Phenotypic and biomarker evaluation of zebrafish larvae as an alternative model to predict mammalian hepatotoxicity

Journal of Applied Toxicology

Volumn 36, Issue 9, 2016, Pages 1194-1206

  Verstraelen, Sandra ^a   Peers, Bernard ^b   Maho, Walid ^c   Hollanders, Karen ^a   Remy, Sylvie ^a,c   Berckmans, Pascale ^a   Covaci, Adrian ^c   Witters, Hilda ^a  

^a FLEMISH INSTITUTE FOR TECHNOLOGICAL RESEARCH VITO   (Belgium)

^b UNIVERSITY OF LIÈGE   (Belgium)

^c UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

compound uptake; gene expression markers; hepatotoxicity; Non animal alternative assay; zebrafish larva

Indexed keywords

AMIODARONE; BIOLOGICAL MARKER; COUMARIN; METHAPYRILENE; MYCLOBUTANIL; PARACETAMOL; PROTEIN P53; SACCHARIN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CASP3A GENE; CONTROLLED STUDY; CP GENE; CYP2K1 GENE; CYP2K19 GENE; CYP3A65 GENE; EMBRYO; EXPOSURE; FABP10A GENE; FEMALE; FISH MODEL; GC GENE; GENE EXPRESSION; GENE P53; IN SITU HYBRIDIZATION; LARVA; LIQUID CHROMATOGRAPHY; LIVER CELL; LIVER SIZE; LIVER TOXICITY; MALE; MARKER GENE; MASS SPECTROMETRY; NONHUMAN; NR1H4 GENE; PHENOTYPE; PRECIPITATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TF GENE; TISSUE DEGENERATION; ZEBRA FISH; ZGC163022 GENE;

EID: 84978886868     PISSN: 0260437X     EISSN: 10991263     Source Type: Journal    
DOI: 10.1002/jat.3288     Document Type: Article

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