Identification of novel liver-specific mrnas in plasma for biomarkers of drug-induced liver injury and quantitative evaluation in rats treated with various hepatotoxic compounds

Toxicological Sciences

Volumn 132, Issue 1, 2013, Pages 21-31

  Okubo, Shingo ^a,b   Miyamoto, Makoto ^a,b   Takami, Kenji ^a,b   Kanki, Masayuki ^b,c   Ono, Atsushi ^b,d   Nakatsu, Noriyuki ^b   Yamada, Hiroshi ^b   Ohno, Yasuo ^d   Urushidani, Tetsuro ^b,e  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^b NATIONAL INSTITUTE OF BIOMEDICAL INNOVATION   (Japan)

^c ASTELLAS PHARMA INC   (Japan)

^d NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^e DOSHISHA WOMEN'S COLLEGE OF LIBERAL ARTS   (Japan)

Author keywords

Biomarker; Circulating liver specific mrnas; Drug induced liver injury; Hepatotoxic compounds; Quantitative analysis

Indexed keywords

AFLATOXIN B1; ALANINE AMINOTRANSFERASE; ALBUMIN; ALPHA 1 MICROGLOBULIN; BETA2 GLYCOPROTEIN 1; BROMOBENZENE; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITROSOMORPHOLINE; PARACETAMOL; THIOACETAMIDE; VITAMIN D BINDING PROTEIN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE MARKER; GENE DOSAGE; GENETIC ANALYSIS; INJURY SEVERITY; LIVER NECROSIS; MALE; NONHUMAN; PROTEIN ANALYSIS; QUANTITATIVE ANALYSIS; RAT; RELIABILITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TOXIC HEPATITIS;

ANIMALS; BASE SEQUENCE; BIOLOGICAL MARKERS; DNA PRIMERS; DRUG-INDUCED LIVER INJURY; LIVER; MALE; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER;

RATTUS;

EID: 84876496042     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfs340     Document Type: Article

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