메뉴 건너뛰기




Volumn 65, Issue 2, 2013, Pages 779-808

Idiosyncratic adverse drug reactions: Current concepts

Author keywords

[No Author keywords available]

Indexed keywords

1 CHLORO 2,4 DINITROBENZENE; BETA LACTAM ANTIBIOTIC; DRUG; HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 2; PARACETAMOL; PENICILLAMINE; PHENYLENEDIAMINE; PROTEIN; SULFAMETHOXAZOLE; SUPEROXIDE DISMUTASE; ANTIINFECTIVE AGENT; BETA LACTAM; CYTOKINE; SULFONAMIDE;

EID: 84880763009     PISSN: 00316997     EISSN: 15210081     Source Type: Journal    
DOI: 10.1124/pr.113.007450     Document Type: Review
Times cited : (240)

References (313)
  • 2
    • 79953664999 scopus 로고    scopus 로고
    • Delayed drug hypersensitivity: Models of T-cell stimulation
    • Adam J., Pichler WJ, and Yerly D (2011) Delayed drug hypersensitivity: models of T-cell stimulation. Br J Clin Pharmacol 71:701-707.
    • (2011) Br J Clin Pharmacol , vol.71 , pp. 701-707
    • Adam, J.1    Pichler, W.J.2    Yerly, D.3
  • 3
    • 58149331700 scopus 로고    scopus 로고
    • Skin sensitization to p-phenylenediamine: The diverging roles of oxidation and N-acetylation for dendritic cell activation and the immune response
    • Aeby P., Sieber T, Beck H, Gerberick GF, and Goebel C (2009) Skin sensitization to p-phenylenediamine: the diverging roles of oxidation and N-acetylation for dendritic cell activation and the immune response. J Invest Dermatol 129: 99-109.
    • (2009) J Invest Dermatol , vol.129 , pp. 99-109
    • Aeby, P.1    Sieber, T.2    Beck, H.3    Gerberick, G.F.4    Goebel, C.5
  • 5
    • 63449090874 scopus 로고    scopus 로고
    • Mechanisms and treatment of allergic disease in the big picture of regulatory T cells
    • Akdis C. A and Akdis M (2009) Mechanisms and treatment of allergic disease in the big picture of regulatory T cells. J Allergy Clin Immunol 123:735-748.
    • (2009) J Allergy Clin Immunol , vol.123 , pp. 735-748
    • Akdis, C.A.1    Akdis, M.2
  • 6
    • 34147124084 scopus 로고    scopus 로고
    • Investigating protein haptenation mechanisms of skin sensitisers using human serum albumin as a model protein
    • Aleksic M., Pease CK, Basketter DA, Panico M, Morris HR, and Dell A (2007) Investigating protein haptenation mechanisms of skin sensitisers using human serum albumin as a model protein. Toxicol In Vitro 21:723-733.
    • (2007) Toxicol In Vitro , vol.21 , pp. 723-733
    • Aleksic, M.1    Pease, C.K.2    Basketter, D.A.3    Panico, M.4    Morris, H.R.5    Dell, A.6
  • 7
    • 46549088893 scopus 로고    scopus 로고
    • Mass spectrometric identification of covalent adducts of the skin allergen 2,4-dinitro-1-chlorobenzene and model skin proteins
    • Aleksic M., Pease CK, Basketter DA, Panico M, Morris HR, and Dell A (2008) Mass spectrometric identification of covalent adducts of the skin allergen 2,4-dinitro-1-chlorobenzene and model skin proteins. Toxicol In Vitro 22:1169-1176.
    • (2008) Toxicol In Vitro , vol.22 , pp. 1169-1176
    • Aleksic, M.1    Pease, C.K.2    Basketter, D.A.3    Panico, M.4    Morris, H.R.5    Dell, A.6
  • 8
    • 64349117376 scopus 로고    scopus 로고
    • Reactivity profiling: Covalent modification of single nucleophile peptides for skin sensitization risk assessment
    • Aleksic M., Thain E, Roger D, Saib O, Davies M, Li J, Aptula A, and Zazzeroni R (2009) Reactivity profiling: covalent modification of single nucleophile peptides for skin sensitization risk assessment. Toxicol Sci 108:401-411.
    • (2009) Toxicol Sci , vol.108 , pp. 401-411
    • Aleksic, M.1    Thain, E.2    Roger, D.3    Saib, O.4    Davies, M.5    Li, J.6    Aptula, A.7    Zazzeroni, R.8
  • 13
    • 0037568064 scopus 로고    scopus 로고
    • Studies of chemical selectivity of hapten, reactivity, and skin sensitization potency. 3. Synthesis and studies on the reactivity toward model nucleophiles of the 13C-labeled skin sensitizers, 5-chloro-2-methylisothiazol-3-one (MCI) and 2-methylisothiazol-3-one (MI)
    • Alvarez-Sánchez R., Basketter D, Pease C, and Lepoittevin JP (2003) Studies of chemical selectivity of hapten, reactivity, and skin sensitization potency. 3. Synthesis and studies on the reactivity toward model nucleophiles of the 13C-labeled skin sensitizers, 5-chloro-2-methylisothiazol-3-one (MCI) and 2-methylisothiazol-3-one (MI). Chem Res Toxicol 16:627-636.
    • (2003) Chem Res Toxicol , vol.16 , pp. 627-636
    • Alvarez-Sánchez, R.1    Basketter, D.2    Pease, C.3    Lepoittevin, J.P.4
  • 14
    • 0032549060 scopus 로고    scopus 로고
    • Sulfation of minoxidil by multiple human cytosolic sulfotransferases
    • Anderson R. J, Kudlacek PE, and Clemens DL (1998) Sulfation of minoxidil by multiple human cytosolic sulfotransferases. Chem Biol Interact 109:53-67.
    • (1998) Chem Biol Interact , vol.109 , pp. 53-67
    • Anderson, R.J.1    Kudlacek, P.E.2    Clemens, D.L.3
  • 15
    • 70449393492 scopus 로고    scopus 로고
    • Molecular mimicry and immune thrombocytopenia
    • Aster R. H (2009) Molecular mimicry and immune thrombocytopenia. Blood 113: 3887-3888.
    • (2009) Blood , vol.113 , pp. 3887-3888
    • Aster, R.H.1
  • 16
    • 65849492850 scopus 로고    scopus 로고
    • Drug-induced immune thrombocytopenia: Pathogenesis, diagnosis, and management
    • Aster R. H, Curtis BR, McFarland JG, and Bougie DW (2009) Drug-induced immune thrombocytopenia: pathogenesis, diagnosis, and management. J Thromb Haemost 7:911-918.
    • (2009) J Thromb Haemost , vol.7 , pp. 911-918
    • Aster, R.H.1    Curtis, B.R.2    McFarland, J.G.3    Bougie, D.W.4
  • 18
    • 0001506594 scopus 로고
    • Glutathione: A vehicle for the transport of chemically reactive metabolites in vivo
    • Baillie T. A and Slatter JG (1991) Glutathione: a vehicle for the transport of chemically reactive metabolites in vivo. Acc Chem Res 24:264-270.
    • (1991) Acc Chem Res , vol.24 , pp. 264-270
    • Baillie, T.A.1    Slatter, J.G.2
  • 19
    • 53849141490 scopus 로고    scopus 로고
    • Expression and function of cytochrome p450-dependent enzymes in human skin cells
    • Baron J. M, Wiederholt T, Heise R, Merk HF, and Bickers DR (2008) Expression and function of cytochrome p450-dependent enzymes in human skin cells. Curr Med Chem 15:2258-2264.
    • (2008) Curr Med Chem , vol.15 , pp. 2258-2264
    • Baron, J.M.1    Wiederholt, T.2    Heise, R.3    Merk, H.F.4    Bickers, D.R.5
  • 20
    • 0000973752 scopus 로고
    • Penicillin allergy: The formation of the penicilloyl determinant
    • Batchelor F. R, Dewdney JM, and Gazzard D (1965) Penicillin allergy: the formation of the penicilloyl determinant. Nature 206:362-364.
    • (1965) Nature , vol.206 , pp. 362-364
    • Batchelor, F.R.1    Dewdney, J.M.2    Gazzard, D.3
  • 21
    • 0034004880 scopus 로고    scopus 로고
    • Sequential assessment of an antidrug antibody response in a patient with a systemic delayed-onset sulphonamide hypersensitivity syndrome reaction
    • Bedard K., Smith S, and Cribb A (2000) Sequential assessment of an antidrug antibody response in a patient with a systemic delayed-onset sulphonamide hypersensitivity syndrome reaction. Br J Dermatol 142:253-258.
    • (2000) Br J Dermatol , vol.142 , pp. 253-258
    • Bedard, K.1    Smith, S.2    Cribb, A.3
  • 22
    • 61349202964 scopus 로고    scopus 로고
    • Preservation of basophils in dapsone-induced agranulocytosis suggests a possible pathogenetic role for leucocyte peroxidases
    • Besser M., Vera J, Clark J, Chitnavis D, Beatty C, and Vassiliou G (2009) Preservation of basophils in dapsone-induced agranulocytosis suggests a possible pathogenetic role for leucocyte peroxidases. Int J Lab Hematol 31:245-247.
    • (2009) Int J Lab Hematol , vol.31 , pp. 245-247
    • Besser, M.1    Vera, J.2    Clark, J.3    Chitnavis, D.4    Beatty, C.5    Vassiliou, G.6
  • 23
    • 77953210655 scopus 로고    scopus 로고
    • Review article: Drug-induced liver injury in clinical practice
    • Björnsson E. (2010) Review article: drug-induced liver injury in clinical practice. Aliment Pharmacol Ther 32:3-13.
    • (2010) Aliment Pharmacol Ther , vol.32 , pp. 3-13
    • Björnsson, E.1
  • 24
    • 23044473682 scopus 로고    scopus 로고
    • Outcome and prognostic markers in severe druginduced liver disease
    • Björnsson E. and Olsson R (2005) Outcome and prognostic markers in severe druginduced liver disease. Hepatology 42:481-489.
    • (2005) Hepatology , vol.42 , pp. 481-489
    • Björnsson, E.1    Olsson, R.2
  • 26
    • 33845357261 scopus 로고    scopus 로고
    • Syndromes and complications of interferon therapy
    • Borg F. A and Isenberg DA (2007) Syndromes and complications of interferon therapy. Curr Opin Rheumatol 19:61-66.
    • (2007) Curr Opin Rheumatol , vol.19 , pp. 61-66
    • Borg, F.A.1    Isenberg, D.A.2
  • 27
    • 0037105428 scopus 로고    scopus 로고
    • Acute thrombocytopenia after treatment with tirofiban or eptifibatide is associated with antibodies specific for ligand-occupied GPIIb/IIIa
    • Bougie D. W, Wilker PR, Wuitschick ED, Curtis BR, Malik M, Levine S, Lind RN, Pereira J., and Aster RH (2002) Acute thrombocytopenia after treatment with tirofiban or eptifibatide is associated with antibodies specific for ligand-occupied GPIIb/IIIa. Blood 100:2071-2076.
    • (2002) Blood , vol.100 , pp. 2071-2076
    • Bougie, D.W.1    Wilker, P.R.2    Wuitschick, E.D.3    Curtis, B.R.4    Malik, M.5    Levine, S.6    Lind, R.N.7    Pereira, J.8    Aster, R.H.9
  • 28
    • 0029068773 scopus 로고
    • Heterogeneous T cell responses to beta-lactam-modified self-structures are observed in penicillin-allergic individuals
    • Brander C., Mauri-Hellweg D, Bettens F, Rolli H, Goldman M, and Pichler WJ (1995) Heterogeneous T cell responses to beta-lactam-modified self-structures are observed in penicillin-allergic individuals. J Immunol 155:2670-2678.
    • (1995) J Immunol , vol.155 , pp. 2670-2678
    • Brander, C.1    Mauri-Hellweg, D.2    Bettens, F.3    Rolli, H.4    Goldman, M.5    Pichler, W.J.6
  • 30
    • 84856937131 scopus 로고    scopus 로고
    • Drug-induced rheumatic diseases: A review of published case reports from the last two years
    • Bukhari M. (2012) Drug-induced rheumatic diseases: a review of published case reports from the last two years. Curr Opin Rheumatol 24:182-186.
    • (2012) Curr Opin Rheumatol , vol.24 , pp. 182-186
    • Bukhari, M.1
  • 31
    • 0035112838 scopus 로고    scopus 로고
    • Influence of reduced glutathione on the proliferative response of sulfamethoxazole-specific and sulfamethoxazole-metabolite-specific human CD4+ T-cells
    • Burkhart C., von Greyerz S, Depta JP, Naisbitt DJ, Britschgi M, Park KB, and Pichler WJ (2001) Influence of reduced glutathione on the proliferative response of sulfamethoxazole-specific and sulfamethoxazole-metabolite-specific human CD4+ T-cells. Br J Pharmacol 132:623-630.
    • (2001) Br J Pharmacol , vol.132 , pp. 623-630
    • Burkhart, C.1    von Greyerz, S.2    Depta, J.P.3    Naisbitt, D.J.4    Britschgi, M.5    Park, K.B.6    Pichler, W.J.7
  • 33
    • 67649992761 scopus 로고    scopus 로고
    • Multiple adduction reactions of nitroso sulfamethoxazole with cysteinyl residues of peptides and proteins: Implications for hapten formation
    • Callan H. E, Jenkins RE, Maggs JL, Lavergne SN, Clarke SE, Naisbitt DJ, and Park BK (2009) Multiple adduction reactions of nitroso sulfamethoxazole with cysteinyl residues of peptides and proteins: implications for hapten formation. Chem Res Toxicol 22:937-948.
    • (2009) Chem Res Toxicol , vol.22 , pp. 937-948
    • Callan, H.E.1    Jenkins, R.E.2    Maggs, J.L.3    Lavergne, S.N.4    Clarke, S.E.5    Naisbitt, D.J.6    Park, B.K.7
  • 34
    • 0034908845 scopus 로고    scopus 로고
    • Drug-induced cutaneous lupus erythematosus, a distinct syndrome that is frequently unrecognized
    • Callen J. P (2001) Drug-induced cutaneous lupus erythematosus, a distinct syndrome that is frequently unrecognized. J Am Acad Dermatol 45:315-316.
