Inhibition of thyroid hormone release from cultured amphibian thyroid glands by methimazole, 6-propylthiouracil, and perchlorate

Toxicological Sciences

Volumn 118, Issue 1, 2010, Pages 42-51

  Hornung, Michael W ^a   Degitz, Sigmund J ^a   Korte, Lisa M ^b   Olson, Jessica M ^b   Kosian, Patricia A ^a   Linnum, Ann L ^a   Tietge, Joseph E ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b Student Contractor Services   (United States)

Author keywords

6 Propylthiouracil; Methimazole; Perchlorate; Thyroid hormone; Tissue culture; Xenopus laevis

Indexed keywords

PERCHLORATE; PROPYLTHIOURACIL; THIAMAZOLE; THYROTROPIN; THYROXINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DETERMINATION; DRUG POTENCY; FEMALE; GENE DISRUPTION; HISTOLOGY; HORMONE INHIBITION; HORMONE SYNTHESIS; IC 50; MALE; METAMORPHOSIS; NONHUMAN; SPAWNING; TADPOLE; THYROID GLAND; THYROID HORMONE RELEASE; THYROID HORMONE SYNTHESIS;

ANIMALS; ANTITHYROID AGENTS; CATTLE; COCULTURE TECHNIQUES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; LARVA; MALE; METHIMAZOLE; ORGAN CULTURE TECHNIQUES; PERCHLORIC ACID; PITUITARY GLAND; PROPYLTHIOURACIL; THYROID GLAND; THYROTROPIN; THYROXINE; XENOPUS LAEVIS;

AMPHIBIA; BOVINAE; XENOPUS LAEVIS;

EID: 77958468129     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfq166     Document Type: Article

References (35)

