-
1
-
-
0037417807
-
The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation
-
N.G.Seidah, S.Benjannet, L.Wickham, The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): liver regeneration and neuronal differentiation. Proc Natl Acad Sci US 2003;100:928–33.
-
(2003)
Proc Natl Acad Sci US
, vol.100
, pp. 928-933
-
-
Seidah, N.G.1
Benjannet, S.2
Wickham, L.3
-
2
-
-
84881538945
-
PCSK9 prosegment chimera as novel inhibitors of LDLR degradation
-
Y.G.Saavedra, J.Zhang, N.G.Seidah. PCSK9 prosegment chimera as novel inhibitors of LDLR degradation. PloS One 2013;8:e72113.
-
(2013)
PloS One
, vol.8
, pp. 72113
-
-
Saavedra, Y.G.1
Zhang, J.2
Seidah, N.G.3
-
3
-
-
84877245019
-
Differential effects of PCSK9 loss of function variants on serum lipid and PCSK9 levels in Caucasian and African Canadian populations
-
J.Mayne, T.C.Ooi, A.Raymond, Differential effects of PCSK9 loss of function variants on serum lipid and PCSK9 levels in Caucasian and African Canadian populations. Lipids Health Disease 2013;12:70.
-
(2013)
Lipids Health Disease
, vol.12
, pp. 70
-
-
Mayne, J.1
Ooi, T.C.2
Raymond, A.3
-
4
-
-
73449143804
-
Effects of PCSK9 variants on common carotid artery intima media thickness and relation to ApoE alleles
-
G.D.Norata, K.Garlaschelli, L.Grigore, Effects of PCSK9 variants on common carotid artery intima media thickness and relation to ApoE alleles. Atherosclerosis 2010;208:177–82.
-
(2010)
Atherosclerosis
, vol.208
, pp. 177-182
-
-
Norata, G.D.1
Garlaschelli, K.2
Grigore, L.3
-
5
-
-
84900799894
-
PCSK9 is present in human cerebrospinal fluid and is maintained at remarkably constant concentrations throughout the course of the day
-
Y.Q.Chen, J.S.Troutt, R.J.Konrad. PCSK9 is present in human cerebrospinal fluid and is maintained at remarkably constant concentrations throughout the course of the day. Lipids 2014;49:445–55.
-
(2014)
Lipids
, vol.49
, pp. 445-455
-
-
Chen, Y.Q.1
Troutt, J.S.2
Konrad, R.J.3
-
6
-
-
84878013844
-
Association of serum proprotein convertase subtilisin/kexin type 9 with carotid intima media thickness in hypertensive subjects
-
C.J.Lee, Y.H.Lee, S.W.Park, Association of serum proprotein convertase subtilisin/kexin type 9 with carotid intima media thickness in hypertensive subjects. Metabolism 2013;62:845–50.
-
(2013)
Metabolism
, vol.62
, pp. 845-850
-
-
Lee, C.J.1
Lee, Y.H.2
Park, S.W.3
-
7
-
-
84901452665
-
Effect of E670G polymorphism in PCSK9 gene on the risk and severity of coronary heart disease and ischemic stroke in a Tunisian cohort
-
A.Slimani, Y.Harira, I.Trabelsi, Effect of E670G polymorphism in PCSK9 gene on the risk and severity of coronary heart disease and ischemic stroke in a Tunisian cohort. J Mol Neurosci 2014;53:150–7.
-
(2014)
J Mol Neurosci
, vol.53
, pp. 150-157
-
-
Slimani, A.1
Harira, Y.2
Trabelsi, I.3
-
8
-
-
84903301550
-
Plasma PCSK9 levels are associated with the severity of coronary stenosis in patients with atherosclerosis
-
S.Li, Y.L.Guo, R.X.Xu, Plasma PCSK9 levels are associated with the severity of coronary stenosis in patients with atherosclerosis. Int J Cardiology 2014;174:863–4.
-
(2014)
Int J Cardiology
, vol.174
, pp. 863-864
-
-
Li, S.1
Guo, Y.L.2
Xu, R.X.3
-
9
-
-
40949104944
-
Proprotein convertase subtilisin/kexin type 9 (PCSK9) gene is a risk factor of large-vessel atherosclerosis stroke
-
S.Abboud, P.J.Karhunen, D.Lutjohann, Proprotein convertase subtilisin/kexin type 9 (PCSK9) gene is a risk factor of large-vessel atherosclerosis stroke. PloS One 2007;2:e1043.
