979032222     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfw047     Document Type: Article

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