1. q/ll. J. Biol. Chem. 269, 13733-13735.
2. Boas, M., Feldt-Rasmussen, U., Skakkebaek, N. E., and Main, K. M. (2006). Environmental chemicals and thyroid function. Eur. J. Endocrinol. 154, 599-611.
3. Brucker-Davis, F. (1998). Effects of environmental synthetic chemicals on thyroid function. Thyroid 8, 827-856.
4. Capen, C. C. (1994). Mechanisms of chemical injury of the thyroid gland. Prog. Clin. Biol. Res. 387, 173-191.
5. Chang, H. C., and Doerge, D. R. (2000). Dietary genistein inactivates rat thyroid peroxidase in vivo without an apparent hypothyroid effect. Toxicol. Appl. Pharmacol. 168, 244-252.
6. Cianchetta, S., di Bernardo, J., Romeo, G., and Rhoden, K. J. (2010). Perchlorate transport and inhibition of the sodium iodide symporter measured with yellow fluorescent protein variant YFP-H148Q/I152L. Toxicol. Appl. Pharmacol. 243, 372-380.
7. Coleman, R., Evennett, P. J., and Dodd, J. M. (1968). Ultrastructural observations on the thyroid gland of Xenopus laevis Daudin throughout metamorphosis. Gen. Comp. Endocrinol. 10, 34-48.
8. Degitz, S. J., Holcombe, G. W., Flynn, K. M., Kosian, P. K., Korte, J. J., and Tietge, J. E. (2005). Progress towards development of an amphibian-based thyroid screening assay using Xenopus laevis. Organismal and thyroidal responses to the model compounds 6-propylthiouracil, methimazole, and thyroxine. Toxicol. Sci. 87, 353-364.
9. Denver, R. J., and Licht, P. (1988). Thyroid status influences in vitro thyrotropin and growth hormone responses to thyrotropin-releasing hormone by pituitary glands of hatchling slider turtles (Pseudemys scripta elegans). J. Exp. Zool. 246, 293-304.
10. DeVito, M., Biegel, L., Brouwer, A., Brown, S., Brucker-Davis, F., Cheek, A. O., Christensen, R., Colborn, T., Cooke, P., Crissman, J., et al. (1999). Screening methods for thyroid hormone disruptors. Environ. Health Perspect. 107, 407-415.
11. Dodd, M. H. I., and Dodd, J. M. (1976). The biology of metamorphosis. In Physiology of the Amphibia (B. Lofts, Ed.), Vol. 3, pp. 467-599. Academic Press, New York.
12. Dumont, J. E., Lamy, F., Roger, P., and Maenhaut, C. (1992). Physiological and pathological regulation of thyroid cell proliferation and differentiation by thyrotropin and other factors. Physiol. Rev. 72, 667-697.
13. Engler, H., Taurog, A., and Nakashima, T. (1982). Mechanism of inactivation of thyroid peroxidase by thioureylene drugs. Biochem. Pharmacol. 31, 3801-3806.
14. Goleman, W. L., Urquidi, L. J., Anderson, T. A., Smith, E. E., Kendall, R. J., and Carr, J. A. (2002). Environmentally relevant concentrations of ammonium perchlorate inhibit development and metamorphosis in Xenopus laevis. Environ. Toxicol. Chem. 21, 424-430.
15. Gray, L. E., Ostby, J., Wilson, V., Lambright, C., Bobseine, K., Hartig, P., Hotchkiss, A., Wolf, C., Furr, J., Price, M., et al. (2002). Xenoendocrine disrupters-tiered screening and testing: filling key data gaps. Toxicology 181-182, 371-382.
16. Huet, M.-C. (2000). OECD activity on endocrine disrupters test guidelines development. Ecotoxicology 9, 77-84.
17. Kimura, T., Van Keymeulen, A., Golstein, J., Fusco, A., Dumont, J. E., and Roger, P. P. (2001). Regulation of thyroid cell proliferation by TSH and other factors: a critical evaluation of in vitro models. Endocr. Rev. 22, 631-656.
18. Kopp, P. (2001). Human genome and diseases: review: the TSH receptor and its role in thyroid disease. Cell. Mol. Life Sci. 58, 1301-1322.
19. Nagasaka, A., and Hidaka, H. (1976). Effect of antithyroid agents 6-propyl-2-thiouracil and 1-methyl-2-mercaptoimidazole on human thyroid iodine peroxidase. J. Clin. Endocrinol. Metab. 43, 142-158.
20. Nieuwkoop, P. D., and Faber, F. (1994). In Normal Table of Xenopus laevis (Daudin). Garland Publishing Inc., New York.
21. Organisation for Economic Co-operation and Development (OECD). (2006). Detailed Review Paper on Thyroid Hormone Disruption Assays. OECD SERIES ON TESTING AND ASSESSMENT, No. 57. ENV/JM/MONO(2006)24. OECD Environment Directorate, Environment, Health and Safety Division, Paris, France. Available at: www.oecd.org/dataoecd/49/35/37235405.pdf. Accessed June 15, 2010.
22. 2+-phosphatidylinositol cascade of human thyrocytes in primary culture. Mol. Cell. Endocrin. 81, 175-183.
23. Sakai, M., Hanaoka, Y., Tanaka, S., Hayashi, H., and Kikuyama, S. (1991). Thyrotropic activity of various adenohypophyseal hormones of bullfrog. Zool. Sci. 8, 929-934.
24. Schmutzler, C., Bacinski, A., Gotthardt, I., Huhne, K., Ambrugger, P., Klammer, H., Schlecht, C., Hoang-Vu, C., Grüters, A., Wuttke, W., et al. (2007). The ultraviolet filter benzophenone 2 interferes with the thyroid hormone axis in rats and is a potent in vitro inhibitor of human recombinant thyroid peroxidase. Endocrinol. 148, 2835-2844.
25. Schmutzler, C., Gotthardt, I., Hofmann, P. J., Radovic, B., Kovacs, G., Stemmler, L., Nobis, I., Bacinski, A., Mentrup, B., Ambrugger, P., et al. (2007). Endocrine disruptors and the thyroid gland-a combined in vitro and in vivo analysis of potential new biomarkers. Environ. Health Perspect. 115(Supp. 1), 77-83.
26. Smith, P. K., Krohn, R. I., Hermanson, G. T., Mallia, A. K., Gartner, F. H., Provenzano, M. D., Fujimoto, E. K., Goeke, N. M., Olson, B. J., and Klenk, D. C. (1985). Measurement of protein using bicinchoninic acid. Anal. Biochem. 150, 76-85.
27. Tietge, J. E., Butterworth, B. C., Haselman, J. T., Holcombe, G. W., Hornung, M. W., Korte, J. J., Kosian, P. K., Wolfe, M., and Degitz, S. J. (2010). Early temporal effects of three thyroid hormone synthesis inhibitors in Xenopus laevis. Aquat. Toxicol. 98, 44-50.
28. Tietge, J. E., Holcombe, G. W., Flynn, K. M., Kosian, P. A., Korte, J. J., Anderson, L. E., Wolf, D. C., and Degitz, S. J. (2005). Metamorphic inhibition of Xenopus laevis by sodium perchlorate: effects on development and thyroid histology. Environ. Toxicol. Chem. 24, 926-933.
29. U.S. Environmental Protection Agency (U.S. EPA). (1998). Endocrine Disruptor Screening and Testing Advisory Committee Final Report. EPA/743/R-98/003. Office of Chemical Safety and Pollution Prevention, U.S. EPA, Washington, DC. Available at: www.epa.gov/scipoly/oscpendo/pubs/edspoverview/finalrpt.htm. Accessed June 15, 2010.
30. U.S. Environmental Protection Agency (U.S. EPA). (2009a). Endocrine Disruptor Screening Program Guidelines, OPPTS 890.1100: Amphibian Metamorphosis (Frog). EPA 740-C-09-002. Office of Chemical Safety and Pollution Prevention, U.S. EPA, Washington, DC. Available at: www.epa .gov/ocspp/pubs/frs/publications/Test_Guidelines/series890.htm. Accessed June 15, 2010.
31. U.S. Environmental Protection Agency (U.S. EPA). (2009b). Endocrine Disruptor Screening Program Guidelines, OPPTS 890.1450: Pubertal Development and Thyroid Function in Intact Juvenile/Peripubertal Female Rats. EPA 740-C-09-009. Office of Chemical Safety and Pollution Prevention, U.S. EPA, Washington, DC. Available at: www.epa.gov/ocspp/pubs/frs/publications/Test_Guidelines/series890.htm. Accessed June 15, 2010.
32. U.S. Environmental Protection Agency (U.S. EPA). (2009c). Endocrine Disruptor Screening Program Guidelines, OPPTS 890.1500: Pubertal Development and Thyroid Function in Intact Juvenile/Peripubertal Male Rats. EPA 740-C-09-012. Office of Chemical Safety and Pollution Prevention, U.S. EPA, Washington, DC. Available at: www.epa.gov/ocspp/pubs/frs/publications/Test_Guidelines/series890.htm. Accessed June 15, 2010.
33. Wolff, J. (1998). Perchlorate and the thyroid gland. Pharmacol. Rev. 50, 89-105.
34. Wright, M. L., Cuthbert, K. L., Donohue, M. J., Solano, S. D., and Proctor, K. L. (2000). Direct influence of melatonin on the thyroid and comparison with prolactin. J. Exp. Zool. 286, 625-631.
35. Zoeller, R. T., Tan, S. W., and Tyl, R. W. (2007). General background on the hypothalamic-pituitary-thyroid (HPT) axis. Crit. Rev. Toxicol. 37, 11-53.