    • (2001) J Am Acad Dermatol , vol.45 , pp. 315-316
    • Callen, J.P.1
  • 35
    • 0021169510 scopus 로고
    • The lupus syndrome induced by hydralazine: A common complication with low dose treatment
    • Cameron H. A and Ramsay LE (1984) The lupus syndrome induced by hydralazine: a common complication with low dose treatment. Br Med J (Clin Res Ed) 289: 410-412.
    • (1984) Br Med J (Clin Res Ed) , vol.289 , pp. 410-412
    • Cameron, H.A.1    Ramsay, L.E.2
  • 36
    • 27444444430 scopus 로고    scopus 로고
    • Immunochemical detection of flucloxacillin adduct formation in livers of treated rats
    • Carey M. A and van Pelt FN (2005) Immunochemical detection of flucloxacillin adduct formation in livers of treated rats. Toxicology 216:41-48.
    • (2005) Toxicology , vol.216 , pp. 41-48
    • Carey, M.A.1    van Pelt, F.N.2
  • 38
    • 75149137515 scopus 로고    scopus 로고
    • Metabolic and chemical origins of crossreactive immunological reactions to arylamine benzenesulfonamides: T-cell responses to hydroxylamine and nitroso derivatives
    • Castrejon J. L, Lavergne SN, El-Sheikh A, Farrell J, Maggs JL, Sabbani S, O'Neill PM, Park BK, and Naisbitt DJ (2010b) Metabolic and chemical origins of crossreactive immunological reactions to arylamine benzenesulfonamides: T-cell responses to hydroxylamine and nitroso derivatives. Chem Res Toxicol 23:184-192.
    • (2010) Chem Res Toxicol , vol.23 , pp. 184-192
    • Castrejon, J.L.1    Lavergne, S.N.2    El-Sheikh, A.3    Farrell, J.4    Maggs, J.L.5    Sabbani, S.6    O'Neill, P.M.7    Park, B.K.8    Naisbitt, D.J.9
  • 39
    • 77952718055 scopus 로고    scopus 로고
    • Risk factors for idiosyncratic drug-induced liver injury
    • Chalasani N. and Björnsson E (2010) Risk factors for idiosyncratic drug-induced liver injury. Gastroenterology 138:2246-2259.
    • (2010) Gastroenterology , vol.138 , pp. 2246-2259
    • Chalasani, N.1    Björnsson, E.2
  • 40
    • 57249086242 scopus 로고    scopus 로고
    • Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States
    • Drug-Induced Liver Injury Network
    • Chalasani N., Fontana RJ, Bonkovsky HL, Watkins PB, Davern T, Serrano J, Yang H, and Rochon J; Drug-Induced Liver Injury Network (2008) Causes, clinical features, and outcomes from a prospective study of drug-induced liver injury in the United States. Gastroenterology 135:1924-1934.
    • (2008) Gastroenterology , vol.135 , pp. 1924-1934
    • Chalasani, N.1    Fontana, R.J.2    Bonkovsky, H.L.3    Watkins, P.B.4    Davern, T.5    Serrano, J.6    Yang, H.7    Rochon, J.8
  • 41
    • 0020380944 scopus 로고
    • Systemic lupus erythematosus during penicillamine therapy for rheumatoid arthritis
    • Chalmers A., Thompson D, Stein HE, Reid G, and Patterson AC (1982) Systemic lupus erythematosus during penicillamine therapy for rheumatoid arthritis. Ann Intern Med 97:659-663.
    • (1982) Ann Intern Med , vol.97 , pp. 659-663
    • Chalmers, A.1    Thompson, D.2    Stein, H.E.3    Reid, G.4    Patterson, A.C.5
  • 42
    • 79955395000 scopus 로고    scopus 로고
    • Drug-induced lupus erythematosus: Incidence, management and prevention
    • Chang C. and Gershwin ME (2011) Drug-induced lupus erythematosus: incidence, management and prevention. Drug Saf 34:357-374.
    • (2011) Drug Saf , vol.34 , pp. 357-374
    • Chang, C.1    Gershwin, M.E.2
  • 45
    • 58949083563 scopus 로고    scopus 로고
    • Effect of polyI:C cotreatment on halothane-induced liver injury in mice
    • Cheng L., You Q, Yin H, Holt M, Franklin C, and Ju C (2009) Effect of polyI:C cotreatment on halothane-induced liver injury in mice. Hepatology 49:215-226.
    • (2009) Hepatology , vol.49 , pp. 215-226
    • Cheng, L.1    You, Q.2    Yin, H.3    Holt, M.4    Franklin, C.5    Ju, C.6
  • 46
    • 77952671411 scopus 로고    scopus 로고
    • Involvement of natural killer T cells in halothane-induced liver injury in mice
    • Cheng L., You Q, Yin H, Holt MP, and Ju C (2010) Involvement of natural killer T cells in halothane-induced liver injury in mice. Biochem Pharmacol 80:255-261.
    • (2010) Biochem Pharmacol , vol.80 , pp. 255-261
    • Cheng, L.1    You, Q.2    Yin, H.3    Holt, M.P.4    Ju, C.5
  • 47
    • 77954692374 scopus 로고    scopus 로고
    • Clinicopathologic manifestations of 36 korean patients with acute generalized exanthematous pustulosis: A case series and review of the literature
    • Choi M. J, Kim HS, Park HJ, Park CJ, Lee JD, Lee JY, Kim HO, and Park YM (2010) Clinicopathologic manifestations of 36 korean patients with acute generalized exanthematous pustulosis: a case series and review of the literature. Ann Dermatol 22:163-169.
    • (2010) Ann Dermatol , vol.22 , pp. 163-169
    • Choi, M.J.1    Kim, H.S.2    Park, H.J.3    Park, C.J.4    Lee, J.D.5    Lee, J.Y.6    Kim, H.O.7    Park, Y.M.8
  • 48
    • 0035826077 scopus 로고    scopus 로고
    • Induction of delayed-type hypersensitivity to sulfamethoxazole in mice: Role of metabolites
    • Choquet-Kastylevsky G., Santolaria N, Tedone R, Aujoulat M, and Descotes J (2001) Induction of delayed-type hypersensitivity to sulfamethoxazole in mice: role of metabolites. Toxicol Lett 119:183-192.
    • (2001) Toxicol Lett , vol.119 , pp. 183-192
    • Choquet-Kastylevsky, G.1    Santolaria, N.2    Tedone, R.3    Aujoulat, M.4    Descotes, J.5
  • 49
    • 0023900984 scopus 로고
    • A survey of the prevalence of penicillin-specific IgG, IgM and IgE antibodies detected by ELISA and defined by hapten inhibition, in patients with suspected penicillin allergy and in healthy volunteers
    • Christie G., Coleman JW, Newby S, McDiarmaid-Gordon A, Hampson JP, Breckenridge AM, and Park BK (1988) A survey of the prevalence of penicillin-specific IgG, IgM and IgE antibodies detected by ELISA and defined by hapten inhibition, in patients with suspected penicillin allergy and in healthy volunteers. Br J Clin Pharmacol 25:381-386.
    • (1988) Br J Clin Pharmacol , vol.25 , pp. 381-386
    • Christie, G.1    Coleman, J.W.2    Newby, S.3    McDiarmaid-Gordon, A.4    Hampson, J.P.5    Breckenridge, A.M.6    Park, B.K.7
  • 50
    • 57349198641 scopus 로고    scopus 로고
    • Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis
    • Chung W. H, Hung SI, Yang JY, Su SC, Huang SP, Wei CY, Chin SW, Chiou CC, Chu SC, and Ho HC, et al. (2008) Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis. Nat Med 14:1343-1350.
    • (2008) Nat Med , vol.14 , pp. 1343-1350
    • Chung, W.H.1    Hung, S.I.2    Yang, J.Y.3    Su, S.C.4    Huang, S.P.5    Wei, C.Y.6    Chin, S.W.7    Chiou, C.C.8    Chu, S.C.9    Ho, H.C.10
  • 51
    • 33645634796 scopus 로고    scopus 로고
    • Brief communication: Severe hepatotoxicity of telithromycin: Three case reports and literature review
    • Clay K. D, Hanson JS, Pope SD, Rissmiller RW, Purdum PP 3rd, and Banks PM (2006) Brief communication: severe hepatotoxicity of telithromycin: three case reports and literature review. Ann Intern Med 144:415-420.
    • (2006) Ann Intern Med , vol.144 , pp. 415-420
    • Clay, K.D.1    Hanson, J.S.2    Pope, S.D.3    Rissmiller, R.W.4    Purdum III, P.P.5    Banks, P.M.6
  • 52
    • 44349171691 scopus 로고    scopus 로고
    • Drug-induced lupus due to antitumor necrosis factor alpha agents
    • Costa M. F, Said NR, and Zimmermann B (2008) Drug-induced lupus due to antitumor necrosis factor alpha agents. Semin Arthritis Rheum 37:381-387.
    • (2008) Semin Arthritis Rheum , vol.37 , pp. 381-387
    • Costa, M.F.1    Said, N.R.2    Zimmermann, B.3
  • 56
    • 0029892271 scopus 로고    scopus 로고
    • Covalent binding of sulfamethoxazole reactive metabolites to human and rat liver subcellular fractions assessed by immunochemical detection
    • Cribb A. E, Nuss CE, Alberts DW, Lamphere DB, Grant DM, Grossman SJ, and Spielberg SP (1996) Covalent binding of sulfamethoxazole reactive metabolites to human and rat liver subcellular fractions assessed by immunochemical detection. Chem Res Toxicol 9:500-507.
    • (1996) Chem Res Toxicol , vol.9 , pp. 500-507
    • Cribb, A.E.1    Nuss, C.E.2    Alberts, D.W.3    Lamphere, D.B.4    Grant, D.M.5    Grossman, S.J.6    Spielberg, S.P.7
  • 57
    • 0026552198 scopus 로고
    • Sulfamethoxazole is metabolized to the hydroxylamine in humans
    • Cribb A. E and Spielberg SP (1992) Sulfamethoxazole is metabolized to the hydroxylamine in humans. Clin Pharmacol Ther 51:522-526.
    • (1992) Clin Pharmacol Ther , vol.51 , pp. 522-526
    • Cribb, A.E.1    Spielberg, S.P.2
  • 58
    • 0028986887 scopus 로고
    • N4-hydroxylation of sulfamethoxazole by cytochrome P450 of the cytochrome P4502C subfamily and reduction of sulfamethoxazole hydroxylamine in human and rat hepatic microsomes
    • Cribb A. E, Spielberg SP, and Griffin GP (1995) N4-hydroxylation of sulfamethoxazole by cytochrome P450 of the cytochrome P4502C subfamily and reduction of sulfamethoxazole hydroxylamine in human and rat hepatic microsomes. Drug Metab Dispos 23:406-414.
    • (1995) Drug Metab Dispos , vol.23 , pp. 406-414
    • Cribb, A.E.1    Spielberg, S.P.2    Griffin, G.P.3
  • 59
    • 79955601004 scopus 로고    scopus 로고
    • Drug-induced autoimmune-like hepatitis
    • Czaja A. J (2011) Drug-induced autoimmune-like hepatitis. Dig Dis Sci 56:958-976.
    • (2011) Dig Dis Sci , vol.56 , pp. 958-976
    • Czaja, A.J.1
  • 61
    • 0027532128 scopus 로고
    • Fresh and cultured Langerhans cells display differential capacities to activate hapten-specific T cells
    • Dai R., Grammer SF, and Streilein JW (1993) Fresh and cultured Langerhans cells display differential capacities to activate hapten-specific T cells. J Immunol 150: 59-66.
    • (1993) J Immunol , vol.150 , pp. 59-66
    • Dai, R.1    Grammer, S.F.2    Streilein, J.W.3
  • 62
    • 0031594159 scopus 로고    scopus 로고
    • Naïve, hapten-specific human T lymphocytes are primed in vitro with derivatized blood mononuclear cells
    • Dai R. and Streilein JW (1998) Naïve, hapten-specific human T lymphocytes are primed in vitro with derivatized blood mononuclear cells. J Invest Dermatol 110: 29-33.
    • (1998) J Invest Dermatol , vol.110 , pp. 29-33
    • Dai, R.1    Streilein, J.W.2
  • 63
    • 84855906545 scopus 로고    scopus 로고
    • Using genome-wide association studies to identify genes important in serious adverse drug reactions
    • Daly A. K (2012) Using genome-wide association studies to identify genes important in serious adverse drug reactions. Annu Rev Pharmacol Toxicol 52:21-35.
    • (2012) Annu Rev Pharmacol Toxicol , vol.52 , pp. 21-35
    • Daly, A.K.1
  • 65
    • 0022623294 scopus 로고
    • Onset of penicillin rashes: Relation between type of penicillin administered and type of immune reactivity
    • de Haan P, Bruynzeel DP, and van Ketel WG (1986) Onset of penicillin rashes: relation between type of penicillin administered and type of immune reactivity. Allergy 41:75-78.
    • (1986) Allergy , vol.41 , pp. 75-78
    • de Haan, P.1    Bruynzeel, D.P.2    van Ketel, W.G.3
  • 68
    • 77956898865 scopus 로고    scopus 로고
    • Tracking human contact allergens: From mass spectrometric identification of peptide-bound reactive small chemicals to chemical-specific naive human T-cell priming
    • Dietz L., Esser PR, Schmucker SS, Goette I, Richter A, Schnölzer M, Martin SF, and Thierse HJ (2010) Tracking human contact allergens: from mass spectrometric identification of peptide-bound reactive small chemicals to chemical-specific naive human T-cell priming. Toxicol Sci 117:336-347.
    • (2010) Toxicol Sci , vol.117 , pp. 336-347
    • Dietz, L.1    Esser, P.R.2    Schmucker, S.S.3    Goette, I.4    Richter, A.5    Schnölzer, M.6    Martin, S.F.7    Thierse, H.J.8
  • 69
    • 27144479286 scopus 로고    scopus 로고
    • Hapten-protein binding: From theory to practical application in the in vitro prediction of skin sensitization
    • Divkovic M., Pease CK, Gerberick GF, and Basketter DA (2005) Hapten-protein binding: from theory to practical application in the in vitro prediction of skin sensitization. Contact Dermat 53:189-200.
