Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the escherichia coli ribosome

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 46, 2014, Pages 16274-16279

  Olivier, Nelson B ^a   Altman, Roger B ^b   Noeske, Jonas ^c   Basarab, Gregory S ^d   Code, Erin ^a   Ferguson, Andrew D ^a   Gao, Ning ^a   Huang, Jian ^a   Juette, Manuel F ^b   Livchak, Stephania ^a   Miller, Matthew D ^d   Prince, D Bryan ^a   Cate, Jamie H D ^c   Buurman, Ed T ^a   Blanchard, Scott C ^b  

^a ASTRAZENECA   (United Kingdom)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c University of California Berkeley   (United States)

^d Department of Chemistry ^*  (United States)

Author keywords

Antibiotic; Fidelity; Negamycin; Ribosome; Translation

Indexed keywords

GENTAMICIN; GUANOSINE TRIPHOSPHATASE; NEGAMYCIN; RNA 16S; TETRACYCLINE; TIGECYCLINE; TRANSFER RNA; ANTIINFECTIVE AGENT; BACTERIAL RNA; DIAMINO ACID; MINOCYCLINE; TETRACYCLINE DERIVATIVE;

ANTIBIOTIC RESISTANCE; ARTICLE; CODON; CONTROLLED STUDY; CROSS RESISTANCE; CRYSTAL STRUCTURE; DRUG BINDING SITE; ENZYME ACTIVATION; ESCHERICHIA COLI; FLUORESCENCE RESONANCE ENERGY TRANSFER; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; POINT MUTATION; PROTEIN DOMAIN; RIBOSOME; RIBOSOME SUBUNIT; TRANSLATION REGULATION; ANALOGS AND DERIVATIVES; BASE PAIRING; BINDING COMPETITION; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DRUG EFFECTS; GENETICS; METABOLISM; MULTIDRUG RESISTANCE; PHYSIOLOGY; PROTEIN SYNTHESIS; ULTRASTRUCTURE; X RAY CRYSTALLOGRAPHY;

ANIMALIA; ESCHERICHIA COLI;

AMINO ACIDS, DIAMINO; ANTI-BACTERIAL AGENTS; BASE PAIRING; BINDING SITES; BINDING, COMPETITIVE; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ESCHERICHIA COLI; MINOCYCLINE; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; POINT MUTATION; PROTEIN BIOSYNTHESIS; RIBOSOMES; RNA, BACTERIAL; RNA, RIBOSOMAL, 16S; RNA, TRANSFER; TETRACYCLINE RESISTANCE; TETRACYCLINES;

EID: 84911883716     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1414401111     Document Type: Article

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