Association of serum proprotein convertase subtilisin/kexin type 9 with carotid intima media thickness in hypertensive subjects

Metabolism: Clinical and Experimental

Volumn 62, Issue 6, 2013, Pages 845-850

  Lee, Chan Joo ^a   Lee, Yong Ho ^a   Park, Sahng Wook ^a   Kim, Kwang Joon ^a   Park, Sungha ^a   Youn, Jong Chan ^a   Lee, Sang Hak ^a   Kang, Seok Min ^a   Jang, Yangsoo ^a  

^a Yonsei University College of Medicine   (South Korea)

Author keywords

Atherosclerosis; Carotid IMT (Intima media thickness); PCSK9

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; PCSK9 PROTEIN; PROTEIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADULT; ARTERIAL WALL THICKNESS; ARTICLE; ATHEROSCLEROSIS; CHOLESTEROL BLOOD LEVEL; FEMALE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL;

AGED; ATHEROSCLEROSIS; CAROTID INTIMA-MEDIA THICKNESS; DISEASE SUSCEPTIBILITY; FEMALE; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; PROPROTEIN CONVERTASES; SERINE ENDOPEPTIDASES;

EID: 84878013844     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2013.01.005     Document Type: Article

References (23)

1. D.W. Zhang, T.A. Lagace, and R. Garuti Binding of proprotein convertase subtilisin/kexin type 9 to epidermal growth factor-like repeat A of low density lipoprotein receptor decreases receptor recycling and increases degradation J Biol Chem 282 2007 18602 18612
2. T.A. Lagace, D.E. Curtis, and R. Garuti Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and in livers of parabiotic mice J Clin Invest 116 2006 2995 3005
3. A. Grefhorst, M.C. McNutt, and T.A. Lagace Plasma PCSK9 preferentially reduces liver LDL receptors in mice J Lipid Res 49 2008 1303 1311
4. R.J. Schmidt, T.P. Beyer, and W.R. Bensch Secreted proprotein convertase subtilisin/kexin type 9 reduces both hepatic and extrahepatic low-density lipoprotein receptors in vivo Biochem Biophys Res Commun 370 2008 634 640
5. D.C. Chan, and G.F. Watts Postprandial lipoprotein metabolism in familial hypercholesterolemia: thinking outside the box Metabolism 61 2012 3 11
6. M. Abifadel, M. Varret, and J.P. Rabes Mutations in PCSK9 cause autosomal dominant hypercholesterolemia Nat Genet 34 2003 154 156
7. J. Cohen, A. Pertsemlidis, and I.K. Kotowski Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9 Nat Genet 37 2005 161 165
8. J.C. Cohen, E. Boerwinkle, and T.H. Mosley Jr. Sequence variations in PCSK9, low LDL, and protection against coronary heart disease N Engl J Med 354 2006 1264 1272
9. S.G. Lakoski, T.A. Lagace, and J.C. Cohen Genetic and metabolic determinants of plasma PCSK9 levels J Clin Endocrinol Metab 94 2009 2537 2543
10. G. Lambert, N. Ancellin, and F. Charlton Plasma PCSK9 concentrations correlate with LDL and total cholesterol in diabetic patients and are decreased by fenofibrate treatment Clin Chem 54 2008 1038 1045
11. Q. Cui, X. Ju, and T. Yang Serum PCSK9 is associated with multiple metabolic factors in a large Han Chinese population Atherosclerosis 213 2010 632 636
12. J.D. Horton, J.C. Cohen, and H.H. Hobbs PCSK9: a convertase that coordinates LDL catabolism J Lipid Res 50 Suppl 2009 S172 S177
13. G.D. Norata, K. Garlaschelli, and L. Grigore Effects of PCSK9 variants on common carotid artery intima media thickness and relation to ApoE alleles Atherosclerosis 208 2010 177 182
14. E. de Groot, G.K. Hovingh, and A. Wiegman Measurement of arterial wall thickness as a surrogate marker for atherosclerosis Circulation 109 2004 III33 III38
15. M.W. Lorenz, H.S. Markus, and M.L. Bots Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis Circulation 115 2007 459 467
16. G. Welder, I. Zineh, and M.A. Pacanowski High-dose atorvastatin causes a rapid sustained increase in human serum PCSK9 and disrupts its correlation with LDL cholesterol J Lipid Res 51 2010 2714 2721
17. M. Suzuki, K. Shinozaki, and A. Kanazawa Insulin resistance as an independent risk factor for carotid wall thickening Hypertension 28 1996 593 598
18. P. Pauletto, P. Palatini, and S. Da Ros Factors underlying the increase in carotid intima-media thickness in borderline hypertensives Arterioscler Thromb Vasc Biol 19 1999 1231 1237
19. G. Vaudo, S. Marchesi, and D. Siepi Metabolic syndrome and preclinical atherosclerosis: focus on femoral arteries Metabolism 56 2007 541 546
20. D. Baldassarre, E. Tremoli, and G. Franceschini Plasma lipoprotein(a) is an independent factor associated with carotid wall thickening in severely but not moderately hypercholesterolemic patients Stroke 27 1996 1044 1049
21. A. Roubtsova, M.N. Munkonda, and Z. Awan Circulating proprotein convertase subtilisin/kexin 9 (PCSK9) regulates VLDLR protein and triglyceride accumulation in visceral adipose tissue Arterioscler Thromb Vasc Biol 31 2011 785 791
22. Y. Hayashi, K. Okumura, and H. Matsui Impact of low-density lipoprotein particle size on carotid intima-media thickness in patients with type 2 diabetes mellitus Metabolism 56 2007 608 613
23. V. Nambi, L. Chambless, and A.R. Folsom Carotid intima-media thickness and presence or absence of plaque improves prediction of coronary heart disease risk: the ARIC (Atherosclerosis Risk In Communities) study J Am Coll Cardiol 55 2010 1600 1607