    • (2005) Contact Dermat , vol.53 , pp. 189-200
    • Divkovic, M.1    Pease, C.K.2    Gerberick, G.F.3    Basketter, D.A.4
  • 70
    • 0021355816 scopus 로고
    • Effects of prolonged administration of D-penicillamine or captopril in various strains of rats. Brown Norway rats treated with D-penicillamine develop autoantibodies, circulating immune complexes, and disseminated intravascular coagulation
    • Donker A. J, Venuto RC, Vladutiu AO, Brentjens JR, and Andres GA (1984) Effects of prolonged administration of D-penicillamine or captopril in various strains of rats. Brown Norway rats treated with D-penicillamine develop autoantibodies, circulating immune complexes, and disseminated intravascular coagulation. Clin Immunol Immunopathol 30:142-155.
    • (1984) Clin Immunol Immunopathol , vol.30 , pp. 142-155
    • Donker, A.J.1    Venuto, R.C.2    Vladutiu, A.O.3    Brentjens, J.R.4    Andres, G.A.5
  • 71
    • 84861235187 scopus 로고    scopus 로고
    • Toxic epidermal necrolysis: Review of pathogenesis and management
    • Downey A., Jackson C, Harun N, and Cooper A (2012) Toxic epidermal necrolysis: review of pathogenesis and management. J Am Acad Dermatol 66:995-1003.
    • (2012) J Am Acad Dermatol , vol.66 , pp. 995-1003
    • Downey, A.1    Jackson, C.2    Harun, N.3    Cooper, A.4
  • 72
    • 79955980376 scopus 로고    scopus 로고
    • Autoimmune hepatitis during infliximab therapy for Crohn's disease: A case report
    • Doyle A., Forbes G, and Kontorinis N (2011) Autoimmune hepatitis during infliximab therapy for Crohn's disease: a case report. J Crohn's Colitis 5:253-255.
    • (2011) J Crohn's Colitis , vol.5 , pp. 253-255
    • Doyle, A.1    Forbes, G.2    Kontorinis, N.3
  • 74
    • 0029786269 scopus 로고    scopus 로고
    • Cytochrome P450 2E1 is a cell surface autoantigen in halothane hepatitis
    • Eliasson E. and Kenna JG (1996) Cytochrome P450 2E1 is a cell surface autoantigen in halothane hepatitis. Mol Pharmacol 50:573-582.
    • (1996) Mol Pharmacol , vol.50 , pp. 573-582
    • Eliasson, E.1    Kenna, J.G.2
  • 75
    • 84864874057 scopus 로고    scopus 로고
    • Type I IFN system in the development and manifestations of SLE
    • Elkon K. B and Wiedeman A (2012) Type I IFN system in the development and manifestations of SLE. Curr Opin Rheumatol 24:499-505.
    • (2012) Curr Opin Rheumatol , vol.24 , pp. 499-505
    • Elkon, K.B.1    Wiedeman, A.2
  • 77
    • 79952117348 scopus 로고    scopus 로고
    • Drug antigenicity, immunogenicity, and costimulatory signaling: Evidence for formation of a functional antigen through immune cell metabolism
    • Elsheikh A., Lavergne SN, Castrejon JL, Farrell J, Wang H, Sathish J, Pichler WJ, Park B. K, and Naisbitt DJ (2010) Drug antigenicity, immunogenicity, and costimulatory signaling: evidence for formation of a functional antigen through immune cell metabolism. J Immunol 185:6448-6460.
    • (2010) J Immunol , vol.185 , pp. 6448-6460
    • Elsheikh, A.1    Lavergne, S.N.2    Castrejon, J.L.3    Farrell, J.4    Wang, H.5    Sathish, J.6    Pichler, W.J.7    Park, B.K.8    Naisbitt, D.J.9
  • 78
    • 1542285424 scopus 로고    scopus 로고
    • A chemically inert drug can stimulate T cells in vitro by their T cell receptor in non-sensitised individuals
    • Engler O. B, Strasser I, Naisbitt DJ, Cerny A, and Pichler WJ (2004) A chemically inert drug can stimulate T cells in vitro by their T cell receptor in non-sensitised individuals. Toxicology 197:47-56.
    • (2004) Toxicology , vol.197 , pp. 47-56
    • Engler, O.B.1    Strasser, I.2    Naisbitt, D.J.3    Cerny, A.4    Pichler, W.J.5
  • 84
    • 2342430991 scopus 로고    scopus 로고
    • Molecular mechanisms of endotoxin tolerance
    • Fan H. and Cook JA (2004) Molecular mechanisms of endotoxin tolerance. J Endotoxin Res 10:71-84.
    • (2004) J Endotoxin Res , vol.10 , pp. 71-84
    • Fan, H.1    Cook, J.A.2
  • 88
    • 0020519003 scopus 로고
    • Quantitative relationships between sensitizing dose of DNCB and reactivity in normal subjects
    • Friedmann P. S, Moss C, Shuster S, and Simpson JM (1983) Quantitative relationships between sensitizing dose of DNCB and reactivity in normal subjects. Clin Exp Immunol 53:709-715.
    • (1983) Clin Exp Immunol , vol.53 , pp. 709-715
    • Friedmann, P.S.1    Moss, C.2    Shuster, S.3    Simpson, J.M.4
  • 89
    • 67049169349 scopus 로고    scopus 로고
    • Sensitivity of liver injury in heterozygous Sod2 knockout mice treated with troglitazone or acetaminophen
    • Fujimoto K., Kumagai K, Ito K, Arakawa S, Ando Y, Oda S, Yamoto T, and Manabe S (2009) Sensitivity of liver injury in heterozygous Sod2 knockout mice treated with troglitazone or acetaminophen. Toxicol Pathol 37:193-200.
    • (2009) Toxicol Pathol , vol.37 , pp. 193-200
    • Fujimoto, K.1    Kumagai, K.2    Ito, K.3    Arakawa, S.4    Ando, Y.5    Oda, S.6    Yamoto, T.7    Manabe, S.8
  • 90
    • 0030838522 scopus 로고    scopus 로고
    • Interaction of lymphocytes with Kupffer cells from halothane-exposed guinea pigs
    • Furst S. M and Gandolfi AJ (1997) Interaction of lymphocytes with Kupffer cells from halothane-exposed guinea pigs. Int Arch Allergy Immunol 114:46-53.
    • (1997) Int Arch Allergy Immunol , vol.114 , pp. 46-53
    • Furst, S.M.1    Gandolfi, A.J.2
  • 91
    • 0030997811 scopus 로고    scopus 로고
    • Kupffer cells from halothaneexposed guinea pigs carry trifluoroacetylated protein adducts
    • Furst S. M, Luedke D, and Gandolfi AJ (1997a) Kupffer cells from halothaneexposed guinea pigs carry trifluoroacetylated protein adducts. Toxicology 120: 119-132.
    • (1997) Toxicology , vol.120 , pp. 119-132
    • Furst, S.M.1    Luedke, D.2    Gandolfi, A.J.3
  • 92
  • 93
    • 84862868480 scopus 로고    scopus 로고
    • Immune hemolytic anemia caused by drugs
    • Garratty G. (2012) Immune hemolytic anemia caused by drugs. Expert Opin Drug Saf 11:635-642.
    • (2012) Expert Opin Drug Saf , vol.11 , pp. 635-642
    • Garratty, G.1
  • 95
    • 34447547764 scopus 로고    scopus 로고
    • Quantification of chemical peptide reactivity for screening contact allergens: A classification tree model approach
    • Gerberick G. F, Vassallo JD, Foertsch LM, Price BB, Chaney JG, and Lepoittevin JP (2007) Quantification of chemical peptide reactivity for screening contact allergens: a classification tree model approach. Toxicol Sci 97:417-427.
    • (2007) Toxicol Sci , vol.97 , pp. 417-427
    • Gerberick, G.F.1    Vassallo, J.D.2    Foertsch, L.M.3    Price, B.B.4    Chaney, J.G.5    Lepoittevin, J.P.6
  • 96
    • 0344043698 scopus 로고
    • Mechanisms of clozapine-induced agranulocytosis
    • Gerson S. L and Meltzer H (1992) Mechanisms of clozapine-induced agranulocytosis. Drug Saf 7 (Suppl 1):17-25.
    • (1992) Drug Saf , vol.7 , Issue.SUPPL. 1 , pp. 17-25
    • Gerson, S.L.1    Meltzer, H.2
  • 97
    • 0023178348 scopus 로고
    • Pure red cell aplasia associated with administration of sustained-release procainamide
    • Giannone L., Kugler JW, and Krantz SB (1987) Pure red cell aplasia associated with administration of sustained-release procainamide. Arch Intern Med 147: 1179-1180.
    • (1987) Arch Intern Med , vol.147 , pp. 1179-1180
    • Giannone, L.1    Kugler, J.W.2    Krantz, S.B.3
  • 98
    • 0029836423 scopus 로고    scopus 로고
    • The effect of fluconazole and ketoconazole on the metabolism of sulphamethoxazole
    • Gill H. J, Maggs JL, Madden S, Pirmohamed M, and Park BK (1996) The effect of fluconazole and ketoconazole on the metabolism of sulphamethoxazole. Br J Clin Pharmacol 42:347-353.
    • (1996) Br J Clin Pharmacol , vol.42 , pp. 347-353
    • Gill, H.J.1    Maggs, J.L.2    Madden, S.3    Pirmohamed, M.4    Park, B.K.5
  • 99
    • 84860347587 scopus 로고    scopus 로고
    • Increased risk of cancer among 3663 patients with cutaneous lupus erythematosus: A Swedish nationwide cohort study
    • Grönhagen C. M, Fored CM, Granath F, and Nyberg F (2012a) Increased risk of cancer among 3663 patients with cutaneous lupus erythematosus: a Swedish nationwide cohort study. Br J Dermatol 166:1053-1059.
    • (2012) Br J Dermatol , vol.166 , pp. 1053-1059
    • Grönhagen, C.M.1    Fored, C.M.2    Granath, F.3    Nyberg, F.4
  • 100
    • 84864413440 scopus 로고    scopus 로고
    • Subacute cutaneous lupus erythematosus and its association with drugs: A populationbased matched case-control study of 234 patients in Sweden
    • Grönhagen C. M, Fored CM, Linder M, Granath F, and Nyberg F (2012b) Subacute cutaneous lupus erythematosus and its association with drugs: a populationbased matched case-control study of 234 patients in Sweden. Br J Dermatol 167: 296-305.
    • (2012) Br J Dermatol , vol.167 , pp. 296-305
    • Grönhagen, C.M.1    Fored, C.M.2    Linder, M.3    Granath, F.4    Nyberg, F.5
  • 101
    • 84859440796 scopus 로고    scopus 로고
    • HMGB1: A multifunctional alarmin driving autoimmune and inflammatory disease
    • Harris H. E, Andersson U, and Pisetsky DS (2012) HMGB1: a multifunctional alarmin driving autoimmune and inflammatory disease. Nat Rev Rheumatol 8:195-202.
    • (2012) Nat Rev Rheumatol , vol.8 , pp. 195-202
    • Harris, H.E.1    Andersson, U.2    Pisetsky, D.S.3
  • 102
    • 13844262708 scopus 로고    scopus 로고
    • Drug-induced hypersensitivity syndrome associated with cytomegalovirus reactivation: Immunological characterization of pathogenic T cells
    • Hashizume H. and Takigawa M (2005) Drug-induced hypersensitivity syndrome associated with cytomegalovirus reactivation: immunological characterization of pathogenic T cells. Acta Derm Venereol 85:47-50.
    • (2005) Acta Derm Venereol , vol.85 , pp. 47-50
    • Hashizume, H.1    Takigawa, M.2
  • 103
    • 0037093996 scopus 로고    scopus 로고
    • Characterization of drug-specific T cells in phenobarbital-induced eruption
    • Hashizume H., Takigawa M, and Tokura Y (2002) Characterization of drug-specific T cells in phenobarbital-induced eruption. J Immunol 168:5359-5368.
    • (2002) J Immunol , vol.168 , pp. 5359-5368
    • Hashizume, H.1    Takigawa, M.2    Tokura, Y.3
  • 105
    • 84867298675 scopus 로고    scopus 로고
    • Human Langerhans cells control Th cells via programmed death-ligand 1 in response to bacterial stimuli and nickel-induced contact allergy
    • Hitzler M., Majdic O, Heine G, Worm M, Ebert G, Luch A, and Peiser M (2012) Human Langerhans cells control Th cells via programmed death-ligand 1 in response to bacterial stimuli and nickel-induced contact allergy. PLoS ONE 7: e46776.
    • (2012) PLoS ONE , vol.7
    • Hitzler, M.1    Majdic, O.2    Heine, G.3    Worm, M.4    Ebert, G.5    Luch, A.6    Peiser, M.7
  • 106
    • 82955227419 scopus 로고    scopus 로고
    • Factors that predict the success of cyclosporine treatment for chronic urticaria
    • Hollander S. M, Joo SS, and Wedner HJ (2011) Factors that predict the success of cyclosporine treatment for chronic urticaria. Ann Allergy Asthma Immunol 107: 523-528.
    • (2011) Ann Allergy Asthma Immunol , vol.107 , pp. 523-528
    • Hollander, S.M.1    Joo, S.S.2    Wedner, H.J.3
  • 107
    • 10044277088 scopus 로고    scopus 로고
    • Exposure of mice to the nitroso metabolite of sulfamethoxazole stimulates interleukin 5 production by CD4+ T-cells
    • Hopkins J. E, Naisbitt DJ, Humphreys N, Dearman RJ, Kimber I, and Park BK (2005) Exposure of mice to the nitroso metabolite of sulfamethoxazole stimulates interleukin 5 production by CD4+ T-cells. Toxicology 206:221-231.
    • (2005) Toxicology , vol.206 , pp. 221-231
    • Hopkins, J.E.1    Naisbitt, D.J.2    Humphreys, N.3    Dearman, R.J.4    Kimber, I.5    Park, B.K.6
  • 108
    • 0030956850 scopus 로고    scopus 로고
    • Comprehensive hospital drug monitoring (CHDM): Adverse skin reactions, a 20-year survey
    • Hunziker T., Künzi UP, Braunschweig S, Zehnder D, and Hoigné R (1997) Comprehensive hospital drug monitoring (CHDM): adverse skin reactions, a 20-year survey. Allergy 52:388-393.
