Non-invasive measurement of solute permeability in cerebral microvessels of the rat

Microvascular Research

Volumn 77, Issue 2, 2009, Pages 166-173

  Yuan, Wei ^a   Lv, Yonggang ^a   Zeng, Min ^a   Fu, Bingmei M ^a  

^a CITY UNIVERSITY OF NEW YORK   (United States)

Author keywords

Dextrans; Fluorescence imaging; In vivo; Mammalian; Pial microvessels; Sodium fluorescein; Solute permeability; The blood brain barrier

Indexed keywords

DEXTRAN; FLUORESCEIN SODIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN BLOOD VESSEL; BRAIN MICROCIRCULATION; CAROTID ARTERY; CONTROLLED STUDY; ERYTHROCYTE; FEMALE; FLUORESCENCE IMAGING; FRONTAL LOBE; MESENTERY BLOOD VESSEL; MICROVASCULATURE; MOLECULAR WEIGHT; NONHUMAN; PARIETAL LOBE; PERFUSION; PERMEABILITY; PIA MATER; PRIORITY JOURNAL; RAT; SOLUTE;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; CAPILLARY PERMEABILITY; DEXTRANS; FEMALE; FLUORESCEIN; FLUORESCEIN-5-ISOTHIOCYANATE; FLUORESCENT DYES; MICROCIRCULATION; MODELS, NEUROLOGICAL; PIA MATER; RATS; RATS, SPRAGUE-DAWLEY; SPLANCHNIC CIRCULATION;

MAMMALIA; RATTUS;

EID: 60449088253     PISSN: 00262862     EISSN: 10959319     Source Type: Journal    
DOI: 10.1016/j.mvr.2008.08.004     Document Type: Article

References (32)