-
(2007)
PloS One
, vol.2
, pp. 1043
-
-
Abboud, S.1
Karhunen, P.J.2
Lutjohann, D.3
-
10
-
-
84895075938
-
PCSK9: From discovery to therapeutic applications
-
M.Farnier. PCSK9: From discovery to therapeutic applications. Arch Cardiovascular Diseases 2014;107:58–66.
-
(2014)
Arch Cardiovascular Diseases
, vol.107
, pp. 58-66
-
-
Farnier, M.1
-
11
-
-
84860383419
-
The biology and therapeutic targeting of the proprotein convertases
-
N.G.Seidah, A.Prat. The biology and therapeutic targeting of the proprotein convertases. Nat Rev Drug Discovery 2012;11:367–83.
-
(2012)
Nat Rev Drug Discovery
, vol.11
, pp. 367-383
-
-
Seidah, N.G.1
Prat, A.2
-
12
-
-
78650361274
-
Effects of the prosegment and pH on the activity of PCSK9: evidence for additional processing events
-
S.Benjannet, Y.G.Saavedra, J.Hamelin, Effects of the prosegment and pH on the activity of PCSK9: evidence for additional processing events. J Biol Chem 2010;285:40965–78.
-
(2010)
J Biol Chem
, vol.285
, pp. 40965-40978
-
-
Benjannet, S.1
Saavedra, Y.G.2
Hamelin, J.3
-
13
-
-
51349161358
-
Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor
-
D.W.Zhang, R.Garuti, W.J.Tang, Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor. Proc Natl Acad Sci USA 2008;105:13045–50.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 13045-13050
-
-
Zhang, D.W.1
Garuti, R.2
Tang, W.J.3
-
14
-
-
82555187008
-
Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH
-
P.Lo Surdo, M.J.Bottomley, A.Calzetta, Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH. EMBO Rep 2011;12:1300–5.
-
(2011)
EMBO Rep
, vol.12
, pp. 1300-1305
-
-
Lo Surdo, P.1
Bottomley, M.J.2
Calzetta, A.3
-
15
-
-
67449085639
-
Antagonism of secreted PCSK9 increases low density lipoprotein receptor expression in HepG2 cells
-
M.C.McNutt, H.J.Kwon, C.Chen, Antagonism of secreted PCSK9 increases low density lipoprotein receptor expression in HepG2 cells. J Biol Chem 2009;284:10561–70.
-
(2009)
J Biol Chem
, vol.284
, pp. 10561-10570
-
-
McNutt, M.C.1
Kwon, H.J.2
Chen, C.3
-
16
-
-
12144285659
-
A mutation in PCSK9 causing autosomal-dominant hypercholesterolemia in a Utah pedigree
-
K.M.Timms, S.Wagner, M.E.Samuels, A mutation in PCSK9 causing autosomal-dominant hypercholesterolemia in a Utah pedigree. Hum Genetics 2004;114:349–53.
-
(2004)
Hum Genetics
, vol.114
, pp. 349-353
-
-
Timms, K.M.1
Wagner, S.2
Samuels, M.E.3
-
17
-
-
34247605063
-
Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia
-
D.Cunningham, D.E.Danley, K.F.Geoghegan, Structural and biophysical studies of PCSK9 and its mutants linked to familial hypercholesterolemia. Nat Struct Mol Biol 2007;14:413–9.
-
(2007)
Nat Struct Mol Biol
, vol.14
, pp. 413-419
-
-
Cunningham, D.1
Danley, D.E.2
Geoghegan, K.F.3
-
18
-
-
84864770647
-
Identification and characterization of new gain-of-function mutations in the PCSK9 gene responsible for autosomal dominant hypercholesterolemia
-
M.Abifadel, M.Guerin, S.Benjannet, Identification and characterization of new gain-of-function mutations in the PCSK9 gene responsible for autosomal dominant hypercholesterolemia. Atherosclerosis 2012;223:394–400.
