Microfluidic blood–brain barrier model provides in vivo-like barrier properties for drug permeability screening

Biotechnology and Bioengineering

Volumn 114, Issue 1, 2017, Pages 184-194

  Wang, Ying I ^a   Abaci, Hasan Erbil ^a   Shuler, Michael L ^a  

^a Cornell University   (United States)

Author keywords

blood brain barrier; human iPS cells; organ on a chip; permeability; TEER

Indexed keywords

BLOOD; BRAIN; ENDOTHELIAL CELLS; MECHANICAL PERMEABILITY; MICROFLUIDICS; PHYSIOLOGY; SHEAR STRESS; STEM CELLS;

BLOOD-BRAIN BARRIER; BLOOD-BRAIN BARRIER MODELS; BRAIN MICROVASCULAR ENDOTHELIAL CELLS; HUMAN-INDUCED PLURIPOTENT STEM CELLS; IPS CELLS; ORGAN ON A CHIP; TEER; TIGHT JUNCTION FORMATIONS;

PHYSIOLOGICAL MODELS;

CAFFEINE; CIMETIDINE; DOXORUBICIN; FLUORESCEIN ISOTHIOCYANATE DEXTRAN;

ANIMAL CELL; ARTICLE; ASTROCYTE; BLOOD BRAIN BARRIER; BRAIN MICROVASCULAR ENDOTHELIAL CELL; BRAIN TISSUE; COCULTURE; COMPUTATIONAL FLUID DYNAMICS; CONTROLLED STUDY; DRUG PENETRATION; ELECTRIC RESISTANCE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; INDUCED PLURIPOTENT STEM CELL; MICROFLUIDICS; NONHUMAN; RAT; RELIABILITY; SHEAR STRESS; SIMULATION; TIGHT JUNCTION; TRANSENDOTHELIAL ELECTRICAL RESISTANCE; VASCULAR ENDOTHELIAL CELL; BIOLOGICAL MODEL; CELL LINE; DEVICES; EQUIPMENT DESIGN; IMPEDANCE; METABOLISM; MICROFLUIDIC ANALYSIS; PERMEABILITY; PHYSIOLOGY; PRECLINICAL STUDY; PROCEDURES; TISSUE MICROARRAY;

BLOOD-BRAIN BARRIER; CELL LINE; DRUG EVALUATION, PRECLINICAL; ELECTRIC IMPEDANCE; EQUIPMENT DESIGN; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MICROFLUIDIC ANALYTICAL TECHNIQUES; MODELS, BIOLOGICAL; PERMEABILITY; TISSUE ARRAY ANALYSIS;

EID: 84978785813     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.26045     Document Type: Article

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