Transcriptome of Extracellular Vesicles Released by Hepatocytes

PLoS ONE

Volumn 8, Issue 7, 2013, Pages

  Royo, Felix ^a   Schlangen, Karin ^a   Palomo, Laura ^a   Gonzalez, Esperanza ^a   Conde Vancells, Javier ^a   Berisa, Agustin ^b   Aransay, Ana M ^a   Falcon Perez, Juan M ^a,c  

^a INSTITUTO DE SALUD CARLOS III   (Spain)

^b Faes Farma SA   (Spain)

^c BASQUE FOUNDATION FOR SCIENCE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

DICLOFENAC; GALACTOSAMINE; PARACETAMOL; RIBONUCLEASE; RNA; TRANSCRIPTOME;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL DENSITY; CELL SUBPOPULATION; CELL VACUOLE; CONTROLLED STUDY; ENZYME ACTIVITY; EXTRACELLULAR SPACE; FETUS; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; MOUSE; NONHUMAN; PRIMARY CELL CULTURE; REAL TIME POLYMERASE CHAIN REACTION; RNA ANALYSIS; STELLATE CELL; STEM CELL; TRANSCRIPTOMICS;

ANIMALS; CELL LINE; EXTRACELLULAR MATRIX; HEPATIC STELLATE CELLS; HEPATOCYTES; LIVER; MALE; MICE; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; STEM CELLS; TRANSCRIPTOME; TRANSPORT VESICLES;

EID: 84880081322     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0068693     Document Type: Article

References (56)