-
(2012)
Atherosclerosis
, vol.223
, pp. 394-400
-
-
Abifadel, M.1
Guerin, M.2
Benjannet, S.3
-
19
-
-
33748661502
-
Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote
-
Z.Zhao, Y.Tuakli, T.A.Lagace, Molecular characterization of loss-of-function mutations in PCSK9 and identification of a compound heterozygote. Am J Hum Genetics 2006;79:514–23.
-
(2006)
Am J Hum Genetics
, vol.79
, pp. 514-523
-
-
Zhao, Z.1
Tuakli, Y.2
Lagace, T.A.3
-
20
-
-
84859868297
-
Effect of mutations in LDLR and PCSK9 genes on phenotypic variability in Tunisian familial hypercholesterolemia patients
-
A.Slimani, A.Jelassi, I.Jguirim, Effect of mutations in LDLR and PCSK9 genes on phenotypic variability in Tunisian familial hypercholesterolemia patients. Atherosclerosis 2012;222:158–66.
-
(2012)
Atherosclerosis
, vol.222
, pp. 158-166
-
-
Slimani, A.1
Jelassi, A.2
Jguirim, I.3
-
21
-
-
60749122013
-
Degradation of LDLR protein mediated by ‘gain of function’ PCSK9 mutants in normal and ARH cells
-
T.Fasano, X.M.Sun, D.D.Patel, Degradation of LDLR protein mediated by ‘gain of function’ PCSK9 mutants in normal and ARH cells. Atherosclerosis 2009;203:166–71.
-
(2009)
Atherosclerosis
, vol.203
, pp. 166-171
-
-
Fasano, T.1
Sun, X.M.2
Patel, D.D.3
-
22
-
-
84876801739
-
The safety of therapeutic monoclonal antibodies: implications for cardiovascular disease and targeting the PCSK9 pathway
-
A.L.Catapano, N.Papadopoulos. The safety of therapeutic monoclonal antibodies: implications for cardiovascular disease and targeting the PCSK9 pathway. Atherosclerosis 2013;228:18–28.
-
(2013)
Atherosclerosis
, vol.228
, pp. 18-28
-
-
Catapano, A.L.1
Papadopoulos, N.2
-
23
-
-
84885072023
-
The biology of PCSK9 from the endoplasmic reticulum to lysosomes: new and emerging therapeutics to control low-density lipoprotein cholesterol
-
S.Poirier, G.Mayer. The biology of PCSK9 from the endoplasmic reticulum to lysosomes: new and emerging therapeutics to control low-density lipoprotein cholesterol. Drug Des Dev Ther 2013;7:1135–48.
-
(2013)
Drug Des Dev Ther
, vol.7
, pp. 1135-1148
-
-
Poirier, S.1
Mayer, G.2
-
24
-
-
84899711770
-
Influence of PCSK9 polymorphisms on plasma lipids and response to atorvastatin treatment in Brazilian subjects
-
J.M.Anderson, A.Cerda, M.H.Hirata, Influence of PCSK9 polymorphisms on plasma lipids and response to atorvastatin treatment in Brazilian subjects. J Clin Lipidology 2014;8:256–64.
-
(2014)
J Clin Lipidology
, vol.8
, pp. 256-264
-
-
Anderson, J.M.1
Cerda, A.2
Hirata, M.H.3
-
25
-
-
38349117118
-
The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2
-
S.Poirier, G.Mayer, S.Benjannet, The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2. J Biol Chem 2008;283:2363–72.
-
(2008)
J Biol Chem
, vol.283
, pp. 2363-2372
-
-
Poirier, S.1
Mayer, G.2
Benjannet, S.3
-
26
-
-
10344253854
-
NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol
-
S.Benjannet, D.Rhainds, R.Essalmani, NARC-1/PCSK9 and its natural mutants: zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol. J Biol Chem 2004;279:48865–75.
-
(2004)
J Biol Chem
, vol.279
, pp. 48865-48875
-
-
Benjannet, S.1
Rhainds, D.2
Essalmani, R.3
-
27
-
-
79953760698
-
Circulating proprotein convertase subtilisin/kexin 9 (PCSK9) regulates VLDLR protein and triglyceride accumulation in visceral adipose tissue
-
A.Roubtsova, M.N.Munkonda, Z.Awan, Circulating proprotein convertase subtilisin/kexin 9 (PCSK9) regulates VLDLR protein and triglyceride accumulation in visceral adipose tissue. Arteriosclerosis Thrombosis Vascular Biol 2011;31:785–91.
