Serum levels of acute phase proteins in patients with nonalcoholic steatohepatitis

Turkish Journal of Gastroenterology

Volumn 14, Issue 1, 2003, Pages 12-17

  Koruk, Mehmet ^a,c   Tayşi, Seyithan ^b   Savaş, M Cemil ^a   Yilmaz, Ömer ^b   Akçay, Fatih ^b   Karakök, Metin ^a  

^a GAZIANTEP UNIVERSITY   (Turkey)

^b ATATURK UNIVERSITY   (Turkey)

^c Department of Biochemistry ^*  (Turkey)

Author keywords

Acute phase proteins; C reactive protein; Nonalcoholic steatohepatitis

Indexed keywords

ACUTE PHASE PROTEIN; ALBUMIN; ALPHA 1 ANTITRYPSIN; ALPHA 2 MACROGLOBULIN; C REACTIVE PROTEIN; CERULOPLASMIN; FERRITIN; HAPTOGLOBIN; LIPOPROTEIN A; OROSOMUCOID; TRANSFERRIN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE CLASSIFICATION; FATTY LIVER; FEMALE; HEPATITIS; HISTOPATHOLOGY; HUMAN; LIVER BIOPSY; LIVER HISTOLOGY; MALE; NEPHELOMETRY; PROTEIN BLOOD LEVEL; SCORING SYSTEM;

ACUTE-PHASE PROTEINS; ADULT; AGED; ALPHA-MACROGLOBULINS; BIOLOGICAL MARKERS; BIOPSY, NEEDLE; C-REACTIVE PROTEIN; CASE-CONTROL STUDIES; FATTY LIVER; FEMALE; FERRITINS; HAPTOGLOBINS; HUMANS; LIVER FUNCTION TESTS; MALE; MIDDLE AGED; PROBABILITY; PROGNOSIS; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY; SEVERITY OF ILLNESS INDEX;

