Overexpression of PGC-1α Influences Mitochondrial Signal Transduction of Dopaminergic Neurons

Molecular Neurobiology

Volumn 53, Issue 6, 2016, Pages 3756-3770

  Ye, Qinyong ^a   Huang, Wanling ^a   Li, Dongzhu ^a   Si, Erwang ^a   Wang, Juhua ^a   Wang, Yingqing ^a   Chen, Chun ^a   Chen, Xiaochun ^a  

^a FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

Adenovirus vector; Nuclear transcription factors; Parkinson s disease; PGC 1 ; SH SY5Y cells

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; ADENOSINE TRIPHOSPHATE; CYTOCHROME C; ESTROGEN RELATED RECEPTOR ALPHA; GA BINDING PROTEIN; HYDROGEN PEROXIDE; NUCLEAR RESPIRATORY FACTOR 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; ERRALPHA ESTROGEN-RELATED RECEPTOR; ESTROGEN RECEPTOR; NFE2L2 PROTEIN, HUMAN; PPARGC1A PROTEIN, HUMAN; TRANSCRIPTION FACTOR NRF2;

ADENOVIRIDAE; ADENOVIRUS INFECTION; ARTICLE; CELL DAMAGE; CELL SURVIVAL; CELL VIABILITY; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL SIGNAL TRANSDUCTION; MOLECULAR MODEL; MORTALITY; NEUROPROTECTION; OXIDATIVE STRESS; PGC 1ALPHA GENE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SECRETION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING; CELL FRACTIONATION; DRUG EFFECTS; METABOLISM; MITOCHONDRION; TUMOR CELL LINE;

1-METHYL-4-PHENYLPYRIDINIUM; ADENOSINE TRIPHOSPHATE; ADENOVIRIDAE; CELL LINE, TUMOR; CELL SURVIVAL; CYTOCHROMES C; DOPAMINERGIC NEURONS; HUMANS; HYDROGEN PEROXIDE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR 1-ALPHA; PPAR GAMMA; RECEPTORS, ESTROGEN; SIGNAL TRANSDUCTION; SUBCELLULAR FRACTIONS;

EID: 84979026081     PISSN: 08937648     EISSN: 15591182     Source Type: Journal    
DOI: 10.1007/s12035-015-9299-7     Document Type: Article

References (47)