-
(2011)
Arteriosclerosis Thrombosis Vascular Biol
, vol.31
, pp. 785-791
-
-
Roubtsova, A.1
Munkonda, M.N.2
Awan, Z.3
-
28
-
-
84880901358
-
Decreased APOE-containing HDL subfractions and cholesterol efflux capacity of serum in mice lacking Pcsk9
-
S.Choi, A.Aljakna, U.Srivastava, Decreased APOE-containing HDL subfractions and cholesterol efflux capacity of serum in mice lacking Pcsk9. Lipids Health Disease 2013;12:112.
-
(2013)
Lipids Health Disease
, vol.12
, pp. 112
-
-
Choi, S.1
Aljakna, A.2
Srivastava, U.3
-
30
-
-
84879569545
-
Immune effector mechanisms implicated in atherosclerosis: from mice to humans
-
P.Libby, A.H.Lichtman, G.K.Hansson. Immune effector mechanisms implicated in atherosclerosis: from mice to humans. Immunity 2013;38:1092–104.
-
(2013)
Immunity
, vol.38
, pp. 1092-1104
-
-
Libby, P.1
Lichtman, A.H.2
Hansson, G.K.3
-
31
-
-
84887572952
-
Low-density lipoprotein subfraction, carotid artery intima-media thickness, nitric oxide, and tumor necrosis factor alpha are associated with newly diagnosed ischemic stroke
-
M.C.Cure, A.Tufekci, E.Cure, Low-density lipoprotein subfraction, carotid artery intima-media thickness, nitric oxide, and tumor necrosis factor alpha are associated with newly diagnosed ischemic stroke. Ann Indian Acad Neurology 2013;16:498–503.
-
(2013)
Ann Indian Acad Neurology
, vol.16
, pp. 498-503
-
-
Cure, M.C.1
Tufekci, A.2
Cure, E.3
-
32
-
-
80052424239
-
A unique microRNA signature associated with plaque instability in humans
-
F.Cipollone, L.Felicioni, R.Sarzani, A unique microRNA signature associated with plaque instability in humans. Stroke 2011;42:2556–63.
-
(2011)
Stroke
, vol.42
, pp. 2556-2563
-
-
Cipollone, F.1
Felicioni, L.2
Sarzani, R.3
-
33
-
-
78751652694
-
A prospective natural-history study of coronary atherosclerosis
-
G.W.Stone, A.Maehara, A.J.Lansky, A prospective natural-history study of coronary atherosclerosis. New England J Med 2011;364:226–35.
-
(2011)
New England J Med
, vol.364
, pp. 226-235
-
-
Stone, G.W.1
Maehara, A.2
Lansky, A.J.3
-
34
-
-
84888258172
-
Bad cholesterol breaking really bad
-
T.C.Nichols. Bad cholesterol breaking really bad. Blood 2013;122:3551–3.
-
(2013)
Blood
, vol.122
, pp. 3551-3553
-
-
Nichols, T.C.1
-
35
-
-
84857600072
-
Gene inactivation of proprotein convertase subtilisin/kexin type 9 reduces atherosclerosis in mice
-
M.Denis, J.Marcinkiewicz, A.Zaid, Gene inactivation of proprotein convertase subtilisin/kexin type 9 reduces atherosclerosis in mice. Circulation 2012;125:894–901.
-
(2012)
Circulation
, vol.125
, pp. 894-901
-
-
Denis, M.1
Marcinkiewicz, J.2
Zaid, A.3
-
36
-
-
84855964405
-
Proprotein convertase subtilisin kexin type 9 (PCSK9) secreted by cultured smooth muscle cells reduces macrophages LDLR levels
-
N.Ferri, G.Tibolla, A.Pirillo, Proprotein convertase subtilisin kexin type 9 (PCSK9) secreted by cultured smooth muscle cells reduces macrophages LDLR levels. Atherosclerosis 2012;220:381–6.
