Inhibition of bacterial thioredoxin reductase: An antibiotic mechanism targeting bacteria lacking glutathione

FASEB Journal

Volumn 27, Issue 4, 2013, Pages 1394-1403

  Lu, Jun ^a   Vlamis Gardikas, Alexios ^a   Kandasamy, Karuppasamy ^a   Zhao, Rong ^a   Gustafsson, Tomas N ^a   Engstrand, Lars ^b   Hoffner, Sven ^b,c   Engman, Lars ^d   Holmgren, Arne ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c WORLD HEALTH ORGANIZATION   (Switzerland)

^d UPPSALA UNIVERSITY   (Sweden)

Author keywords

Ebselen; Isothiazolone; Oxidative stress; Thiol

Indexed keywords

BACTERIAL ENZYME; DITHIOL DERIVATIVE; EBSELEN; EBSULFUR; GLUTAREDOXIN; GLUTATHIONE; THIOREDOXIN 1; THIOREDOXIN 2; THIOREDOXIN REDUCTASE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL STRAIN; DNA SYNTHESIS; DRUG SENSITIVITY; DRUG TARGETING; ELECTRON TRANSPORT; ENZYME ACTIVE SITE; ENZYME INHIBITION; ESCHERICHIA COLI; GROWTH INHIBITION; HELICOBACTER PYLORI; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIOXIDANTS; AZOLES; CELLS, CULTURED; ESCHERICHIA COLI; GLUTATHIONE; NADP; ORGANOSELENIUM COMPOUNDS; OXIDATIVE STRESS; SIGNAL TRANSDUCTION; THIOREDOXIN-DISULFIDE REDUCTASE; THIOREDOXINS;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; HELICOBACTER PYLORI; MAMMALIA; STAPHYLOCOCCUS AUREUS;

EID: 84875701168     PISSN: None     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.12-223305     Document Type: Article

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