1. D’Ame lio M, Ragonese P, Sconzo G et al (2009) Parkinson’s disease and cancer: insights for pathogenesis from epidemiology. Ann N Y Acad Sci 1155:324–334
2. Spillantini MG, Schmidt ML, Lee VM, Trojanowski JQ et al (1997) Alpha-synuclein in Lewy bodies. Nature 388(6645):839–840
3. +-induced mitochondrial dysfunctions in neuronal cells. Biochim Biophys Acta 1820(5):577–585
4. Nicole E, Anne Kathrin L, Christian H et al (2012) Mitochondrial dysfunction in Parkinson’s disease: molecular mechanisms and pathophysiological consequences. EMBO J 31:3038–3062
5. Klein C, Schlossmacher MG (2006) The genetics of Parkinson disease: implications for neurological care. Nat Clin Pract Neurol 2(3):136–146
6. Tsunemi T, La Spada AR (2012) PGC-1α at the intersection of bioenergetics regulation and neuron function: from Huntington’s disease to Parkinson’s disease and beyond. Prog Neurobiol 97(2):142–151
7. Hu MT, Taylor-Robinson SD, Chaudhuri KR et al (2000) Cortical dysfunction in non-demented Parkinson’s disease patients: a combined (31)P-MRS and (18) FDG-PET study. Brain 123(Pt2):340–352
8. Esterbauer H, Oberkofler H, Krempler F et al (1999) Human peroxisome proliferator activated receptor gamma coactivator1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression. Genomics 62(1):98–102
9. Perier C, Vila M (2012) Mitochondrial biology and Parkinson’s disease. Cold Spring Harb Perspect Med 2(2):a009332
10. Feige JN, Auwerx J (2008) Transcriptional targets of sirtuins in the coordination of mammalian physiology. Curr Opin Cell Biol 20(3):303–309
11. Tritos NA, Mastaitis JW, Kokkotou EG, Puigserver P, Spiegelman BM, Maratos-Flier E (2003) Characterization of the peroxisome proliferator activated receptor coactivator 1 alpha (PGC 1alpha) expression in the murine brain. Brain Res 961(2):255–260
12. Wareski P, Vaarmann A, Choubey V et al (2009) PGC-1{alpha} and PGC-1{beta} regulate mitochondrial density in neurons. J Biol Chem 284(32):21379–21385
13. Mudo G, Makela J, Di Liberto V et al (2012) Transgenic expression and activation of PGC-1α protect dopaminergic neurons in the MPTP mouse model of Parkinson’s disease. Cell Mol Life Sci 69(7):1153–1165
14. Shamina MR, Li XY, Loren L et al (2007) Estrogen-related receptor a is essential for the expression of antioxidant protection genes and mitochondrial function. Biochem Biophys Res Commun 357:231–236
15. Dhar SS, Ongwijitwat S, Wong-Riley MT (2008) Nuclear respiratory factor 1 regulates all ten nuclear-encoded subunits of cytochrome c oxidase in neurons. J Biol Chem 283(6):3120–3129
16. Scarpulla RC (2012) Nucleus-encoded regulators of mitochondrial function: integration of respiratory chain expression, nutrient sensing and metabolic stress. Biochim Biophys Acta 1819(9–10):1088–1097
17. Schreiber SN, Emter R, Hock MB et al (2004) The estrogen-related receptor α (ERRα) functions in PPARγ coactivator 1α (PGC-1α)-induced mitochondrial biogenesis. Proc Natl Acad Sci U S A 101(17):6472–6477
18. Aaron PR, Shogo W, Lodovica V et al (2013) Disruption of skeletal muscle mitochondrial network genes and miRNAs in amyotrophic lateral sclerosis. Neurobiol Dis 49:107–117
19. Francesc XS, Marc L, Daniel B et al (2006) Evidence for a mitochondrial regulatory pathway defined by peroxisome proliferator-activated receptor-r-coactivator-1α, estrogen-related receptor-α, and mitofusin 2. Diabetes 55:1783–1791
20. Bastin J, Aubey F, Rötig A et al (2008) Activation of peroxisome proliferator-activated receptor pathway stimulates the mitochondrial respiratory chain and can correct deficiencies in patients’ cells lacking its components. J Clin Endocrinol Metab 93(4):1433–1441
21. Wenz T, Diaz F, Spiegelman BM et al (2008) Activation of the PPAR/PGC-1alpha pathway prevents a bioenergetic deficit and effectively improves a mitochondrial myopathy phenotype. Cell Metab 8(3):249–256
22. Ellis HP, Kurian KM (2014) Biological rationale for the use of PPARγ agonists in glioblastoma. Front Oncol 4:52
23. Zolezzi JM, Silva-Alvarez C, Ordenes D (2013) Peroxisome proliferator-activated receptor (PPAR) γ and PPARα agonists modulate mitochondrial fusion-fission dynamics: relevance to reactive oxygen species (ROS)-related neurodegenerative disorders? PLoS One 8(5), e64019