    • (1997) Allergy , vol.52 , pp. 388-393
    • Hunziker, T.1    Künzi, U.P.2    Braunschweig, S.3    Zehnder, D.4    Hoigné, R.5
  • 109
    • 38449123465 scopus 로고    scopus 로고
    • Idiosyncratic drug-induced liver injury: An overview
    • Hussaini S. H and Farrington EA (2007) Idiosyncratic drug-induced liver injury: an overview. Expert Opin Drug Saf 6:673-684.
    • (2007) Expert Opin Drug Saf , vol.6 , pp. 673-684
    • Hussaini, S.H.1    Farrington, E.A.2
  • 111
    • 83255192265 scopus 로고    scopus 로고
    • Acetaminophen hepatotoxicity and repair: The role of sterile inflammation and innate immunity
    • Jaeschke H., Williams CD, Ramachandran A, and Bajt ML (2012) Acetaminophen hepatotoxicity and repair: the role of sterile inflammation and innate immunity. Liver Int 32:8-20.
    • (2012) Liver Int , vol.32 , pp. 8-20
    • Jaeschke, H.1    Williams, C.D.2    Ramachandran, A.3    Bajt, M.L.4
  • 112
    • 84861316134 scopus 로고    scopus 로고
    • Electrochemistry/liquid chromatography/mass spectrometry to demonstrate irreversible binding of the skin allergen p-phenylenediamine to proteins
    • Jahn S., Faber H, Zazzeroni R, and Karst U (2012) Electrochemistry/liquid chromatography/mass spectrometry to demonstrate irreversible binding of the skin allergen p-phenylenediamine to proteins. Rapid Commun Mass Spectrom 26: 1415-1425.
    • (2012) Rapid Commun Mass Spectrom , vol.26 , pp. 1415-1425
    • Jahn, S.1    Faber, H.2    Zazzeroni, R.3    Karst, U.4
  • 113
    • 0025850902 scopus 로고
    • Systemic lupus erythematosus (SLE)-like syndromes associated with carbamazepine therapy
    • Jain K. K (1991) Systemic lupus erythematosus (SLE)-like syndromes associated with carbamazepine therapy. Drug Saf 6:350-360.
    • (1991) Drug Saf , vol.6 , pp. 350-360
    • Jain, K.K.1
  • 117
    • 76649128409 scopus 로고    scopus 로고
    • Characterization of p-phenylenediamine-albumin binding sites and T-cell responses to hapten-modified protein
    • Jenkinson C., Jenkins RE, Aleksic M, Pirmohamed M, Naisbitt DJ, and Park BK (2010) Characterization of p-phenylenediamine-albumin binding sites and T-cell responses to hapten-modified protein. J Invest Dermatol 130:732-742.
    • (2010) J Invest Dermatol , vol.130 , pp. 732-742
    • Jenkinson, C.1    Jenkins, R.E.2    Aleksic, M.3    Pirmohamed, M.4    Naisbitt, D.J.5    Park, B.K.6
  • 121
    • 84862877720 scopus 로고    scopus 로고
    • Drug discovery for a new generation of covalent drugs
    • Kalgutkar A. S and Dalvie DK (2012) Drug discovery for a new generation of covalent drugs. Expert Opin Drug Discov 7:561-581.
    • (2012) Expert Opin Drug Discov , vol.7 , pp. 561-581
    • Kalgutkar, A.S.1    Dalvie, D.K.2
  • 122
    • 0033012134 scopus 로고    scopus 로고
    • Molecular mechanisms of CD8+ T cell-mediated delayed hypersensitivity: Implications for allergies, asthma, and autoimmunity
    • Kalish R. S and Askenase PW (1999) Molecular mechanisms of CD8+ T cell-mediated delayed hypersensitivity: implications for allergies, asthma, and autoimmunity. J Allergy Clin Immunol 103:192-199.
    • (1999) J Allergy Clin Immunol , vol.103 , pp. 192-199
    • Kalish, R.S.1    Askenase, P.W.2
  • 123
    • 35748964706 scopus 로고    scopus 로고
    • Utility of the lymphocyte transformation test in the diagnosis of drug sensitivity: Dependence on its timing and the type of drug eruption
    • Kano Y., Hirahara K, Mitsuyama Y, Takahashi R, and Shiohara T (2007) Utility of the lymphocyte transformation test in the diagnosis of drug sensitivity: dependence on its timing and the type of drug eruption. Allergy 62:1439-1444.
    • (2007) Allergy , vol.62 , pp. 1439-1444
    • Kano, Y.1    Hirahara, K.2    Mitsuyama, Y.3    Takahashi, R.4    Shiohara, T.5
  • 124
    • 33745926866 scopus 로고    scopus 로고
    • Several herpesviruses can reactivate in a severe drug-induced multiorgan reaction in the same sequential order as in graft-versus-host disease
    • Kano Y., Hiraharas K, Sakuma K, and Shiohara T (2006) Several herpesviruses can reactivate in a severe drug-induced multiorgan reaction in the same sequential order as in graft-versus-host disease. Br J Dermatol 155:301-306.
    • (2006) Br J Dermatol , vol.155 , pp. 301-306
    • Kano, Y.1    Hiraharas, K.2    Sakuma, K.3    Shiohara, T.4
  • 127
    • 77949312944 scopus 로고    scopus 로고
    • Drug-induced liver injury in humans: The case of ximelagatran
    • Keisu M. and Andersson TB (2010) Drug-induced liver injury in humans: the case of ximelagatran. Handb Exp Pharmacol 196:407-418.
    • (2010) Handb Exp Pharmacol , vol.196 , pp. 407-418
    • Keisu, M.1    Andersson, T.B.2
  • 129
    • 36348994962 scopus 로고    scopus 로고
    • Effect of arylhydroxylamine metabolites of sulfamethoxazole and dapsone on stress signal expression in human keratinocytes
    • Khan F. D, Vyas PM, Gaspari AA, and Svensson CK (2007) Effect of arylhydroxylamine metabolites of sulfamethoxazole and dapsone on stress signal expression in human keratinocytes. J Pharmacol Exp Ther 323:771-777.
    • (2007) J Pharmacol Exp Ther , vol.323 , pp. 771-777
    • Khan, F.D.1    Vyas, P.M.2    Gaspari, A.A.3    Svensson, C.K.4
  • 131
    • 84856939971 scopus 로고    scopus 로고
    • IL-1 receptor signaling is required at multiple stages of sensitization and elicitation of the contact hypersensitivity response
    • Kish D. D, Gorbachev AV, and Fairchild RL (2012) IL-1 receptor signaling is required at multiple stages of sensitization and elicitation of the contact hypersensitivity response. J Immunol 188:1761-1771.
    • (2012) J Immunol , vol.188 , pp. 1761-1771
    • Kish, D.D.1    Gorbachev, A.V.2    Fairchild, R.L.3
  • 132
    • 0021955499 scopus 로고
    • Drug-protein conjugates-VIII. The metabolic fate of the dinitrophenyl hapten conjugated to albumin
    • Kitteringham N. R, Maggs JL, Newby S, and Park BK (1985) Drug-protein conjugates-VIII. The metabolic fate of the dinitrophenyl hapten conjugated to albumin. Biochem Pharmacol 34:1763-1771.
    • (1985) Biochem Pharmacol , vol.34 , pp. 1763-1771
    • Kitteringham, N.R.1    Maggs, J.L.2    Newby, S.3    Park, B.K.4
  • 136
    • 10044230408 scopus 로고    scopus 로고
    • NADH cytochrome b5 reductase and cytochrome b5 catalyze the microsomal reduction of xenobiotic hydroxylamines and amidoximes in humans
    • Kurian J. R, Bajad SU, Miller JL, Chin NA, and Trepanier LA (2004) NADH cytochrome b5 reductase and cytochrome b5 catalyze the microsomal reduction of xenobiotic hydroxylamines and amidoximes in humans. J Pharmacol Exp Ther 311: 1171-1178.
    • (2004) J Pharmacol Exp Ther , vol.311 , pp. 1171-1178
    • Kurian, J.R.1    Bajad, S.U.2    Miller, J.L.3    Chin, N.A.4    Trepanier, L.A.5
  • 137
    • 0023739183 scopus 로고
    • Fixation of penicilloyl groups to albumin and appearance of anti-penicilloyl antibodies in penicillin-treated patients
    • Lafaye P. and Lapresle C (1988) Fixation of penicilloyl groups to albumin and appearance of anti-penicilloyl antibodies in penicillin-treated patients. J Clin Invest 82:7-12.
    • (1988) J Clin Invest , vol.82 , pp. 7-12
    • Lafaye, P.1    Lapresle, C.2
  • 138
    • 84973718396 scopus 로고
    • Studies on the sensitization of animals with simple chemical compounds
    • Landsteiner K. and Jacobs J (1935) Studies on the sensitization of animals with simple chemical compounds. J Exp Med 61:643-656.
    • (1935) J Exp Med , vol.61 , pp. 643-656
    • Landsteiner, K.1    Jacobs, J.2
  • 139
    • 38849101765 scopus 로고    scopus 로고
    • Pillars article: Antigen-specific interaction between T and B cells. 1985
    • Lanzavecchia A. (2007) Pillars article: Antigen-specific interaction between T and B cells. 1985. J Immunol 179:7206-7208.
    • (2007) J Immunol , vol.179 , pp. 7206-7208
    • Lanzavecchia, A.1
  • 140
    • 70350452589 scopus 로고    scopus 로고
    • "Danger" conditions increase sulfamethoxazole-protein adduct formation in human antigenpresenting cells
    • Lavergne S. N, Wang H, Callan HE, Park BK, and Naisbitt DJ (2009) "Danger" conditions increase sulfamethoxazole-protein adduct formation in human antigenpresenting cells. J Pharmacol Exp Ther 331:372-381.
    • (2009) J Pharmacol Exp Ther , vol.331 , pp. 372-381
    • Lavergne, S.N.1    Wang, H.2    Callan, H.E.3    Park, B.K.4    Naisbitt, D.J.5
  • 141
    • 77953760907 scopus 로고    scopus 로고
    • Drug metabolite-specific lymphocyte responses in sulfamethoxazole allergic patients with cystic fibrosis
    • Lavergne S. N, Whitaker P, Peckham D, Conway S, Park BK, and Naisbitt DJ (2010) Drug metabolite-specific lymphocyte responses in sulfamethoxazole allergic patients with cystic fibrosis. Chem Res Toxicol 23:1009-1011.
    • (2010) Chem Res Toxicol , vol.23 , pp. 1009-1011
    • Lavergne, S.N.1    Whitaker, P.2    Peckham, D.3    Conway, S.4    Park, B.K.5    Naisbitt, D.J.6
  • 142
    • 0029790276 scopus 로고    scopus 로고
    • Tienilic acid-induced autoimmune hepatitis: Anti-liver and-kidney microsomal type 2 autoantibodies recognize a threesite conformational epitope on cytochrome P4502C9
    • Lecoeur S., André C, and Beaune PH (1996) Tienilic acid-induced autoimmune hepatitis: anti-liver and-kidney microsomal type 2 autoantibodies recognize a threesite conformational epitope on cytochrome P4502C9. Mol Pharmacol 50:326-333.
    • (1996) Mol Pharmacol , vol.50 , pp. 326-333
    • Lecoeur, S.1    André, C.2    Beaune, P.H.3
  • 144
    • 2142733653 scopus 로고
    • Studies on the mechanism of the formation of the penicillin antigen. I. Delayed allergic cross-reactions among penicillin G and its degradation products
    • Levine B. B (1960) Studies on the mechanism of the formation of the penicillin antigen. I. Delayed allergic cross-reactions among penicillin G and its degradation products. J Exp Med 112:1131-1156.
    • (1960) J Exp Med , vol.112 , pp. 1131-1156
    • Levine, B.B.1
  • 145
    • 0014456652 scopus 로고
    • Minor haptenic determinant-specific reagins of penicillin hypersensitivity in man
    • Levine B. B and Redmond AP (1969) Minor haptenic determinant-specific reagins of penicillin hypersensitivity in man. Int Arch Allergy Appl Immunol 35:445-455.
    • (1969) Int Arch Allergy Appl Immunol , vol.35 , pp. 445-455
    • Levine, B.B.1    Redmond, A.P.2
  • 146
  • 150
    • 79957523368 scopus 로고    scopus 로고
    • Susceptibility to amoxicillin-clavulanate-induced liver injury is influenced by multiple HLA class I and II alleles
    • Spanish DILI Registry;; EUDRAGENE;; DILIN;; DILIGEN;; International SAEC
    • Lucena M. I, Molokhia M, Shen Y, Urban TJ, Aithal GP, Andrade RJ, Day CP, Ruiz-Cabello F., Donaldson PT, and Stephens C, et al.; Spanish DILI Registry;; EUDRAGENE;; DILIN;; DILIGEN;; International SAEC (2011) Susceptibility to amoxicillin-clavulanate-induced liver injury is influenced by multiple HLA class I and II alleles. Gastroenterology 141:338-347.
    • (2011) Gastroenterology , vol.141 , pp. 338-347
    • Lucena, M.I.1    Molokhia, M.2    Shen, Y.3    Urban, T.J.4    Aithal, G.P.5    Andrade, R.J.6    Day, C.P.7    Ruiz-Cabello, F.8    Donaldson, P.T.9    Stephens, C.10
  • 151
    • 0141563559 scopus 로고    scopus 로고
    • Ranitidine treatment during a modest inflammatory response precipitates idiosyncrasy-like liver injury in rats
    • Luyendyk J. P, Maddox JF, Cosma GN, Ganey PE, Cockerell GL, and Roth RA (2003) Ranitidine treatment during a modest inflammatory response precipitates idiosyncrasy-like liver injury in rats. J Pharmacol Exp Ther 307:9-16.