-
(2012)
Atherosclerosis
, vol.220
, pp. 381-386
-
-
Ferri, N.1
Tibolla, G.2
Pirillo, A.3
-
37
-
-
79451474588
-
Guidelines for the prevention of stroke in patients with stroke or transient ischemic attack: a guideline for healthcare professionals from the american heart association/american stroke association
-
K.L.Furie, S.E.Kasner, R.J.Adams, Guidelines for the prevention of stroke in patients with stroke or transient ischemic attack: a guideline for healthcare professionals from the american heart association/american stroke association. Stroke 2011;42:227–76.
-
(2011)
Stroke
, vol.42
, pp. 227-276
-
-
Furie, K.L.1
Kasner, S.E.2
Adams, R.J.3
-
38
-
-
61449444418
-
PCSK9 as a therapeutic target of dyslipidemia
-
N.G.Seidah. PCSK9 as a therapeutic target of dyslipidemia. Expert Opin Therapeutic Targets 2009;13:19–28.
-
(2009)
Expert Opin Therapeutic Targets
, vol.13
, pp. 19-28
-
-
Seidah, N.G.1
-
39
-
-
84885447918
-
Targeting the proprotein convertase subtilisin/kexin type 9 for the treatment of dyslipidemia and atherosclerosis
-
D.Urban, J.Poss, M.Bohm, Targeting the proprotein convertase subtilisin/kexin type 9 for the treatment of dyslipidemia and atherosclerosis. J Am Coll. Cardiology 2013;62:1401–8.
-
(2013)
J Am Coll. Cardiology
, vol.62
, pp. 1401-1408
-
-
Urban, D.1
Poss, J.2
Bohm, M.3
-
40
-
-
84866499818
-
PCSK9 siRNA suppresses the inflammatory response induced by oxLDL through inhibition of NF-kappaB activation in THP-1-derived macrophages
-
Z.Tang, L.Jiang, J.Peng, PCSK9 siRNA suppresses the inflammatory response induced by oxLDL through inhibition of NF-kappaB activation in THP-1-derived macrophages. Int J Mol Med 2012;30:931–8.
-
(2012)
Int J Mol Med
, vol.30
, pp. 931-938
-
-
Tang, Z.1
Jiang, L.2
Peng, J.3
-
41
-
-
83555173282
-
PCSK9 siRNA inhibits HUVEC apoptosis induced by ox-LDL via Bcl/Bax-caspase9-caspase3 pathway
-
C.Y.Wu, Z.H.Tang, L.Jiang, PCSK9 siRNA inhibits HUVEC apoptosis induced by ox-LDL via Bcl/Bax-caspase9-caspase3 pathway. Mol Cell Biochem 2012;359:347–58.
-
(2012)
Mol Cell Biochem
, vol.359
, pp. 347-358
-
-
Wu, C.Y.1
Tang, Z.H.2
Jiang, L.3
-
42
-
-
77649274263
-
PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities
-
M.Mbikay, F.Sirois, J.Mayne, PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities. FEBS Lett 2010;584:701–6.
-
(2010)
FEBS Lett
, vol.584
, pp. 701-706
-
-
Mbikay, M.1
Sirois, F.2
Mayne, J.3
-
43
-
-
84861728908
-
Regulation of epithelial sodium channel trafficking by proprotein convertase subtilisin/kexin type 9 (PCSK9)
-
V.Sharotri, D.M.Collier, D.R.Olson, Regulation of epithelial sodium channel trafficking by proprotein convertase subtilisin/kexin type 9 (PCSK9). J Biol Chem 2012;287:19266–74.
-
(2012)
J Biol Chem
, vol.287
, pp. 19266-19274
-
-
Sharotri, V.1
Collier, D.M.2
Olson, D.R.3
-
44
-
-
84881268496
-
Epidemiology of stroke and its subtypes in Chinese vs white populations: a systematic review
-
C.F.Tsai, B.Thomas, C.L.Sudlow. Epidemiology of stroke and its subtypes in Chinese vs white populations: a systematic review. Neurology 2013;81:264–72.