1. Gutierrez-Vazquez C, Villarroya-Beltri C, Mittelbrunn M, Sanchez-Madrid F, (2013) Transfer of extracellular vesicles during immune cell-cell interactions. Immunol Rev 251: 125-142.
2. Mathivanan S, Ji H, Simpson RJ, (2010) Exosomes: extracellular organelles important in intercellular communication. J Proteomics 73: 1907-1920.
3. Ohno SI, Ishikawa A, Kuroda M, (2012) Roles of exosomes and microvesicles in disease pathogenesis. Adv Drug Deliv Rev 2012: 00249-00249.
4. Simons M, Raposo G, (2009) Exosomes-vesicular carriers for intercellular communication. Curr Opin Cell Biol 21: 575-581.
5. Cocucci E, Racchetti G, Meldolesi J, (2009) Shedding microvesicles: artefacts no more. Trends Cell Biol 19: 43-51.
6. Kalra H, Simpson RJ, Ji H, Aikawa E, Altevogt P, et al. (2012) Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation. PLoS Biol 10: e1001450.
7. Simpson RJ, Jensen SS, Lim JW, (2008) Proteomic profiling of exosomes: current perspectives. Proteomics 8: 4083-4099.
8. Bobrie A, Colombo M, Raposo G, Thery C, (2011) Exosome secretion: molecular mechanisms and roles in immune responses. Traffic 12: 1659-1668.
9. Mittelbrunn M, Gutierrez-Vazquez C, Villarroya-Beltri C, Gonzalez S, Sanchez-Cabo F, et al. (2011) Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells. Nat Commun 2: 282.
10. Montecalvo A, Larregina AT, Shufesky WJ, Stolz DB, Sullivan ML, et al. (2012) Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes. Blood 119: 756-766.
11. Peinado H, Aleckovic M, Lavotshkin S, Matei I, Costa-Silva B, et al. (2012) Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. Nat Med 18: 883-891.
12. Skog J, Wurdinger T, van Rijn S, Meijer DH, Gainche L, et al. (2008) Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat Cell Biol 10: 1470-1476.
13. Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, et al. (2007) Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat Cell Biol 9: 654-659.
14. Simpson RJ, Lim JW, Moritz RL, Mathivanan S, (2009) Exosomes: proteomic insights and diagnostic potential. Expert Rev Proteomics 6: 267-283.
15. Mittelbrunn M, Sanchez-Madrid F, (2012) Intercellular communication: diverse structures for exchange of genetic information. Nat Rev Mol Cell Biol 13: 328-335.
16. O'Loughlin AJ, Woffindale CA, Wood MJ, (2012) Exosomes and the emerging field of exosome-based gene therapy. Curr Gene Ther 12: 262-274.
17. Conde-Vancells J, Rodriguez-Suarez E, Embade N, Gil D, Matthiesen R, et al. (2008) Characterization and comprehensive proteome profiling of exosomes secreted by hepatocytes. J Proteome Res 7: 5157-5166.
18. Conde-Vancells J, Gonzalez E, Lu SC, Mato JM, Falcon-Perez JM, (2010) Overview of extracellular microvesicles in drug metabolism. Expert Opin Drug Metab Toxicol 6: 543-554.
19. Medico E, Mongiovi AM, Huff J, Jelinek MA, Follenzi A, et al. (1996) The tyrosine kinase receptors Ron and Sea control "scattering" and morphogenesis of liver progenitor cells in vitro. Mol Biol Cell 7: 495-504.
20. Greenwel P, Schwartz M, Rosas M, Peyrol S, Grimaud JA, et al. (1991) Characterization of fat-storing cell lines derived from normal and CCl4-cirrhotic livers. Differences in the production of interleukin-6. Lab Invest 65: 644-653.
21. Thery C, Regnault A, Garin J, Wolfers J, Zitvogel L, et al. (1999) Molecular characterization of dendritic cell-derived exosomes. Selective accumulation of the heat shock protein hsc73. J Cell Biol 147: 599-610.
22. Raposo G, Nijman HW, Stoorvogel W, Liejendekker R, Harding CV, et al. (1996) B lymphocytes secrete antigen-presenting vesicles. J Exp Med 183: 1161-1172.
23. Lamparski HG, Metha-Damani A, Yao JY, Patel S, Hsu DH, et al. (2002) Production and characterization of clinical grade exosomes derived from dendritic cells. J Immunol Methods 270: 211-226.
24. Dragovic RA, Gardiner C, Brooks AS, Tannetta DS, Ferguson DJ, et al. (2011) Sizing and phenotyping of cellular vesicles using Nanoparticle Tracking Analysis. Nanomedicine 7: 780-788.
25. Rozen S, Skaletsky H, (2000) Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol 132: 365-386.
26. Du P, Kibbe WA, Lin SM, (2008) lumi: a pipeline for processing Illumina microarray. Bioinformatics 24: 1547-1548.
27. Wettenhall JM, Smyth GK, (2004) limmaGUI: a graphical user interface for linear modeling of microarray data. Bioinformatics 20: 3705-3706.
28. Eldh M, Lotvall J, Malmhall C, Ekstrom K, (2012) Importance of RNA isolation methods for analysis of exosomal RNA: evaluation of different methods. Mol Immunol 50: 278-286.
29. Chiba M, Kimura M, Asari S, (2012) Exosomes secreted from human colorectal cancer cell lines contain mRNAs, microRNAs and natural antisense RNAs, that can transfer into the human hepatoma HepG2 and lung cancer A549 cell lines. Oncol Rep 28: 1551-1558.