EID: 0037651218     PISSN: 13004948     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Citturi S, Farrell GC. Etiopathogenesis of nonalcoholic steatohepatitis. Semin Liver Dis 2001; 21: 27-41.
2. McCullough AJ. Update on nonalcoholic fatty liver disease. J Clin Gastroenterol 2002; 34(3): 255-62.
3. Day CP, James OFW. Steatohepatitis: a tale of two "hits"? Gastroenterology 1998; 114: 842-5.
4. Angulo P. Medical Progress: Nonalcoholic fatty liver disease. N Engl J Med 2002: 346(16); 1221-31.
5. Ramadori G, Armbrust T. Cytokines and Liver. In: Bircher J, Benhamou JP, McIntyre N, Rizetto M, Rodes J (eds). Oxford Textbook of Clinical Hepatology. Second edition, vol 1. New York, Oxford University Press, 1999: 169-85.
6. Mackiewicz A, Speroff T, Ganapathi MK, et al. Effect of cytokine combinations on acute phase protein production in two human hepatoma cell lines. J Immunol 1991; 146: 3032-37.
7. Streetz KL, Wustefeld T, Klein C, et al. Mediators of inflammation and acute phase response in the liver. Cell Mol Biol 2001; 47: 661-73.
8. Heinrich PC, Castell JV, Andus T. Interleukin-6 and the acute phase response. Biochem J 1990; 265: 621-36.
9. Angulo P, Keach J, Batts K, Lindor K. Independent predictors of liver fibrosis in patients with nonalcoholic steatohepatitis. Hepatology 1999; 30: 1356-62.
10. Bray GA. Pathophysiology of obesity. Am J Clin Nutr 1992; 55(suppl): 488S-494S.
11. Brunt EM, Janney CG, DiBisceglie AM, et al. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am J Gastroenterol 1999; 94: 2467-74.
12. Diehl A. Nonalcoholic steatohepatitis. Semin Liver Dis 1999; 19: 221-9.
13. Ratziu V, Giral P, Charlotte F, et al. Liver fibrosis in overweight patients. Gastroenterology 2000; 118: 1117-23.
14. Powell E, Cooksley W, Hanson R, et al. The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years. Hepatology 1990; 11: 74-80.
15. Neuschwander-Tetri BA. Evolving pathophysiologic concepts in nonalcoholic steatohepatitis. Current Gastroenterology Reports 2002; 4: 31-6.
16. Fagan EA, Dyck RF, Maton PN, et al. Serum levels of C-reactive protein in Crohns disease and ulcerative colitis. Eur J Clin Invest 1982; 12: 351-9.
17. Scholmerich J, Heinisch A, Leser HG. Diagnostic approach to acute pancreatitis: diagnosis assesment of etiology. Hepatogastroenterology 1993; 40: 531-7.
18. Lee FY, Lee SD, Tsai YD, et al. Serum C-reactive protein as a serum marker for the diagnosis of hepatocellular carcinoma. Cancer 1989; 63: 1567-71.
19. Gupto S, Slaughter S, Akriviadis EA, et al. Serial measurement of serum C-reactive protein facilitates evaluation in alcoholic hepatitis. Hepatogastroenterology 1995; 42: 516-21.
20. Shiota G, Umeki K, Okano J, Kawasaki H. Hepatocyte growth factor and acute phase proteins in patients with chronic liver diseases. J Med 1995; 26: 295-308.
21. Shima M, Nakao K, Kato Y, et al. Comparative study of C-reactive protein in chronic hepatitis B and chronic hepatitis C. Tohoku J Exp Med 1996; 178: 287-97.
22. Bell H, Skinningsrud A, Raknerud N, et al. Serum ferritin and transferrin saturation in patients with chronic alcoholic and non-alcoholic liver diasease. J Intern Med 1994; 236: 315-22.
23. Bacon B, Farahvash M, Janney C, Neuschwander-Tetri B. Non-alcoholic steatohepatitis: an expanded clinical entity. Gastroenterology 1994; 107: 1103-9.
24. George D, Goldwum S, McDonald G, et al. Increased hepatic iron concentration in nonalcoholic steatohepatitis is associated with increased fibrosis. Gastroenterology 1998; 114: 311-8.
25. Moirand R, Mortaji AM, Loreal O, et al. A new syndrome of liver iron overload with normal transferrin saturation. Lancet 1997; 349: 95-7.
26. Mendler MH, Turlin B, Moirand R, et al. Insulin resistance-associated hepatic iron overload. Gastroenterology 1999; 117: 1155-63.
27. Fargion S, Mattioli M, Fracanzani AL, et al. Hyperferritinemia, iron overload, and multiple metabolic alterations identify patients at risk for nonalcoholic steatohepatitis. Am J Gastroenterol 2001; 96: 2448-54.
28. Gerok W, Gross V. Protein secretion, degredation and function. In:Bircher J, Benhamou JP, McIntyre N, Rizetto M, Rodes J, eds. Oxford Textbook of Clinical Hepatology, second edition, vol 1. New York, Oxford University Press 1999; 346-67.
29. Tuck CH, Holleran S, Berglund L. Hormonal regulation of lipoprotein(a) levels: effects of estrogen replacement therapy on lipoprotein (a) and acute phase reactants in postmenopausal women. Arterioscler Thromb Biol 1997; 17: 1822-9.
30. Ramharack R, Barkalow D, Spahr MA. Dominant negative effect of TGF-beta1 and TNF-alpha on basal and IL-6-induced lipoprotein(a) and apolipoprotein(a) mRNA expression in primary monkey hepatocyte cultures. Arterioscler Thromb Vasc Biol 1998; 18: 984-90.
31. Min WK, Chun S, Hwang SH, Park H. No relationship between serum lipoprotein(a) and albumin concentrations in patients with acute phase response. Ann Clin Biochem 1999; 36: 617-21.