Mycobacterium tuberculosis Thioredoxin Reductase Is Essential for Thiol Redox Homeostasis but Plays a Minor Role in Antioxidant Defense

PLoS Pathogens

Volumn 12, Issue 6, 2016, Pages

  Lin, Kan ^a,b   O'Brien, Kathryn M ^a   Trujillo, Carolina ^a   Wang, Ruojun ^a,b   Wallach, Joshua B ^a   Schnappinger, Dirk ^a   Ehrt, Sabine ^a,b  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b Weill Cornell Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BAMBERMYCIN; DITHIOTHREITOL; MITOMYCIN; RIFAMPICIN; THIOREDOXIN REDUCTASE; VANCOMYCIN; BACTERIAL PROTEIN;

ANIMAL CELL; ANIMAL MODEL; ANTIBIOTIC SENSITIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BACTERIAL GROWTH; BACTERIAL SURVIVAL; COLONY FORMING UNIT; CONTROLLED STUDY; DNA METABOLISM; DNA MICROARRAY; DNA REPAIR; FEMALE; GENE DELETION; GENE INACTIVATION; HOMEOSTASIS; IMMUNOBLOTTING; MINIMUM INHIBITORY CONCENTRATION; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; OPTICAL DENSITY; OXIDATIVE STRESS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN DEPLETION; ANIMAL; C57BL MOUSE; DISEASE MODEL; METABOLISM; OXIDATION REDUCTION REACTION; PHYSIOLOGY; TUBERCULOSIS;

ANIMALS; BACTERIAL PROTEINS; DISEASE MODELS, ANIMAL; FEMALE; HOMEOSTASIS; IMMUNOBLOTTING; MICE; MICE, INBRED C57BL; MYCOBACTERIUM TUBERCULOSIS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXIDATION-REDUCTION; OXIDATIVE STRESS; THIOREDOXIN-DISULFIDE REDUCTASE; TUBERCULOSIS;

EID: 84978811483     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1005675     Document Type: Article

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