    • (2003) J Pharmacol Exp Ther , vol.307 , pp. 9-16
    • Luyendyk, J.P.1    Maddox, J.F.2    Cosma, G.N.3    Ganey, P.E.4    Cockerell, G.L.5    Roth, R.A.6
  • 153
    • 0022586789 scopus 로고
    • Drug-protein conjugates-X. The role of protein conjugation in the disposition of dinitrofluorobenzene
    • Maggs J. L, Kitteringham NR, Grabowski PS, and Park BK (1986) Drug-protein conjugates-X. The role of protein conjugation in the disposition of dinitrofluorobenzene. Biochem Pharmacol 35:505-513.
    • (1986) Biochem Pharmacol , vol.35 , pp. 505-513
    • Maggs, J.L.1    Kitteringham, N.R.2    Grabowski, P.S.3    Park, B.K.4
  • 154
    • 0037006623 scopus 로고    scopus 로고
    • Association between presence of HLAB* 5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reversetranscriptase inhibitor abacavir
    • Mallal S., Nolan D, Witt C, Masel G, Martin AM, Moore C, Sayer D, Castley A, Mamotte C., and Maxwell D, et al. (2002) Association between presence of HLAB* 5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reversetranscriptase inhibitor abacavir. Lancet 359:727-732.
    • (2002) Lancet , vol.359 , pp. 727-732
    • Mallal, S.1    Nolan, D.2    Witt, C.3    Masel, G.4    Martin, A.M.5    Moore, C.6    Sayer, D.7    Castley, A.8    Mamotte, C.9    Maxwell, D.10
  • 156
    • 0036840668 scopus 로고    scopus 로고
    • Haptenation of sulfonamide reactive metabolites to cellular proteins
    • Manchanda T., Hess D, Dale L, Ferguson SG, and Rieder MJ (2002) Haptenation of sulfonamide reactive metabolites to cellular proteins. Mol Pharmacol 62: 1011-1026.
    • (2002) Mol Pharmacol , vol.62 , pp. 1011-1026
    • Manchanda, T.1    Hess, D.2    Dale, L.3    Ferguson, S.G.4    Rieder, M.J.5
  • 157
    • 9844252868 scopus 로고    scopus 로고
    • Diagnostic value of specific T cell reactivity to drugs in 95 cases of drug induced liver injury
    • Maria V. A and Victorino RM (1997) Diagnostic value of specific T cell reactivity to drugs in 95 cases of drug induced liver injury. Gut 41:534-540.
    • (1997) Gut , vol.41 , pp. 534-540
    • Maria, V.A.1    Victorino, R.M.2
  • 159
    • 0026666103 scopus 로고
    • Role of hapten-anchoring peptides in defining hapten-epitopes for MHC-restricted cytotoxic T cells. Cross-reactive TNP-determinants on different peptides
    • Martin S., Ortmann B, Pflugfelder U, Birsner U, and Weltzien HU (1992) Role of hapten-anchoring peptides in defining hapten-epitopes for MHC-restricted cytotoxic T cells. Cross-reactive TNP-determinants on different peptides. J Immunol 149:2569-2575.
    • (1992) J Immunol , vol.149 , pp. 2569-2575
    • Martin, S.1    Ortmann, B.2    Pflugfelder, U.3    Birsner, U.4    Weltzien, H.U.5
  • 160
    • 0027179039 scopus 로고
    • Structural complexity of antigenic derminants for class I MHC-restricted, hapten-specific T cells. Two qualitatively differing types of H-2Kb-restricted TNP epitopes
    • Martin S., von Bonin A, Fessler C, Pflugfelder U, and Weltzien HU (1993) Structural complexity of antigenic derminants for class I MHC-restricted, hapten-specific T cells. Two qualitatively differing types of H-2Kb-restricted TNP epitopes. J Immunol 151:678-687.
    • (1993) J Immunol , vol.151 , pp. 678-687
    • Martin, S.1    von Bonin, A.2    Fessler, C.3    Pflugfelder, U.4    Weltzien, H.U.5
  • 161
    • 0028347172 scopus 로고
    • T cell recognition of haptens, a molecular view
    • Martin S. and Weltzien HU (1994) T cell recognition of haptens, a molecular view. Int Arch Allergy Immunol 104:10-16.
    • (1994) Int Arch Allergy Immunol , vol.104 , pp. 10-16
    • Martin, S.1    Weltzien, H.U.2
  • 165
    • 0029060517 scopus 로고
    • Activation of drug-specific CD4+ and CD8+ T cells in individuals allergic to sulfonamides, phenytoin, and carbamazepine
    • Mauri-Hellweg D., Bettens F, Mauri D, Brander C, Hunziker T, and Pichler WJ (1995) Activation of drug-specific CD4+ and CD8+ T cells in individuals allergic to sulfonamides, phenytoin, and carbamazepine. J Immunol 155:462-472.
    • (1995) J Immunol , vol.155 , pp. 462-472
    • Mauri-Hellweg, D.1    Bettens, F.2    Mauri, D.3    Brander, C.4    Hunziker, T.5    Pichler, W.J.6
  • 168
    • 84859708101 scopus 로고    scopus 로고
    • The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation
    • McGill M. R, Sharpe MR, Williams CD, Taha M, Curry SC, and Jaeschke H (2012) The mechanism underlying acetaminophen-induced hepatotoxicity in humans and mice involves mitochondrial damage and nuclear DNA fragmentation. J Clin Invest 122: 1574-1583.
    • (2012) J Clin Invest , vol.122 , pp. 1574-1583
    • McGill, M.R.1    Sharpe, M.R.2    Williams, C.D.3    Taha, M.4    Curry, S.C.5    Jaeschke, H.6
  • 169
    • 0018689336 scopus 로고
    • An animal model of halothane hepatotoxicity: Roles of enzyme induction and hypoxia
    • McLain G. E, Sipes IG, and Brown BR Jr (1979) An animal model of halothane hepatotoxicity: roles of enzyme induction and hypoxia. Anesthesiology 51:321-326.
    • (1979) Anesthesiology , vol.51 , pp. 321-326
    • McLain, G.E.1    Sipes, I.G.2    Brown Jr., B.R.3
  • 172
    • 0035148018 scopus 로고    scopus 로고
    • Studies of the chemical selectivity of hapten, reactivity, and skin sensitization potency. 1. Synthesis and studies on the reactivity toward model nucleophiles of the (13)C-labeled skin sensitizers hex-1-ene-and hexane-1,3-sultones
    • Meschkat E., Barratt MD, and Lepoittevin J (2001a) Studies of the chemical selectivity of hapten, reactivity, and skin sensitization potency. 1. Synthesis and studies on the reactivity toward model nucleophiles of the (13)C-labeled skin sensitizers hex-1-ene-and hexane-1,3-sultones. Chem Res Toxicol 14:110-117.
    • (2001) Chem Res Toxicol , vol.14 , pp. 110-117
    • Meschkat, E.1    Barratt, M.D.2    Lepoittevin, J.3
  • 173
    • 0035156321 scopus 로고    scopus 로고
    • Studies of the chemical selectivity of hapten, reactivity, and skin sensitization potency. 2. NMR studies of the covalent binding of the (13)c-labeled skin sensitizers 2-[13C]-and 3-[13C]hex-1-ene-and 3-[13C]hexane-1,3-sultones to human serum albumin
    • Meschkat E., Barratt MD, and Lepoittevin J (2001b) Studies of the chemical selectivity of hapten, reactivity, and skin sensitization potency. 2. NMR studies of the covalent binding of the (13)c-labeled skin sensitizers 2-[13C]-and 3-[13C]hex-1-ene-and 3-[13C]hexane-1,3-sultones to human serum albumin. Chem Res Toxicol 14:118-126.
    • (2001) Chem Res Toxicol , vol.14 , pp. 118-126
    • Meschkat, E.1    Barratt, M.D.2    Lepoittevin, J.3
  • 174
    • 0020537640 scopus 로고
    • Cutaneous reaction to trimethoprimsulfamethoxazole in patients with AIDS and Kaposi's sarcoma
    • Mitsuyasu R., Groopman J, and Volberding P (1983) Cutaneous reaction to trimethoprimsulfamethoxazole in patients with AIDS and Kaposi's sarcoma. N Engl J Med 308: 1535-1536.
    • (1983) N Engl J Med , vol.308 , pp. 1535-1536
    • Mitsuyasu, R.1    Groopman, J.2    Volberding, P.3
  • 175
    • 0003069475 scopus 로고
    • Agranulocytosis due to the occurrence of leucocyte-agglutinins; pyramidon and cold agglutinins
    • Moeschlin S. and Wagner K (1952) [Agranulocytosis due to the occurrence of leucocyte-agglutinins; pyramidon and cold agglutinins]. Acta Haematol 8:29-41.
    • (1952) Acta Haematol , vol.8 , pp. 29-41
    • Moeschlin, S.1    Wagner, K.2
  • 177
    • 84872140163 scopus 로고    scopus 로고
    • Antigen processing for MHC class II presentation via autophagy
    • DOI: 10.3389/fimmu.2012.00009
    • Münz C. (2012) Antigen processing for MHC class II presentation via autophagy. Front Immunol 3:9 DOI: 10.3389/fimmu.2012.00009.
    • (2012) Front Immunol , vol.3 , pp. 9
    • Münz, C.1
  • 178
    • 0344951264 scopus 로고    scopus 로고
    • Hypersensitivity reactions to carbamazepine: Characterization of the specificity, phenotype, and cytokine profile of drugspecific T cell clones
    • Naisbitt D. J, Britschgi M, Wong G, Farrell J, Depta JP, Chadwick DW, Pichler WJ, Pirmohamed M., and Park BK (2003a) Hypersensitivity reactions to carbamazepine: characterization of the specificity, phenotype, and cytokine profile of drugspecific T cell clones. Mol Pharmacol 63:732-741.
    • (2003) Mol Pharmacol , vol.63 , pp. 732-741
    • Naisbitt, D.J.1    Britschgi, M.2    Wong, G.3    Farrell, J.4    Depta, J.P.5    Chadwick, D.W.6    Pichler, W.J.7    Pirmohamed, M.8    Park, B.K.9
  • 180
    • 0036765861 scopus 로고    scopus 로고
    • Covalent binding of the nitroso metabolite of sulfamethoxazole leads to toxicity and major histocompatibility complex-restricted antigen presentation
    • Naisbitt D. J, Farrell J, Gordon SF, Maggs JL, Burkhart C, Pichler WJ, Pirmohamed M, and Park BK (2002) Covalent binding of the nitroso metabolite of sulfamethoxazole leads to toxicity and major histocompatibility complex-restricted antigen presentation. Mol Pharmacol 62:628-637.
    • (2002) Mol Pharmacol , vol.62 , pp. 628-637
    • Naisbitt, D.J.1    Farrell, J.2    Gordon, S.F.3    Maggs, J.L.4    Burkhart, C.5    Pichler, W.J.6    Pirmohamed, M.7    Park, B.K.8
  • 182
    • 0034980953 scopus 로고    scopus 로고
    • Antigenicity and immunogenicity of sulphamethoxazole: Demonstration of metabolism-dependent haptenation and T-cell proliferation in vivo
    • Naisbitt D. J, Gordon SF, Pirmohamed M, Burkhart C, Cribb AE, Pichler WJ, and Park BK (2001) Antigenicity and immunogenicity of sulphamethoxazole: demonstration of metabolism-dependent haptenation and T-cell proliferation in vivo. Br J Pharmacol 133:295-305.
    • (2001) Br J Pharmacol , vol.133 , pp. 295-305
    • Naisbitt, D.J.1    Gordon, S.F.2    Pirmohamed, M.3    Burkhart, C.4    Cribb, A.E.5    Pichler, W.J.6    Park, B.K.7
  • 184
    • 70349103856 scopus 로고    scopus 로고
    • A zone classification system for risk assessment of idiosyncratic drug toxicity using daily dose and covalent binding
    • Nakayama S., Atsumi R, Takakusa H, Kobayashi Y, Kurihara A, Nagai Y, Nakai D, and Okazaki O (2009) A zone classification system for risk assessment of idiosyncratic drug toxicity using daily dose and covalent binding. Drug Metab Dispos 37:1970-1977.
    • (2009) Drug Metab Dispos , vol.37 , pp. 1970-1977
    • Nakayama, S.1    Atsumi, R.2    Takakusa, H.3    Kobayashi, Y.4    Kurihara, A.5    Nagai, Y.6    Nakai, D.7    Okazaki, O.8
  • 185
    • 78449286274 scopus 로고    scopus 로고
    • Isoniazid-triggered pure red cell aplasia in systemic lupus erythematosus complicated with myasthenia gravis
    • Nakamura H., Okada A, Kawakami A, Yamasaki S, Ida H, Motomura M, Imanishi D, and Eguchi K (2010) Isoniazid-triggered pure red cell aplasia in systemic lupus erythematosus complicated with myasthenia gravis. Rheumatol Int 30:1643-1645.
    • (2010) Rheumatol Int , vol.30 , pp. 1643-1645
    • Nakamura, H.1    Okada, A.2    Kawakami, A.3    Yamasaki, S.4    Ida, H.5    Motomura, M.6    Imanishi, D.7    Eguchi, K.8
  • 187
    • 82255164138 scopus 로고    scopus 로고
    • Towards a systems understanding of MHC class I and MHC class II antigen presentation
    • Neefjes J., Jongsma ML, Paul P, and Bakke O (2011) Towards a systems understanding of MHC class I and MHC class II antigen presentation. Nat Rev Immunol 11:823-836.
    • (2011) Nat Rev Immunol , vol.11 , pp. 823-836
    • Neefjes, J.1    Jongsma, M.L.2    Paul, P.3    Bakke, O.4
  • 190
    • 84862263590 scopus 로고    scopus 로고
    • HLA-A31 strongly associates with carbamazepine-induced adverse drug reactions but not with carbamazepine-induced lymphocyte proliferation in a Japanese population
    • Niihara H., Kakamu T, Fujita Y, Kaneko S, and Morita E (2012) HLA-A31 strongly associates with carbamazepine-induced adverse drug reactions but not with carbamazepine-induced lymphocyte proliferation in a Japanese population. J Dermatol 39:594-601.