24. De Nuccio C, Bernardo A, De Simone R et al (2011) Peroxisome proliferator-activated receptor γ agonists accelerate oligodendrocyte maturation and influence mitochondrial functions and oscillatory Ca(2+) waves. J Neuropathol Exp Neurol 70(10):900–912
25. Moreno M, Lombardi A, Silvestri E et al (2010) PPARs: nuclear receptors controlled by, and controlling, nutrient handling through nuclear and cytosolic signaling. PPAR Res. doi:10.1155/2010/435689
26. Ye Q, Huang B, Zhang X et al (2012) Astaxanthin protects against MPP(+)-induced oxidative stress in PC12 cells via the HO-1/NOX2 axis. BMC Neurosci 13:156
27. Joo-Ho S, Han Seok K, Hochul K et al (2011) PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson’s disease. Cell 144(5):689–702
28. Clark J, Silvaggi JM, Kiselak T et al (2012) PGC-1α overexpression downregulates Pitx3 and increases susceptibility to MPTP toxicity associated with decreased Bdnf. PLoS One 7(11), e48925
29. St-Pierre J, Drori S, Uldry M et al (2006) Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell 127(2):397–408
30. Scarpulla RC, Vega RB, Kelly DP (2012) Transcriptional integration of mitochondrial biogenesis. Trends Endocrinol Metab 23(9):459–466
31. 2-induced apoptosis in PC12 cells. Biochem Biophys Res Commun 393:773–778
32. Jia H, Liu Z, Li X et al (2010) Synergistic anti-Parkinsonism activity of high doses of B vitamins in a chronic cellular model. Neurobiol Aging 31(4):636–646
33. Lin TK, Cheng CH, Chen SD et al (2012) Mitochondrial dysfunction and oxidative stress promote apoptotic cell death in the striatum via cytochrome c/caspase-3 signaling cascade following chronic rotenone intoxication in rats. Int J Mol Sci 13(7):8722–8739
34. Perier C, Bové J, Vila M (2012) Mitochondria and programmed cell death in Parkinson’s disease: apoptosis and beyond. Antioxid Redox Signal 16(9):883–895
35. Berger AK, Cortese GP, Amodeo KD et al (2009) Parkin selectively alters the intrinsic threshold for mitochondrial cytochrome c release. Hum Mol Genet 18(22):4317–4328
36. Cowell RM, Talati P, Blake KR et al (2009) Identification of novel targets for PGC-1alpha and histone deacetylase inhibitors in neuroblastoma cells. Biochem Biophys Res Commun 379(2):578–582
37. Ebadi M, Govitrapong P, Sharma S et al (2001) Ubiquinone (coenzyme q10) and mitochondria in oxidative stress of Parkinson’s disease. Biol Signals Recept 10(3–4):224–253
38. Gleyzer N, Vercauteren K, Scarpulla RC (2005) Control of mitochondrial transcription specificity factors (TFB1 M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators. Mol Cell Biol 25(4):1354–1366
39. Litonin D, Sologub M, Shi Y et al (2010) Human mitochondrial transcription revisited: only TFAM and TFB2M are required for transcription of the mitochondrial genes in vitro. J Biol Chem 285(24):18129–18133
40. Knutti D, Kaul A, Kralli A (2000) A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen. Mol Cell Biol 20(7):2411–2422
41. Lu XY, Peng LJ, Lv M et al (2012) Recent advance in the design of small molecular modulators of estrogen-related receptors. Curr Pharm Des 18(23):3421–3431
42. Anderson RM, Barger JL, Edwards MG et al (2008) Dynamic regulation of PGC-1alpha localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response. Aging Cell 7(1):101–111
43. Zhu JH, Gusdon AM, Cimen H et al (2012) Impaired mitochondrial biogenesis contributes to depletion of functional mitochondria in chronic MPP+ toxicity: dual roles for ERK1/2. Cell Death Dis 3, e312
44. Aquilano K, Vigilanza P, Baldelli S et al (2010) Peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α) and sirtuin 1 (SIRT1) reside in mitochondria. J Biol Chem 285(28):21590–21599
45. Felder TK, Soyal SM, Oberkofler H et al (2011) Characterization of novel peroxisome proliferator-activated receptor coactivator-1α (PGC-1α) isoform in human liver. J Biol Chem 286(50):42923–42936
46. Ji Suk C, Peter H, Yubin Z et al (2010) Regulation of NT-PGC-1α subcellular localization and function by protein kinase A-dependent modulation of nuclear export by CRM1. J Biol Chem 285(23):18039–18050
47. Soyal SM, Felder TK, Auer S (2012) A greatly extended PPARGC1A genomic locus encodes several new brain-specific isoforms and influences Huntington disease age of onset. Hum Mol Genet 21(15):3461–3473