Polydatin inhibits the oxidative stress-induced proliferation of vascular smooth muscle cells by activating the eNOS/SIRT1 pathway

International Journal of Molecular Medicine

Volumn 37, Issue 6, 2016, Pages 1652-1660

  Ma, Yi ^a,b   Gong, Xun ^c   Mo, Yingli ^a   Wu, Saizhu ^a  

^a SOUTHERN MEDICAL UNIVERSITY   (China)

^b ZUNYI MEDICAL UNIVERSITY   (China)

^c CHANGSHA CENTRAL HOSPITAL   (China)

Author keywords

Atherosclerosis; Oxidative stress; Polydatin; Proliferation; Signaling pathway; Vascular smooth muscle cell

Indexed keywords

CYCLIN B1; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE INHIBITOR 1B; ENDOTHELIAL NITRIC OXIDE SYNTHASE; MYC PROTEIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; PICEID; REACTIVE OXYGEN METABOLITE; SELISISTAT; SIRTUIN 1; 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE; ANTIOXIDANT; CARBAZOLE DERIVATIVE; CCNB1 PROTEIN, RAT; CDK1 PROTEIN, RAT; CDKN1B PROTEIN, RAT; CYCLIN DEPENDENT KINASE; ENZYME INHIBITOR; GLUCOSIDE; HYDROGEN PEROXIDE; NOS3 PROTEIN, RAT; SIRT1 PROTEIN, RAT; STILBENE DERIVATIVE;

ANIMAL CELL; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; VASCULAR SMOOTH MUSCLE CELL; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CYCLE; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PRIMARY CELL CULTURE; SIGNAL TRANSDUCTION; SMOOTH MUSCLE CELL; SPRAGUE DAWLEY RAT; THORACIC AORTA; VASCULAR SMOOTH MUSCLE;

ANIMALS; ANTIOXIDANTS; AORTA, THORACIC; CARBAZOLES; CELL CYCLE; CELL PROLIFERATION; CYCLIN B1; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; GLUCOSIDES; HYDROGEN PEROXIDE; MALE; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; PRIMARY CELL CULTURE; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SIRTUIN 1; STILBENES;

EID: 84978872962     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2016.2554     Document Type: Article

References (48)