    • (2012) J Dermatol , vol.39 , pp. 594-601
    • Niihara, H.1    Kakamu, T.2    Fujita, Y.3    Kaneko, S.4    Morita, E.5
  • 192
    • 34347250517 scopus 로고    scopus 로고
    • Troglitazone-induced hepatic necrosis in an animal model of silent genetic mitochondrial abnormalities
    • Ong M. M, Latchoumycandane C, and Boelsterli UA (2007) Troglitazone-induced hepatic necrosis in an animal model of silent genetic mitochondrial abnormalities. Toxicol Sci 97:205-213.
    • (2007) Toxicol Sci , vol.97 , pp. 205-213
    • Ong, M.M.1    Latchoumycandane, C.2    Boelsterli, U.A.3
  • 195
    • 0030918532 scopus 로고    scopus 로고
    • Penicilloyl peptides are recognized as T cell antigenic determinants in penicillin allergy
    • Padovan E., Bauer T, Tongio MM, Kalbacher H, and Weltzien HU (1997) Penicilloyl peptides are recognized as T cell antigenic determinants in penicillin allergy. Eur J Immunol 27:1303-1307.
    • (1997) Eur J Immunol , vol.27 , pp. 1303-1307
    • Padovan, E.1    Bauer, T.2    Tongio, M.M.3    Kalbacher, H.4    Weltzien, H.U.5
  • 196
    • 76949107229 scopus 로고    scopus 로고
    • New insights in toxic epidermal necrolysis (Lyell's syndrome): Clinical considerations, pathobiology and targeted treatments revisited
    • Paquet P. and Piérard GE (2010a) New insights in toxic epidermal necrolysis (Lyell's syndrome): clinical considerations, pathobiology and targeted treatments revisited. Drug Saf 33:189-212.
    • (2010) Drug Saf , vol.33 , pp. 189-212
    • Paquet, P.1    Piérard, G.E.2
  • 197
    • 77957095686 scopus 로고    scopus 로고
    • Topical treatment options for drug-induced toxic epidermal necrolysis (TEN)
    • Paquet P. and Piérard GE (2010b) Topical treatment options for drug-induced toxic epidermal necrolysis (TEN). Expert Opin Pharmacother 11:2447-2458.
    • (2010) Expert Opin Pharmacother , vol.11 , pp. 2447-2458
    • Paquet, P.1    Piérard, G.E.2
  • 199
    • 0031719374 scopus 로고    scopus 로고
    • Role of drug disposition in drug hypersensitivity: A chemical, molecular, and clinical perspective
    • Park B. K, Pirmohamed M, and Kitteringham NR (1998) Role of drug disposition in drug hypersensitivity: a chemical, molecular, and clinical perspective. Chem Res Toxicol 11:969-988.
    • (1998) Chem Res Toxicol , vol.11 , pp. 969-988
    • Park, B.K.1    Pirmohamed, M.2    Kitteringham, N.R.3
  • 200
    • 84865516911 scopus 로고    scopus 로고
    • HLA and pharmacogenetics of drug hypersensitivity
    • Pavlos R., Mallal S, and Phillips E (2012) HLA and pharmacogenetics of drug hypersensitivity. Pharmacogenomics 13:1285-1306.
    • (2012) Pharmacogenomics , vol.13 , pp. 1285-1306
    • Pavlos, R.1    Mallal, S.2    Phillips, E.3
  • 204
    • 33745894681 scopus 로고    scopus 로고
    • Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: Does a DRESS syndrome really exist?
    • Network of the French Pharmacovigilance Centers
    • Peyrière H., Dereure O, Breton H, Demoly P, Cociglio M, Blayac JP, and Hillaire-Buys D; Network of the French Pharmacovigilance Centers (2006) Variability in the clinical pattern of cutaneous side-effects of drugs with systemic symptoms: does a DRESS syndrome really exist? Br J Dermatol 155:422-428.
    • (2006) Br J Dermatol , vol.155 , pp. 422-428
    • Peyrière, H.1    Dereure, O.2    Breton, H.3    Demoly, P.4    Cociglio, M.5    Blayac, J.P.6    Hillaire-Buys, D.7
  • 206
    • 64349088125 scopus 로고    scopus 로고
    • Successful translation of pharmacogenetics into the clinic: The abacavir example
    • Phillips E. and Mallal S (2009) Successful translation of pharmacogenetics into the clinic: the abacavir example. Mol Diagn Ther 13:1-9.
    • (2009) Mol Diagn Ther , vol.13 , pp. 1-9
    • Phillips, E.1    Mallal, S.2
  • 210
    • 0142087834 scopus 로고    scopus 로고
    • Delayed drug hypersensitivity reactions
    • Pichler W. J (2003) Delayed drug hypersensitivity reactions. Ann Intern Med 139: 683-693.
    • (2003) Ann Intern Med , vol.139 , pp. 683-693
    • Pichler, W.J.1
  • 211
    • 17644416780 scopus 로고    scopus 로고
    • Direct T-cell stimulations by drugs-bypassing the innate immune system
    • Pichler W. J (2005) Direct T-cell stimulations by drugs-bypassing the innate immune system. Toxicology 209:95-100.
    • (2005) Toxicology , vol.209 , pp. 95-100
    • Pichler, W.J.1
  • 212
    • 73349087840 scopus 로고    scopus 로고
    • The cutaneous biochemical redox barrier: A component of the innate immune defenses against sensitization by highly reactive environmental xenobiotics
    • Pickard C., Louafi F, McGuire C, Lowings K, Kumar P, Cooper H, Dearman RJ, Cumberbatch M., Kimber I, and Healy E, et al. (2009) The cutaneous biochemical redox barrier: a component of the innate immune defenses against sensitization by highly reactive environmental xenobiotics. J Immunol 183:7576-7584.
    • (2009) J Immunol , vol.183 , pp. 7576-7584
    • Pickard, C.1    Louafi, F.2    McGuire, C.3    Lowings, K.4    Kumar, P.5    Cooper, H.6    Dearman, R.J.7    Cumberbatch, M.8    Kimber, I.9    Healy, E.10
  • 214
    • 77957092502 scopus 로고    scopus 로고
    • Facing up to toxic epidermal necrolysis
    • Piérard G. E and Paquet P (2010) Facing up to toxic epidermal necrolysis. Expert Opin Pharmacother 11:2443-2446.
    • (2010) Expert Opin Pharmacother , vol.11 , pp. 2443-2446
    • Piérard, G.E.1    Paquet, P.2
  • 215
    • 0033656847 scopus 로고    scopus 로고
    • Association analysis of drug metabolizing enzyme gene polymorphisms in HIV-positive patients with co-trimoxazole hypersensitivity
    • Pirmohamed M., Alfirevic A, Vilar J, Stalford A, Wilkins EG, Sim E, and Park BK (2000) Association analysis of drug metabolizing enzyme gene polymorphisms in HIV-positive patients with co-trimoxazole hypersensitivity. Pharmacogenetics 10: 705-713.
    • (2000) Pharmacogenetics , vol.10 , pp. 705-713
    • Pirmohamed, M.1    Alfirevic, A.2    Vilar, J.3    Stalford, A.4    Wilkins, E.G.5    Sim, E.6    Park, B.K.7
  • 216
    • 0030954195 scopus 로고    scopus 로고
    • Altered hapten ligands antagonize trinitrophenyl-specific cytotoxic T cells and block internalization of hapten-specific receptors
    • Preckel T., Grimm R, Martin S, and Weltzien HU (1997) Altered hapten ligands antagonize trinitrophenyl-specific cytotoxic T cells and block internalization of hapten-specific receptors. J Exp Med 185:1803-1813.
    • (1997) J Exp Med , vol.185 , pp. 1803-1813
    • Preckel, T.1    Grimm, R.2    Martin, S.3    Weltzien, H.U.4
  • 218
    • 0014191061 scopus 로고
    • Hypersensitivity reactions to antibacterial drugs in infectious mononucleosis
    • Pullen H., Wright N, and Murdoch JM (1967) Hypersensitivity reactions to antibacterial drugs in infectious mononucleosis. Lancet 2:1176-1178.
    • (1967) Lancet , vol.2 , pp. 1176-1178
    • Pullen, H.1    Wright, N.2    Murdoch, J.M.3
  • 219
    • 0027477180 scopus 로고
    • Immunochemical detection of liver protein adducts of the nonsteroidal antiinflammatory drug diclofenac
    • Pumford N. R, Myers TG, Davila JC, Highet RJ, and Pohl LR (1993) Immunochemical detection of liver protein adducts of the nonsteroidal antiinflammatory drug diclofenac. Chem Res Toxicol 6:147-150.
    • (1993) Chem Res Toxicol , vol.6 , pp. 147-150
    • Pumford, N.R.1    Myers, T.G.2    Davila, J.C.3    Highet, R.J.4    Pohl, L.R.5
  • 220
    • 0034123730 scopus 로고    scopus 로고
    • A role for bioactivation and covalent binding within epidermal keratinocytes in sulfonamide-induced cutaneous drug reactions
    • Reilly T. P, Lash LH, Doll MA, Hein DW, Woster PM, and Svensson CK (2000) A role for bioactivation and covalent binding within epidermal keratinocytes in sulfonamide-induced cutaneous drug reactions. J Invest Dermatol 114:1164-1173.
    • (2000) J Invest Dermatol , vol.114 , pp. 1164-1173
    • Reilly, T.P.1    Lash, L.H.2    Doll, M.A.3    Hein, D.W.4    Woster, P.M.5    Svensson, C.K.6
  • 221
    • 0142247168 scopus 로고    scopus 로고
    • DNA methylation and autoimmune disease
    • Richardson B. (2003) DNA methylation and autoimmune disease. Clin Immunol 109: 72-79.
    • (2003) Clin Immunol , vol.109 , pp. 72-79
    • Richardson, B.1
  • 222
    • 84868585470 scopus 로고    scopus 로고
    • Murine models of lupus induced by hypomethylated T cells (DNA hypomethylation and lupus.)
    • Richardson B., Sawalha AH, Ray D, and Yung R (2012) Murine models of lupus induced by hypomethylated T cells (DNA hypomethylation and lupus.). Methods Mol Biol 900:169-180.
    • (2012) Methods Mol Biol , vol.900 , pp. 169-180
    • Richardson, B.1    Sawalha, A.H.2    Ray, D.3    Yung, R.4
  • 223
    • 0029778819 scopus 로고    scopus 로고
    • Antigenic targets in tienilic acid hepatitis. Both cytochrome P450 2C11 and 2C11-tienilic acid adducts are transported to the plasma membrane of rat hepatocytes and recognized by human sera
    • Robin M. A, Maratrat M, Le Roy M, Le Breton FP, Bonierbale E, Dansette P, Ballet F, Mansuy D., and Pessayre D (1996) Antigenic targets in tienilic acid hepatitis. Both cytochrome P450 2C11 and 2C11-tienilic acid adducts are transported to the plasma membrane of rat hepatocytes and recognized by human sera. J Clin Invest 6:1471-1480.
    • (1996) J Clin Invest , vol.6 , pp. 1471-1480
    • Robin, M.A.1    Maratrat, M.2    Le Roy, M.3    Le Breton, F.P.4    Bonierbale, E.5    Dansette, P.6    Ballet, F.7    Mansuy, D.8    Pessayre, D.9
  • 226
    • 17644375873 scopus 로고    scopus 로고
    • Clinical heterogeneity of drug hypersensitivity
    • Roujeau J. C (2005) Clinical heterogeneity of drug hypersensitivity. Toxicology 209: 123-129.
    • (2005) Toxicology , vol.209 , pp. 123-129
    • Roujeau, J.C.1
  • 229
    • 73949092712 scopus 로고    scopus 로고
    • Cytochrome b5 and NADH cytochrome b5 reductase: Genotype-phenotype correlations for hydroxylamine reduction
    • Sacco J. C and Trepanier LA (2010) Cytochrome b5 and NADH cytochrome b5 reductase: genotype-phenotype correlations for hydroxylamine reduction. Pharmacogenet Genomics 20:26-37.
    • (2010) Pharmacogenet Genomics , vol.20 , pp. 26-37
    • Sacco, J.C.1    Trepanier, L.A.2
  • 232
    • 58149337013 scopus 로고    scopus 로고
    • Tr1 and naturally occurring regulatory T cells induce IgG4 in B cells through GITR/GITR-L interaction, IL-10 and TGF-beta
    • Satoguina J. S, Adjobimey T, Arndts K, Hoch J, Oldenburg J, Layland LE, and Hoerauf A (2008) Tr1 and naturally occurring regulatory T cells induce IgG4 in B cells through GITR/GITR-L interaction, IL-10 and TGF-beta. Eur J Immunol 38:3101-3113.
    • (2008) Eur J Immunol , vol.38 , pp. 3101-3113
    • Satoguina, J.S.1    Adjobimey, T.2    Arndts, K.3    Hoch, J.4    Oldenburg, J.5    Layland, L.E.6    Hoerauf, A.7
  • 235
    • 0030822702 scopus 로고    scopus 로고
    • Direct, MHC-dependent presentation of the drug sulfamethoxazole to human alphabeta T cell clones
    • Schnyder B., Mauri-Hellweg D, Zanni M, Bettens F, and Pichler WJ (1997) Direct, MHC-dependent presentation of the drug sulfamethoxazole to human alphabeta T cell clones. J Clin Invest 100:136-141.
    • (1997) J Clin Invest , vol.100 , pp. 136-141
    • Schnyder, B.1    Mauri-Hellweg, D.2    Zanni, M.3    Bettens, F.4    Pichler, W.J.5
  • 236
    • 84875135492 scopus 로고    scopus 로고
    • Nevirapine bioactivation and covalent binding in the skin
    • DOI: 10.1021/tx3004938
    • Sharma A. M, Klarskov K, and Uetrecht J (2013) Nevirapine bioactivation and covalent binding in the skin. Chem Res Toxicol DOI: 10.1021/tx3004938.
    • (2013) Chem Res Toxicol
    • Sharma, A.M.1    Klarskov, K.2    Uetrecht, J.3
  • 237
    • 84865211587 scopus 로고    scopus 로고
    • Bioactivation of nevirapine to a reactive quinone methide: Implications for liver injury
    • Sharma A. M, Li Y, Novalen M, Hayes MA, and Uetrecht J (2012) Bioactivation of nevirapine to a reactive quinone methide: implications for liver injury. Chem Res Toxicol 25:1708-1719.
