Resistance mutations generate divergent antibiotic susceptibility profiles against translation inhibitors

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 29, 2016, Pages 8188-8193

  Cocozaki, Alexis I ^a   Altman, Roger B ^b   Huang, Jian ^a,e   Buurman, Ed T ^a,f   Kazmirski, Steven L ^a   Doig, Peter ^a   Prince, D Bryan ^a   Blanchard, Scott C ^b   Cate, Jamie H D ^c,d   Ferguson, Andrew D ^a  

^a ASTRAZENECA   (United Kingdom)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c University of California Berkeley   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e TAKEDA PHARMACEUTICALS   (United States)

^f Vaccine Research East and Early Development   (United States)

Author keywords

Antibiotic resistance; Negamycin; Ribosome structure; Tetracycline; TRNA selection

Indexed keywords

BACTERIAL PROTEIN; BACTERIAL RNA; NEGAMYCIN; RIBOSOME PROTEIN; RIBOSOME RNA; TETRACYCLINE; TRANSFER RNA; ANTIINFECTIVE AGENT; DIAMINO ACID; PROTEIN SYNTHESIS INHIBITOR;

ANTIBIOTIC SENSITIVITY; BACTERIAL CELL; BACTERIAL STRAIN; CELL MUTANT; CHEMICAL MODIFICATION; CONFERENCE PAPER; CONTROLLED STUDY; DRUG BINDING; DRUG BINDING SITE; ESCHERICHIA COLI; FLUORESCENCE RESONANCE ENERGY TRANSFER; HYDROGEN BOND; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL; SMALL RIBOSOMAL SUBUNIT; X RAY CRYSTALLOGRAPHY; ANTIBIOTIC RESISTANCE; GENETICS; MUTATION; RIBOSOME;

AMINO ACIDS, DIAMINO; ANTI-BACTERIAL AGENTS; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; MUTATION; PROTEIN SYNTHESIS INHIBITORS; RIBOSOMES; RNA, BACTERIAL; RNA, RIBOSOMAL; TETRACYCLINE;

EID: 84978914890     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1605127113     Document Type: Article

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