1. Das S and Das DK: Resveratrol: a therapeutic promise for cardiovascular diseases. Recent Patents Cardiovasc Drug Discov 2: 133-138, 2007.
2. Chen H, Tuck T, Ji X, Zhou X, Kelly G, Cuerrier A and Zhang J: Quality assessment of Japanese knotweed (Fallopia japonica) grown on Prince Edward Island as a source of resveratrol. J Agric Food Chem 61: 6383-6392, 2013.
3. Du QH, Peng C and Zhang H: Polydatin: a review of pharmacology and pharmacokinetics. Pharm Biol 51: 1347-1354, 2013.
4. Chen L, Lan Z, Lin Q, Mi X, He Y, Wei L, Lin Y, Zhang Y and Deng X: Polydatin ameliorates renal injury by attenuating oxidative stress-related inflammatory responses in fructose induced urate nephropathic mice. Food Chem Toxicol 52: 28-35, 2013.
5. Wen H, Gao X and Qin J: Probing the anti-aging role of polydatin in Caenorhabditis elegans on a chip. Integr Biol (Camb) 6: 35-43, 2014.
6. 2 in vascular smooth muscle cells: potential involvement in vascular disease (Review). Int J Mol Med 11: 229-234, 2003.
7. Jiang D, Li D and Wu W: Inhibitory effects and mechanisms of luteolin on proliferation and migration of vascular smooth muscle cells. Nutrients 5: 1648-1659, 2013.
8. Lan TH, Huang XQ and Tan HM: Vascular fibrosis in atherosclerosis. Cardiovasc Pathol 22: 401-407, 2013.
9. Jiang X, Liu W, Deng J, Lan L, Xue X, Zhang C, Cai G, Luo X and Liu J: Polydatin protects cardiac function against burn injury by inhibiting sarcoplasmic reticulum Ca2+ leak by reducing oxidative modification of ryanodine receptors. Free Radic Biol Med 60: 292-299, 2013.
10. Zhao KS, Jin C, Huang X, Liu J, Yan WS, Huang Q and Kan W: The mechanism of polydatin in shock treatment. Clin Hemorheol Microcirc 29: 211-217, 2003.
11. Salminen A, Kaarniranta K and Kauppinen A: Crosstalk between oxidative stress and SIRT1: Impact on the aging process. Int J Mol Sci 14: 3834-3859, 2013.
12. Zhang H, Zhai Z, Wang Y, Zhang J, Wu H, Wang Y, Li C, Li D, Lu L, Wang X, et al: Resveratrol ameliorates ionizing irradiation induced long-term hematopoietic stem cell injury in mice. Free Radic Biol Med 54: 40-50, 2013.
13. Zarzuelo MJ, López-Sepúlveda R, Sánchez M, Romero M, Gómez-Guzmán M, Ungvary Z, Pérez-Vizcaíno F, Jiménez R and Duarte J: SIRT1 inhibits NADPH oxidase activation and protects endothelial function in the rat aorta: implications for vascular aging. Biochem Pharmacol 85: 1288-1296, 2013.
14. 2-induced oxidative stress and senescence via SirT1 activation. J Atheroscler Thromb 17: 970-979, 2010.
15. Gong X, Ma Y, Ruan Y, Fu G and Wu S: Long-term atorvastatin improves age-related endothelial dysfunction by ameliorating oxidative stress and normalizing eNOS/iNOS imbalance in rat aorta. Exp Gerontol 52: 9-17, 2014.
16. Salabei JK, Cummins TD, Singh M, Jones SP, Bhatnagar A and Hill BG: PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and resistance to oxidative stress. Biochem J 451: 375-388, 2013.
17. Ni L, Li T, Liu B, Song X, Yang G, Wang L, Miao S and Liu C: The protective effect of Bcl-xl overexpression against oxidative stress-induced vascular endothelial cell injury and the role of the Akt/eNOS pathway. Int J Mol Sci 14: 22149-22162, 2013.
18. San Martin A, Foncea R, Laurindo FR, Ebensperger R, Griendling KK and Leighton F: Nox1-based NADPH oxidase derived superoxide is required for VSMC activation by advanced glycation end-products. Free Radic Biol Med 42: 1671-1679, 2007.
19. Botden IP, Oeseburg H, Durik M, Leijten FP, Van Vark-Van Der Zee LC, Musterd-Bhaggoe UM, Garrelds IM, Seynhaeve AL, Langendonk JG, Sijbrands EJ, et al: Red wine extract protects against oxidative-stress-induced endothelial senescence. Clin Sci (Lond) 123: 499-507, 2012.
20. Wang Q, Zhou H, Gao H, Chen SH, Chu CH, Wilson B and Hong JS: Naloxone inhibits immune cell function by suppressing superoxide production through a direct interaction with gp91phox subunit of NADPH oxidase. J Neuroinflammation 9: 32, 2012.
21. Miranda KM, Espey MG and Wink DA: A rapid, simple spectrophotometric method for simultaneous detection of nitrate and nitrite. Nitric Oxide 5: 62-71, 2001.
22. Shi Y, Hou X, Zhang X, Wang Y, Chen Y and Zou J: Inhibition of oxidized-phospholipid-induced vascular smooth muscle cell proliferation by resveratrol is associated with reducing Cx43 phosphorylation. J Agric Food Chem 61: 10534-10541, 2013.
23. Prasad K: Resveratrol, wine, and atherosclerosis. Int J Angiol 21: 7-18, 2012.
24. Gutiérrez-Pérez A, Cortés-Rojo C, Noriega-Cisneros R, Calderón-Cortés E, Manzo-Avalos S, Clemente-Guerrero M, Godínez-Hernández D, Boldogh I and Saavedra-Molina A: Protective effects of resveratrol on calcium-induced oxidative stress in rat heart mitochondria. J Bioenerg Biomembr 43: 101-107, 2011.
25. Han X, Ling S, Gan W, Sun L, Duan J and Xu JW: 2,3,5,4'-tetrahydroxystilbene-2-O-d-glucoside ameliorates vascular senescence and improves blood flow involving a mechanism of p53 deacetylation. Atherosclerosis 225: 76-82, 2012.