    • (2012) Chem Res Toxicol , vol.25 , pp. 1708-1719
    • Sharma, A.M.1    Li, Y.2    Novalen, M.3    Hayes, M.A.4    Uetrecht, J.5
  • 238
    • 8044252758 scopus 로고
    • Chloramphenicol-induced blood dyscrasias: Analysis of 40 cases
    • Sharp A. A (1963) Chloramphenicol-induced blood dyscrasias: analysis of 40 cases. BMJ 1:735-736.
    • (1963) BMJ , vol.1 , pp. 735-736
    • Sharp, A.A.1
  • 239
    • 0024208020 scopus 로고
    • Anticonvulsant hypersensitivity syndrome. In vitro assessment of risk
    • Shear N. H and Spielberg SP (1988) Anticonvulsant hypersensitivity syndrome. In vitro assessment of risk. J Clin Invest 82:1826-1832.
    • (1988) J Clin Invest , vol.82 , pp. 1826-1832
    • Shear, N.H.1    Spielberg, S.P.2
  • 240
    • 29644438945 scopus 로고    scopus 로고
    • Evidence of an immune-mediated mechanism for an idiosyncratic nevirapine-induced reaction in the female Brown Norway rat
    • Shenton J. M, Popovic M, Chen J, Masson MJ, and Uetrecht JP (2005) Evidence of an immune-mediated mechanism for an idiosyncratic nevirapine-induced reaction in the female Brown Norway rat. Chem Res Toxicol 18:1799-1813.
    • (2005) Chem Res Toxicol , vol.18 , pp. 1799-1813
    • Shenton, J.M.1    Popovic, M.2    Chen, J.3    Masson, M.J.4    Uetrecht, J.P.5
  • 241
    • 0141624936 scopus 로고    scopus 로고
    • Characterization of a potential animal model of an idiosyncratic drug reaction: Nevirapineinduced skin rash in the rat
    • Shenton J. M, Teranishi M, Abu-Asab MS, Yager JA, and Uetrecht JP (2003) Characterization of a potential animal model of an idiosyncratic drug reaction: nevirapineinduced skin rash in the rat. Chem Res Toxicol 16:1078-1089.
    • (2003) Chem Res Toxicol , vol.16 , pp. 1078-1089
    • Shenton, J.M.1    Teranishi, M.2    Abu-Asab, M.S.3    Yager, J.A.4    Uetrecht, J.P.5
  • 242
    • 0141998606 scopus 로고    scopus 로고
    • Molecular identification of a danger signal that alerts the immune system to dying cells
    • Shi Y., Evans JE, and Rock KL (2003) Molecular identification of a danger signal that alerts the immune system to dying cells. Nature 425:516-521.
    • (2003) Nature , vol.425 , pp. 516-521
    • Shi, Y.1    Evans, J.E.2    Rock, K.L.3
  • 243
    • 68549106084 scopus 로고    scopus 로고
    • Fixed drug eruption: Pathogenesis and diagnostic tests
    • Shiohara T. (2009) Fixed drug eruption: pathogenesis and diagnostic tests. Curr Opin Allergy Clin Immunol 9:316-321.
    • (2009) Curr Opin Allergy Clin Immunol , vol.9 , pp. 316-321
    • Shiohara, T.1
  • 244
    • 34247329801 scopus 로고    scopus 로고
    • The diagnosis of a DRESS syndrome has been sufficiently established on the basis of typical clinical features and viral reactivations
    • Shiohara T., Iijima M, Ikezawa Z, and Hashimoto K (2007) The diagnosis of a DRESS syndrome has been sufficiently established on the basis of typical clinical features and viral reactivations. Br J Dermatol 156:1083-1084.
    • (2007) Br J Dermatol , vol.156 , pp. 1083-1084
    • Shiohara, T.1    Iijima, M.2    Ikezawa, Z.3    Hashimoto, K.4
  • 245
    • 35748968848 scopus 로고    scopus 로고
    • A complex interaction between drug allergy and viral infection
    • Shiohara T. and Kano Y (2007) A complex interaction between drug allergy and viral infection. Clin Rev Allergy Immunol 33:124-133.
    • (2007) Clin Rev Allergy Immunol , vol.33 , pp. 124-133
    • Shiohara, T.1    Kano, Y.2
  • 246
    • 84926075581 scopus 로고    scopus 로고
    • Drug-induced hypersensitivity syndrome: Recent advances in the diagnosis, pathogenesis and management
    • Shiohara T., Kano Y, Takahashi R, Ishida T, and Mizukawa Y (2012) Drug-induced hypersensitivity syndrome: recent advances in the diagnosis, pathogenesis and management. Chem Immunol Allergy 97:122-138.
    • (2012) Chem Immunol Allergy , vol.97 , pp. 122-138
    • Shiohara, T.1    Kano, Y.2    Takahashi, R.3    Ishida, T.4    Mizukawa, Y.5
  • 247
    • 0036279452 scopus 로고    scopus 로고
    • Delayedtype hypersensitivity reaction to paraphenylenediamine is mediated by 2 different pathways of antigen recognition by specific alphabeta human T-cell clones
    • Sieben S., Kawakubo Y, Al Masaoudi T, Merk HF, and Blömeke B (2002) Delayedtype hypersensitivity reaction to paraphenylenediamine is mediated by 2 different pathways of antigen recognition by specific alphabeta human T-cell clones. J Allergy Clin Immunol 109:1005-1011.
    • (2002) J Allergy Clin Immunol , vol.109 , pp. 1005-1011
    • Sieben, S.1    Kawakubo, Y.2    Al Masaoudi, T.3    Merk, H.F.4    Blömeke, B.5
  • 249
    • 0037103384 scopus 로고    scopus 로고
    • Intracellular interferon-gamma in circulating and marrow T cells detected by flow cytometry and the response to immunosuppressive therapy in patients with aplastic anemia
    • Sloand E., Kim S, Maciejewski JP, Tisdale J, Follmann D, and Young NS (2002) Intracellular interferon-gamma in circulating and marrow T cells detected by flow cytometry and the response to immunosuppressive therapy in patients with aplastic anemia. Blood 100:1185-1191.
    • (2002) Blood , vol.100 , pp. 1185-1191
    • Sloand, E.1    Kim, S.2    McIejewski, J.P.3    Tisdale, J.4    Follmann, D.5    Young, N.S.6
  • 252
    • 0037058248 scopus 로고    scopus 로고
    • Novel non-labile covalent binding of sulfamethoxazole reactive metabolites to cultured human lymphoid cells
    • Summan M. and Cribb AE (2002) Novel non-labile covalent binding of sulfamethoxazole reactive metabolites to cultured human lymphoid cells. Chem Biol Interact 142:155-173.
    • (2002) Chem Biol Interact , vol.142 , pp. 155-173
    • Summan, M.1    Cribb, A.E.2
  • 253
    • 0031707391 scopus 로고    scopus 로고
    • Human herpesvirus 6 infection as a risk factor for the development of severe drug-induced hypersensitivity syndrome
    • Suzuki Y., Inagi R, Aono T, Yamanishi K, and Shiohara T (1998) Human herpesvirus 6 infection as a risk factor for the development of severe drug-induced hypersensitivity syndrome. Arch Dermatol 134:1108-1112.
    • (1998) Arch Dermatol , vol.134 , pp. 1108-1112
    • Suzuki, Y.1    Inagi, R.2    Aono, T.3    Yamanishi, K.4    Shiohara, T.5
  • 254
    • 67749130968 scopus 로고    scopus 로고
    • Analysis of the mechanism for the development of allergic skin inflammation and the application for its treatment: Aspirin modulation of IgEdependent mast cell activation: Role of aspirin-induced exacerbation of immediate allergy
    • Suzuki Y. and Ra C (2009) Analysis of the mechanism for the development of allergic skin inflammation and the application for its treatment: aspirin modulation of IgEdependent mast cell activation: role of aspirin-induced exacerbation of immediate allergy. J Pharmacol Sci 110:237-244.
    • (2009) J Pharmacol Sci , vol.110 , pp. 237-244
    • Suzuki, Y.1    Ra, C.2
  • 256
    • 67649160590 scopus 로고    scopus 로고
    • Defective regulatory T cells in patients with severe drug eruptions: Timing of the dysfunction is associated with the pathological phenotype and outcome
    • Takahashi R., Kano Y, Yamazaki Y, Kimishima M, Mizukawa Y, and Shiohara T (2009) Defective regulatory T cells in patients with severe drug eruptions: timing of the dysfunction is associated with the pathological phenotype and outcome. J Immunol 182:8071-8079.
    • (2009) J Immunol , vol.182 , pp. 8071-8079
    • Takahashi, R.1    Kano, Y.2    Yamazaki, Y.3    Kimishima, M.4    Mizukawa, Y.5    Shiohara, T.6
  • 257
  • 258
    • 84856438378 scopus 로고    scopus 로고
    • Poor relevance of a lymphocyte proliferation assay in lamotrigine-induced Stevens-Johnson syndrome or toxic epidermal necrolysis
    • Tang Y. H, Mockenhaupt M, Henry A, Bounoua M, Naldi L, Le Gouvello S, Bensussan A, and Roujeau JC (2012) Poor relevance of a lymphocyte proliferation assay in lamotrigine-induced Stevens-Johnson syndrome or toxic epidermal necrolysis. Clin Exp Allergy 42:248-254.
    • (2012) Clin Exp Allergy , vol.42 , pp. 248-254
    • Tang, Y.H.1    Mockenhaupt, M.2    Henry, A.3    Bounoua, M.4    Naldi, L.5    Le Gouvello, S.6    Bensussan, A.7    Roujeau, J.C.8
  • 259
    • 33646024613 scopus 로고    scopus 로고
    • Hy's law: Predicting serious hepatotoxicity
    • Temple R. (2006) Hy's law: predicting serious hepatotoxicity. Pharmacoepidemiol Drug Saf 15:241-243.
    • (2006) Pharmacoepidemiol Drug Saf , vol.15 , pp. 241-243
    • Temple, R.1
  • 260
    • 67649742556 scopus 로고    scopus 로고
    • Idiosyncratic drug-induced agranulocytosis: Possible mechanisms and management
    • Tesfa D., Keisu M, and Palmblad J (2009) Idiosyncratic drug-induced agranulocytosis: possible mechanisms and management. Am J Hematol 84:428-434.
    • (2009) Am J Hematol , vol.84 , pp. 428-434
    • Tesfa, D.1    Keisu, M.2    Palmblad, J.3
  • 261
    • 81255210741 scopus 로고    scopus 로고
    • Late-onset neutropenia following rituximab therapy: Incidence, clinical features and possible mechanisms
    • Tesfa D. and Palmblad J (2011) Late-onset neutropenia following rituximab therapy: incidence, clinical features and possible mechanisms. Expert Rev Hematol 4: 619-625.
    • (2011) Expert Rev Hematol , vol.4 , pp. 619-625
    • Tesfa, D.1    Palmblad, J.2
  • 263
    • 84864283287 scopus 로고    scopus 로고
    • Immunological mechanisms of epidermal damage in toxic epidermal necrolysis
    • Tohyama M. and Hashimoto K (2012) Immunological mechanisms of epidermal damage in toxic epidermal necrolysis. Curr Opin Allergy Clin Immunol 12: 376-382.
    • (2012) Curr Opin Allergy Clin Immunol , vol.12 , pp. 376-382
    • Tohyama, M.1    Hashimoto, K.2
  • 264
    • 0031693835 scopus 로고    scopus 로고
    • Severe hypersensitivity syndrome due to sulfasalazine associated with reactivation of human herpesvirus 6
    • Tohyama M., Yahata Y, Yasukawa M, Inagi R, Urano Y, Yamanishi K, and Hashimoto K (1998) Severe hypersensitivity syndrome due to sulfasalazine associated with reactivation of human herpesvirus 6. Arch Dermatol 134:1113-1117.
    • (1998) Arch Dermatol , vol.134 , pp. 1113-1117
    • Tohyama, M.1    Yahata, Y.2    Yasukawa, M.3    Inagi, R.4    Urano, Y.5    Yamanishi, K.6    Hashimoto, K.7
  • 266
    • 0025318090 scopus 로고
    • Dpenicillamine-induced autoimmunity in Brown-Norway rats. Similarities with HgCl2-induced autoimmunity
    • Tournade H., Pelletier L, Pasquier R, Vial MC, Mandet C, and Druet P (1990) Dpenicillamine-induced autoimmunity in Brown-Norway rats. Similarities with HgCl2-induced autoimmunity. J Immunol 144:2985-2991.
    • (1990) J Immunol , vol.144 , pp. 2985-2991
    • Tournade, H.1    Pelletier, L.2    Pasquier, R.3    Vial, M.C.4    Mandet, C.5    Druet, P.6
  • 267
    • 3042800902 scopus 로고    scopus 로고
    • Idiosyncratic toxicity associated with potentiated sulfonamides in the dog
    • Trepanier L. A (2004) Idiosyncratic toxicity associated with potentiated sulfonamides in the dog. J Vet Pharmacol Ther 27:129-138.
    • (2004) J Vet Pharmacol Ther , vol.27 , pp. 129-138
    • Trepanier, L.A.1
  • 268
    • 21244468587 scopus 로고    scopus 로고
    • Current trends in drug-induced autoimmunity
    • Uetrecht J. (2005) Current trends in drug-induced autoimmunity. Autoimmun Rev 4: 309-314.
    • (2005) Autoimmun Rev , vol.4 , pp. 309-314
    • Uetrecht, J.1
  • 269
    • 33847081148 scopus 로고    scopus 로고
    • Idiosyncratic drug reactions: Current understanding
    • Uetrecht J. (2007) Idiosyncratic drug reactions: current understanding. Annu Rev Pharmacol Toxicol 47:513-539.
    • (2007) Annu Rev Pharmacol Toxicol , vol.47 , pp. 513-539
    • Uetrecht, J.1
  • 270
    • 38949104743 scopus 로고    scopus 로고
    • Idiosyncratic drug reactions: Past, present, and future
    • Uetrecht J. (2008) Idiosyncratic drug reactions: past, present, and future. Chem Res Toxicol 21:84-92.