-
(2013)
Neurology
, vol.81
, pp. 264-272
-
-
Tsai, C.F.1
Thomas, B.2
Sudlow, C.L.3
-
45
-
-
84892550381
-
Secondary stroke prevention
-
G.J.Hankey. Secondary stroke prevention. Lancet Neurology 2014;13:178–94.
-
(2014)
Lancet Neurology
, vol.13
, pp. 178-194
-
-
Hankey, G.J.1
-
46
-
-
84892420349
-
Statin therapy reduces oxidized low density lipoprotein level, a risk factor for stroke outcome
-
N.W.Tsai, L.H.Lee, C.R.Huang, Statin therapy reduces oxidized low density lipoprotein level, a risk factor for stroke outcome. Crit Care 2014;18:R16.
-
(2014)
Crit Care
, vol.18
, pp. 6
-
-
Tsai, N.W.1
Lee, L.H.2
Huang, C.R.3
-
47
-
-
84871502638
-
Exploring the interaction between SNP genotype and postmenopausal hormone therapy effects on stroke risk
-
Y.Huang, D.G.Ballinger, R.Stokowski, Exploring the interaction between SNP genotype and postmenopausal hormone therapy effects on stroke risk. Genome Med 2012;4:57.
-
(2012)
Genome Med
, vol.4
, pp. 57
-
-
Huang, Y.1
Ballinger, D.G.2
Stokowski, R.3
-
48
-
-
33745897916
-
Serum cholesterol, haemorrhagic stroke, ischaemic stroke, and myocardial infarction: Korean national health system prospective cohort study
-
S.Ebrahim, J.Sung, Y.M.Song, Serum cholesterol, haemorrhagic stroke, ischaemic stroke, and myocardial infarction: Korean national health system prospective cohort study. BMJ 2006;333:22.
-
(2006)
BMJ
, vol.333
, pp. 22
-
-
Ebrahim, S.1
Sung, J.2
Song, Y.M.3
-
49
-
-
84922481055
-
Guideline-directed low-density lipoprotein management in high-risk patients with ischemic stroke: findings from get with the guidelines-stroke 2003 to 2012
-
G.Saposnik, G.C.Fonarow, W.Pan, Guideline-directed low-density lipoprotein management in high-risk patients with ischemic stroke: findings from get with the guidelines-stroke 2003 to 2012. Stroke 2014;45:3343–51.
-
(2014)
Stroke
, vol.45
, pp. 3343-3351
-
-
Saposnik, G.1
Fonarow, G.C.2
Pan, W.3
-
50
-
-
84908142482
-
Correlation of PCSK9 gene polymorphism with cerebral ischemic stroke in Xinjiang Han and Uygur populations
-
D.Han, J.Ma, X.Zhang, Correlation of PCSK9 gene polymorphism with cerebral ischemic stroke in Xinjiang Han and Uygur populations. Med Sci Monitor 2014;20:1758–67.
-
(2014)
Med Sci Monitor
, vol.20
, pp. 1758-1767
-
-
Han, D.1
Ma, J.2
Zhang, X.3
-
51
-
-
84921323646
-
Efficacy and safety of alirocumab, a fully human PCSK9 monoclonal antibody, in high cardiovascular risk patients with poorly controlled hypercholesterolemia on maximally tolerated doses of statins: rationale and design of the ODYSSEY COMBO I and II trials
-
H.M.Colhoun, J.G.Robinson, M.Farnier, Efficacy and safety of alirocumab, a fully human PCSK9 monoclonal antibody, in high cardiovascular risk patients with poorly controlled hypercholesterolemia on maximally tolerated doses of statins: rationale and design of the ODYSSEY COMBO I and II trials. BMC Cardiovascular Disorders 2014;14:121.
-
(2014)
BMC Cardiovascular Disorders
, vol.14
, pp. 121
-
-
Colhoun, H.M.1
Robinson, J.G.2
Farnier, M.3
-
52
-
-
84870056266
-
Proprotein convertase subtilisin/kexin type 9 inhibition
-
D.A.Marais, D.J.Blom, F.Petrides, Proprotein convertase subtilisin/kexin type 9 inhibition. Curr Opin Lipidology 2012;23:511–7.
-
(2012)
Curr Opin Lipidology
, vol.23
, pp. 511-517
-
-
Marais, D.A.1
Blom, D.J.2
Petrides, F.3
|