26. Park SJ, Ahmad F, Philp A, Baar K, Williams T, Luo H, Ke H, Rehmann H, Taussig R, Brown AL, et al: Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell 148: 421-433, 2012.
27. Robb EL and Stuart JA: The stilbenes resveratrol, pterostilbene and piceid affect growth and stress resistance in mammalian cells via a mechanism requiring estrogen receptor beta and the induction of Mn-superoxide dismutase. Phytochemistry 98: 164-173, 2014.
28. Yang H, Baur JA, Chen A, Miller C, Adams JK, Kisielewski A, Howitz KT, Zipkin RE and Sinclair DA: Design and synthesis of compounds that extend yeast replicative lifespan. Aging Cell 6: 35-43, 2007.
29. Szekeres T, Fritzer-Szekeres M, Saiko P and Jäger W: Resveratrol and resveratrol analogues-structure-activity relationship. Pharm Res 27: 1042-1048, 2010.
30. Storniolo CE, Quifer-Rada P, Lamuela-Raventos RM and Moreno JJ: Piceid presents antiproliferative effects in intestinal epithelial Caco-2 cells, effects unrelated to resveratrol release. Food Funct 5: 2137-2144, 2014.
31. Bicknell KA, Surry EL and Brooks G: Targeting the cell cycle machinery for the treatment of cardiovascular disease. J Pharm Pharmacol 55: 571-591, 2003.
32. Bonelli P, Tuccillo FM, Borrelli A, Schiattarella A and Buonaguro FM: CDK/CCN and CDKI alterations for cancer prognosis and therapeutic predictivity. Biomed Res Int 2014: 361020, 2014.
33. Wang Z, Fan M, Candas D, Zhang TQ, Qin L, Eldridge A, Wachsmann-Hogiu S, Ahmed KM, Chromy BA, Nantajit D, et al: Cyclin B1/Cdk1 coordinates mitochondrial respiration for cell cycle G2/M progression. Dev Cell 29: 217-232, 2014.
34. Payne SR, Zhang S, Tsuchiya K, Moser R, Gurley KE, Longton G, deBoer J and Kemp CJ: p27kip1 deficiency impairs G2/M arrest in response to DNA damage, leading to an increase in genetic instability. Mol Cell Biol 28: 258-268, 2008.
35. Wang J, Liu K, Shen L, Wu H and Jing H: Small interfering RNA to c-myc inhibits vein graft restenosis in a rat vein graft model. J Surg Res 169: e85-e91, 2011.
36. Su D, Cheng Y, Liu M, Liu D, Cui H, Zhang B, Zhou S, Yang T and Mei Q: Comparision of piceid and resveratrol in antioxidation and antiproliferation activities in vitro. PLoS One 8: e54505, 2013.
37. Huang J, Li LS, Yang DL, Gong QH, Deng J and Huang XN: Inhibitory effect of ginsenoside Rg1 on vascular smooth muscle cell proliferation induced by PDGF-BB is involved in nitric oxide formation. Evid Based Complement Alternat Med 2012: 314395, 2012.
38. Gonon AT, Widegren U, Bulhak A, Salehzadeh F, Persson J, Sjöquist PO and Pernow J: Adiponectin protects against myocardial ischaemia-reperfusion injury via AMP-activated protein kinase, Akt, and nitric oxide. Cardiovasc Res 78: 116-122, 2008.
39. Trott DW, Luttrell MJ, Seawright JW and Woodman CR: Aging impairs PI3K/Akt signaling and NO-mediated dilation in soleus muscle feed arteries. Eur J Appl Physiol 113: 2039-2046, 2013.
40. Takahashi S and Nakashima Y: Repeated and long-term treatment with physiological concentrations of resveratrol promotes NO production in vascular endothelial cells. Br J Nutr 107: 774-780, 2012.
41. Ekshyyan VP, Hebert VY, Khandelwal A and Dugas TR: Resveratrol inhibits rat aortic vascular smooth muscle cell proliferation via estrogen receptor dependent nitric oxide production. J Cardiovasc Pharmacol 50: 83-93, 2007.
42. Hori YS, Kuno A, Hosoda R and Horio Y: Regulation of FOXOs and p53 by SIRT1 modulators under oxidative stress. PLoS One 8: e73875, 2013.
43. Potente M and Dimmeler S: NO targets SIRT1: A novel signaling network in endothelial senescence. Arterioscler Thromb Vasc Biol 28: 1577-1579, 2008.
44. Thompson AM, Martin KA and Rzucidlo EM: Resveratrol induces vascular smooth muscle cell differentiation through stimulation of SirT1 and AMPK. PLoS One 9: e85495, 2014.
45. Tanno M, Kuno A, Horio Y and Miura T: Emerging beneficial roles of sirtuins in heart failure. Basic Res Cardiol 107: 273, 2012.
46. Xia N, Strand S, Schlufter F, Siuda D, Reifenberg G, Kleinert H, Förstermann U and Li H: Role of SIRT1 and FOXO factors in eNOS transcriptional activation by resveratrol. Nitric Oxide 32: 29-35, 2013.
47. Takizawa Y, Kosuge Y, Awaji H, Tamura E, Takai A, Yanai T, Yamamoto R, Kokame K, Miyata T, Nakata R and Inoue H: Up-regulation of endothelial nitric oxide synthase (eNOS), silent mating type information regulation 2 homologue 1 (SIRT1) and autophagy related genes by repeated treatments with resveratrol in human umbilical vein endothelial cells. Br J Nutr 110: 2150-2155, 2013.
48. Ota H, Eto M, Ogawa S, Iijima K, Akishita M and Ouchi Y: SIRT1/eNOS axis as a potential target against vascular senescence, dysfunction and atherosclerosis. J Atheroscler Thromb 17: 431-435, 2010.