    • (2008) Chem Res Toxicol , vol.21 , pp. 84-92
    • Uetrecht, J.1
  • 271
    • 61849182463 scopus 로고    scopus 로고
    • Immune-mediated adverse drug reactions
    • Uetrecht J. (2009a) Immune-mediated adverse drug reactions. Chem Res Toxicol 22: 24-34.
    • (2009) Chem Res Toxicol , vol.22 , pp. 24-34
    • Uetrecht, J.1
  • 272
    • 70449117614 scopus 로고    scopus 로고
    • Immunoallergic drug-induced liver injury in humans
    • Uetrecht J. (2009b) Immunoallergic drug-induced liver injury in humans. Semin Liver Dis 29:383-392.
    • (2009) Semin Liver Dis , vol.29 , pp. 383-392
    • Uetrecht, J.1
  • 273
    • 0019417547 scopus 로고
    • The implications of procainamide metabolism to its induction of lupus
    • Uetrecht J. P, Freeman RW, and Woosley RL (1981a) The implications of procainamide metabolism to its induction of lupus. Arthritis Rheum 24:994-1003.
    • (1981) Arthritis Rheum , vol.24 , pp. 994-1003
    • Uetrecht, J.P.1    Freeman, R.W.2    Woosley, R.L.3
  • 274
    • 0019807955 scopus 로고
    • Acetylator phenotype and lupus erythematosus
    • Uetrecht J. P and Woosley RL (1981) Acetylator phenotype and lupus erythematosus. Clin Pharmacokinet 6:118-134.
    • (1981) Clin Pharmacokinet , vol.6 , pp. 118-134
    • Uetrecht, J.P.1    Woosley, R.L.2
  • 279
    • 0027939552 scopus 로고
    • Formation and elimination of sulphamethoxazole hydroxylamine after oral administration of sulphamethoxazole
    • van der Ven AJ, Mantel MA, Vree TB, Koopmans PP, and van der Meer JW (1994b) Formation and elimination of sulphamethoxazole hydroxylamine after oral administration of sulphamethoxazole. Br J Clin Pharmacol 38:147-150.
    • (1994) Br J Clin Pharmacol , vol.38 , pp. 147-150
    • van der Ven, A.J.1    Mantel, M.A.2    Vree, T.B.3    Koopmans, P.P.4    van der Meer, J.W.5
  • 281
    • 0033197966 scopus 로고    scopus 로고
    • Blocking antibodies induced by specific allergy vaccination prevent the activation of CD4+ T cells by inhibiting serum-IgE-facilitated allergen presentation
    • van Neerven RJ, Wikborg T, Lund G, Jacobsen B, Brinch-Nielsen A, Arnved J, and Ipsen H (1999) Blocking antibodies induced by specific allergy vaccination prevent the activation of CD4+ T cells by inhibiting serum-IgE-facilitated allergen presentation. J Immunol 163:2944-2952.
    • (1999) J Immunol , vol.163 , pp. 2944-2952
    • van Neerven, R.J.1    Wikborg, T.2    Lund, G.3    Jacobsen, B.4    Brinch-Nielsen, A.5    Arnved, J.6    Ipsen, H.7
  • 283
    • 56349121140 scopus 로고    scopus 로고
    • New concepts in chronic urticaria
    • Vonakis B. M and Saini SS (2008) New concepts in chronic urticaria. Curr Opin Immunol 20:709-716.
    • (2008) Curr Opin Immunol , vol.20 , pp. 709-716
    • Vonakis, B.M.1    Saini, S.S.2
  • 285
    • 33749010103 scopus 로고    scopus 로고
    • Enzyme-mediated protein haptenation of dapsone and sulfamethoxazole in human keratinocytes: II. Expression and role of flavin-containing monooxygeanses and peroxidases
    • Vyas P. M, Roychowdhury S, Koukouritaki SB, Hines RN, Krueger SK, Williams DE, Nauseef W. M, and Svensson CK (2006b) Enzyme-mediated protein haptenation of dapsone and sulfamethoxazole in human keratinocytes: II. Expression and role of flavin-containing monooxygeanses and peroxidases. J Pharmacol Exp Ther 319: 497-505.
    • (2006) J Pharmacol Exp Ther , vol.319 , pp. 497-505
    • Vyas, P.M.1    Roychowdhury, S.2    Koukouritaki, S.B.3    Hines, R.N.4    Krueger, S.K.5    Williams, D.E.6    Nauseef, W.M.7    Svensson, C.K.8
  • 286
    • 0030566910 scopus 로고    scopus 로고
    • Antibodies to myeloperoxidase in propylthiouracil-induced autoimmune disease in the cat
    • Waldhauser L. and Uetrecht J (1996) Antibodies to myeloperoxidase in propylthiouracil-induced autoimmune disease in the cat. Toxicology 114:155-162.
    • (1996) Toxicology , vol.114 , pp. 155-162
    • Waldhauser, L.1    Uetrecht, J.2
  • 287
  • 288
    • 0030831664 scopus 로고    scopus 로고
    • Oxidative stress and thiol depletion in plasma and peripheral blood lymphocytes from HIVinfected patients: Toxicological and pathological implications
    • Walmsley S. L, Winn LM, Harrison ML, Uetrecht JP, and Wells PG (1997) Oxidative stress and thiol depletion in plasma and peripheral blood lymphocytes from HIVinfected patients: toxicological and pathological implications. AIDS 11:1689-1697.
    • (1997) AIDS , vol.11 , pp. 1689-1697
    • Walmsley, S.L.1    Winn, L.M.2    Harrison, M.L.3    Uetrecht, J.P.4    Wells, P.G.5
  • 289
    • 78650162681 scopus 로고    scopus 로고
    • Drug reaction with eosinophilia and systemic symptoms (DRESS): A clinical update and review of current thinking
    • Walsh S. A and Creamer D (2011) Drug reaction with eosinophilia and systemic symptoms (DRESS): a clinical update and review of current thinking. Clin Exp Dermatol 36:6-11.
    • (2011) Clin Exp Dermatol , vol.36 , pp. 6-11
    • Walsh, S.A.1    Creamer, D.2
  • 290
    • 0032777711 scopus 로고    scopus 로고
    • Local lymph node assay responses to paraphenylenediamine: Intra-and inter-laboratory evaluations
    • Warbrick E. V, Dearman RJ, Lea LJ, Basketter DA, and Kimber I (1999) Local lymph node assay responses to paraphenylenediamine: intra-and inter-laboratory evaluations. J Appl Toxicol 19:255-260.
    • (1999) J Appl Toxicol , vol.19 , pp. 255-260
    • Warbrick, E.V.1    Dearman, R.J.2    Lea, L.J.3    Basketter, D.A.4    Kimber, I.5
  • 291
    • 0038392539 scopus 로고    scopus 로고
    • Heparin-induced thrombocytopenia: Pathogenesis and management
    • Warkentin T. E (2003) Heparin-induced thrombocytopenia: pathogenesis and management. Br J Haematol 121:535-555.
    • (2003) Br J Haematol , vol.121 , pp. 535-555
    • Warkentin, T.E.1
  • 292
    • 0035797925 scopus 로고    scopus 로고
    • Delayed-onset heparin-induced thrombocytopenia and thrombosis
    • Warkentin T. E and Kelton JG (2001) Delayed-onset heparin-induced thrombocytopenia and thrombosis. Ann Intern Med 135:502-506.
    • (2001) Ann Intern Med , vol.135 , pp. 502-506
    • Warkentin, T.E.1    Kelton, J.G.2
  • 294
    • 13444305469 scopus 로고    scopus 로고
    • Idiosyncratic liver injury: Challenges and approaches
    • Watkins P. B (2005) Idiosyncratic liver injury: challenges and approaches. Toxicol Pathol 33:1-5.
    • (2005) Toxicol Pathol , vol.33 , pp. 1-5
    • Watkins, P.B.1
  • 295
    • 79951784125 scopus 로고    scopus 로고
    • Evaluation of drug-induced serious hepatotoxicity (eDISH): Application of this data organization approach to phase III clinical trials of rivaroxaban after total hip or knee replacement surgery
    • Watkins P. B, Desai M, Berkowitz SD, Peters G, Horsmans Y, Larrey D, and Maddrey W (2011) Evaluation of drug-induced serious hepatotoxicity (eDISH): application of this data organization approach to phase III clinical trials of rivaroxaban after total hip or knee replacement surgery. Drug Saf 34:243-252.
    • (2011) Drug Saf , vol.34 , pp. 243-252
    • Watkins, P.B.1    Desai, M.2    Berkowitz, S.D.3    Peters, G.4    Horsmans, Y.5    Larrey, D.6    Maddrey, W.7
  • 296
    • 0027267589 scopus 로고
    • Suppressive effect of antibody on processing of T cell epitopes
    • Watts C. and Lanzavecchia A (1993) Suppressive effect of antibody on processing of T cell epitopes. J Exp Med 178:1459-1463.
    • (1993) J Exp Med , vol.178 , pp. 1459-1463
    • Watts, C.1    Lanzavecchia, A.2
  • 297
    • 84862776700 scopus 로고    scopus 로고
    • Direct interaction between HLA-B and carbamazepine activates T cells in patients with Stevens-Johnson syndrome
    • Wei C. Y, Chung WH, Huang HW, Chen YT, and Hung SI (2012) Direct interaction between HLA-B and carbamazepine activates T cells in patients with Stevens-Johnson syndrome. J Allergy Clin Immunol 129:1562-1569.
    • (2012) J Allergy Clin Immunol , vol.129 , pp. 1562-1569
    • Wei, C.Y.1    Chung, W.H.2    Huang, H.W.3    Chen, Y.T.4    Hung, S.I.5
  • 299
    • 40349116031 scopus 로고    scopus 로고
    • Drug-induced vasculitis
    • Wiik A. (2008) Drug-induced vasculitis. Curr Opin Rheumatol 20:35-39.
    • (2008) Curr Opin Rheumatol , vol.20 , pp. 35-39
    • Wiik, A.1
  • 300
    • 79955003756 scopus 로고    scopus 로고
    • TNF alpha antagonist-induced lupus-like syndrome: Report and review of the literature with implications for treatment with alternative TNF alpha antagonists
    • Williams V. L and Cohen PR (2011) TNF alpha antagonist-induced lupus-like syndrome: report and review of the literature with implications for treatment with alternative TNF alpha antagonists. Int J Dermatol 50:619-625.
    • (2011) Int J Dermatol , vol.50 , pp. 619-625
    • Williams, V.L.1    Cohen, P.R.2
  • 302
    • 34047103842 scopus 로고    scopus 로고
    • Generation and characterization of antigen-specific CD4+, CD8+, and CD4+CD8+ T-cell clones from patients with carbamazepine hypersensitivity
    • Wu Y., Farrell J, Pirmohamed M, Park BK, and Naisbitt DJ (2007) Generation and characterization of antigen-specific CD4+, CD8+, and CD4+CD8+ T-cell clones from patients with carbamazepine hypersensitivity. J Allergy Clin Immunol 119: 973-981.
    • (2007) J Allergy Clin Immunol , vol.119 , pp. 973-981
    • Wu, Y.1    Farrell, J.2    Pirmohamed, M.3    Park, B.K.4    Naisbitt, D.J.5
  • 305
    • 77950865023 scopus 로고    scopus 로고
    • Generation of T cell responses targeting the reactive metabolite of halothane in mice
    • You Q., Cheng L, and Ju C (2010) Generation of T cell responses targeting the reactive metabolite of halothane in mice. Toxicol Lett 194:79-85.
    • (2010) Toxicol Lett , vol.194 , pp. 79-85
    • You, Q.1    Cheng, L.2    Ju, C.3
  • 306
    • 33845681113 scopus 로고    scopus 로고
    • Role of neutrophils in a mouse model of halothane-induced liver injury
    • You Q., Cheng L, Reilly TP, Wegmann D, and Ju C (2006) Role of neutrophils in a mouse model of halothane-induced liver injury. Hepatology 44:1421-1431.
    • (2006) Hepatology , vol.44 , pp. 1421-1431
    • You, Q.1    Cheng, L.2    Reilly, T.P.3    Wegmann, D.4    Ju, C.5
  • 307
    • 84867557298 scopus 로고    scopus 로고
    • Human leukocyte antigens (HLA) associated drug hypersensitivity: Consequences of drug binding to HLA
    • Yun J., Adam J, Yerly D, and Pichler WJ (2012) Human leukocyte antigens (HLA) associated drug hypersensitivity: consequences of drug binding to HLA. Allergy 67: 1338-1346.
    • (2012) Allergy , vol.67 , pp. 1338-1346
    • Yun, J.1    Adam, J.2    Yerly, D.3    Pichler, W.J.4
  • 308
    • 0037006957 scopus 로고
    • Aplastic Anemia: Acquired and Inherited, W. B. Saunders Company, Philadelphia. Young N. S (2002) Acquired aplastic anemia
    • Young N. and Alter BP (1994) Aplastic Anemia: Acquired and Inherited, W. B. Saunders Company, Philadelphia. Young N. S (2002) Acquired aplastic anemia. Ann Intern Med 136:534-546.
    • (1994) Ann Intern Med , vol.136 , pp. 534-546
    • Young, N.1    Alter, B.P.2
  • 309
    • 33750628439 scopus 로고    scopus 로고
    • Current concepts in the pathophysiology and treatment of aplastic anemia
    • Young N. S, Calado RT, and Scheinberg P (2006) Current concepts in the pathophysiology and treatment of aplastic anemia. Blood 108:2509-2519.
    • (2006) Blood , vol.108 , pp. 2509-2519
    • Young, N.S.1    Calado, R.T.2    Scheinberg, P.3
  • 312
    • 79953099798 scopus 로고    scopus 로고
    • Involvement of T helper 17 cells in Dpenicillamine-induced autoimmune disease in Brown Norway rats
    • Zhu X., Li J, Liu F, and Uetrecht JP (2011) Involvement of T helper 17 cells in Dpenicillamine-induced autoimmune disease in Brown Norway rats. Toxicol Sci 120: 331-338.
    • (2011) Toxicol Sci , vol.120 , pp. 331-338
    • Zhu, X.1    Li, J.2    Liu, F.3    Uetrecht, J.P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.