30. Hessvik NP, Phuyal S, Brech A, Sandvig K, Llorente A, (2012) Profiling of microRNAs in exosomes released from PC-3 prostate cancer cells. Biochim Biophys Acta 1819: 1154-1163.
31. Huan J, Hornick NI, Skinner AM, Goloviznina NA, Roberts CT, et al. (2012) RNA trafficking by acute myeloid leukemia exosomes. Cancer Res 2012: 13.
32. Kogure T, Lin WL, Yan IK, Braconi C, Patel T, (2011) Intercellular nanovesicle-mediated microRNA transfer: a mechanism of environmental modulation of hepatocellular cancer cell growth. Hepatology 54: 1237-1248.
33. Waldenstrom A, Genneback N, Hellman U, Ronquist G, (2012) Cardiomyocyte microvesicles contain DNA/RNA and convey biological messages to target cells. PLoS ONE 7: e34653.
34. de Jong OG, Verhaar MC, Chen Y, Vader P, Gremmels H, et al. (2012) Cellular stress conditions are reflected in the protein and RNA content of endothelial cell-derived exosomes. Journal of Extracellular Vesicles; Vol 1 (2012) incl Supplements.
35. Thery C, Amigorena S, Raposo G, Clayton A (2006) Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Curr Protoc Cell Biol Chapter 3: Unit 3 22.
36. Royo F, Falcon-Perez JM (2012) Liver extracellular vesicles in health and disease. Journal of Extracellular Vesicles; Vol 1 (2012) incl Supplements.
37. Friedman SL, (2000) Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem 275: 2247-2250.
38. Witek RP, Yang L, Liu R, Jung Y, Omenetti A, et al. (2009) Liver cell-derived microparticles activate hedgehog signaling and alter gene expression in hepatic endothelial cells. Gastroenterology 136: 320-330 e322.
39. DeLeve LD, Wang X, Hu L, McCuskey MK, McCuskey RS, (2004) Rat liver sinusoidal endothelial cell phenotype is maintained by paracrine and autocrine regulation. Am J Physiol Gastrointest Liver Physiol 287: G757-763.
40. Rockey DC, Chung JJ, (1997) Regulation of inducible nitric oxide synthase and nitric oxide during hepatic injury and fibrogenesis. Am J Physiol 273: G124-130.
41. Vlassov AV, Magdaleno S, Setterquist R, Conrad R, (2012) Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials. Biochim Biophys Acta 1820: 940-948.
42. Keppler D, Lesch R, Reutter W, Decker K, (1968) Experimental hepatitis induced by D-galactosamine. Exp Mol Pathol 9: 279-290.
43. James LP, Mayeux PR, Hinson JA, (2003) Acetaminophen-induced hepatotoxicity. Drug Metab Dispos 31: 1499-1506.
44. Castell JV, Gomez-Lechon MJ, Ponsoda X, Bort R, (1997) The use of cultured hepatocytes to investigate the mechanisms of drug hepatotoxicity. Cell Biol Toxicol 13: 331-338.
45. El-Andaloussi S, Lee Y, Lakhal-Littleton S, Li J, Seow Y, et al. (2012) Exosome-mediated delivery of siRNA in vitro and in vivo. Nat Protoc 7: 2112-2126.
46. Duijvesz D, Luider T, Bangma CH, Jenster G, (2011) Exosomes as biomarker treasure chests for prostate cancer. Eur Urol 59: 823-831.
47. Eldh M, Ekstrom K, Valadi H, Sjostrand M, Olsson B, et al. (2010) Exosomes communicate protective messages during oxidative stress; possible role of exosomal shuttle RNA. PLoS ONE 5: e15353.
48. Deregibus MC, Cantaluppi V, Calogero R, Lo Iacono M, Tetta C, et al. (2007) Endothelial progenitor cell derived microvesicles activate an angiogenic program in endothelial cells by a horizontal transfer of mRNA. Blood 110: 2440-2448.
49. Ratajczak J, Miekus K, Kucia M, Zhang J, Reca R, et al. (2006) Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery. Leukemia 20: 847-856.
50. Herrera MB, Fonsato V, Gatti S, Deregibus MC, Sordi A, et al. (2010) Human liver stem cell-derived microvesicles accelerate hepatic regeneration in hepatectomized rats. J Cell Mol Med 14: 1605-1618.
51. Garcia-Trevijano ER, Martinez-Chantar ML, Latasa MU, Mato JM, Avila MA, (2002) NO sensitizes rat hepatocytes to proliferation by modifying S-adenosylmethionine levels. Gastroenterology 122: 1355-1363.
52. Hellerbrand C (2013) Hepatic stellate cells-the pericytes in the liver. Pflugers Arch.
53. Kornek M, Popov Y, Libermann TA, Afdhal NH, Schuppan D, (2011) Human T cell microparticles circulate in blood of hepatitis patients and induce fibrolytic activation of hepatic stellate cells. Hepatology 53: 230-242.
54. Schmelzle M, Splith K, Andersen LW, Kornek M, Schuppan D, et al. (2013) Increased plasma levels of microparticles expressing CD39 and CD133 in acute liver injury. Transplantation 95: 63-69.
55. Brodsky SV, Facciuto ME, Heydt D, Chen J, Islam HK, et al. (2008) Dynamics of circulating microparticles in liver transplant patients. J Gastrointestin Liver Dis 17: 261-268.
56. Wetmore BA, Brees DJ, Singh R, Watkins PB, Andersen ME, et al. (2010) Quantitative analyses and transcriptomic profiling of circulating messenger RNAs as biomarkers of rat liver injury. Hepatology 51: 2127-2139.