1. Adamson R.H., Huxley V.H., and Curry F.E. Single capillary permeability to proteins having similar size but different charge. Am. J. Physiol. 254 (1988) H304-H312
2. Adamson R.H., Lenz J.F., and Curry F.E. Quantitative laser scanning confocal microscopy on single capillaries: permeability measurement. Microcirculation 1 (1994) 251-265
3. Allt G., and Lawrenson J.G. Is the pial microvessel a good model for blood-brain barrier studies?. Brain Res. Brain Res. Rev. 24 (1997) 67-76
4. Butt A.M., Jones H.C., and Abbott N.J. Electrical resistance across the blood-brain barrier in anaesthetized rats: a developmental study. J. Physiol. 429 (1990) 47-62
5. Cornford E.M., Young D., Paxton J.W., and Sofia R.D. Blood-brain barrier penetration of felbamate. Epilepsia 33 (1992) 944-954
6. Curry F.E., and Frokjaer-Jensen J. Water flow across the walls of single muscle capillaries in the frog, Rana pipiens. J. Physiol. 350 (1984) 293-307
7. de Boer A.G., and Gaillard P.J. Blood-brain barrier dysfunction and recovery. J. Neural Transm. 113 (2006) 455-462
8. Easton A.S., and Fraser P.A. Variable restriction of albumin diffusion across inflamed cerebral microvessels of the anaesthetized rat. J. Physiol. 475 (1994) 147-157
9. Easton A.S., Sarker M.H., and Fraser P.A. Two components of blood-brain barrier disruption in the rat. J. Physiol. 503 Pt 3 (1997) 613-623
10. Elsinga P.H., Hendrikse N.H., Bart J., Vaalburg W., and van Waarde A. PET Studies on P-glycoprotein function in the blood-brain barrier: how it affects uptake and binding of drugs within the CNS. Curr. Pharm. Des. 10 (2004) 1493-1503
11. Fraser P.A., Dallas A.D., and Davies S. Measurement of filtration coefficient in single cerebral microvessels of the frog. J. Physiol. 423 (1990) 343-361
12. Fu B.M., and Shen S. Structural mechanisms of acute VEGF effect on microvessel permeability. Am. J. Physiol. Heart Circ. Physiol. 284 (2003) H2124-H2135
13. Fu B.M., and Shen S. Acute VEGF effect on solute permeability of mammalian microvessels in vivo. Microvasc. Res. 68 (2004) 51-62
14. Fu B.M., Adamson R.H., and Curry F.E. Test of a two-pathway model for small-solute exchange across the capillary wall. Am. J. Physiol. 274 (1998) H2062-H2073
15. Gaber M.W., Yuan H., Killmar J.T., Naimark M.D., Kiani M.F., and Merchant T.E. An intravital microscopy study of radiation-induced changes in permeability and leukocyte-endothelial cell interactions in the microvessels of the rat pia mater and cremaster muscle. Brain Res. Brain Res. Protoc. 13 (2004) 1-10
16. Garcia-Villalon A.L., Roda J.M., Alvarez F., Gomez B., and Dieguez G. Carotid blood flow in anesthetized rats: effects of carotid ligation and anastomosis. Microsurgery 13 (1992) 258-261
17. Hawkins B.T., and Davis T.P. The blood-brain barrier/neurovascular unit in health and disease. Pharmacol. Rev. 57 (2005) 173-185
18. Hu D.E., Easton A.S., and Fraser P.A. TRPV1 activation results in disruption of the blood-brain barrier in the rat. Br. J. Pharmacol. 146 (2005) 576-584
19. Huxley V.H., Curry F.E., and Adamson R.H. Quantitative fluorescence microscopy on single capillaries: alpha-lactalbumin transport. Am. J. Physiol. 252 (1987) H188-H197
20. Kaur C., Sivakumar V., Zhang Y., and Ling E.A. Hypoxia-induced astrocytic reaction and increased vascular permeability in the rat cerebellum. Glia 54 (2006) 826-839
21. Kendall S., and Michel C.C. The measurement of permeability in single rat venules using the red cell microperfusion technique. Exp. Physiol. 80 (1995) 359-372
22. Mayhan W.G., and Heistad D.D. Role of veins and cerebral venous pressure in disruption of the blood-brain barrier. Circ. Res. 59 (1986) 216-220
23. Michel C.C., and Curry F.E. Microvascular permeability. Physiol. Rev. 79 (1999) 703-761
24. Nagaraja T.N., Knight R.A., Croxen R.L., Konda K.P., and Fenstermacher J.D. Acute neurovascular unit protection by simvastatin in transient cerebral ischemia. Neurol. Res. 28 (2006) 826-830
25. Nicolazzo J.A., Charman S.A., and Charman W.N. Methods to assess drug permeability across the blood-brain barrier. J. Pharm. Pharmacol. 58 (2006) 281-293
26. Pardridge W.M. CNS drug design based on principles of blood-brain barrier transport. J. Neurochem. 70 (1998) 1781-1792
27. Pardridge W.M. Molecular trojan horses for blood-brain barrier drug delivery. Discov. Med. 6 (2006) 139-143
28. van Uitert R.L., Sage J.I., Levy D.E., and Duffy T.E. Comparison of radio-labeled butanol and iodoantipyrine as cerebral blood flow markers. Brain Res. 222 (1981) 365-372
29. Sandor P., Cox-van Put J., de Jong W., and de Wied D. Continuous measurement of cerebral blood volume in rats with the photoelectric technique: effect of morphine and naloxone. Life Sci. 39 18 (1986) 1657-1665
30. Wang R., Ashwal S., Tone B., Tian H.R., Badaut J., Rasmussen A., and Obenaus A. Albumin reduces blood-brain barrier permeability but does not alter infarct size in a rat model of neonatal stroke. Pediatr. Res. 62 (2007) 261-266
31. Yuan F., Leunig M., Berk D.A., and Jain R.K. Microvascular permeability of albumin, vascular surface area, and vascular volume measured in human adenocarcinoma LS174T using dorsal chamber in SCID mice. Microvasc. Res. 45 (1993) 269-289
32. Zlokovic B.V., Begley D.J., Djuricic B.M., and Mitrovic D.M. Measurement of solute transport across the blood-brain barrier in the perfused guinea pig brain: method and application to N-methyl-alpha-aminoisobutyric acid. J. Neurochem. 46 (1986) 1444-1451